| Type |
Details |
Score |
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
275 |
| Description: |
Necessary for synergistic transcriptional activity with SMAD3 |
| Type: |
site |
| End: |
275 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nagarajan RP |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
Regulation of Smad7 promoter by direct association with Smad3 and Smad4. |
| Volume: |
274 |
| Issue: |
47 |
| Pages: |
33412-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Osseni A |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
7108 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seo HY |
| Year: |
2019 |
| Journal: |
Cells |
| Title: |
Clusterin Attenuates Hepatic Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Downregulating the Smad3 Signaling Pathway. |
| Volume: |
8 |
| Issue: |
11 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Han CY |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt. |
| Volume: |
7 |
|
| Pages: |
13817 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang YN |
| Year: |
2015 |
| Journal: |
Nat Commun |
| Title: |
Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis. |
| Volume: |
6 |
|
| Pages: |
8230 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
He H |
| Year: |
2024 |
| Journal: |
Int J Biol Sci |
| Title: |
Treatment for type 2 diabetes and diabetic nephropathy by targeting Smad3 signaling. |
| Volume: |
20 |
| Issue: |
1 |
| Pages: |
200-217 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kelley TJ |
| Year: |
2001 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
Reduced Smad3 protein expression and altered transforming growth factor-beta1-mediated signaling in cystic fibrosis epithelial cells. |
| Volume: |
25 |
| Issue: |
6 |
| Pages: |
732-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shi Y |
| Year: |
2020 |
| Journal: |
J Biol Chem |
| Title: |
PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells. |
| Volume: |
295 |
| Issue: |
40 |
| Pages: |
13798-13811 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grocott T |
| Year: |
2007 |
| Journal: |
Nucleic Acids Res |
| Title: |
The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. |
| Volume: |
35 |
| Issue: |
3 |
| Pages: |
890-901 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lokireddy S |
| Year: |
2011 |
| Journal: |
Mol Endocrinol |
| Title: |
Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting. |
| Volume: |
25 |
| Issue: |
11 |
| Pages: |
1936-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiang H |
| Year: |
2020 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Angiocrine FSTL1 (Follistatin-Like Protein 1) Insufficiency Leads to Atrial and Venous Wall Fibrosis via SMAD3 Activation. |
| Volume: |
40 |
| Issue: |
4 |
| Pages: |
958-972 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kashiwagi I |
| Year: |
2015 |
| Journal: |
Immunity |
| Title: |
Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells. |
| Volume: |
43 |
| Issue: |
1 |
| Pages: |
65-79 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koike T |
| Year: |
2012 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Chondroitin sulfate-E fine-tunes osteoblast differentiation via ERK1/2, Smad3 and Smad1/5/8 signaling by binding to N-cadherin and cadherin-11. |
| Volume: |
420 |
| Issue: |
3 |
| Pages: |
523-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen F |
| Year: |
2021 |
| Journal: |
Front Cell Dev Biol |
| Title: |
Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation. |
| Volume: |
9 |
|
| Pages: |
676789 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang HL |
| Year: |
2022 |
| Journal: |
Theranostics |
| Title: |
Smad3 deficiency improves islet-based therapy for diabetes and diabetic kidney injury by promoting β cell proliferation via the E2F3-dependent mechanism. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
379-395 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Casali P |
| Year: |
2021 |
| Journal: |
Front Immunol |
| Title: |
Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4. |
| Volume: |
12 |
|
| Pages: |
761450 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Calvier L |
| Year: |
2019 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
Chronic TGF-β1 Signaling in Pulmonary Arterial Hypertension Induces Sustained Canonical Smad3 Pathways in Vascular Smooth Muscle Cells. |
| Volume: |
61 |
| Issue: |
1 |
| Pages: |
121-123 |
|
•
•
•
•
•
|
| Allele |
| Name: |
SMAD family member 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
425
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin F |
| Year: |
2005 |
| Journal: |
Hum Mol Genet |
| Title: |
MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling. |
| Volume: |
14 |
| Issue: |
3 |
| Pages: |
437-45 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE55808 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bruce DL |
| Year: |
2012 |
| Journal: |
Cell Signal |
| Title: |
Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-β pathway. |
| Volume: |
24 |
| Issue: |
11 |
| Pages: |
1999-2006 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kurisaki A |
| Year: |
2006 |
| Journal: |
Mol Cell Biol |
| Title: |
The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. |
| Volume: |
26 |
| Issue: |
4 |
| Pages: |
1318-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo X |
| Year: |
2008 |
| Journal: |
Genes Dev |
| Title: |
Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling. |
| Volume: |
22 |
| Issue: |
1 |
| Pages: |
106-20 |
|
•
•
•
•
•
|
| Allele |
| Name: |
regulatory region 49; endonuclease-mediated mutation 1, Axel Visel |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Modified regulatory region |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu X |
| Year: |
1997 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. |
| Volume: |
94 |
| Issue: |
20 |
| Pages: |
10669-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bernard DJ |
| Year: |
2004 |
| Journal: |
Mol Endocrinol |
| Title: |
Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells. |
| Volume: |
18 |
| Issue: |
3 |
| Pages: |
606-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Minoo P |
| Year: |
2008 |
| Journal: |
Nucleic Acids Res |
| Title: |
SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains. |
| Volume: |
36 |
| Issue: |
1 |
| Pages: |
179-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Q |
| Year: |
2013 |
| Journal: |
J Mol Cell Biol |
| Title: |
TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway. |
| Volume: |
5 |
| Issue: |
2 |
| Pages: |
85-98 |
|
•
•
•
•
•
|
| Allele |
| Name: |
SMAD family member 2; targeted mutation 4, Elizabeth J Robertson |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
transforming growth factor, beta receptor I; targeted mutation 1, Christine L Mummery |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tgfbr1/Tgfbr1 |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Rr49/Rr49 |
| Background: |
FVB-Rr49 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Arndt S |
| Year: |
2007 |
| Journal: |
Mol Cell Neurosci |
| Title: |
Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling. |
| Volume: |
34 |
| Issue: |
4 |
| Pages: |
603-11 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Smad2/Smad2 |
| Background: |
involves: 129S/SvEv * C57BL/6 * ICR |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
572
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanaka T |
| Year: |
2017 |
| Journal: |
Cell Signal |
| Title: |
Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4. |
| Volume: |
29 |
|
| Pages: |
115-126 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MartÃn-Cuadrado AB |
| Year: |
2005 |
| Journal: |
Mol Biol Cell |
| Title: |
Role of septins and the exocyst complex in the function of hydrolytic enzymes responsible for fission yeast cell separation. |
| Volume: |
16 |
| Issue: |
10 |
| Pages: |
4867-81 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes Sec8 from fungi and EXOC4 from animals. Sec8 is a component of the exocyst complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane []. In fission yeasts, the exocyst complex is also required for polarized cell growth and division septum assembly []. EXOC4 has been shown to regulate N-cadherin expression by controlling Smad3 and Smad4 expression through CREB binding protein, thereby mediating the epithelial-mesenchymal transition and early embryonic development []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carvalho RL |
| Year: |
2007 |
| Journal: |
J Cell Sci |
| Title: |
Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice. |
| Volume: |
120 |
| Issue: |
Pt 24 |
| Pages: |
4269-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Itoh F |
| Year: |
2009 |
| Journal: |
Lab Invest |
| Title: |
Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation. |
| Volume: |
89 |
| Issue: |
7 |
| Pages: |
800-10 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Ski family transcriptional corepressor 1 (SKOR1), also known as ladybird homeobox corepressor 1 or fussel-15 homologue, belongs to Ski family. Like the other members, it is characterised by a Ski homologue domain and a SAND domain - a domain found in some nuclear proteins involved in chromatin-dependent transcriptional regulation. Fussel-15 is mainly expressed in the central nervous system (CNS). The Ski family of nuclear oncoproteins is known to repress transforming growth factor-beta (TGF-beta) signalling through inhibition of transcriptional activity of Smad proteins. Fussel-15 interacts with Smad1, Smad2 and Smad3 molecules and suppresses mainly BMP signalling pathway, but it has only minor effects on TGF-beta signalling []. |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE70208 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Abel B |
| Year: |
2012 |
| Journal: |
FEBS Lett |
| Title: |
N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming growth factor beta in endothelial cells. |
| Volume: |
586 |
| Issue: |
19 |
| Pages: |
3317-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cohen TV |
| Year: |
2007 |
| Journal: |
Development |
| Title: |
The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac. |
| Volume: |
134 |
| Issue: |
7 |
| Pages: |
1385-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mansharamani M |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor. |
| Volume: |
280 |
| Issue: |
14 |
| Pages: |
13863-70 |
|
•
•
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•
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| Publication |
| First Author: |
Wu W |
| Year: |
2002 |
| Journal: |
J Cell Sci |
| Title: |
Intracellular trafficking of MAN1, an integral protein of the nuclear envelope inner membrane. |
| Volume: |
115 |
| Issue: |
Pt 7 |
| Pages: |
1361-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Korman B |
| Year: |
2016 |
| Journal: |
Case Rep Dermatol Med |
| Title: |
Mutation in LEMD3 (Man1) Associated with Osteopoikilosis and Late-Onset Generalized Morphea: A New Buschke-Ollendorf Syndrome Variant. |
| Volume: |
2016 |
|
| Pages: |
2483041 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
975
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
506
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
522
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
413
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
275
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
977
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
642
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the RNA recognition motif 1 (RRM1) of Man1, an integral protein of the inner nuclear membrane that binds to nuclear lamins and emerin, thus playing a role in nuclear organization []. It is part of a protein complex essential for chromatin organization and cell division. It also functions as an important negative regulator for the transforming growth factor (TGF) beta/activin/Nodal signaling pathway by directly interacting with chromatin-associated proteins and transcriptional regulators, including the R-Smads, Smad1, Smad2, and Smad3 [, ]. Moreover, Man1 is a unique type of left-right (LR) signaling regulator that acts on the inner nuclear membrane. Man1 plays a crucial role in angiogenesis. The vascular remodeling can be regulated at the inner nuclear membrane through the interaction between Man1 and Smads []. Man1 contains an N-terminal LEM domain, two putative transmembrane domains, a MAN1-Src1p C-terminal (MSC) domain, and a C-terminal RNA recognition motif (RRM) []. The LEM domain interacts with the DNA and chromatin-binding protein Barrier-to-Autointegration Factor, and is also necessary for efficient localization of MAN1 in the inner nuclear membrane []. Research has indicated that C-terminal nucleoplasmic region of Man1 exhibits a DNA binding winged helix domain and is responsible for both DNA- and Smad-binding [].Mutations in the Man1 gene cause Buschke-Ollendorf syndrome (BOS), an uncommon syndrome characterised by osteopoikilosis and other bone abnormalities []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the inner nuclear membrane proteins Man1 (also known as LEM domain-containing protein 3). Man1 is an integral protein of the inner nuclear membrane that binds to nuclear lamins and emerin, thus playing a role in nuclear organization []. It is part of a protein complex essential for chromatin organization and cell division. It also functions as an important negative regulator for the transforming growth factor (TGF) beta/activin/Nodal signaling pathway by directly interacting with chromatin-associated proteins and transcriptional regulators, including the R-Smads, Smad1, Smad2, and Smad3 [, ]. Moreover, Man1 is a unique type of left-right (LR) signaling regulator that acts on the inner nuclear membrane. Man1 plays a crucial role in angiogenesis. The vascular remodeling can be regulated at the inner nuclear membrane through the interaction between Man1 and Smads []. Man1 contains an N-terminal LEM domain, two putative transmembrane domains, a MAN1-Src1p C-terminal (MSC) domain, and a C-terminal RNA recognition motif (RRM) []. The LEM domain interacts with the DNA and chromatin-binding protein Barrier-to-Autointegration Factor, and is also necessary for efficient localization of MAN1 in the inner nuclear membrane []. Research has indicated that C-terminal nucleoplasmic region of Man1 exhibits a DNA binding winged helix domain and is responsible for both DNA- and Smad-binding [].Mutations in the Man1 gene cause Buschke-Ollendorf syndrome (BOS), an uncommon syndrome characterised by osteopoikilosis and other bone abnormalities []. |
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•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth []. The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Dpp []. This domain is also found in nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF).This entry represents the MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [, , ]. |
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| Publication |
| First Author: |
Watanabe Y |
| Year: |
2010 |
| Journal: |
Mol Cell |
| Title: |
TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. |
| Volume: |
37 |
| Issue: |
1 |
| Pages: |
123-34 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Nakao A |
| Year: |
1997 |
| Journal: |
Nature |
| Title: |
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. |
| Volume: |
389 |
| Issue: |
6651 |
| Pages: |
631-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Siebert N |
| Year: |
2011 |
| Journal: |
Lab Invest |
| Title: |
Erythropoietin improves skin wound healing and activates the TGF-β signaling pathway. |
| Volume: |
91 |
| Issue: |
12 |
| Pages: |
1753-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zeng Q |
| Year: |
2009 |
| Journal: |
Cancer Res |
| Title: |
Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development. |
| Volume: |
69 |
| Issue: |
2 |
| Pages: |
678-86 |
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•
•
•
•
|
| Publication |
| First Author: |
Yang R |
| Year: |
2015 |
| Journal: |
Immunity |
| Title: |
Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. |
| Volume: |
43 |
| Issue: |
2 |
| Pages: |
251-63 |
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•
•
•
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| Publication |
| First Author: |
Saito K |
| Year: |
2020 |
| Journal: |
iScience |
| Title: |
Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ. |
| Volume: |
23 |
| Issue: |
7 |
| Pages: |
101329 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Kim SS |
| Year: |
2006 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF. |
| Volume: |
344 |
| Issue: |
4 |
| Pages: |
1216-23 |
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•
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•
•
•
|
| Publication |
| First Author: |
Vijayachandra K |
| Year: |
2009 |
| Journal: |
Mol Carcinog |
| Title: |
Induction of p16ink4a and p19ARF by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes. |
| Volume: |
48 |
| Issue: |
3 |
| Pages: |
181-186 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Arnò B |
| Year: |
2019 |
| Journal: |
J Cell Sci |
| Title: |
TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors. |
| Volume: |
132 |
| Issue: |
15 |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Reynolds LE |
| Year: |
2005 |
| Journal: |
Nat Med |
| Title: |
Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
167-74 |
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