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Search results 1001 to 1089 out of 1089 for Jak2

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Type Details Score
Publication
First Author: Magni P
Year: 2007
Journal: Mol Endocrinol
Title: Leukemia inhibitory factor induces the chemomigration of immortalized gonadotropin-releasing hormone neurons through the independent activation of the Janus kinase/signal transducer and activator of transcription 3, mitogen-activated protein kinase/extracellularly regulated kinase 1/2, and phosphatidylinositol 3-kinase/Akt signaling pathways.
Volume: 21
Issue: 5
Pages: 1163-74
Publication
First Author: Huang Z
Year: 2007
Journal: J Clin Invest
Title: STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice.
Volume: 117
Issue: 12
Pages: 3890-9
Publication
First Author: Zhang Z
Year: 2009
Journal: J Biol Chem
Title: Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3.
Volume: 284
Issue: 5
Pages: 3345-53
Publication
First Author: Ma Y
Year: 2009
Journal: Biochim Biophys Acta
Title: Real-time bioluminescence imaging of polycythemia vera development in mice.
Volume: 1792
Issue: 11
Pages: 1073-9
Publication
First Author: Venkitachalam S
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene.
Volume: 417
Issue: 3
Pages: 1058-62
Publication
First Author: Akada H
Year: 2012
Journal: Blood
Title: Efficacy of vorinostat in a murine model of polycythemia vera.
Volume: 119
Issue: 16
Pages: 3779-89
Publication
First Author: Yue H
Year: 2012
Journal: Biochim Biophys Acta
Title: Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3.
Volume: 1823
Issue: 8
Pages: 1316-23
Publication
First Author: Lin X
Year: 2013
Journal: Leukemia
Title: miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation.
Volume: 27
Issue: 2
Pages: 344-52
Publication
First Author: Takeshita Y
Year: 2013
Journal: J Biol Chem
Title: SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.
Volume: 288
Issue: 34
Pages: 24691-704
Publication
First Author: Montresor A
Year: 2013
Journal: J Cell Biol
Title: JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation.
Volume: 203
Issue: 6
Pages: 1003-19
Publication
First Author: Yoda A
Year: 2015
Journal: Nat Med
Title: Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.
Volume: 21
Issue: 1
Pages: 71-5
Publication
First Author: Prick J
Year: 2014
Journal: Exp Hematol
Title: Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms.
Volume: 42
Issue: 10
Pages: 841-51
Publication
First Author: Pomicter AD
Year: 2015
Journal: Exp Hematol
Title: Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm.
Volume: 43
Issue: 7
Pages: 537-45.e1-11
Publication
First Author: Murakami K
Year: 2017
Journal: PLoS One
Title: A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro.
Volume: 12
Issue: 7
Pages: e0181126
Publication
First Author: Silva JV
Year: 2017
Journal: Biochim Biophys Acta
Title: Construction and analysis of a human testis/sperm-enriched interaction network: Unraveling the PPP1CC2 interactome.
Volume: 1861
Issue: 2
Pages: 375-385
Publication  
First Author: He W
Year: 2017
Journal: Biochem Pharmacol
Title: A Jak2-selective inhibitor potently reverses the immune suppression by modulating the tumor microenvironment for cancer immunotherapy.
Volume: 145
Pages: 132-146
Publication
First Author: Fenelon JC
Year: 2019
Journal: Zygote
Title: Focal adhesion kinase PTK2 autophosphorylation is not required for the activation of sodium-hydrogen exchange by decreased cell volume in the preimplantation mouse embryo.
Volume: 27
Issue: 3
Pages: 173-179
Publication
First Author: Liu K
Year: 2016
Journal: Exp Ther Med
Title: Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice.
Volume: 12
Issue: 2
Pages: 1153-1158
Publication  
First Author: Li SJ
Year: 2019
Journal: Neurosci Lett
Title: EPO promotes axonal sprouting via upregulating GDF10.
Volume: 711
Pages: 134412
Publication  
First Author: Barnes TM
Year: 2020
Journal: Mol Metab
Title: Identification of the leptin receptor sequences crucial for the STAT3-Independent control of metabolism.
Volume: 32
Pages: 168-175
Publication
First Author: Jayavelu AK
Year: 2020
Journal: Nature
Title: Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Volume: 588
Issue: 7836
Pages: 157-163
Publication
First Author: Dutta A
Year: 2021
Journal: Cancer Res
Title: CDK6 Is a Therapeutic Target in Myelofibrosis.
Volume: 81
Issue: 16
Pages: 4332-4345
Publication
First Author: Yin K
Year: 2013
Journal: Acta Pharmacol Sin
Title: Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE(-/-) mice possibly via activated STAT3-mediated upregulation of tristetraprolin.
Volume: 34
Issue: 6
Pages: 837-46
Publication  
First Author: Dong X
Year: 2021
Journal: Int Immunopharmacol
Title: Intrauterine hyperglycemia induces liver inflammation in mouse male offspring.
Volume: 99
Pages: 107974
Publication
First Author: Li J
Year: 2021
Journal: Cell Death Dis
Title: CHBP induces stronger immunosuppressive CD127(+) M-MDSC via erythropoietin receptor.
Volume: 12
Issue: 2
Pages: 177
Publication
First Author: Matsuura S
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice.
Volume: 40
Issue: 10
Pages: e262-e272
Publication
First Author: Antonia RJ
Year: 2022
Journal: J Cell Mol Med
Title: STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20.
Volume: 26
Issue: 16
Pages: 4591-4601
Publication  
First Author: Li H
Year: 2022
Journal: Cells
Title: The Structure, Function and Regulation of Protein Tyrosine Phosphatase Receptor Type J and Its Role in Diseases.
Volume: 12
Issue: 1
Publication
First Author: Baek KH
Year: 2004
Journal: J Biol Chem
Title: DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.
Volume: 279
Issue: 4
Pages: 2368-76
Publication
First Author: Yoshimura A
Year: 1996
Journal: EMBO J
Title: Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.
Volume: 15
Issue: 5
Pages: 1055-63
Publication  
First Author: Ding X
Year: 2017
Journal: Gene
Title: Leptin siRNA promotes ovarian granulosa cell apoptosis and affects steroidogenesis by increasing NPY2 receptor expression.
Volume: 633
Pages: 28-34
Publication
First Author: Dawn B
Year: 2004
Journal: Cardiovasc Res
Title: IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2.
Volume: 64
Issue: 1
Pages: 61-71
Publication
First Author: Jaiswal S
Year: 2017
Journal: N Engl J Med
Title: Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.
Volume: 377
Issue: 2
Pages: 111-121
Publication
First Author: Pang Q
Year: 2000
Journal: Mol Cell Biol
Title: The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors.
Volume: 20
Issue: 13
Pages: 4724-35
Publication
First Author: Porpaczy E
Year: 2018
Journal: Blood
Title: Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy.
Volume: 132
Issue: 7
Pages: 694-706
Publication
First Author: Woo YD
Year: 2021
Journal: J Allergy Clin Immunol
Title: Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine-tuning of GM-CSF receptor signaling.
Volume: 147
Issue: 4
Pages: 1242-1260
Publication
First Author: Zhang YG
Year: 2020
Journal: Cell Mol Gastroenterol Hepatol
Title: Vitamin D Receptor Protects Against Dysbiosis and Tumorigenesis via the JAK/STAT Pathway in Intestine.
Volume: 10
Issue: 4
Pages: 729-746
Publication  
First Author: Chhabra Y
Year: 2024
Journal: Endocrinology
Title: Roles of Growth Hormone-Dependent JAK-STAT5 and Lyn Kinase Signaling in Determining Lifespan and Cancer Incidence.
Volume: 165
Issue: 11
Publication
First Author: Lakshmanan I
Year: 2017
Journal: Clin Cancer Res
Title: MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53.
Volume: 23
Issue: 14
Pages: 3906-3917
Publication
First Author: Tong W
Year: 2007
Journal: Exp Hematol
Title: Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal.
Volume: 35
Issue: 9
Pages: 1447-55
Publication
First Author: He L
Year: 2019
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Renin-angiotensin system promotes colonic inflammation by inducing T(H)17 activation via JAK2/STAT pathway.
Volume: 316
Issue: 6
Pages: G774-G784
Publication
First Author: Jiang H
Year: 2020
Journal: Blood
Title: The role of AGK in thrombocytopoiesis and possible therapeutic strategies.
Volume: 136
Issue: 1
Pages: 119-129
Publication
First Author: Huang YQ
Year: 2000
Journal: J Biol Chem
Title: Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway.
Volume: 275
Issue: 9
Pages: 6462-8
Publication
First Author: Xu X
Year: 1995
Journal: Endocrinology
Title: Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age.
Volume: 136
Issue: 10
Pages: 4551-7
Publication
First Author: Chin H
Year: 1996
Journal: Blood
Title: Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3.
Volume: 88
Issue: 12
Pages: 4415-25
Publication
First Author: Ilaria RL Jr
Year: 1999
Journal: Blood
Title: Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation.
Volume: 93
Issue: 12
Pages: 4154-66
Publication
First Author: Yang FC
Year: 1999
Journal: Blood
Title: Differential effects of human granulocyte colony-stimulating factor (hG-CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice.
Volume: 94
Issue: 3
Pages: 950-8
Publication
First Author: Hintzen C
Year: 2008
Journal: J Immunol
Title: Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression.
Volume: 181
Issue: 10
Pages: 7341-9
Publication
First Author: Espinoza-Derout J
Year: 2007
Journal: Cardiovasc Res
Title: Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy.
Volume: 75
Issue: 1
Pages: 129-38
Publication
First Author: Chaturvedi P
Year: 1998
Journal: Oncogene
Title: Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation.
Volume: 16
Issue: 13
Pages: 1749-58
Publication
First Author: Pauloin A
Year: 2012
Journal: Biochim Biophys Acta
Title: Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway.
Volume: 1823
Issue: 5
Pages: 987-96
Publication
First Author: Gan Y
Year: 2014
Journal: Mol Endocrinol
Title: Human GH receptor-IGF-1 receptor interaction: implications for GH signaling.
Volume: 28
Issue: 11
Pages: 1841-54
Publication
First Author: Buchholz B
Year: 2018
Journal: Am J Physiol Heart Circ Physiol
Title: Vagal stimulation mimics preconditioning and postconditioning of ischemic myocardium in mice by activating different protection mechanisms.
Volume: 314
Issue: 6
Pages: H1289-H1297
Publication
First Author: Dieter BP
Year: 2019
Journal: PLoS One
Title: Serum amyloid A and Janus kinase 2 in a mouse model of diabetic kidney disease.
Volume: 14
Issue: 2
Pages: e0211555
Publication
First Author: Mager LF
Year: 2015
Journal: J Clin Invest
Title: IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms.
Volume: 125
Issue: 7
Pages: 2579-91
Publication
First Author: Dou H
Year: 2021
Journal: Circulation
Title: Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.
Volume: 144
Issue: 24
Pages: 1940-1954
Publication  
First Author: Ebong S
Year: 2004
Journal: Mol Vis
Title: Characterization of the roles of STAT1 and STAT3 signal transduction pathways in mammalian lens development.
Volume: 10
Pages: 122-31
Publication
First Author: Tu X
Year: 2018
Journal: Reprod Biol Endocrinol
Title: The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.
Volume: 16
Issue: 1
Pages: 44
Publication
First Author: Hunter S
Year: 1999
Journal: J Biol Chem
Title: Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
Volume: 274
Issue: 4
Pages: 2097-106
Publication
First Author: Pestka S
Year: 1997
Journal: Semin Oncol
Title: The interferon receptors.
Volume: 24
Issue: 3 Suppl 9
Pages: S9-18-S9-40
Publication
First Author: Simoncic PD
Year: 2002
Journal: Curr Biol
Title: The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.
Volume: 12
Issue: 6
Pages: 446-53
Publication
First Author: Usacheva A
Year: 2002
Journal: J Immunol
Title: Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors.
Volume: 169
Issue: 3
Pages: 1302-8
Publication
First Author: Gruber CN
Year: 2020
Journal: Immunity
Title: Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function.
Volume: 53
Issue: 3
Pages: 672-684.e11
Protein Domain
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].Janus kinases (JAKs) are tyrosine kinases that function in membrane-proximal signalling events initiated by a variety of extracellular factors binding to cell surface receptors []. Many type I and II cytokine receptors lack a protein tyrosine kinase domain and rely on JAKs to initiate the cytoplasmic signal transduction cascade. Ligand binding induces oligomerisation of the receptors, which then activates the cytoplasmic receptor-associated JAKs. These subsequently phosphorylate tyrosine residues along the receptor chains with which they are associated. The phosphotyrosine residues are a target for a variety of SH2 domain-containing transducer proteins. Amongst these are the signal transducers and activators of transcription (STAT) proteins, which, after binding to the receptor chains, are phosphorylated by the JAK proteins. Phosphorylation enables the STAT proteins to dimerise and translocate into the nucleus, where they alter the expression of cytokine-regulated genes. This system is known as the JAK-STAT pathway.Four mammalian JAK family members have been identified: JAK1, JAK2, JAK3, and TYK2. They are relatively large kinases of approximately 1150 amino acids, with molecular weights of ~120-130kDa. Their amino acid sequences are characterised by the presence of 7 highly conserved domains, termed JAK homology (JH) domains. The C-terminal domain (JH1) is responsible for the tyrosine kinase function. The next domain in the sequence (JH2) is known as the tyrosine kinase-like domain, as its sequence shows high similarity to functional kinases but does not possess any catalytic activity. Although the function of this domain is not well established, there is some evidence for a regulatory role on the JH1 domain, thus modulating catalytic activity. The N-terminal portion of the JAKs (spanning JH7 to JH3) is important for receptor association and non-catalytic activity, and consists of JH3-JH4, which is homologous to the SH2 domain, and lastly JH5-JH7, which is a FERM domain.This represents the non-receptor tyrosine kinase JAK1, which is involved in the IFN-alpha/beta/gamma signal pathway. Jak1 acts as the kinase partner for the interleukin (IL)-2 receptor []and interleukin (IL)-10 receptor []. It directly phosphorylates STAT but also activates STAT signalling through the transactivation of other JAK kinases associated with signalling receptors [, ].JAK1 was initially cloned using a PCR-based strategy utilising degenerateprimers corresponding to conserved motifs within the catalytic domain of protein-tyrosine kinases []. In common with JAK2 and TYK2, and by contrastwith JAK3, JAK1 appears to be ubiquitously expressed.
Protein
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
Publication  
First Author: Kasembeli MM
Year: 2009
Journal: Front Biosci (Landmark Ed)
Title: SH2 domain binding to phosphopeptide ligands: potential for drug targeting.
Volume: 14
Pages: 1010-22
Publication
First Author: Filippakopoulos P
Year: 2009
Journal: Curr Opin Struct Biol
Title: SH2 domains: modulators of nonreceptor tyrosine kinase activity.
Volume: 19
Issue: 6
Pages: 643-9
Protein
Organism: Mus musculus/domesticus
Length: 1153  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1126  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1153  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1153  
Fragment?: false
Publication
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
Publication
First Author: Sharma PS
Year: 2009
Journal: Curr Pharm Des
Title: Receptor tyrosine kinase inhibitors as potent weapons in war against cancers.
Volume: 15
Issue: 7
Pages: 758-76
Publication
First Author: Li E
Year: 2006
Journal: Biochemistry
Title: Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies.
Volume: 45
Issue: 20
Pages: 6241-51
Publication
First Author: Roskoski R Jr
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Src kinase regulation by phosphorylation and dephosphorylation.
Volume: 331
Issue: 1
Pages: 1-14
Publication
First Author: Hanks SK
Year: 1988
Journal: Science
Title: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Volume: 241
Issue: 4861
Pages: 42-52
Publication
First Author: Manning G
Year: 2002
Journal: Trends Biochem Sci
Title: Evolution of protein kinase signaling from yeast to man.
Volume: 27
Issue: 10
Pages: 514-20
Publication
First Author: Manning G
Year: 2002
Journal: Science
Title: The protein kinase complement of the human genome.
Volume: 298
Issue: 5600
Pages: 1912-34
Publication
First Author: Stout TJ
Year: 2004
Journal: Curr Pharm Des
Title: High-throughput structural biology in drug discovery: protein kinases.
Volume: 10
Issue: 10
Pages: 1069-82
Publication
First Author: Li B
Year: 2004
Journal: Comb Chem High Throughput Screen
Title: Creating chemical diversity to target protein kinases.
Volume: 7
Issue: 5
Pages: 453-72
Publication      
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112