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Search results 1001 to 1049 out of 1049 for Nkx6-1

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Type

Details

Score

Publication

- | J:57747

First Author:	MGI Genome Annotation Group and UniGene Staff
Year:	2015
Journal:	Database Download
Title:	MGI-UniGene Interconnection Effort

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Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

•

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

•

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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Publication

- | J:78475

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database

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Publication

17376808 | -

First Author:	Hutchinson SA
Year:	2007
Journal:	Development
Title:	Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression.
Volume:	134
Issue:	9
Pages:	1671-7

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Protein Domain

IPR033630 | NKX-6.1

Type:

Family

Description:

Homeobox protein NKX-6.1 is a transcription factor required for the formation and secretory function of insulin-producing beta cells within the pancreas [, , ]. To promote proper differentiation and function of beta-cells, Nkx6.1 binds to specific A/T-rich DNA sequences in the promoter regions of relevant genes and regulate their transcription [, ]. In fully differentiated beta-cells, Nkx6.1 is necessary for the normal insulin secretory response [].Nkx6.1 also has been implicated in the regulation of migration and axon pathfinding of motoneurons [, , ].

•

Publication

28919426 | J:254324

First Author:	Jung H
Year:	2017
Journal:	Biochem Biophys Res Commun
Title:	Improving glycemic control in model mice with type 2 diabetes by increasing superoxide dismutase (SOD) activity using silk fibroin hydrolysate (SFH).
Volume:	493
Issue:	1
Pages:	115-119

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Publication

29914854 | J:315908

First Author:	Burke SJ
Year:	2018
Journal:	Mol Metab
Title:	Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation.
Volume:	14

Pages:	95-107

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Publication

27064285 | J:234937

First Author:	Dai C
Year:	2016
Journal:	J Clin Invest
Title:	Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.
Volume:	126
Issue:	5
Pages:	1857-70

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Publication

26546129 | J:230840

First Author:	Jurczyk A
Year:	2016
Journal:	FASEB J
Title:	Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.
Volume:	30
Issue:	2
Pages:	983-93

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Publication

27408770 | J:268878

First Author:	Ye R
Year:	2016
Journal:	Mol Metab
Title:	Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges.
Volume:	5
Issue:	7
Pages:	437-448

•

Publication

19780200 | J:159342

First Author:	Cai J
Year:	2010
Journal:	Glia
Title:	Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes.
Volume:	58
Issue:	4
Pages:	458-68

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Publication

15331541 | J:297690

First Author:	Gesina E
Year:	2004
Journal:	Diabetes
Title:	Dissecting the role of glucocorticoids on pancreas development.
Volume:	53
Issue:	9
Pages:	2322-9

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Publication

30045859 | J:263902

First Author:	May M
Year:	2018
Journal:	Biol Open
Title:	Cell tracking in vitro reveals that the extracellular matrix glycoprotein Tenascin-C modulates cell cycle length and differentiation in neural stem/progenitor cells of the developing mouse spinal cord.
Volume:	7
Issue:	7

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Publication

28765173 | J:253315

First Author:	Csóka B
Year:	2017
Journal:	FASEB J
Title:	A_2A adenosine receptors control pancreatic dysfunction in high-fat-diet-induced obesity.
Volume:	31
Issue:	11
Pages:	4985-4997

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Allele

Nkx6-2<tm1Qiu> | MGI:2182286

Name:	NK6 homeobox 2; targeted mutation 1, Mengsheng Qiu
Allele Type:	Targeted
Attribute String:	Null/knockout

•

Publication

19363146 | J:155164

First Author:	Sousa VH
Year:	2009
Journal:	Cereb Cortex
Title:	Characterization of Nkx6-2-derived neocortical interneuron lineages.
Volume:	19 Suppl 1

Pages:	i1-10

•

Publication

23382448 | J:208553

First Author:	Kanji MS
Year:	2013
Journal:	Diabetes
Title:	Dicer1 is required to repress neuronal fate during endocrine cell maturation.
Volume:	62
Issue:	5
Pages:	1602-11

•

Publication

23251699 | J:195661

First Author:	van der Meulen T
Year:	2012
Journal:	PLoS One
Title:	Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells.
Volume:	7
Issue:	12
Pages:	e52181

•

Publication

18347062 | J:136085

First Author:	Choi MY
Year:	2008
Journal:	Mol Cell Biol
Title:	Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum.
Volume:	28
Issue:	10
Pages:	3208-18

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Publication

37659738 | J:340591

First Author:	Xing C
Year:	2023
Journal:	Biochem Pharmacol
Title:	Eicosapentaenoic acid metabolites promotes the trans-differentiation of pancreatic α cells to β cells.
Volume:	216

Pages:	115775

•

Publication

39379383 | J:355262

First Author:	Kadhim AZ
Year:	2024
Journal:	Nat Commun
Title:	Transcriptional coactivator MED15 is required for beta cell maturation.
Volume:	15
Issue:	1
Pages:	8711

•

Publication

- | J:204202

First Author:	The Pleiades Promoter and CanEuCre Project
Year:	2014
Journal:	MGI Direct Data Submission
Title:	Generation of reporter and cre-expressing targeted transgenic mice in the Hprt1 gene using human MiniPromoters that drive region- and cell-specific gene expression in the mouse brain

•

Allele

Hprt1<tm342a(Ple282-icre/ERT2)Ems> | MGI:5532390

Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 342a, Elizabeth M Simpson
Allele Type:	Targeted
Attribute String:	Inducible, Recombinase

•

Strain

MGI:5529948 | B6.Cg-Hprt1<tm342a(Ple282-icre/ERT2)Ems>/Mmjax

Attribute String:

congenic, mutant strain, targeted mutation

•

Strain

MGI:5538365 | B6.Cg-Hprt1<tm342a(Ple282-icre/ERT2)Ems>

Attribute String:

targeted mutation, mutant strain, congenic

•

Genotype

Symbol:	Nkx6-2/Nkx6-2
Background:	Not Specified
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nkx6-2/Nkx6-2
Background:	involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster
Zygosity:	cn
Has Mutant Allele:	true

•

Genotype

Symbol:	Hprt1/?
Background:	B6.Cg-Hprt1
Zygosity:	ot
Has Mutant Allele:	true

•

Publication

14973276 | J:88591

First Author:	Craven SE
Year:	2004
Journal:	Development
Title:	Gata2 specifies serotonergic neurons downstream of sonic hedgehog.
Volume:	131
Issue:	5
Pages:	1165-73

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Publication

10567713 | J:58644

First Author:	Jørgensen MC
Year:	1999
Journal:	FEBS Lett
Title:	Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1.
Volume:	461
Issue:	3
Pages:	287-94

•

Publication

12473241 | J:80768

First Author:	Brimnes MK
Year:	2002
Journal:	J Autoimmun
Title:	Low expression of insulin in the thymus of non-obese diabetic mice.
Volume:	19
Issue:	4
Pages:	203-13

•

Publication

12128210 | J:80783

First Author:	Uhler J
Year:	2002
Journal:	Mech Dev
Title:	Nk6, a novel Drosophila homeobox gene regulated by vnd.
Volume:	116
Issue:	1-2
Pages:	105-16

•

Publication

12031967 | J:107199

First Author:	Laybutt DR
Year:	2002
Journal:	Diabetes
Title:	Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.
Volume:	51
Issue:	6
Pages:	1793-804

•

Publication

16434037 | J:107826

First Author:	Bréjot T
Year:	2006
Journal:	Exp Neurol
Title:	Forced expression of the motor neuron determinant HB9 in neural stem cells affects neurogenesis.
Volume:	198
Issue:	1
Pages:	167-82

•

Publication

18778483 | J:142415

First Author:	Hoffman BG
Year:	2008
Journal:	BMC Dev Biol
Title:	Expression of Groucho/TLE proteins during pancreas development.
Volume:	8

Pages:	81

•

Publication

21107520 | J:166435

First Author:	Kluth O
Year:	2011
Journal:	Diabetologia
Title:	Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.
Volume:	54
Issue:	3
Pages:	605-16

•

Publication

21381031 | J:171249

First Author:	Riopel M
Year:	2011
Journal:	J Pathol
Title:	Conditional β1-integrin-deficient mice display impaired pancreatic β cell function.
Volume:	224
Issue:	1
Pages:	45-55

•

Publication

28424159 | J:246321

First Author:	Isaac R
Year:	2017
Journal:	Diabetes
Title:	Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Impairs β-Cell Function In Vivo.
Volume:	66
Issue:	7
Pages:	1879-1889

•

Publication

29879176 | J:262842

First Author:	Dong Y
Year:	2018
Journal:	PLoS One
Title:	Changes of MODY signal pathway genes in the endoplasmic reticulum stress in INS-1-3 cells.
Volume:	13
Issue:	6
Pages:	e0198614

•

GXD Expression


Assay Type:	In situ reporter (knock in)
Annotation Date:	2018-03-07
Strength:	Present
Sex:	Not Specified
Emaps:	EMAPS:3564522
Pattern:	Not Specified
Stage:	TS22
Assay Id:	MGI:6119679
Age:	embryonic day 14.5
Image:	3A top center
Note:	Some S-Gal stained cells also expressed Nkx6.1 (endocrine progenitor) cells.
Specimen Label:	3A top center
Detected:	true
Specimen Num:	2

•

GXD Expression

Probe:	MGI:6360995
Assay Type:	Immunohistochemistry
Annotation Date:	2019-09-26
Strength:	Present
Sex:	Not Specified
Emaps:	EMAPS:3530523
Pattern:	Regionally restricted
Stage:	TS23
Assay Id:	MGI:6361021
Age:	embryonic day 15.5
Image:	8A
Note:	Expression in only some of Nkx6.1 expressing cells.
Specimen Label:	8A
Detected:	true
Specimen Num:	1

•

GXD Expression

Probe:	MGI:2386007
Assay Type:	Immunohistochemistry
Annotation Date:	2002-09-17
Strength:	Present
Sex:	Not Specified
Emaps:	EMAPS:1750323
Pattern:	Not Specified
Stage:	TS23
Assay Id:	MGI:2386028
Age:	embryonic day 15.5


Specimen Label:	Nkx6-1 -/- E15.5
Detected:	true
Specimen Num:	3

•

GXD Expression

Probe:	MGI:2386007
Assay Type:	Immunohistochemistry
Annotation Date:	2002-09-17
Strength:	Present
Sex:	Not Specified
Emaps:	EMAPS:1750326
Pattern:	Not Specified
Stage:	TS26
Assay Id:	MGI:2386028
Age:	embryonic day 18.5


Specimen Label:	Nkx6-1 -/- E18.5
Detected:	true
Specimen Num:	4

•

GXD Expression

Probe:	MGI:7510072
Assay Type:	Immunohistochemistry
Annotation Date:	2023-07-24
Strength:	Present
Sex:	Not Specified
Emaps:	EMAPS:3564922
Pattern:	Not Specified
Stage:	TS22
Assay Id:	MGI:7510116
Age:	embryonic day 14.5
Image:	S4C
Note:	No Nkx6-1 expression at these positive tip cells, which mainly contributes to acinar fates.
Specimen Label:	S4C
Detected:	true
Specimen Num:	8

•

HT Experiment

GSE137145 | Transcriptional coactivator MED15 is required for beta cell maturation


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

•

Interaction Detail

Role 2:	bait
Type:	physical
Role 1:	prey

Name:	Nkx6-2-Sertad1

Relationship Type:	direct interaction

•

Interaction Detail

Role 2:	prey
Type:	physical
Role 1:	bait

Name:	Nkx6-2-Sertad1

Relationship Type:	direct interaction

•

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