| Type |
Details |
Score |
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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•
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•
•
•
|
| GXD Expression |
| Probe: |
MGI:2149733 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-12-31 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1691021 |
| Pattern: |
Regionally restricted |
| Stage: |
TS21 |
| Assay Id: |
MGI:7790978 |
| Age: |
embryonic day 13.5 |
|
| Note: |
Coexpressed with Robo1 in corridor cells. |
| Specimen Label: |
5H/H' |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3718595 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-08-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5431797 |
| Age: |
postnatal adult |
| Image: |
3B |
| Note: |
Co-expressed with Robo1 in the spinal cord. |
| Specimen Label: |
3B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3718595 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-08-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5431797 |
| Age: |
postnatal adult |
| Image: |
3C |
| Note: |
Co-expressed with Robo1 in the spinal cord. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Allele |
| Name: |
roundabout guidance receptor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5752616 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2016-03-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3266520 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:5752744 |
| Age: |
embryonic day 12.5 |
|
| Note: |
Expression appeared to be complementary to that of Robo3 within the subpallium, while overlapping with Robo1 in the lateral ganglionic eminence. |
| Specimen Label: |
S1E |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5752616 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2016-03-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3747020 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:5752744 |
| Age: |
embryonic day 12.5 |
|
| Note: |
Expression appeared to be complementary to that of Robo3 within the subpallium, while overlapping with Robo1 in the lateral ganglionic eminence. |
| Specimen Label: |
S1E |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5752618 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2016-03-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3747020 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:5752742 |
| Age: |
embryonic day 12.5 |
|
| Note: |
Robo1 and Robo3 showed similar patterns of expression both within the lateral and medial ganglionic eminences, and overlapped in regions where Robo1 protein was most robustly localized. |
| Specimen Label: |
S1F |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5752618 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2016-03-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3747120 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:5752742 |
| Age: |
embryonic day 12.5 |
|
| Note: |
Robo1 and Robo3 showed similar patterns of expression both within the lateral and medial ganglionic eminences, and overlapped in regions where Robo1 protein was most robustly localized. |
| Specimen Label: |
S1F |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2153065 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2016-03-22 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:5752757 |
| Age: |
embryonic day 13.5 |
|
| Note: |
Expressed in the cortical interneurons. There was a decrease in the total number of labeled cells relative to an animal which was heterozygote for both Robo1 and Robo2 receptors and fully deficient for the Robo3 receptor. |
| Specimen Label: |
not shown |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
The SLIT-ROBO Rho GTPase-activating protein (srGAP) family consists of four members: srGAP1, -2, -3 and -4. They contain F-BAR, RhoGAP and SH3 domains. Their RhoGAP domain is involved in negative regulation of Rho GTPase activities important for cytoskeleton rearrangement []. The srGAP family members have an "inverse F-BAR"or IF-BAR domain that is distinct from other F-BAR domains such as FBP17. They are multifunctional adaptor proteins involved in various aspects of neuronal development [].This entry represents the F-BAR domain of srGAP1. srGAP1, also called Rho GTPase-Activating Protein 13 (ARHGAP13), is a Cdc42- and RhoA-specific GAP and is expressed later in the development of CNS (central nervous system) tissues. It is an important downstream signaling molecule of Robo1 [, ]. |
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•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang XM |
| Year: |
2010 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis. |
| Volume: |
396 |
| Issue: |
2 |
| Pages: |
571-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dun XP |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge. |
| Volume: |
26 |
| Issue: |
6 |
| Pages: |
1458-1472.e4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bacon C |
| Year: |
2009 |
| Journal: |
J Comp Neurol |
| Title: |
Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system. |
| Volume: |
513 |
| Issue: |
2 |
| Pages: |
224-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Castillo-Paterna M |
| Year: |
2015 |
| Journal: |
EMBO Rep |
| Title: |
DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity. |
| Volume: |
16 |
| Issue: |
7 |
| Pages: |
851-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li S |
| Year: |
2015 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Slit2 Promotes Angiogenic Activity Via the Robo1-VEGFR2-ERK1/2 Pathway in Both In Vivo and In Vitro Studies. |
| Volume: |
56 |
| Issue: |
9 |
| Pages: |
5210-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tavora B |
| Year: |
2020 |
| Journal: |
Nature |
| Title: |
Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis. |
| Volume: |
586 |
| Issue: |
7828 |
| Pages: |
299-304 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sano N |
| Year: |
2017 |
| Journal: |
Front Cell Neurosci |
| Title: |
Enhanced Axonal Extension of Subcortical Projection Neurons Isolated from Murine Embryonic Cortex using Neuropilin-1. |
| Volume: |
11 |
|
| Pages: |
123 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Andrews WD |
| Year: |
2016 |
| Journal: |
J Comp Neurol |
| Title: |
Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice. |
| Volume: |
524 |
| Issue: |
3 |
| Pages: |
518-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Verissimo AR |
| Year: |
2009 |
| Journal: |
Biochem Soc Trans |
| Title: |
Functionally defining the endothelial transcriptome, from Robo4 to ECSCR. |
| Volume: |
37 |
| Issue: |
Pt 6 |
| Pages: |
1214-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang YH |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion. |
| Volume: |
110 |
| Issue: |
41 |
| Pages: |
16480-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharifpanah F |
| Year: |
2016 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Mechanical strain stimulates vasculogenesis and expression of angiogenesis guidance molecules of embryonic stem cells through elevation of intracellular calcium, reactive oxygen species and nitric oxide generation. |
| Volume: |
1863 |
| Issue: |
12 |
| Pages: |
3096-3105 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park SJ |
| Year: |
2019 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
SLIT2 inhibits osteoclastogenesis and bone resorption by suppression of Cdc42 activity. |
| Volume: |
514 |
| Issue: |
3 |
| Pages: |
868-874 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang X |
| Year: |
2020 |
| Journal: |
Am J Pathol |
| Title: |
miR-218 Expressed in Endothelial Progenitor Cells Contributes to the Development and Repair of the Kidney Microvasculature. |
| Volume: |
190 |
| Issue: |
3 |
| Pages: |
642-659 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang L |
| Year: |
2020 |
| Journal: |
Front Cell Dev Biol |
| Title: |
SLIT2 Overexpression in Periodontitis Intensifies Inflammation and Alveolar Bone Loss, Possibly via the Activation of MAPK Pathway. |
| Volume: |
8 |
|
| Pages: |
593 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma Y |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells. |
| Volume: |
8 |
| Issue: |
3 |
| Pages: |
e57865 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo S |
| Year: |
2010 |
| Journal: |
J Biol Chem |
| Title: |
srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization. |
| Volume: |
285 |
| Issue: |
45 |
| Pages: |
35133-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Q |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. |
| Volume: |
106 |
| Issue: |
31 |
| Pages: |
12700-5 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1062
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1085
 |
| Fragment?: |
false |
|
•
•
•
•
•
|