Type |
Details |
Score |
Publication |
First Author: |
Magni P |
Year: |
2007 |
Journal: |
Mol Endocrinol |
Title: |
Leukemia inhibitory factor induces the chemomigration of immortalized gonadotropin-releasing hormone neurons through the independent activation of the Janus kinase/signal transducer and activator of transcription 3, mitogen-activated protein kinase/extracellularly regulated kinase 1/2, and phosphatidylinositol 3-kinase/Akt signaling pathways. |
Volume: |
21 |
Issue: |
5 |
Pages: |
1163-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang Z |
Year: |
2007 |
Journal: |
J Clin Invest |
Title: |
STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice. |
Volume: |
117 |
Issue: |
12 |
Pages: |
3890-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Z |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3. |
Volume: |
284 |
Issue: |
5 |
Pages: |
3345-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma Y |
Year: |
2009 |
Journal: |
Biochim Biophys Acta |
Title: |
Real-time bioluminescence imaging of polycythemia vera development in mice. |
Volume: |
1792 |
Issue: |
11 |
Pages: |
1073-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Venkitachalam S |
Year: |
2012 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene. |
Volume: |
417 |
Issue: |
3 |
Pages: |
1058-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Akada H |
Year: |
2012 |
Journal: |
Blood |
Title: |
Efficacy of vorinostat in a murine model of polycythemia vera. |
Volume: |
119 |
Issue: |
16 |
Pages: |
3779-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yue H |
Year: |
2012 |
Journal: |
Biochim Biophys Acta |
Title: |
Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3. |
Volume: |
1823 |
Issue: |
8 |
Pages: |
1316-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin X |
Year: |
2013 |
Journal: |
Leukemia |
Title: |
miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation. |
Volume: |
27 |
Issue: |
2 |
Pages: |
344-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeshita Y |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase. |
Volume: |
288 |
Issue: |
34 |
Pages: |
24691-704 |
|
•
•
•
•
•
|
Publication |
First Author: |
Montresor A |
Year: |
2013 |
Journal: |
J Cell Biol |
Title: |
JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation. |
Volume: |
203 |
Issue: |
6 |
Pages: |
1003-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoda A |
Year: |
2015 |
Journal: |
Nat Med |
Title: |
Mutations in G protein β subunits promote transformation and kinase inhibitor resistance. |
Volume: |
21 |
Issue: |
1 |
Pages: |
71-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Prick J |
Year: |
2014 |
Journal: |
Exp Hematol |
Title: |
Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms. |
Volume: |
42 |
Issue: |
10 |
Pages: |
841-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pomicter AD |
Year: |
2015 |
Journal: |
Exp Hematol |
Title: |
Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm. |
Volume: |
43 |
Issue: |
7 |
Pages: |
537-45.e1-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murakami K |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro. |
Volume: |
12 |
Issue: |
7 |
Pages: |
e0181126 |
|
•
•
•
•
•
|
Publication |
First Author: |
Silva JV |
Year: |
2017 |
Journal: |
Biochim Biophys Acta |
Title: |
Construction and analysis of a human testis/sperm-enriched interaction network: Unraveling the PPP1CC2 interactome. |
Volume: |
1861 |
Issue: |
2 |
Pages: |
375-385 |
|
•
•
•
•
•
|
Publication |
First Author: |
He W |
Year: |
2017 |
Journal: |
Biochem Pharmacol |
Title: |
A Jak2-selective inhibitor potently reverses the immune suppression by modulating the tumor microenvironment for cancer immunotherapy. |
Volume: |
145 |
|
Pages: |
132-146 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fenelon JC |
Year: |
2019 |
Journal: |
Zygote |
Title: |
Focal adhesion kinase PTK2 autophosphorylation is not required for the activation of sodium-hydrogen exchange by decreased cell volume in the preimplantation mouse embryo. |
Volume: |
27 |
Issue: |
3 |
Pages: |
173-179 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu K |
Year: |
2016 |
Journal: |
Exp Ther Med |
Title: |
Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice. |
Volume: |
12 |
Issue: |
2 |
Pages: |
1153-1158 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li SJ |
Year: |
2019 |
Journal: |
Neurosci Lett |
Title: |
EPO promotes axonal sprouting via upregulating GDF10. |
Volume: |
711 |
|
Pages: |
134412 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barnes TM |
Year: |
2020 |
Journal: |
Mol Metab |
Title: |
Identification of the leptin receptor sequences crucial for the STAT3-Independent control of metabolism. |
Volume: |
32 |
|
Pages: |
168-175 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jayavelu AK |
Year: |
2020 |
Journal: |
Nature |
Title: |
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms. |
Volume: |
588 |
Issue: |
7836 |
Pages: |
157-163 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dutta A |
Year: |
2021 |
Journal: |
Cancer Res |
Title: |
CDK6 Is a Therapeutic Target in Myelofibrosis. |
Volume: |
81 |
Issue: |
16 |
Pages: |
4332-4345 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yin K |
Year: |
2013 |
Journal: |
Acta Pharmacol Sin |
Title: |
Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE(-/-) mice possibly via activated STAT3-mediated upregulation of tristetraprolin. |
Volume: |
34 |
Issue: |
6 |
Pages: |
837-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dong X |
Year: |
2021 |
Journal: |
Int Immunopharmacol |
Title: |
Intrauterine hyperglycemia induces liver inflammation in mouse male offspring. |
Volume: |
99 |
|
Pages: |
107974 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2021 |
Journal: |
Cell Death Dis |
Title: |
CHBP induces stronger immunosuppressive CD127(+) M-MDSC via erythropoietin receptor. |
Volume: |
12 |
Issue: |
2 |
Pages: |
177 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuura S |
Year: |
2020 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice. |
Volume: |
40 |
Issue: |
10 |
Pages: |
e262-e272 |
|
•
•
•
•
•
|
Publication |
First Author: |
Antonia RJ |
Year: |
2022 |
Journal: |
J Cell Mol Med |
Title: |
STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20. |
Volume: |
26 |
Issue: |
16 |
Pages: |
4591-4601 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li H |
Year: |
2022 |
Journal: |
Cells |
Title: |
The Structure, Function and Regulation of Protein Tyrosine Phosphatase Receptor Type J and Its Role in Diseases. |
Volume: |
12 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Baek KH |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes. |
Volume: |
279 |
Issue: |
4 |
Pages: |
2368-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshimura A |
Year: |
1996 |
Journal: |
EMBO J |
Title: |
Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway. |
Volume: |
15 |
Issue: |
5 |
Pages: |
1055-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding X |
Year: |
2017 |
Journal: |
Gene |
Title: |
Leptin siRNA promotes ovarian granulosa cell apoptosis and affects steroidogenesis by increasing NPY2 receptor expression. |
Volume: |
633 |
|
Pages: |
28-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dawn B |
Year: |
2004 |
Journal: |
Cardiovasc Res |
Title: |
IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2. |
Volume: |
64 |
Issue: |
1 |
Pages: |
61-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jaiswal S |
Year: |
2017 |
Journal: |
N Engl J Med |
Title: |
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. |
Volume: |
377 |
Issue: |
2 |
Pages: |
111-121 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pang Q |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. |
Volume: |
20 |
Issue: |
13 |
Pages: |
4724-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Porpaczy E |
Year: |
2018 |
Journal: |
Blood |
Title: |
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy. |
Volume: |
132 |
Issue: |
7 |
Pages: |
694-706 |
|
•
•
•
•
•
|
Publication |
First Author: |
Woo YD |
Year: |
2021 |
Journal: |
J Allergy Clin Immunol |
Title: |
Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine-tuning of GM-CSF receptor signaling. |
Volume: |
147 |
Issue: |
4 |
Pages: |
1242-1260 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang YG |
Year: |
2020 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Vitamin D Receptor Protects Against Dysbiosis and Tumorigenesis via the JAK/STAT Pathway in Intestine. |
Volume: |
10 |
Issue: |
4 |
Pages: |
729-746 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chhabra Y |
Year: |
2024 |
Journal: |
Endocrinology |
Title: |
Roles of Growth Hormone-Dependent JAK-STAT5 and Lyn Kinase Signaling in Determining Lifespan and Cancer Incidence. |
Volume: |
165 |
Issue: |
11 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lakshmanan I |
Year: |
2017 |
Journal: |
Clin Cancer Res |
Title: |
MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53. |
Volume: |
23 |
Issue: |
14 |
Pages: |
3906-3917 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tong W |
Year: |
2007 |
Journal: |
Exp Hematol |
Title: |
Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal. |
Volume: |
35 |
Issue: |
9 |
Pages: |
1447-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
He L |
Year: |
2019 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Renin-angiotensin system promotes colonic inflammation by inducing T(H)17 activation via JAK2/STAT pathway. |
Volume: |
316 |
Issue: |
6 |
Pages: |
G774-G784 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang H |
Year: |
2020 |
Journal: |
Blood |
Title: |
The role of AGK in thrombocytopoiesis and possible therapeutic strategies. |
Volume: |
136 |
Issue: |
1 |
Pages: |
119-129 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang YQ |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway. |
Volume: |
275 |
Issue: |
9 |
Pages: |
6462-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu X |
Year: |
1995 |
Journal: |
Endocrinology |
Title: |
Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age. |
Volume: |
136 |
Issue: |
10 |
Pages: |
4551-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chin H |
Year: |
1996 |
Journal: |
Blood |
Title: |
Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. |
Volume: |
88 |
Issue: |
12 |
Pages: |
4415-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ilaria RL Jr |
Year: |
1999 |
Journal: |
Blood |
Title: |
Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation. |
Volume: |
93 |
Issue: |
12 |
Pages: |
4154-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang FC |
Year: |
1999 |
Journal: |
Blood |
Title: |
Differential effects of human granulocyte colony-stimulating factor (hG-CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice. |
Volume: |
94 |
Issue: |
3 |
Pages: |
950-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hintzen C |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression. |
Volume: |
181 |
Issue: |
10 |
Pages: |
7341-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Espinoza-Derout J |
Year: |
2007 |
Journal: |
Cardiovasc Res |
Title: |
Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy. |
Volume: |
75 |
Issue: |
1 |
Pages: |
129-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chaturvedi P |
Year: |
1998 |
Journal: |
Oncogene |
Title: |
Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation. |
Volume: |
16 |
Issue: |
13 |
Pages: |
1749-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pauloin A |
Year: |
2012 |
Journal: |
Biochim Biophys Acta |
Title: |
Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway. |
Volume: |
1823 |
Issue: |
5 |
Pages: |
987-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gan Y |
Year: |
2014 |
Journal: |
Mol Endocrinol |
Title: |
Human GH receptor-IGF-1 receptor interaction: implications for GH signaling. |
Volume: |
28 |
Issue: |
11 |
Pages: |
1841-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buchholz B |
Year: |
2018 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Vagal stimulation mimics preconditioning and postconditioning of ischemic myocardium in mice by activating different protection mechanisms. |
Volume: |
314 |
Issue: |
6 |
Pages: |
H1289-H1297 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dieter BP |
Year: |
2019 |
Journal: |
PLoS One |
Title: |
Serum amyloid A and Janus kinase 2 in a mouse model of diabetic kidney disease. |
Volume: |
14 |
Issue: |
2 |
Pages: |
e0211555 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mager LF |
Year: |
2015 |
Journal: |
J Clin Invest |
Title: |
IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. |
Volume: |
125 |
Issue: |
7 |
Pages: |
2579-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dou H |
Year: |
2021 |
Journal: |
Circulation |
Title: |
Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. |
Volume: |
144 |
Issue: |
24 |
Pages: |
1940-1954 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ebong S |
Year: |
2004 |
Journal: |
Mol Vis |
Title: |
Characterization of the roles of STAT1 and STAT3 signal transduction pathways in mammalian lens development. |
Volume: |
10 |
|
Pages: |
122-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tu X |
Year: |
2018 |
Journal: |
Reprod Biol Endocrinol |
Title: |
The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement. |
Volume: |
16 |
Issue: |
1 |
Pages: |
44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hunter S |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase. |
Volume: |
274 |
Issue: |
4 |
Pages: |
2097-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pestka S |
Year: |
1997 |
Journal: |
Semin Oncol |
Title: |
The interferon receptors. |
Volume: |
24 |
Issue: |
3 Suppl 9 |
Pages: |
S9-18-S9-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Simoncic PD |
Year: |
2002 |
Journal: |
Curr Biol |
Title: |
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. |
Volume: |
12 |
Issue: |
6 |
Pages: |
446-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Usacheva A |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors. |
Volume: |
169 |
Issue: |
3 |
Pages: |
1302-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gruber CN |
Year: |
2020 |
Journal: |
Immunity |
Title: |
Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function. |
Volume: |
53 |
Issue: |
3 |
Pages: |
672-684.e11 |
|
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•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].Janus kinases (JAKs) are tyrosine kinases that function in membrane-proximal signalling events initiated by a variety of extracellular factors binding to cell surface receptors []. Many type I and II cytokine receptors lack a protein tyrosine kinase domain and rely on JAKs to initiate the cytoplasmic signal transduction cascade. Ligand binding induces oligomerisation of the receptors, which then activates the cytoplasmic receptor-associated JAKs. These subsequently phosphorylate tyrosine residues along the receptor chains with which they are associated. The phosphotyrosine residues are a target for a variety of SH2 domain-containing transducer proteins. Amongst these are the signal transducers and activators of transcription (STAT) proteins, which, after binding to the receptor chains, are phosphorylated by the JAK proteins. Phosphorylation enables the STAT proteins to dimerise and translocate into the nucleus, where they alter the expression of cytokine-regulated genes. This system is known as the JAK-STAT pathway.Four mammalian JAK family members have been identified: JAK1, JAK2, JAK3, and TYK2. They are relatively large kinases of approximately 1150 amino acids, with molecular weights of ~120-130kDa. Their amino acid sequences are characterised by the presence of 7 highly conserved domains, termed JAK homology (JH) domains. The C-terminal domain (JH1) is responsible for the tyrosine kinase function. The next domain in the sequence (JH2) is known as the tyrosine kinase-like domain, as its sequence shows high similarity to functional kinases but does not possess any catalytic activity. Although the function of this domain is not well established, there is some evidence for a regulatory role on the JH1 domain, thus modulating catalytic activity. The N-terminal portion of the JAKs (spanning JH7 to JH3) is important for receptor association and non-catalytic activity, and consists of JH3-JH4, which is homologous to the SH2 domain, and lastly JH5-JH7, which is a FERM domain.This represents the non-receptor tyrosine kinase JAK1, which is involved in the IFN-alpha/beta/gamma signal pathway. Jak1 acts as the kinase partner for the interleukin (IL)-2 receptor []and interleukin (IL)-10 receptor []. It directly phosphorylates STAT but also activates STAT signalling through the transactivation of other JAK kinases associated with signalling receptors [, ].JAK1 was initially cloned using a PCR-based strategy utilising degenerateprimers corresponding to conserved motifs within the catalytic domain of protein-tyrosine kinases []. In common with JAK2 and TYK2, and by contrastwith JAK3, JAK1 appears to be ubiquitously expressed. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
523
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
548
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
548
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
462
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
553
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
523
 |
Fragment?: |
false |
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Publication |
First Author: |
Kasembeli MM |
Year: |
2009 |
Journal: |
Front Biosci (Landmark Ed) |
Title: |
SH2 domain binding to phosphopeptide ligands: potential for drug targeting. |
Volume: |
14 |
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Pages: |
1010-22 |
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Publication |
First Author: |
Filippakopoulos P |
Year: |
2009 |
Journal: |
Curr Opin Struct Biol |
Title: |
SH2 domains: modulators of nonreceptor tyrosine kinase activity. |
Volume: |
19 |
Issue: |
6 |
Pages: |
643-9 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1153
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1126
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1153
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1153
 |
Fragment?: |
false |
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Publication |
First Author: |
Trost M |
Year: |
2009 |
Journal: |
Immunity |
Title: |
The phagosomal proteome in interferon-gamma-activated macrophages. |
Volume: |
30 |
Issue: |
1 |
Pages: |
143-54 |
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Publication |
First Author: |
Sharma PS |
Year: |
2009 |
Journal: |
Curr Pharm Des |
Title: |
Receptor tyrosine kinase inhibitors as potent weapons in war against cancers. |
Volume: |
15 |
Issue: |
7 |
Pages: |
758-76 |
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Publication |
First Author: |
Li E |
Year: |
2006 |
Journal: |
Biochemistry |
Title: |
Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies. |
Volume: |
45 |
Issue: |
20 |
Pages: |
6241-51 |
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Publication |
First Author: |
Roskoski R Jr |
Year: |
2005 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Src kinase regulation by phosphorylation and dephosphorylation. |
Volume: |
331 |
Issue: |
1 |
Pages: |
1-14 |
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Publication |
First Author: |
Hanks SK |
Year: |
1988 |
Journal: |
Science |
Title: |
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. |
Volume: |
241 |
Issue: |
4861 |
Pages: |
42-52 |
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Publication |
First Author: |
Manning G |
Year: |
2002 |
Journal: |
Trends Biochem Sci |
Title: |
Evolution of protein kinase signaling from yeast to man. |
Volume: |
27 |
Issue: |
10 |
Pages: |
514-20 |
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Publication |
First Author: |
Manning G |
Year: |
2002 |
Journal: |
Science |
Title: |
The protein kinase complement of the human genome. |
Volume: |
298 |
Issue: |
5600 |
Pages: |
1912-34 |
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Publication |
First Author: |
Stout TJ |
Year: |
2004 |
Journal: |
Curr Pharm Des |
Title: |
High-throughput structural biology in drug discovery: protein kinases. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1069-82 |
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Publication |
First Author: |
Li B |
Year: |
2004 |
Journal: |
Comb Chem High Throughput Screen |
Title: |
Creating chemical diversity to target protein kinases. |
Volume: |
7 |
Issue: |
5 |
Pages: |
453-72 |
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Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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