|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1001 to 1100 out of 1171 for Pkd1

<< First    < Previous  |  Next >    Last >>
0.028s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
8643665 | -
First Author: Ward CJ
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney.
Volume: 93
Issue: 4
Pages: 1524-8
•
•
•
•
•
Publication
8650545 | J:48348
First Author: Mochizuki T
Year: 1996
Journal: Science
Title: PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein.
Volume: 272
Issue: 5266
Pages: 1339-42
•
•
•
•
•
Publication
9326320 | -
First Author: Veldhuisen B
Year: 1997
Journal: Am J Hum Genet
Title: A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2).
Volume: 61
Issue: 3
Pages: 547-55
•
•
•
•
•
Protein Domain
IPR002859 | PKD/REJ-like
Type: Domain
Description: The REJ (Receptor for Egg Jelly) domain is found in PKD1 and the sperm receptor for egg jelly []. The exact function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.Sequence similarity between a region of the autosomal dominant polycystic kidney disease (ADPKD) protein, polycystin-1 and a sea urchin sperm glycoprotein involved in fertilization, the receptor for egg jelly (suREJ) has been known for some time. The suREJ protein binds the glycoprotein coat of the egg (egg jelly), triggering the acrosomereaction, which transforms the sperm into a fusogenic cell. The sequence similarity and expression pattern suggests that the predicted human PKDREJ protein is a mammalian equivalent of the suREJ protein and therefore may have a central role in human fertilization [].
•
•
•
•
•
Publication
7663510 | -
First Author: Hughes J
Year: 1995
Journal: Nat Genet
Title: The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains.
Volume: 10
Issue: 2
Pages: 151-60
•
•
•
•
•
Publication
19135240 | J:146185
First Author: Sumara G
Year: 2009
Journal: Cell
Title: Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.
Volume: 136
Issue: 2
Pages: 235-48
•
•
•
•
•
Publication
27214281 | J:236814
First Author: Kim S
Year: 2016
Journal: Nat Cell Biol
Title: The polycystin complex mediates Wnt/Ca(2+) signalling.
Volume: 18
Issue: 7
Pages: 752-764
•
•
•
•
•
Publication
16243292 | J:102836
First Author: Nagano J
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling.
Volume: 338
Issue: 2
Pages: 880-9
•
•
•
•
•
Publication
9716661 | J:49651
First Author: Pennekamp P
Year: 1998
Journal: Mamm Genome
Title: Characterization of the murine polycystic kidney disease (Pkd2) gene.
Volume: 9
Issue: 9
Pages: 749-52
•
•
•
•
•
Publication
25639845 | J:221429
 
First Author: Avriyanti E
Year: 2015
Journal: Neurosci Res
Title: Functional redundancy of protein kinase D1 and protein kinase D2 in neuronal polarity.
Volume: 95
Pages: 12-20
•
•
•
•
•
Publication
19414785 | J:148236
First Author: Park JE
Year: 2009
Journal: J Immunol
Title: Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway.
Volume: 182
Issue: 10
Pages: 6316-27
•
•
•
•
•
Publication
18552856 | J:138625
First Author: Li X
Year: 2008
Journal: Nat Med
Title: A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease.
Volume: 14
Issue: 8
Pages: 863-8
•
•
•
•
•
Publication
25698580 | J:221790
 
First Author: Liou GY
Year: 2015
Journal: Nat Commun
Title: Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.
Volume: 6
Pages: 6200
•
•
•
•
•
Publication
23253477 | J:195233
First Author: Ngok SP
Year: 2012
Journal: J Cell Biol
Title: VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx.
Volume: 199
Issue: 7
Pages: 1103-15
•
•
•
•
•
Publication
16652363 | J:110146
First Author: Lantinga-van Leeuwen IS
Year: 2006
Journal: Genesis
Title: Transgenic mice expressing tamoxifen-inducible Cre for somatic gene modification in renal epithelial cells.
Volume: 44
Issue: 5
Pages: 225-32
•
•
•
•
•
Publication
17485491 | J:206919
First Author: White DP
Year: 2007
Journal: J Cell Biol
Title: alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration.
Volume: 177
Issue: 3
Pages: 515-25
•
•
•
•
•
Publication
2339691 | J:10497
First Author: Germino GG
Year: 1990
Journal: Am J Hum Genet
Title: Identification of a locus which shows no genetic recombination with the autosomal dominant polycystic kidney disease gene on chromosome 16.
Volume: 46
Issue: 5
Pages: 925-33
•
•
•
•
•
Publication
16111639 | J:100514
First Author: Medeiros RB
Year: 2005
Journal: Immunity
Title: Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.
Volume: 23
Issue: 2
Pages: 213-26
•
•
•
•
•
Publication
16377259 | J:105949
First Author: Oster H
Year: 2006
Journal: Gene Expr Patterns
Title: Expression of the protein kinase D (PKD) family during mouse embryogenesis.
Volume: 6
Issue: 4
Pages: 400-8
•
•
•
•
•
Publication
18641342 | J:139235
First Author: Park JE
Year: 2008
Journal: J Immunol
Title: Protein kinase D1: a new component in TLR9 signaling.
Volume: 181
Issue: 3
Pages: 2044-55
•
•
•
•
•
Publication
31515477 | J:279347
First Author: Lee EC
Year: 2019
Journal: Nat Commun
Title: Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease.
Volume: 10
Issue: 1
Pages: 4148
•
•
•
•
•
Publication
27565965 | J:318391
First Author: Kraus A
Year: 2016
Journal: Purinergic Signal
Title: P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells.
Volume: 12
Issue: 4
Pages: 687-695
•
•
•
•
•
Protein
O35245
Organism: Mus musculus/domesticus
Length: 966  
Fragment?: false
•
•
•
•
•
Protein
A2A259
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
•
•
•
•
•
Protein
Q3UQ78
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
•
•
•
•
•
Protein
Q3UU38
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
•
•
•
•
•
Publication
23762046 | -
 
First Author: Xu M
Year: 2013
Journal: J Biophys
Title: Analysis of the REJ Module of Polycystin-1 Using Molecular Modeling and Force-Spectroscopy Techniques.
Volume: 2013
Pages: 525231
•
•
•
•
•
Publication
12829240 | -
First Author: Rykx A
Year: 2003
Journal: FEBS Lett
Title: Protein kinase D: a family affair.
Volume: 546
Issue: 1
Pages: 81-6
•
•
•
•
•
Publication
28428613 | -
First Author: Cobbaut M
Year: 2017
Journal: Sci Rep
Title: Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.
Volume: 7
Issue: 1
Pages: 887
•
•
•
•
•
Protein Domain
IPR000601 | PKD_dom
Type: Domain
Description: The polycystic kidney disease (PKD) domain is an 80-90 amino acid module originally found in 16 copies in the extracellular segment of polycystin-1, a large cell surface glycoprotein. Polycystin-1 is encoded by the PKD1 gene, which is mutated in autosomal dominant polycystic kidney disease (ADPKD).Although its function is unknown, it may be involved in protein-protein and protein-carbohydrate interactions based on its predicted domain structure. One or more copies of the PKD domain are also found in several other extracellular proteins from higher organisms, eubacteria, and archaebacteria. Singles copies of the PKD domain are found in the melanocytes heavily glycosylated cell-surface proteins Pmel 17, MMP and Nmp. Some bacterial collagenases and proteases also contain a single PKD domain adjacent to their catalytic domains, whereas four copies are present in the heavily glycosylated surface layer protein of archaebacteria []. The PKD modules are often observed, within a same protein sequence, in association with FnIII domains [].The most conserved motif is the WDFGDGS sequence that is found in the central part of many PKD domains and could play a structural role [, ]. Determination of the solution structure of the first PKD domain from human polycystin-1 has shown that the module is built from two β-sheet, one of three strands and one of four strands, which are packed face-to-face [].
•
•
•
•
•
Protein Domain
IPR015727 | Protein_Kinase_C_mu-related
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].The protein kinase D family of enzymes consists of three isoforms: PKD1 (PKCmu), PKD2, and PKD3 (PKCnu). They all share a similar architecture with regulatory sub-domains that play specific roles in the activation, translocation and function of the enzymes. The PKD enzymes have recently been implicated in very diverse cellular functions, including Golgi organisation and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation []. Each isoform is differentially regulated through phosphorylation [].
•
•
•
•
•
Protein Domain
IPR003915 | PKD_2
Type: Family
Description: Polycystic kidney diseases (PKD) are disorders characterised by large numbers of cysts distributed throughout grossly-enlarged kidneys. Cystdevelopment is associated with impairment of kidney function, and ultimately kidney failure and death [, ]. Most cases of autosomal dominant PKD result from mutations in the PKD1 gene that cause premature protein termination. A second gene for autosomal dominant polycystic kidney disease has been identified by positional cloning []. The predicted 968-amino acid sequence of the PKD2 gene product (polycystin-2) contains 6 transmembrane domains, with intracellular N- and C-termini. Polycystin-2 shares some similarity with the family of voltage-activated calcium (and sodium) channels, and contains a potential calcium-binding domain [].Polycystin-2 is strongly expressed in ovary, foetal and adult kidney, testis, and small intestine. Polycystin-1 requires the presence of this protein for stable expression and is believed to interact with it via its C terminus. All mutations between exons 1 and 11 result in a truncated polycystin-2 that lacks a calcium-binding EF-hand domain and the cytoplasmic domains required for the interaction of polycystin-2 with polycystin-1 []. PKD2, although clinically milder than PKD1, has a deleterious impact on life expectancy.
•
•
•
•
•
Protein Domain
IPR035986 | PKD_dom_sf
Type: Homologous_superfamily
Description: The polycystic kidney disease (PKD) domain is an 80-90 amino acid module originally found in 16 copies in the extracellular segment of polycystin-1, a large cell surface glycoprotein. Polycystin-1 is encoded by the PKD1 gene, which is mutated in autosomal dominant polycystic kidney disease (ADPKD).Although its function is unknown, it may be involved in protein-protein and protein-carbohydrate interactions based on its predicted domain structure. One or more copies of the PKD domain are also found in several other extracellular proteins from higher organisms, eubacteria, and archaebacteria. Singles copies of the PKD domain are found in the melanocytes heavily glycosylated cell-surface proteins Pmel 17, MMP and Nmp. Some bacterial collagenases and proteases also contain a single PKD domain adjacent to their catalytic domains, whereas four copies are present in the heavily glycosylated surface layer protein of archaebacteria []. The PKD modules are often observed, within a same protein sequence, in association with FnIII domains [].The most conserved motif is the WDFGDGS sequence that is found in the central part of many PKD domains and could play a structural role [, ]. Determination of the solution structure of the first PKD domain from human polycystin-1 has shown that the module is built from two β-sheet, one of three strands and one of four strands, which are packed face-to-face [].
•
•
•
•
•
Protein
Q8BQQ0
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
•
•
•
•
•
Publication
10933504 | -
First Author: Callebaut I
Year: 2000
Journal: Protein Sci
Title: HYR, an extracellular module involved in cellular adhesion and related to the immunoglobulin-like fold.
Volume: 9
Issue: 7
Pages: 1382-90
•
•
•
•
•
Protein
Q9Z0T6
Organism: Mus musculus/domesticus
Length: 2126  
Fragment?: false
•
•
•
•
•
Protein
F8VQF3
Organism: Mus musculus/domesticus
Length: 2126  
Fragment?: false
•
•
•
•
•
Publication
24161911 | J:238039
 
First Author: Taglieri DM
Year: 2014
Journal: J Mol Cell Cardiol
Title: The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.
Volume: 66
Pages: 27-40
•
•
•
•
•
Publication
10760273 | J:175122
First Author: Gallagher AR
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton.
Volume: 97
Issue: 8
Pages: 4017-22
•
•
•
•
•
Publication
20819079 | J:166867
First Author: Matthews SA
Year: 2010
Journal: Biochem J
Title: Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells.
Volume: 432
Issue: 1
Pages: 153-63
•
•
•
•
•
Publication
19029091 | J:180571
First Author: Jensen ED
Year: 2009
Journal: J Biol Chem
Title: Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2.
Volume: 284
Issue: 4
Pages: 2225-34
•
•
•
•
•
Publication
18202188 | J:131370
First Author: Gallagher AR
Year: 2008
Journal: Am J Pathol
Title: Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1.
Volume: 172
Issue: 2
Pages: 417-29
•
•
•
•
•
Publication
12782129 | J:83807
First Author: Li A
Year: 2003
Journal: Genomics
Title: Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes.
Volume: 81
Issue: 6
Pages: 596-608
•
•
•
•
•
Publication
24336289 | J:207900
First Author: DeCaen PG
Year: 2013
Journal: Nature
Title: Direct recording and molecular identification of the calcium channel of primary cilia.
Volume: 504
Issue: 7479
Pages: 315-8
•
•
•
•
•
Publication
11863367 | J:75162
First Author: Yuasa T
Year: 2002
Journal: Genomics
Title: The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human.
Volume: 79
Issue: 3
Pages: 376-86
•
•
•
•
•
Publication
28549111 | J:258999
First Author: Abdurrachim D
Year: 2017
Journal: Cardiovasc Res
Title: Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations.
Volume: 113
Issue: 10
Pages: 1148-1160
•
•
•
•
•
Publication
25464512 | J:225694
First Author: Xiao Z
Year: 2014
Journal: PLoS One
Title: Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposity.
Volume: 9
Issue: 12
Pages: e114198
•
•
•
•
•
Publication
19729489 | J:153052
First Author: Prasad S
Year: 2009
Journal: Am J Pathol
Title: Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury.
Volume: 175
Issue: 4
Pages: 1493-503
•
•
•
•
•
Publication
28376279 | J:302949
First Author: Ay M
Year: 2017
Journal: J Neurochem
Title: Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease.
Volume: 141
Issue: 5
Pages: 766-782
•
•
•
•
•
Publication
19692352 | J:153717
First Author: Zhou J
Year: 2009
Journal: Hum Mol Genet
Title: Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1.
Volume: 18
Issue: 22
Pages: 4428-41
•
•
•
•
•
Publication
9748274 | J:50327
First Author: Nomura H
Year: 1998
Journal: J Biol Chem
Title: Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects.
Volume: 273
Issue: 40
Pages: 25967-73
•
•
•
•
•
Publication
33536341 | J:301986
 
First Author: Barone S
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.
Volume: 118
Issue: 6
•
•
•
•
•
Publication
21736870 | J:176476
First Author: Bhavanasi D
Year: 2011
Journal: Biochem Pharmacol
Title: Protein kinase Cδ mediates the activation of protein kinase D2 in platelets.
Volume: 82
Issue: 7
Pages: 720-7
•
•
•
•
•
Publication
24345679 | J:259563
First Author: Xiang SY
Year: 2013
Journal: Sci Signal
Title: PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart.
Volume: 6
Issue: 306
Pages: ra108
•
•
•
•
•
Publication
18378694 | J:137270
First Author: Kim MS
Year: 2008
Journal: Mol Cell Biol
Title: Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance.
Volume: 28
Issue: 11
Pages: 3600-9
•
•
•
•
•
Publication
22820510 | J:189149
First Author: Ferdaoussi M
Year: 2012
Journal: Diabetologia
Title: G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.
Volume: 55
Issue: 10
Pages: 2682-2692
•
•
•
•
•
Publication
18025234 | J:155206
First Author: Murphy TR
Year: 2007
Journal: J Immunol
Title: Activation of protein kinase D1 in mast cells in response to innate, adaptive, and growth factor signals.
Volume: 179
Issue: 11
Pages: 7876-82
•
•
•
•
•
Publication
28461572 | J:247883
First Author: Upadhyay K
Year: 2017
Journal: J Immunol
Title: Group B Streptococci Induce Proinflammatory Responses via a Protein Kinase D1-Dependent Pathway.
Volume: 198
Issue: 11
Pages: 4448-4457
•
•
•
•
•
Publication
20142359 | J:160123
First Author: Kim YI
Year: 2010
Journal: J Immunol
Title: Protein kinase D1 is essential for the proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic actinomycetes Saccharopolyspora rectivirgula.
Volume: 184
Issue: 6
Pages: 3145-56
•
•
•
•
•
Publication
25753731 | J:349057
First Author: Fang X
Year: 2015
Journal: Prostate
Title: Novel In Vivo model for combinatorial fluorescence labeling in mouse prostate.
Volume: 75
Issue: 9
Pages: 988-1000
•
•
•
•
•
Publication
33675805 | J:307694
First Author: Li G
Year: 2021
Journal: Exp Cell Res
Title: Adipose-specific knockout of Protein Kinase D1 suppresses de novo lipogenesis in mice via SREBP1c-dependent signaling.
Volume: 401
Issue: 2
Pages: 112548
•
•
•
•
•
Publication
36172952 | J:331801
First Author: Bossuyt J
Year: 2022
Journal: J Am Heart Assoc
Title: Protein Kinase D1 Regulates Cardiac Hypertrophy, Potassium Channel Remodeling, and Arrhythmias in Heart Failure.
Volume: 11
Issue: 19
Pages: e027573
•
•
•
•
•
Publication
24213370 | J:207335
First Author: Rashel M
Year: 2014
Journal: J Invest Dermatol
Title: Protein kinase D1 has a key role in wound healing and skin carcinogenesis.
Volume: 134
Issue: 4
Pages: 902-909
•
•
•
•
•
Publication
26292219 | J:340233
First Author: Hajarnis SS
Year: 2015
Journal: J Biol Chem
Title: Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA.
Volume: 290
Issue: 41
Pages: 24793-805
•
•
•
•
•
Publication
36503993 | J:338389
First Author: Belyea BC
Year: 2023
Journal: Clin Sci (Lond)
Title: Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype.
Volume: 137
Issue: 1
Pages: 35-45
•
•
•
•
•
Publication
30389661 | J:270453
 
First Author: Löffler MC
Year: 2018
Journal: EMBO J
Title: Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity.
Volume: 37
Issue: 22
•
•
•
•
•
Publication
29038309 | J:255151
First Author: Bergeron V
Year: 2018
Journal: Diabetes
Title: Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice.
Volume: 67
Issue: 1
Pages: 71-77
•
•
•
•
•
Publication
31809526 | J:282669
First Author: Yoon TW
Year: 2019
Journal: PLoS One
Title: Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis.
Volume: 14
Issue: 12
Pages: e0226145
•
•
•
•
•
Publication
23970783 | J:203949
First Author: Ford JJ
Year: 2013
Journal: Endocrinology
Title: Protein kinase D1 is essential for bone acquisition during pubertal growth.
Volume: 154
Issue: 11
Pages: 4182-91
•
•
•
•
•
Publication
24492625 | J:229519
First Author: Atik N
Year: 2014
Journal: Cell Struct Funct
Title: The role of PKD in cell polarity, biosynthetic pathways, and organelle/F-actin distribution.
Volume: 39
Issue: 1
Pages: 61-77
•
•
•
•
•
Publication
16261614 | J:106427
First Author: Butscheid Y
Year: 2006
Journal: Mol Reprod Dev
Title: Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head.
Volume: 73
Issue: 3
Pages: 350-60
•
•
•
•
•
Publication
20408813 | J:182478
First Author: Molland KL
Year: 2010
Journal: Biochem J
Title: Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2.
Volume: 429
Issue: 1
Pages: 171-83
•
•
•
•
•
Publication
18922886 | J:162985
First Author: Islam MR
Year: 2008
Journal: Am J Physiol Renal Physiol
Title: Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter.
Volume: 295
Issue: 6
Pages: F1845-54
•
•
•
•
•
Publication
12547704 | J:94888
First Author: Cai S
Year: 2003
Journal: Am J Pathol
Title: Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.
Volume: 162
Issue: 2
Pages: 457-68
•
•
•
•
•
Publication
16648482 | J:109064
First Author: Harrison BC
Year: 2006
Journal: Mol Cell Biol
Title: Regulation of cardiac stress signaling by protein kinase d1.
Volume: 26
Issue: 10
Pages: 3875-88
•
•
•
•
•
Publication
16797938 | J:116032
First Author: Wilson SJ
Year: 2006
Journal: Biochim Biophys Acta
Title: Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia.
Volume: 1762
Issue: 7
Pages: 647-55
•
•
•
•
•
Publication
18439271 | J:136668
 
First Author: Ellwanger K
Year: 2008
Journal: BMC Dev Biol
Title: Expression patterns of protein kinase D 3 during mouse development.
Volume: 8
Pages: 47
•
•
•
•
•
Publication
18753385 | J:138787
First Author: Yin DM
Year: 2008
Journal: J Neurosci
Title: Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus.
Volume: 28
Issue: 35
Pages: 8832-43
•
•
•
•
•
Publication
19028687 | J:146944
First Author: Chen LA
Year: 2009
Journal: J Biol Chem
Title: PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion.
Volume: 284
Issue: 4
Pages: 2459-71
•
•
•
•
•
Publication
19244406 | J:149856
First Author: Tsiokas L
Year: 2009
Journal: Am J Physiol Renal Physiol
Title: Function and regulation of TRPP2 at the plasma membrane.
Volume: 297
Issue: 1
Pages: F1-9
•
•
•
•
•
Publication
31492751 | J:283073
First Author: Wang Y
Year: 2019
Journal: J Biol Chem
Title: Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2β.
Volume: 294
Issue: 43
Pages: 15759-15767
•
•
•
•
•
Publication
24370592 | J:207308
First Author: Vijayakumar S
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD.
Volume: 306
Issue: 6
Pages: F640-54
•
•
•
•
•
Publication
24928905 | J:216242
First Author: Aicart-Ramos C
Year: 2014
Journal: J Cell Sci
Title: Protein kinase D activity controls endothelial nitric oxide synthesis.
Volume: 127
Issue: Pt 15
Pages: 3360-72
•
•
•
•
•
Publication
24925129 | J:217953
First Author: Jin X
Year: 2014
Journal: Biochim Biophys Acta
Title: L-type calcium channel modulates cystic kidney phenotype.
Volume: 1842
Issue: 9
Pages: 1518-26
•
•
•
•
•
Publication
25802335 | J:222160
First Author: Ryvkin V
Year: 2015
Journal: J Biol Chem
Title: Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.
Volume: 290
Issue: 17
Pages: 11199-208
•
•
•
•
•
Publication
26148697 | J:254419
 
First Author: Müller M
Year: 2015
Journal: Sci Rep
Title: A time frame permissive for Protein Kinase D2 activity to direct angiogenesis in mouse embryonic stem cells.
Volume: 5
Pages: 11742
•
•
•
•
•
Publication
26045048 | J:258901
First Author: Mazzeo C
Year: 2016
Journal: Cell Death Differ
Title: Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes.
Volume: 23
Issue: 1
Pages: 99-109
•
•
•
•
•
Publication
29530879 | J:260422
 
First Author: Zhang B
Year: 2018
Journal: Development
Title: Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney.
Volume: 145
Issue: 6
•
•
•
•
•
Publication
29426897 | J:262638
First Author: Lin CC
Year: 2018
Journal: Sci Rep
Title: A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed.
Volume: 8
Issue: 1
Pages: 2743
•
•
•
•
•
Publication
30215740 | J:268290
First Author: Merrick D
Year: 2019
Journal: Hum Mol Genet
Title: Polycystin-1 regulates bone development through an interaction with the transcriptional coactivator TAZ.
Volume: 28
Issue: 1
Pages: 16-30
•
•
•
•
•
Publication
19211839 | J:273038
First Author: Czöndör K
Year: 2009
Journal: Mol Biol Cell
Title: Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons.
Volume: 20
Issue: 7
Pages: 2108-20
•
•
•
•
•
Publication
28722750 | J:272691
First Author: Liliom H
Year: 2017
Journal: J Neurochem
Title: Protein kinase D exerts neuroprotective functions during oxidative stress via nuclear factor kappa B-independent signaling pathways.
Volume: 142
Issue: 6
Pages: 948-961
•
•
•
•
•
Publication
31441214 | J:282579
First Author: Wang Z
Year: 2019
Journal: EMBO Rep
Title: The ion channel function of polycystin-1 in the polycystin-1/polycystin-2 complex.
Volume: 20
Issue: 11
Pages: e48336
•
•
•
•
•
Publication
30928102 | J:290917
First Author: Kashyap P
Year: 2019
Journal: Biochem Biophys Res Commun
Title: A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site.
Volume: 512
Issue: 4
Pages: 812-818
•
•
•
•
•
Publication
31544793 | J:289773
   
First Author: Suto JI
Year: 2019
Journal: J Genet
Title: Genetic analysis of the mandible morphology in DDD.Cg-Ay/Sgn and C57BL/6J inbred mice.
Volume: 98
•
•
•
•
•
Publication
34315885 | J:322289
First Author: Ding H
Year: 2021
Journal: Nat Commun
Title: Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease.
Volume: 12
Issue: 1
Pages: 4548
•
•
•
•
•
Publication
24647541 | J:319057
First Author: Sinnett-Smith J
Year: 2014
Journal: Am J Physiol Cell Physiol
Title: Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling.
Volume: 306
Issue: 10
Pages: C961-71
•
•
•
•
•
Publication
25450094 | J:319113
First Author: Choudhary V
Year: 2014
Journal: J Dermatol Sci
Title: Protein kinase D1 deficiency promotes differentiation in epidermal keratinocytes.
Volume: 76
Issue: 3
Pages: 186-95
•
•
•
•
•
Publication
27278932 | J:319202
First Author: de Stephanis L
Year: 2017
Journal: Clin Exp Nephrol
Title: Double inhibition of cAMP and mTOR signalling may potentiate the reduction of cell growth in ADPKD cells.
Volume: 21
Issue: 2
Pages: 203-211
•
•
•
•
•
Publication
25173922 | J:318299
 
First Author: Dirkx E
Year: 2014
Journal: J Mol Cell Cardiol
Title: Protein kinase-D1 overexpression prevents lipid-induced cardiac insulin resistance.
Volume: 76
Pages: 208-17
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom