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Search results 1001 to 1100 out of 1160 for Notch3

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Notch3/Notch3 Tg(Tagln-cre)1Her/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Tagln-cre)1Her/?
Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Allele
Notch3<tm1Grid> | MGI:2687010
Name: notch 3; targeted mutation 1, Tom Gridley
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Notch3<tm1Ul> | MGI:3528497
Name: notch 3; targeted mutation 1, Urban Lendahl
Allele Type: Targeted
Attribute String: Humanized sequence, Modified isoform(s)
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Allele
Notch3<hpbk> | MGI:4418503
 
Name: notch 3; humpback
Allele Type: Chemically induced (ENU)
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Allele
Notch3<tm1.1Dwr> | MGI:5462093
Name: notch 3; targeted mutation 1.1, Mieke Dewerchin
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Tg(Pdx1-Notch3)1Heed | MGI:3693633
Name: transgene insertion 1, Helena Edlund
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Notch3)129Bbb | MGI:7284359
Name: transgene insertion 129, Norbert Hubner
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Notch3<em3Smoc> | MGI:7291354
Name: notch 3; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GO Term
GO:0071177 | MAML2-RBP-Jkappa-ICN3 complex
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GO Term
GO:0071181 | MAML3-RBP-Jkappa-ICN3 complex
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Allele
Gt(ROSA)26Sor<tm1(NOTCH3)Sat> | MGI:4830990
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Spyros Artavanis-Tsakonas
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Notch3<em1Smoc> | MGI:7291352
Name: notch 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6355072 | C57BL/6JSmoc-Notch3<em3Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Tg(Pdx1-Notch3)1Heed/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch3/Notch3
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch3/Notch3<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch3/Notch3
Background: C57BL/6J-Notch3/GrsrJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch3/Notch3<+>
Background: involves: 129S/SvEv * Swiss
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch3/Notch3
Background: involves: 129S/SvEv * Swiss
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch3/Notch3
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch1/Notch1<+> Notch3/Notch3
Background: involves: 129S1/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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DO Term
DOID:0111035 | CADASIL 1
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DO Term
DOID:0111343 | lateral meningocele syndrome
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Strain
MGI:4830974 | 129S-Gt(ROSA)26Sor<tm1(NOTCH3)Sat>/Mmjax
Attribute String: mutant strain, targeted mutation, coisogenic
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Allele
Gt(ROSA)26Sor<tm2(NOTCH3*C455R)Sat> | MGI:5007800
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Spyros Artavanis-Tsakonas
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Gt(ROSA)26Sor<tm1(Notch3*)Sfr> | MGI:5556106
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Silvia Fre
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
20071773 | J:156682
First Author: Joutel A
Year: 2010
Journal: J Clin Invest
Title: Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease.
Volume: 120
Issue: 2
Pages: 433-45
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Publication
28345617 | J:329829
 
First Author: Klein C
Year: 2017
Journal: Sci Rep
Title: Stimulation of adult hippocampal neurogenesis by physical exercise and enriched environment is disturbed in a CADASIL mouse model.
Volume: 7
Pages: 45372
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Publication
25646445 | J:220006
First Author: Dabertrand F
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease.
Volume: 112
Issue: 7
Pages: E796-805
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Transgene
MGI:4429554 | Tg(Notch3*R169C)88Bbb
Type: transgene
Organism: mouse, laboratory
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HT Experiment
E-GEOD-36437 | Expression data from caudal artery of Notch3WT and Notch3KO mice
Series Id: GSE36437
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-58244 | Role of Notch receptors in ozone induced lung injury in mice
Series Id: GSE58244
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:1098270 | Jag2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104659 | Dll1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1859388 | Dll4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61483
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
Q9JI71
Organism: Mus musculus/domesticus
Length: 686  
Fragment?: false
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Protein
Q9QYE5
Organism: Mus musculus/domesticus
Length: 1247  
Fragment?: false
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Publication
34483880 | J:312898
 
First Author: Rosehart AC
Year: 2021
Journal: Front Aging Neurosci
Title: Prostaglandin E2 Dilates Intracerebral Arterioles When Applied to Capillaries: Implications for Small Vessel Diseases.
Volume: 13
Pages: 695965
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Strain
MGI:5008442 | B6;129S-Gt(ROSA)26Sor<tm1(NOTCH3*R1031C)Sat>/Mmjax
Attribute String: mutant stock, targeted mutation
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Strain
MGI:5008303 | 129S-Gt(ROSA)26Sor<tm2(NOTCH3*C455R)Sat>/Mmjax
Attribute String: targeted mutation, mutant strain, coisogenic
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Strain
MGI:6770993 | C57BL/6JSmoc-Notch3<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein
Q61982
Organism: Mus musculus/domesticus
Length: 2318  
Fragment?: false
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Publication
25251607 | J:218448
 
First Author: Liu XY
Year: 2015
Journal: Neurobiol Dis
Title: Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL.
Volume: 73
Pages: 189-203
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HT Experiment
GSE237040 | Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Coding Gene
MGI:1095416 | Jag1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99146 | Ybx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914144 | Wwp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109548 | Adam10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O35598
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
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Protein
Q9QXX0
Organism: Mus musculus/domesticus
Length: 1218  
Fragment?: false
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Protein
Q9DBH0
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
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Protein
P62960
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Publication
15569862 | J:134742
First Author: Dubroca C
Year: 2005
Journal: Stroke
Title: Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy.
Volume: 36
Issue: 1
Pages: 113-7
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Publication
15817893 | J:133984
First Author: Lacombe P
Year: 2005
Journal: Stroke
Title: Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy.
Volume: 36
Issue: 5
Pages: 1053-8
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Allele
Tg(TAGLN-NOTCH3*R90C)1Etl | MGI:5823251
Name: transgene insertion 1, Elisabeth Tournier-Lasserve
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(TAGLN-NOTCH3*R90C)2Etl | MGI:5823253
Name: transgene insertion 2, Elisabeth Tournier-Lasserve
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Protein Coding Gene
MGI:1891700 | Ncstn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109284 | Psen2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1202717 | Psen1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2385110 | Aph1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913590 | Psenen
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3522097 | Aph1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8C7N7
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
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Protein
Q9CQR7
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: false
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Protein
Q8BVF7
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
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Protein
P49769
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
P57716
Organism: Mus musculus/domesticus
Length: 708  
Fragment?: false
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Protein
Q61144
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Protein Coding Gene
MGI:95290 | Egf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P01132
Organism: Mus musculus/domesticus
Length: 1217  
Fragment?: false
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Publication
32852523 | J:298816
 
First Author: Koch U
Year: 2020
Journal: J Exp Med
Title: A third Notch in colorectal cancer progression and metastasis.
Volume: 217
Issue: 10
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Publication
27476853 | J:235433
   
First Author: Capone C
Year: 2016
Journal: Elife
Title: Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.
Volume: 5
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Notch3/Notch3 Tg(Tagln-cre)1Her/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Notch3/Notch3 Tg(Tagln-cre)1Her/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Protein
Q6T264
Organism: Mus musculus/domesticus
Length: 1020  
Fragment?: false
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Protein
D4QGC2
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: false
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Protein
Q7TPU6
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
F6U238
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
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Publication
16530044 | -
First Author: Nam Y
Year: 2006
Journal: Cell
Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Volume: 124
Issue: 5
Pages: 973-83
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Publication
18758478 | -
First Author: Kovall RA
Year: 2008
Journal: Oncogene
Title: More complicated than it looks: assembly of Notch pathway transcription complexes.
Volume: 27
Issue: 38
Pages: 5099-109
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Publication
18758483 | J:141198
First Author: McElhinny AS
Year: 2008
Journal: Oncogene
Title: Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.
Volume: 27
Issue: 38
Pages: 5138-47
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Publication
16510869 | J:106711
First Author: Shen H
Year: 2006
Journal: Genes Dev
Title: The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Volume: 20
Issue: 6
Pages: 675-88
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Publication
17317671 | -
First Author: Zhao Y
Year: 2007
Journal: J Biol Chem
Title: The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Volume: 282
Issue: 16
Pages: 11969-81
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Publication
17875709 | -
First Author: Alves-Guerra MC
Year: 2007
Journal: Cancer Res
Title: Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival.
Volume: 67
Issue: 18
Pages: 8690-8
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Publication
16880534 | -
First Author: Chiang MY
Year: 2006
Journal: Mol Cell Biol
Title: Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
Volume: 26
Issue: 16
Pages: 6261-71
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Publication
17699740 | J:149110
First Author: Wu L
Year: 2007
Journal: Blood
Title: The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
Volume: 110
Issue: 10
Pages: 3618-23
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Publication
15961999 | -
First Author: Wu L
Year: 2005
Journal: EMBO J
Title: Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
Volume: 24
Issue: 13
Pages: 2391-402
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Publication
15546612 | -
First Author: Fryer CJ
Year: 2004
Journal: Mol Cell
Title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Volume: 16
Issue: 4
Pages: 509-20
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Publication
12370315 | J:79612
First Author: Wu L
Year: 2002
Journal: Mol Cell Biol
Title: Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
Volume: 22
Issue: 21
Pages: 7688-700
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Publication
34590699 | J:312438
 
First Author: Cameron B
Year: 2021
Journal: Biol Open
Title: Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway.
Volume: 10
Issue: 9
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Publication
15592506 | J:96010
First Author: Felli MP
Year: 2005
Journal: Oncogene
Title: PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.
Volume: 24
Issue: 6
Pages: 992-1000
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Publication
14566327 | J:86506
First Author: Talora C
Year: 2003
Journal: EMBO Rep
Title: Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.
Volume: 4
Issue: 11
Pages: 1067-72
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Publication
17081781 | J:116137
First Author: Kared H
Year: 2006
Journal: Immunity
Title: Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling.
Volume: 25
Issue: 5
Pages: 823-34
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Publication
23277114 | J:194992
First Author: Zhu MY
Year: 2013
Journal: Gene Expr Patterns
Title: The expression of NOTCH2, HES1 and SOX9 during mouse retinal development.
Volume: 13
Issue: 3-4
Pages: 78-83
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Publication
23684539 | J:199317
First Author: Gu B
Year: 2013
Journal: Cell Stem Cell
Title: Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells.
Volume: 13
Issue: 1
Pages: 48-61
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Publication
29230914 | J:261529
First Author: Low S
Year: 2018
Journal: Stem Cells
Title: Delta-Like 4 Activates Notch 3 to Regulate Self-Renewal in Skeletal Muscle Stem Cells.
Volume: 36
Issue: 3
Pages: 458-466
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Publication
24749067 | J:329722
First Author: Gopinath SD
Year: 2014
Journal: Stem Cell Reports
Title: FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal.
Volume: 2
Issue: 4
Pages: 414-26
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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