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Search results 1001 to 1100 out of 1155 for Rrm2

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Type Details Score
Publication
10499800 | -
First Author: Deo RC
Year: 1999
Journal: Cell
Title: Recognition of polyadenylate RNA by the poly(A)-binding protein.
Volume: 98
Issue: 6
Pages: 835-45
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Publication
14717712 | -
First Author: Sladic RT
Year: 2004
Journal: Eur J Biochem
Title: Human PABP binds AU-rich RNA via RNA-binding domains 3 and 4.
Volume: 271
Issue: 2
Pages: 450-7
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Publication
26554031 | -
First Author: Kini HK
Year: 2016
Journal: RNA
Title: Cytoplasmic poly(A) binding protein-1 binds to genomically encoded sequences within mammalian mRNAs.
Volume: 22
Issue: 1
Pages: 61-74
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Publication
21940797 | J:183010
First Author: Burgess HM
Year: 2011
Journal: J Cell Sci
Title: Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs.
Volume: 124
Issue: Pt 19
Pages: 3344-55
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Publication
9418852 | -
First Author: Kessler SH
Year: 1998
Journal: Mol Cell Biol
Title: RNA recognition motif 2 of yeast Pab1p is required for its functional interaction with eukaryotic translation initiation factor 4G.
Volume: 18
Issue: 1
Pages: 51-7
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Protein Domain
IPR045305 | RRM2_I_PABPs
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of type I poly(A)-binding proteins (PABPs).Poly(A)-binding proteins (PABPs) are highly conserved proteins that bind to the poly(A) tail present at the 3' ends of most eukaryotic mRNAs []. These highly conserved proteins are found only in eukaryotes; single-celled eukaryotes each have a single PABP, whereas humans have five and Arabidopis has eight. In humans, three lineages of PABP proteins are observed: cytoplasmic PABPs (PABPC1, PABPC3, and iPABP); nuclear PABP (PABPN1); and X-linked PABP (PABPC5) []. The mammalian PABPs contain four RNA recognition motifs (RRMs). RRM 1 and 2 are primarily responsible for the high-affinity binding to homopolymeric adenosines, while RRMs 3 and 4 can bind to nonhomopolymeric AU sequences []. Proteins containing this motif include:Polyadenylate-binding protein 1 (PABP-1 or PABPC1): PABP-1 is the major cytoplasmic PABP isoform in adult mouse somatic cells. It is able to bindsimultaneously to the cap-binding complex subunit eIF4G and to the poly(A) tail. Therefore, it has been suggested to play a role in altering the structure and/or function of the translation termination complex. It may have additional functions within the eukaryotic mRNA transcriptome. PABP-1 possesses an A-rich sequence in its 5'-UTR and allows binding of PABP and blockage of translation of its own mRNA []. Polyadenylate-binding protein 3 (PABP-3 or PABPC3): PABP-3 is a testis-specific poly(A)-binding protein specifically expressed in round spermatids. It is mainly found in mammalian and may play an important role in the testis-specific regulation of mRNA homeostasis. PABP-3 shows significant sequence similarity to PABP-1. However, it binds to poly(A) with a lower affinity than PABP-1. Dislike PABP-1, PABP-3 lacks the A-rich sequence in its 5'-UTR []. Polyadenylate-binding protein 4 (PABP-4 or APP-1 or iPABP): PABP-4 is an inducible poly(A)-binding protein (iPABP) that is primarily localized to the cytoplasm. It shows significant sequence similarity to PABP-1 as well. The RNA binding properties of PABP-1 and PABP-4 appear to be identical []. Polyadenylate-binding protein 5 (PABP-5 or PABPC5):PABP-5 is encoded by PABPC5 gene within the X-specific subinterval, and expressed in fetal brain and in a range of adult tissues in mammals, such as ovary and testis. It may play an important role in germ cell development []. Moreover, unlike other PABPs, PABP-5 contains only four RRMs, but lacks both the linker region and the CTD. Polyadenylate-binding protein 1-like (PABP-1-like or PABPC1L): orthologue of PABP-1.Polyadenylate-binding protein 1-like 2 (PABPC1L2 or RBM32): orthologue of PABP-1. Polyadenylate-binding protein 4-like (PABP-4-like or PABPC4L): orthologue of PABP-5. Polyadenylate-binding protein, cytoplasmic and nuclear (PABP or ACBP-67): PABP is a conserved poly(A) binding protein containing poly(A) tails that can be attached to the 3'-ends of mRNAs. The yeast PABP, also known as Pab1, and its homologues may play important roles in the initiation of translation and in mRNA decay []. Like vertebrate PABP-1, Pab1 contains four RRMs, a linker region, and a proline-rich CTD as well. The first two RRMs are mainly responsible for specific binding to poly(A). The proline-rich region may be involved in protein-protein interactions. The association of RRM2 of yeast Pab1 with eIF4G is a prerequisite for the poly(A) tail to stimulate the translation of mRNA in vitro []. Polyadenylate-binding protein Pes4 and Mip6.
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Protein
P17225
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
Q922I7
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q3UBR5
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
Q3T984
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
Q5RJV5
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q8C2R5
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
Q8K144
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q3TQW3
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
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Protein
Q6NZB8
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q3U5I2
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
E9QMW9
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein
Q80T07
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: false
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Protein
Q8BGJ5
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Publication
29802307 | J:262555
First Author: Vogt MA
Year: 2018
Journal: Sci Rep
Title: TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons.
Volume: 8
Issue: 1
Pages: 8097
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Publication
28832631 | J:247223
First Author: Penndorf D
Year: 2017
Journal: PLoS One
Title: DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1G93A model of amyotrophic lateral sclerosis in vivo and in vitro.
Volume: 12
Issue: 8
Pages: e0183684
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Publication
35262486 | J:327262
   
First Author: Harb K
Year: 2022
Journal: Elife
Title: Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex.
Volume: 11
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Publication
31355778 | J:294122
First Author: Araki K
Year: 2019
Journal: J Clin Invest
Title: TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
Volume: 129
Issue: 9
Pages: 3578-3593
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Publication
25457553 | J:219503
First Author: Liu Y
Year: 2015
Journal: Neurobiol Aging
Title: Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse.
Volume: 36
Issue: 2
Pages: 1151-9
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Publication
30410094 | J:278089
First Author: Vaughan SK
Year: 2018
Journal: Sci Rep
Title: The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress.
Volume: 8
Issue: 1
Pages: 16582
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Publication
24154542 | J:206221
First Author: Magrané J
Year: 2014
Journal: Hum Mol Genet
Title: Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models.
Volume: 23
Issue: 6
Pages: 1413-24
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Publication
34112844 | J:323697
First Author: Mejia Maza A
Year: 2021
Journal: Sci Rep
Title: NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease.
Volume: 11
Issue: 1
Pages: 12251
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Publication
22718760 | J:190254
First Author: Wu LS
Year: 2012
Journal: J Biol Chem
Title: Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice.
Volume: 287
Issue: 33
Pages: 27335-44
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Publication
33689679 | J:303815
   
First Author: Chang KJ
Year: 2021
Journal: Elife
Title: TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells.
Volume: 10
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Publication
18238900 | J:131829
First Author: Kim HJ
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia.
Volume: 105
Issue: 6
Pages: 2094-9
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Publication
38585660 | J:348975
First Author: Zhang H
Year: 2024
Journal: iScience
Title: TDP-43 deficiency in suprachiasmatic nucleus perturbs rhythmicity of neuroactivity in prefrontal cortex.
Volume: 27
Issue: 4
Pages: 109522
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Publication
26136049 | J:227087
First Author: Vaughan SK
Year: 2015
Journal: J Comp Neurol
Title: Degeneration of proprioceptive sensory nerve endings in mice harboring amyotrophic lateral sclerosis-causing mutations.
Volume: 523
Issue: 17
Pages: 2477-94
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Publication
33613100 | J:304881
First Author: Zhang R
Year: 2021
Journal: Int J Biol Sci
Title: Spreading of pathological TDP-43 along corticospinal tract axons induces ALS-like phenotypes in Atg5+/- mice.
Volume: 17
Issue: 2
Pages: 390-401
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Publication
24986919 | J:323507
First Author: Galloway JN
Year: 2014
Journal: Hum Mol Genet
Title: CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome.
Volume: 23
Issue: 22
Pages: 5906-15
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Publication
20040602 | J:159888
First Author: Sephton CF
Year: 2010
Journal: J Biol Chem
Title: TDP-43 is a developmentally regulated protein essential for early embryonic development.
Volume: 285
Issue: 9
Pages: 6826-34
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Publication
23798570 | J:201688
First Author: Dang TN
Year: 2013
Journal: Dis Model Mech
Title: Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model.
Volume: 6
Issue: 5
Pages: 1198-204
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Publication
37118836 | J:335444
First Author: Swanson MEV
Year: 2023
Journal: Acta Neuropathol Commun
Title: Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain.
Volume: 11
Issue: 1
Pages: 69
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Publication
28487370 | J:245965
First Author: Gu J
Year: 2017
Journal: J Biol Chem
Title: Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathies.
Volume: 292
Issue: 25
Pages: 10600-10612
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Publication
22733568 | J:188420
First Author: Wils H
Year: 2012
Journal: J Pathol
Title: Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.
Volume: 228
Issue: 1
Pages: 67-76
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Publication
26525917 | J:346362
First Author: MacNair L
Year: 2016
Journal: Brain
Title: MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
Volume: 139
Issue: Pt 1
Pages: 86-100
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Publication
19046946 | J:147807
 
First Author: Moisse K
Year: 2009
Journal: Brain Res
Title: Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury.
Volume: 1249
Pages: 202-11
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Publication
19910924 | J:156405
First Author: Fiesel FC
Year: 2010
Journal: EMBO J
Title: Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6.
Volume: 29
Issue: 1
Pages: 209-21
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Publication
37315918 | J:360449
 
First Author: Bai D
Year: 2023
Journal: Prog Neurobiol
Title: Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.
Volume: 227
Pages: 102484
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Publication
26037142 | J:223381
First Author: Lee S
Year: 2015
Journal: FEBS Lett
Title: Hyperproduction of IL-6 caused by aberrant TDP-43 overexpression in high-fat diet-induced obese mice.
Volume: 589
Issue: 15
Pages: 1825-31
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Publication
25256353 | J:318262
First Author: Liu YJ
Year: 2015
Journal: Hum Mol Genet
Title: Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.
Volume: 24
Issue: 3
Pages: 787-801
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Protein
Q61701
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Protein
P70372
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
Q6PEE3
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
P11157
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
Q60900
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Protein
Q8BW03
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
D3Z2A4
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
Q8CII5
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: false
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Protein
Q3TT05
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: true
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Protein
D3YY02
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
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Protein
Q8BTQ1
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: true
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Protein
F6RUC3
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: true
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Protein
Q3THV8
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
Q9DBE3
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Protein
A0A0A6YWT2
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
Q8BVF8
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
V9GXG3
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Protein
Q8BM84
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
D3Z0D8
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: true
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Protein
Q3UFF9
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
Q9CXQ0
Organism: Mus musculus/domesticus
Length: 371  
Fragment?: false
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Protein
Q8BT02
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: true
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Protein
Q921B8
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Publication
36584679 | J:336664
First Author: Jung J
Year: 2023
Journal: Neuron
Title: mRNA transport, translation, and decay in adult mammalian central nervous system axons.
Volume: 111
Issue: 5
Pages: 650-668.e4
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Publication
32866962 | J:300323
First Author: Zhang J
Year: 2020
Journal: Nature
Title: Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
Volume: 588
Issue: 7838
Pages: 459-465
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Publication
20660762 | J:164406
First Author: Chiang PM
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.
Volume: 107
Issue: 37
Pages: 16320-4
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Publication
19619516 | J:157211
 
First Author: Moisse K
Year: 2009
Journal: Brain Res
Title: Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-/- mice: support for a role for TDP-43 in the physiological response to neuronal injury.
Volume: 1296
Pages: 176-86
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Publication
24595038 | J:214698
First Author: Perera ND
Year: 2014
Journal: PLoS One
Title: Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.
Volume: 9
Issue: 3
Pages: e90449
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Publication
35767949 | J:337175
First Author: Krus KL
Year: 2022
Journal: Cell Rep
Title: Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy.
Volume: 39
Issue: 13
Pages: 111001
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Publication
34916658 | J:336207
First Author: Xie M
Year: 2022
Journal: Nat Neurosci
Title: TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.
Volume: 25
Issue: 1
Pages: 26-38
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Publication
38157451 | J:352540
First Author: Yang X
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation.
Volume: 121
Issue: 1
Pages: e2307395120
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Publication
38615036 | J:348472
First Author: Guo C
Year: 2024
Journal: Sci Rep
Title: Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease.
Volume: 14
Issue: 1
Pages: 8581
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Publication
33031745 | J:298617
First Author: Yu CH
Year: 2020
Journal: Cell
Title: TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.
Volume: 183
Issue: 3
Pages: 636-649.e18
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Publication
31242080 | J:313181
First Author: Donde A
Year: 2020
Journal: Autophagy
Title: Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Volume: 16
Issue: 4
Pages: 672-682
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Publication
25155018 | J:218705
First Author: Ward ME
Year: 2014
Journal: J Exp Med
Title: Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
Volume: 211
Issue: 10
Pages: 1937-45
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Publication
34988393 | J:342505
First Author: Devoy A
Year: 2021
Journal: iScience
Title: Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models.
Volume: 24
Issue: 12
Pages: 103463
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Publication
27378374 | J:240782
 
First Author: Kapeli K
Year: 2016
Journal: Nat Commun
Title: Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Volume: 7
Pages: 12143
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Publication
30354839 | J:284994
   
First Author: Gasperini L
Year: 2018
Journal: Mol Biol Cell
Title: The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.
Pages: mbcE18020108
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Publication
22526419 | J:197777
First Author: Zheng M
Year: 2012
Journal: J Cell Sci
Title: Regulation of nuclear TDP-43 by NR2A-containing NMDA receptors and PTEN.
Volume: 125
Issue: Pt 6
Pages: 1556-67
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Publication
31611772 | J:282177
 
First Author: Brettle M
Year: 2019
Journal: Front Mol Neurosci
Title: Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice.
Volume: 12
Pages: 231
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Protein
Q3V2M1
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: true
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Protein
Q8C7D3
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
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Protein
G5E8X2
Organism: Mus musculus/domesticus
Length: 370  
Fragment?: false
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Publication
27123980 | J:283196
First Author: Hirano A
Year: 2016
Journal: PLoS One
Title: USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock.
Volume: 11
Issue: 4
Pages: e0154263
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Publication
22570411 | J:190257
First Author: Berkovits BD
Year: 2012
Journal: Nucleic Acids Res
Title: The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids.
Volume: 40
Issue: 15
Pages: 7162-75
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Publication
26044557 | J:298381
First Author: Koppers M
Year: 2015
Journal: Ann Neurol
Title: C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits.
Volume: 78
Issue: 3
Pages: 426-38
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Publication
34130995 | J:308471
 
First Author: Homma H
Year: 2021
Journal: Life Sci Alliance
Title: DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.
Volume: 4
Issue: 7
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Publication
34687812 | J:324271
 
First Author: Kao TJ
Year: 2022
Journal: Neurosci Res
Title: TDP-43 is essential for Eph receptor-class-specific spinal motor axon trajectory into the limb.
Volume: 176
Pages: 31-39
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Publication
34385591 | J:348199
First Author: Jin M
Year: 2021
Journal: Commun Biol
Title: Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis.
Volume: 4
Issue: 1
Pages: 961
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Publication
20139417 | J:162046
First Author: Schebelle L
Year: 2010
Journal: Nucleic Acids Res
Title: Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.
Volume: 38
Issue: 9
Pages: e106
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Publication
29764981 | J:265666
 
First Author: Fratta P
Year: 2018
Journal: EMBO J
Title: Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
Volume: 37
Issue: 11
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Publication
38343132 | J:347607
First Author: Benzow K
Year: 2024
Journal: Alzheimers Dement
Title: Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.
Volume: 20
Issue: 4
Pages: 3080-3087
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Publication
34630013 | J:312418
 
First Author: Gagné M
Year: 2021
Journal: Front Neurosci
Title: hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated.
Volume: 15
Pages: 724307
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Protein
P29341
Organism: Mus musculus/domesticus
Length: 636  
Fragment?: false
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Protein
A2A5N3
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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