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Search results 1001 to 1100 out of 1209 for Itch

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Type Details Score
Publication
31103358 | J:278487
First Author: Pagani M
Year: 2019
Journal: Neuron
Title: How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch.
Volume: 103
Issue: 1
Pages: 102-117.e5
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Publication
18931680 | J:143560
First Author: Yang B
Year: 2008
Journal: Nat Immunol
Title: Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells.
Volume: 9
Issue: 12
Pages: 1356-63
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Publication
21655234 | J:223911
First Author: Patel KN
Year: 2011
Journal: PLoS One
Title: Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.
Volume: 6
Issue: 5
Pages: e20559
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Publication
31676846 | J:283305
First Author: Bardoni R
Year: 2019
Journal: Sci Rep
Title: Pain Inhibits GRPR Neurons via GABAergic Signaling in the Spinal Cord.
Volume: 9
Issue: 1
Pages: 15804
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Publication
33247430 | J:312192
First Author: Agostinelli LJ
Year: 2021
Journal: J Comp Neurol
Title: Novel inhibitory brainstem neurons with selective projections to spinal lamina I reduce both pain and itch.
Volume: 529
Issue: 8
Pages: 2125-2137
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Publication
30944432 | J:277431
First Author: Nocchi L
Year: 2019
Journal: Nat Biomed Eng
Title: Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice.
Volume: 3
Issue: 2
Pages: 114-125
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Publication
34411514 | J:328598
First Author: Wimalasena NK
Year: 2021
Journal: Neuron
Title: Dissecting the precise nature of itch-evoked scratching.
Volume: 109
Issue: 19
Pages: 3075-3087.e2
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Publication
24094650 | J:334117
First Author: Wilson SR
Year: 2013
Journal: Cell
Title: The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch.
Volume: 155
Issue: 2
Pages: 285-95
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Publication
28219706 | J:318459
First Author: Azimi E
Year: 2017
Journal: J Allergy Clin Immunol
Title: Substance P activates Mas-related G protein-coupled receptors to induce itch.
Volume: 140
Issue: 2
Pages: 447-453.e3
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Publication
36272417 | J:349200
First Author: Okano M
Year: 2022
Journal: Immunity
Title: Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch.
Volume: 55
Issue: 12
Pages: 2352-2368.e7
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Publication
25420068 | J:356570
First Author: Usoskin D
Year: 2015
Journal: Nat Neurosci
Title: Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
Volume: 18
Issue: 1
Pages: 145-53
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Publication
15037633 | -
First Author: Shinohara T
Year: 2004
Journal: J Biol Chem
Title: Identification of a G protein-coupled receptor specifically responsive to beta-alanine.
Volume: 279
Issue: 22
Pages: 23559-64
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Protein Domain
IPR028328 | MRGPCRB8
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].Mas-related G protein-coupled receptors B are found in rodents and they are thought to be involved in the function of nociceptive neurons. The receptors are currently orphaned, no specific endogenous ligand having been identified.This entry represents mas-related G protein-coupled receptor B8.
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Protein Domain
IPR026230 | MRGPCRE
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor E, it is thought to be involved with nociceptor function and development, and is directly involved in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified.
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Protein Domain
IPR026232 | MRGPCRD
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor D (MRGPRD), it is thought to be involved with nociceptor function and development, and is directly involved in the modulation of pain. It has been demonstrated that beta-alanine can act as an agonist at MRGPRD [].
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Protein Domain
IPR026233 | MRGPCRA
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor A, it is found in rodents and is expressed only in specific subsets of sensory neurons that are known to detect painful stimuli. The receptor is coupled to the Galpha (q/11) signalling pathway, and potently activated by members of the rf-amide(npff/npaf) neuropeptide family. Stimulation by rf-amide agonists results in a dose-dependent release of free cytoplasmic Ca2+ [].
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Protein Domain
IPR027336 | MRGPCRG
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor G. It is thought to be involved with nociceptor function and development, and directly involved in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified.
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Protein Domain
IPR026221 | MRGPCRH
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor H. It is thought to be involved with nociceptor function and development, and directly involved in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified.
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Protein Domain
IPR026228 | MRGPCRF
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor F. It is thought to be involved with nociceptor function and development, and directly involved in the modulation of pain. The receptor is currently orphaned; however, it is thought to be activated by a neuropeptide.
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Protein
Q91ZB5
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
A0A140LHD7
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
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Protein
E0CX40
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Publication
11850634 | J:74961
First Author: Lembo PM
Year: 2002
Journal: Nat Neurosci
Title: Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.
Volume: 5
Issue: 3
Pages: 201-9
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Publication
12915402 | -
First Author: Robas N
Year: 2003
Journal: J Biol Chem
Title: MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.
Volume: 278
Issue: 45
Pages: 44400-4
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Publication
15862286 | -
 
First Author: Yang S
Year: 2005
Journal: Gene
Title: Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception.
Volume: 352
Pages: 30-5
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Publication
15823563 | -
First Author: Kamohara M
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides.
Volume: 330
Issue: 4
Pages: 1146-52
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Protein Domain
IPR027338 | MRGPCRX1/MRGPCRX2
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents Mas-related G protein-coupled receptor X1 and X2.Mas-related G protein-coupled receptor X1 (MRGPRX1) is thought to be involved with nociceptor function and development, and in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified. However, it may potently be activated by enkephalins: BAM22 evokes a large and dose-dependent release of intracellular calcium in cells stably transfected with the receptor []. Mas-related G protein-coupled receptor X2 (MRGPRX2) is thought to be involved with nociceptor function and development, and directly involved in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified. However, it may be activated by neuropeptides: stimulation by cortistatin-14 in receptor-expressing cells potently increases intracellular Ca2 [, ]. MRGPRX2 is also thought to be a human PAMP-12 receptor that regulates catecholamine secretion from adrenal glands [].
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Publication
- | J:163587
 
First Author: Cattanach BM
Year: 1987
Journal: Mouse News Lett
Title: Agouti locus mutations at Harwell
Volume: 77
Pages: 123-125
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Publication
24520172 | J:206813
First Author: Altin JA
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells.
Volume: 111
Issue: 6
Pages: 2067-74
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Publication
21933692 | J:320340
First Author: Andoh T
Year: 2011
Journal: Peptides
Title: Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice.
Volume: 32
Issue: 10
Pages: 2098-103
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Publication
25092867 | J:224341
First Author: Chen XL
Year: 2014
Journal: Mol Cell Biol
Title: Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.
Volume: 34
Issue: 20
Pages: 3855-66
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Publication
24140646 | J:207026
First Author: Oh MH
Year: 2013
Journal: J Immunol
Title: TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis.
Volume: 191
Issue: 11
Pages: 5371-82
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Publication
16945588 | J:115967
First Author: Chang X
Year: 2006
Journal: Clin Immunol
Title: Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection.
Volume: 121
Issue: 3
Pages: 274-85
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Publication
37984799 | J:351162
First Author: Trier AM
Year: 2024
Journal: J Allergy Clin Immunol
Title: IL-33 potentiates histaminergic itch.
Volume: 153
Issue: 3
Pages: 852-859.e3
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Publication
33753496 | J:304478
 
First Author: Voisin T
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch.
Volume: 118
Issue: 13
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Publication
22504036 | J:196831
 
First Author: Andoh T
Year: 2012
Journal: Exp Eye Res
Title: Involvement of leukotriene B4 in itching in a mouse model of ocular allergy.
Volume: 98
Pages: 97-103
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Publication
17208599 | J:169999
First Author: Dunford PJ
Year: 2007
Journal: J Allergy Clin Immunol
Title: Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus.
Volume: 119
Issue: 1
Pages: 176-83
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Publication
29866844 | J:263966
First Author: Zhang Y
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: BP180 dysfunction triggers spontaneous skin inflammation in mice.
Volume: 115
Issue: 25
Pages: 6434-6439
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Publication
33039402 | J:307431
First Author: Liu X
Year: 2021
Journal: J Invest Dermatol
Title: GRPR/Extracellular Signal-Regulated Kinase and NPRA/Extracellular Signal-Regulated Kinase Signaling Pathways Play a Critical Role in Spinal Transmission of Chronic Itch.
Volume: 141
Issue: 4
Pages: 863-873
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Publication
26193341 | J:228834
First Author: Shiratori-Hayashi M
Year: 2015
Journal: Nat Med
Title: STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.
Volume: 21
Issue: 8
Pages: 927-31
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Publication
29474943 | J:264080
First Author: Matsumoto A
Year: 2018
Journal: J Invest Dermatol
Title: Attenuated Activation of Homeostatic Glucocorticoid in Keratinocytes Induces Alloknesis via Aberrant Artemin Production.
Volume: 138
Issue: 7
Pages: 1491-1500
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Publication
19564617 | J:150810
First Author: Imamachi N
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.
Volume: 106
Issue: 27
Pages: 11330-5
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Publication
32089077 | J:304239
 
First Author: Kittaka H
Year: 2020
Journal: Mol Pain
Title: Differential contribution of sensory transient receptor potential channels in response to the bioactive lipid sphingosine-1-phosphate.
Volume: 16
Pages: 1744806920903515
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Publication
24812665 | J:212917
First Author: Kido-Nakahara M
Year: 2014
Journal: J Clin Invest
Title: Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus.
Volume: 124
Issue: 6
Pages: 2683-95
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Publication
27566399 | J:238283
First Author: Lin SH
Year: 2017
Journal: J Invest Dermatol
Title: Involvement of TRPV1 and TDAG8 in Pruriception Associated with Noxious Acidosis.
Volume: 137
Issue: 1
Pages: 170-178
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Publication
22565312 | J:188291
First Author: Liu T
Year: 2012
Journal: J Clin Invest
Title: TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.
Volume: 122
Issue: 6
Pages: 2195-207
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Publication
30527377 | J:295541
First Author: Zhou Y
Year: 2018
Journal: J Dermatol Sci
Title: TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.
Volume: 92
Issue: 3
Pages: 264-271
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Publication
26763435 | J:229909
First Author: Akiyama T
Year: 2016
Journal: J Invest Dermatol
Title: Involvement of TRPV4 in Serotonin-Evoked Scratching.
Volume: 136
Issue: 1
Pages: 154-60
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Publication
25589759 | J:248632
First Author: Solorzano C
Year: 2015
Journal: J Neurosci
Title: Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns.
Volume: 35
Issue: 2
Pages: 648-57
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Publication
30087177 | J:284366
 
First Author: Ho JH
Year: 2018
Journal: Sci Signal
Title: G protein signaling-biased agonism at the κ-opioid receptor is maintained in striatal neurons.
Volume: 11
Issue: 542
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Publication
30395542 | J:270913
First Author: Salvatierra J
Year: 2018
Journal: J Clin Invest
Title: A disease mutation reveals a role for NaV1.9 in acute itch.
Volume: 128
Issue: 12
Pages: 5434-5447
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Publication
30627644 | J:295047
 
First Author: Dembo T
Year: 2018
Journal: eNeuro
Title: Primary Afferent-Derived BDNF Contributes Minimally to the Processing of Pain and Itch.
Volume: 5
Issue: 6
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Publication
31954829 | J:291794
 
First Author: Wang TT
Year: 2020
Journal: Neuroscience
Title: Activation of Different Heterodimers of TLR2 Distinctly Mediates Pain and Itch.
Volume: 429
Pages: 245-255
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Publication
22787056 | J:186470
First Author: Lopes C
Year: 2012
Journal: J Neurosci
Title: Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.
Volume: 32
Issue: 28
Pages: 9706-15
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Publication
15740588 | J:109809
First Author: Seike M
Year: 2005
Journal: Exp Dermatol
Title: Inhibition of scratching behaviour caused by contact dermatitis in histidine decarboxylase gene knockout mice.
Volume: 14
Issue: 3
Pages: 169-75
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Publication
33636390 | J:307695
 
First Author: Tang J
Year: 2021
Journal: Neurobiol Dis
Title: ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis.
Volume: 153
Pages: 105315
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Publication
38302010 | J:360534
First Author: Yeo H
Year: 2024
Journal: J Invest Dermatol
Title: The EGR1-Artemin Axis in Keratinocytes Enhances the Innervation of Epidermal Sensory Neurons during Skin Inflammation Induced by House Dust Mite Extract from Dermatophagoidesfarinae.
Volume: 144
Issue: 8
Pages: 1817-1828.e17
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Publication
22563493 | J:187267
First Author: McCoy ES
Year: 2012
Journal: PLoS One
Title: CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.
Volume: 7
Issue: 5
Pages: e36355
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Publication
39218273 | J:353788
First Author: Tang Y
Year: 2024
Journal: Biochim Biophys Acta Mol Basis Dis
Title: TRPV4-β-catenin axis is a novel therapeutic target for dry skin-induced chronic itch.
Volume: 1870
Issue: 8
Pages: 167491
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Publication
30637823 | J:273154
First Author: Robering JW
Year: 2019
Journal: Glia
Title: Lysophosphatidic acid activates satellite glia cells and Schwann cells.
Volume: 67
Issue: 5
Pages: 999-1012
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Publication
34560104 | J:351163
First Author: Trier AM
Year: 2022
Journal: J Allergy Clin Immunol
Title: IL-33 signaling in sensory neurons promotes dry skin itch.
Volume: 149
Issue: 4
Pages: 1473-1480.e6
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Publication
26775031 | J:255360
First Author: Bolier R
Year: 2016
Journal: Biochim Biophys Acta
Title: Enteroendocrine cells are a potential source of serum autotaxin in men.
Volume: 1862
Issue: 4
Pages: 696-704
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Publication
33819507 | J:343991
First Author: Kamikaseda Y
Year: 2021
Journal: J Allergy Clin Immunol
Title: Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.
Volume: 148
Issue: 2
Pages: 633-638
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Publication
30108138 | J:321494
First Author: Sun XY
Year: 2018
Journal: Mol Pharmacol
Title: Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of Thermosensitive TRPV3 Channel in the Skin.
Volume: 94
Issue: 4
Pages: 1164-1173
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Publication
25955385 | J:226002
First Author: Patricio ES
Year: 2015
Journal: J Invest Dermatol
Title: Mechanisms Underlying the Scratching Behavior Induced by the Activation of Proteinase-Activated Receptor-4 in Mice.
Volume: 135
Issue: 10
Pages: 2484-2491
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Publication
31536477 | J:287663
 
First Author: Castro J
Year: 2019
Journal: JCI Insight
Title: Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity.
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