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Search results 1001 to 1075 out of 1075 for Lrrk2

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Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:5008580 | FVB-Tg(LRRK2*G2019S)1Mjfa
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:4460781 | B6.FVB-Tg(LRRK2*G2019S)1Mjfa/J
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:5004001 | STOCK Tg(Lrrk2-EGFP)KJ162Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Tg(PDGFB-LRRK2*G2019S)340Djmo | MGI:4950671
Name: transgene insertion 340, Darren Moore
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:4950691 | B6;C3-Tg(PDGFB-LRRK2*G2019S)340Djmo/J
Attribute String: transgenic, mutant strain
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Allele
Tg(PDGFB-LRRK2*R1441C)574Djmo | MGI:4950673
Name: transgene insertion 574, Darren Moore
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:4950692 | B6;C3-Tg(PDGFB-LRRK2*R1441C)574Djmo/J
Attribute String: mutant stock, transgenic
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Strain
MGI:5502369 | C57BL/6J-Tg(LRRK2*G2019S)2AMjff/J
Attribute String: coisogenic, mutant strain, transgenic
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Publication
36671436 | J:347452
 
First Author: Yao N
Year: 2022
Journal: Biomolecules
Title: Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice.
Volume: 13
Issue: 1
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Publication
35152441 | J:351293
First Author: Skiteva O
Year: 2022
Journal: J Neurochem
Title: LRRK2-G2019S mice display alterations in glutamatergic synaptic transmission in midbrain dopamine neurons.
Volume: 161
Issue: 2
Pages: 158-172
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Strain
MGI:5560147 | FVB/N-Tg(PDGFB-LRRK2*G2019S)32Hlw
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(Lrrk2)6Yue/?
Background: involves: C3H * C57BL/6 * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(LRRK2*G2019S)1Mjfa/Tg(LRRK2*G2019S)1Mjfa
Background: involves: FVB/NTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(LRRK2)WT1Mjfa/?
Background: FVB-Tg(LRRK2)WT1Mjfa
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(LRRK2*G2019S)1Mjfa/?
Background: FVB-Tg(LRRK2*G2019S)1Mjfa
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PDGFB-LRRK2*G2019S)340Djmo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PDGFB-LRRK2*R1441C)574Djmo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(LRRK2)1Cjli/?
Background: FVB/N-Tg(LRRK2)1Cjli/J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(LRRK2)1Cjli/?
Background: FVB-Tg(LRRK2)1Cjli
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PDGFB-LRRK2*G2019S)32Hlw/?
Background: FVB/N-Tg(PDGFB-LRRK2*G2019S)32Hlw
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(LRRK2*G2019S)2AMjff/?
Background: C57BL/6J-Tg(LRRK2*G2019S)2AMjff/J
Zygosity: ot
Has Mutant Allele: true
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Protein Domain
IPR045627 | FBXL18_LRR
Type: Domain
Description: In general, F-box proteins share a F-box motif and also have either WD40 repeat domains, LRR domains or various other domains. F-box proteins recruit specific substrates for ubiquitination via different protein-protein interaction domains, such as WD40 repeats and leucine rich repeats (LRRs) [, ].This entry represents the leucine-rich repeats (LRR) domain of F-box/LRR repeat protein 18 (FBXL18). This protein is a component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF-Fbxl18 complex has been shown to ubiquitinate Fbxl7 and LRRK2 and promote their degradation through the proteasome pathway [, ].
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Publication
25654763 | -
First Author: Liu Y
Year: 2015
Journal: Cell Death Dis
Title: F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.
Volume: 6
Issue: 2
Pages: e1630
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Publication
11130075 | -
First Author: Grimson MJ
Year: 2000
Journal: Nature
Title: Adherens junctions and beta-catenin-mediated cell signalling in a non-metazoan organism.
Volume: 408
Issue: 6813
Pages: 727-31
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Protein Domain
IPR056597 | ARM_LRRK2
Type: Domain
Description: This entry represents the armadillo repeat (ARM) found at the N-terminal end of Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) from eukaryotes. The domain adopts an ARM-like fold, consisting of a right-handed superhelix formed by two curved layers of repeated helical structural units []. A patch of negatively charged residues within the ARM domain has been pointed to contribute to complex formation by binding a positive residue in Rab switch 1 region [, , ]. ARM domain is also suggested to form connections between adjacent microtubules []. Also included in this entry is the armadillo repeat domain of Protein aardvark from Dictyostelium discoideum, a component of the junctional complex, both involved in cell adhesion and signalling [].LRRK2 is a serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, primary ciliogenesis, autophagy, and vesicle trafficking [, , , ]. Mutations in LRRK2 are the most common genetic cause of Parkinson's disease []. LRRK2 phosphorylates a group of Rab GTPase proteins, including Rab29.
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Publication
25104559 | J:218328
First Author: Wen Z
Year: 2014
Journal: Neurobiol Aging
Title: CDK5-mediated phosphorylation and autophagy of RKIP regulate neuronal death in Parkinson's disease.
Volume: 35
Issue: 12
Pages: 2870-2880
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Allele
Tg(LRRK2*R1441G)3IMjff | MGI:5466850
Name: transgene insertion 3I, The Michael J Fox Foundation
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:5800409 | FVB/N-Tg(PDGFB-LRRK2*R1441C)31Hlw
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Lrrk2<tm1.1Dral> | MGI:7865614
Name: leucine-rich repeat kinase 2; targeted mutation 1.1, Dario R Alessi
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Tg(PDGFB-LRRK2*R1441C)31Hlw/?
Background: FVB/N-Tg(PDGFB-LRRK2*R1441C)31Hlw
Zygosity: ot
Has Mutant Allele: true
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Publication
27926990 | -
First Author: Zhang J
Year: 2017
Journal: FEBS Lett
Title: The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt.
Volume: 591
Issue: 1
Pages: 145-154
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Protein Domain
IPR047948 | FBXL18_F-box
Type: Domain
Description: In general, F-box proteins share a F-box motif and also have either WD40 repeat domains, LRR domains or various other domains. F-box proteins recruit specific substrates for ubiquitination via different protein-protein interaction domains, such as WD40 repeats and leucine rich repeats (LRRs) [, ].This entry represents the F-box domain of F-box/LRR repeat protein 18 (FBXL18). This protein is a component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF-Fbxl18 complex has been shown to ubiquitinate FBXL7 and LRRK2 and promote their degradation through the proteasome pathway [, ]. By mediating ubiquitin-dependent proteasomal degradation of the pro-apoptotic protein FBXL7 that may impact cellular processes involved in cell cycle progression. It promotes glioma progression by promoting K63-linked ubiquitination of Akt [].
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Allele
Khdrbs2<Tg(LRRK2*R1441G)135Cjli> | MGI:3847811
Name: KH domain containing, RNA binding, signal transduction associated 2; transgene insertion 135, Chenjian Li
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
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Strain
MGI:4437457 | B6.Cg-Tg(Lrrk2*G2019S)2Yue/J
Attribute String: transgenic, congenic, mutant strain
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Publication
34108219 | J:350971
 
First Author: Cornblath EJ
Year: 2021
Journal: Sci Adv
Title: Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor.
Volume: 7
Issue: 24
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Strain
MGI:5502378 | C57BL/6J-Tg(LRRK2*R1441G)3IMjff/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:7865615 | C57BL/6N-Lrrk2<tm1.1Dral>/J
Attribute String: mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2)C77Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2*)D10Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lrrk2*G2019S)2Yue/?
Background: involves: C3H * C57BL/6 * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Publication
21603132 | J:232312
 
First Author: Li T
Year: 2011
Journal: Parkinsons Dis
Title: Models for LRRK2-Linked Parkinsonism.
Volume: 2011
Pages: 942412
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Strain
MGI:3848711 | FVB-Khdrbs2<Tg(LRRK2*R1441G)135Cjli>
Attribute String: coisogenic, transgenic
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Strain
MGI:3847896 | FVB/N-Khdrbs2<Tg(LRRK2*R1441G)135Cjli>/J
Attribute String: transgenic, coisogenic
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Genotype
Genotype
Symbol: Khdrbs2/Khdrbs2<+>
Background: FVB-Khdrbs2
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2)C77Cai/? Tg(tetO-SNCA*A53T)E2Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2*)D10Cai/? Tg(tetO-SNCA*A53T)E2Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2)C7874Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-LRRK2)C7874Cai/? Tg(tetO-SNCA*A53T)E2Cai/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Khdrbs2/Khdrbs2<+>
Background: FVB/N-Khdrbs2/J
Zygosity: ht
Has Mutant Allele: true
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Publication
25471590 | J:218853
First Author: Cao M
Year: 2014
Journal: J Neurosci
Title: Upregulation of Parkin in endophilin mutant mice.
Volume: 34
Issue: 49
Pages: 16544-9
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Publication
41680444 | J:392194
First Author: Jacquemyn J
Year: 2026
Journal: Nat Cell Biol
Title: Glucosylceramide-induced ectosomes propagate pathogenic ??-synuclein in Parkinson's disease.
Volume: 28
Issue: 3
Pages: 492-506
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Publication
38091401 | J:349290
First Author: Pal P
Year: 2023
Journal: Sci Adv
Title: Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B.
Volume: 9
Issue: 50
Pages: eadj1205
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Publication
40690364 | J:371845
First Author: Chiang CY
Year: 2025
Journal: Cell Rep
Title: PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson's disease.
Volume: 44
Issue: 8
Pages: 116031
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Publication
41083601 | J:383201
First Author: Nguyen M
Year: 2025
Journal: Nat Cell Biol
Title: MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death.
Volume: 27
Issue: 10
Pages: 1708-1724
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Publication
20547124 | J:163293
First Author: Dawson TM
Year: 2010
Journal: Neuron
Title: Genetic animal models of Parkinson's disease.
Volume: 66
Issue: 5
Pages: 646-61
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Protein
Q5S006
Organism: Mus musculus/domesticus
Length: 2527  
Fragment?: false
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Protein
E9PYR1
Organism: Mus musculus/domesticus
Length: 771  
Fragment?: false
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Publication
9346238 | -
First Author: Skowyra D
Year: 1997
Journal: Cell
Title: F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
Volume: 91
Issue: 2
Pages: 209-19
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Publication
10581972 | -
First Author: Craig KL
Year: 1999
Journal: Prog Biophys Mol Biol
Title: The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction.
Volume: 72
Issue: 3
Pages: 299-328
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Protein
F6YIW9
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: true
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Publication
26310625 | J:226415
First Author: Zhou ZD
Year: 2015
Journal: Hum Mol Genet
Title: F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy.
Volume: 24
Issue: 22
Pages: 6314-30
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Protein
Q9CQG8
Organism: Mus musculus/domesticus
Length: 561  
Fragment?: false
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Protein
A4VCH8
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: true
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Protein
F8VQK6
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
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Protein
Q14BU8
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: true
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Protein
Q3U4A0
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
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Publication
35345836 | J:322799
 
First Author: Liu XZ
Year: 2021
Journal: Front Mol Neurosci
Title: F-Actin Dysplasia Involved in Organ of Corti Deformity in Gjb2 Knockdown Mouse Model.
Volume: 14
Pages: 808553
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Publication
33727250 | J:334026
 
First Author: Dhekne HS
Year: 2021
Journal: Life Sci Alliance
Title: LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.
Volume: 4
Issue: 5
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Publication
26744328 | J:229469
First Author: Liu J
Year: 2016
Journal: Hum Mol Genet
Title: Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.
Volume: 25
Issue: 4
Pages: 672-80
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Publication
31449520 | J:279444
First Author: Gigu?re N
Year: 2019
Journal: PLoS Genet
Title: Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout.
Volume: 15
Issue: 8
Pages: e1008352
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Publication
23013868 | J:324569
 
First Author: Sekigawa A
Year: 2012
Journal: Mol Brain
Title: Distinct mechanisms of axonal globule formation in mice expressing human wild type ?-synuclein or dementia with Lewy bodies-linked P123H ?-synuclein.
Volume: 5
Pages: 34
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Publication
10361086 | -
First Author: Groves MR
Year: 1999
Journal: Curr Opin Struct Biol
Title: Topological characteristics of helical repeat proteins.
Volume: 9
Issue: 3
Pages: 383-9
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Protein
Q3UHC2
Organism: Mus musculus/domesticus
Length: 2014  
Fragment?: false
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Publication
30659012 | J:276927
First Author: Goodwin LO
Year: 2019
Journal: Genome Res
Title: Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.
Volume: 29
Issue: 3
Pages: 494-505
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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