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Search results 1001 to 1100 out of 1389 for Smad3

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Type Details Score
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
UniProt Feature
Begin: 275
Description: Necessary for synergistic transcriptional activity with SMAD3
Type: site
End: 275
Publication
First Author: Nagarajan RP
Year: 1999
Journal: J Biol Chem
Title: Regulation of Smad7 promoter by direct association with Smad3 and Smad4.
Volume: 274
Issue: 47
Pages: 33412-8
Publication
First Author: Osseni A
Year: 2022
Journal: Nat Commun
Title: Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation.
Volume: 13
Issue: 1
Pages: 7108
Publication  
First Author: Seo HY
Year: 2019
Journal: Cells
Title: Clusterin Attenuates Hepatic Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Downregulating the Smad3 Signaling Pathway.
Volume: 8
Issue: 11
Publication  
First Author: Han CY
Year: 2016
Journal: Nat Commun
Title: Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt.
Volume: 7
Pages: 13817
Publication  
First Author: Tang YN
Year: 2015
Journal: Nat Commun
Title: Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis.
Volume: 6
Pages: 8230
Publication
First Author: He H
Year: 2024
Journal: Int J Biol Sci
Title: Treatment for type 2 diabetes and diabetic nephropathy by targeting Smad3 signaling.
Volume: 20
Issue: 1
Pages: 200-217
Publication
First Author: Kelley TJ
Year: 2001
Journal: Am J Respir Cell Mol Biol
Title: Reduced Smad3 protein expression and altered transforming growth factor-beta1-mediated signaling in cystic fibrosis epithelial cells.
Volume: 25
Issue: 6
Pages: 732-8
Publication
First Author: Shi Y
Year: 2020
Journal: J Biol Chem
Title: PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells.
Volume: 295
Issue: 40
Pages: 13798-13811
Publication
First Author: Grocott T
Year: 2007
Journal: Nucleic Acids Res
Title: The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter.
Volume: 35
Issue: 3
Pages: 890-901
Publication
First Author: Lokireddy S
Year: 2011
Journal: Mol Endocrinol
Title: Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting.
Volume: 25
Issue: 11
Pages: 1936-49
Publication
First Author: Jiang H
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Angiocrine FSTL1 (Follistatin-Like Protein 1) Insufficiency Leads to Atrial and Venous Wall Fibrosis via SMAD3 Activation.
Volume: 40
Issue: 4
Pages: 958-972
Publication
First Author: Kashiwagi I
Year: 2015
Journal: Immunity
Title: Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells.
Volume: 43
Issue: 1
Pages: 65-79
Publication
First Author: Koike T
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Chondroitin sulfate-E fine-tunes osteoblast differentiation via ERK1/2, Smad3 and Smad1/5/8 signaling by binding to N-cadherin and cadherin-11.
Volume: 420
Issue: 3
Pages: 523-9
Publication  
First Author: Chen F
Year: 2021
Journal: Front Cell Dev Biol
Title: Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation.
Volume: 9
Pages: 676789
Publication
First Author: Wang HL
Year: 2022
Journal: Theranostics
Title: Smad3 deficiency improves islet-based therapy for diabetes and diabetic kidney injury by promoting β cell proliferation via the E2F3-dependent mechanism.
Volume: 12
Issue: 1
Pages: 379-395
Publication  
First Author: Casali P
Year: 2021
Journal: Front Immunol
Title: Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4.
Volume: 12
Pages: 761450
DO Term
Interaction Experiment
Description: Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling.
Interaction Experiment
Description: Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2.
GO Term
Publication
First Author: Calvier L
Year: 2019
Journal: Am J Respir Cell Mol Biol
Title: Chronic TGF-β1 Signaling in Pulmonary Arterial Hypertension Induces Sustained Canonical Smad3 Pathways in Vascular Smooth Muscle Cells.
Volume: 61
Issue: 1
Pages: 121-123
Allele
Name: SMAD family member 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Protein
Organism: Mus musculus/domesticus
Length: 425  
Fragment?: false
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: Lin F
Year: 2005
Journal: Hum Mol Genet
Title: MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.
Volume: 14
Issue: 3
Pages: 437-45
HT Experiment
Series Id: GSE55808
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Bruce DL
Year: 2012
Journal: Cell Signal
Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-β pathway.
Volume: 24
Issue: 11
Pages: 1999-2006
Publication
First Author: Kurisaki A
Year: 2006
Journal: Mol Cell Biol
Title: The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.
Volume: 26
Issue: 4
Pages: 1318-32
Publication
First Author: Guo X
Year: 2008
Journal: Genes Dev
Title: Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling.
Volume: 22
Issue: 1
Pages: 106-20
Allele
Name: regulatory region 49; endonuclease-mediated mutation 1, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Publication
First Author: Liu X
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.
Volume: 94
Issue: 20
Pages: 10669-74
Publication
First Author: Bernard DJ
Year: 2004
Journal: Mol Endocrinol
Title: Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells.
Volume: 18
Issue: 3
Pages: 606-23
Publication
First Author: Minoo P
Year: 2008
Journal: Nucleic Acids Res
Title: SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains.
Volume: 36
Issue: 1
Pages: 179-88
Publication
First Author: Zhang Q
Year: 2013
Journal: J Mol Cell Biol
Title: TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway.
Volume: 5
Issue: 2
Pages: 85-98
Allele
Name: SMAD family member 2; targeted mutation 4, Elizabeth J Robertson
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
Allele  
Name: transforming growth factor, beta receptor I; targeted mutation 1, Christine L Mummery
Allele Type: Targeted
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
Genotype
Symbol: Tgfbr1/Tgfbr1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rr49/Rr49
Background: FVB-Rr49
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Arndt S
Year: 2007
Journal: Mol Cell Neurosci
Title: Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.
Volume: 34
Issue: 4
Pages: 603-11
Strain
Attribute String: mutant stock, targeted mutation
Genotype
Symbol: Smad2/Smad2
Background: involves: 129S/SvEv * C57BL/6 * ICR
Zygosity: hm
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
Publication  
First Author: Tanaka T
Year: 2017
Journal: Cell Signal
Title: Sec8 modulates TGF-β induced EMT by controlling N-cadherin via regulation of Smad3/4.
Volume: 29
Pages: 115-126
Publication
First Author: Martín-Cuadrado AB
Year: 2005
Journal: Mol Biol Cell
Title: Role of septins and the exocyst complex in the function of hydrolytic enzymes responsible for fission yeast cell separation.
Volume: 16
Issue: 10
Pages: 4867-81
Protein Domain
Type: Family
Description: This entry includes Sec8 from fungi and EXOC4 from animals. Sec8 is a component of the exocyst complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane []. In fission yeasts, the exocyst complex is also required for polarized cell growth and division septum assembly []. EXOC4 has been shown to regulate N-cadherin expression by controlling Smad3 and Smad4 expression through CREB binding protein, thereby mediating the epithelial-mesenchymal transition and early embryonic development [].
Publication
First Author: Carvalho RL
Year: 2007
Journal: J Cell Sci
Title: Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice.
Volume: 120
Issue: Pt 24
Pages: 4269-77
Publication
First Author: Itoh F
Year: 2009
Journal: Lab Invest
Title: Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation.
Volume: 89
Issue: 7
Pages: 800-10
Protein Domain
Type: Family
Description: Ski family transcriptional corepressor 1 (SKOR1), also known as ladybird homeobox corepressor 1 or fussel-15 homologue, belongs to Ski family. Like the other members, it is characterised by a Ski homologue domain and a SAND domain - a domain found in some nuclear proteins involved in chromatin-dependent transcriptional regulation. Fussel-15 is mainly expressed in the central nervous system (CNS). The Ski family of nuclear oncoproteins is known to repress transforming growth factor-beta (TGF-beta) signalling through inhibition of transcriptional activity of Smad proteins. Fussel-15 interacts with Smad1, Smad2 and Smad3 molecules and suppresses mainly BMP signalling pathway, but it has only minor effects on TGF-beta signalling [].
HT Experiment
Series Id: GSE70208
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Abel B
Year: 2012
Journal: FEBS Lett
Title: N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming growth factor beta in endothelial cells.
Volume: 586
Issue: 19
Pages: 3317-23
Publication
First Author: Cohen TV
Year: 2007
Journal: Development
Title: The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac.
Volume: 134
Issue: 7
Pages: 1385-95
Publication
First Author: Mansharamani M
Year: 2005
Journal: J Biol Chem
Title: Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor.
Volume: 280
Issue: 14
Pages: 13863-70
Publication
First Author: Wu W
Year: 2002
Journal: J Cell Sci
Title: Intracellular trafficking of MAN1, an integral protein of the nuclear envelope inner membrane.
Volume: 115
Issue: Pt 7
Pages: 1361-71
Publication  
First Author: Korman B
Year: 2016
Journal: Case Rep Dermatol Med
Title: Mutation in LEMD3 (Man1) Associated with Osteopoikilosis and Late-Onset Generalized Morphea: A New Buschke-Ollendorf Syndrome Variant.
Volume: 2016
Pages: 2483041
Protein
Organism: Mus musculus/domesticus
Length: 975  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 506  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: false
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of Man1, an integral protein of the inner nuclear membrane that binds to nuclear lamins and emerin, thus playing a role in nuclear organization []. It is part of a protein complex essential for chromatin organization and cell division. It also functions as an important negative regulator for the transforming growth factor (TGF) beta/activin/Nodal signaling pathway by directly interacting with chromatin-associated proteins and transcriptional regulators, including the R-Smads, Smad1, Smad2, and Smad3 [, ]. Moreover, Man1 is a unique type of left-right (LR) signaling regulator that acts on the inner nuclear membrane. Man1 plays a crucial role in angiogenesis. The vascular remodeling can be regulated at the inner nuclear membrane through the interaction between Man1 and Smads []. Man1 contains an N-terminal LEM domain, two putative transmembrane domains, a MAN1-Src1p C-terminal (MSC) domain, and a C-terminal RNA recognition motif (RRM) []. The LEM domain interacts with the DNA and chromatin-binding protein Barrier-to-Autointegration Factor, and is also necessary for efficient localization of MAN1 in the inner nuclear membrane []. Research has indicated that C-terminal nucleoplasmic region of Man1 exhibits a DNA binding winged helix domain and is responsible for both DNA- and Smad-binding [].Mutations in the Man1 gene cause Buschke-Ollendorf syndrome (BOS), an uncommon syndrome characterised by osteopoikilosis and other bone abnormalities [].
Protein Domain
Type: Family
Description: This entry represents the inner nuclear membrane proteins Man1 (also known as LEM domain-containing protein 3). Man1 is an integral protein of the inner nuclear membrane that binds to nuclear lamins and emerin, thus playing a role in nuclear organization []. It is part of a protein complex essential for chromatin organization and cell division. It also functions as an important negative regulator for the transforming growth factor (TGF) beta/activin/Nodal signaling pathway by directly interacting with chromatin-associated proteins and transcriptional regulators, including the R-Smads, Smad1, Smad2, and Smad3 [, ]. Moreover, Man1 is a unique type of left-right (LR) signaling regulator that acts on the inner nuclear membrane. Man1 plays a crucial role in angiogenesis. The vascular remodeling can be regulated at the inner nuclear membrane through the interaction between Man1 and Smads []. Man1 contains an N-terminal LEM domain, two putative transmembrane domains, a MAN1-Src1p C-terminal (MSC) domain, and a C-terminal RNA recognition motif (RRM) []. The LEM domain interacts with the DNA and chromatin-binding protein Barrier-to-Autointegration Factor, and is also necessary for efficient localization of MAN1 in the inner nuclear membrane []. Research has indicated that C-terminal nucleoplasmic region of Man1 exhibits a DNA binding winged helix domain and is responsible for both DNA- and Smad-binding [].Mutations in the Man1 gene cause Buschke-Ollendorf syndrome (BOS), an uncommon syndrome characterised by osteopoikilosis and other bone abnormalities [].
Protein Domain
Type: Domain
Description: Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth []. The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Dpp []. This domain is also found in nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF).This entry represents the MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [, , ].
Publication
First Author: Watanabe Y
Year: 2010
Journal: Mol Cell
Title: TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.
Volume: 37
Issue: 1
Pages: 123-34
Publication
First Author: Nakao A
Year: 1997
Journal: Nature
Title: Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
Volume: 389
Issue: 6651
Pages: 631-5
Publication
First Author: Siebert N
Year: 2011
Journal: Lab Invest
Title: Erythropoietin improves skin wound healing and activates the TGF-β signaling pathway.
Volume: 91
Issue: 12
Pages: 1753-65
Publication
First Author: Zeng Q
Year: 2009
Journal: Cancer Res
Title: Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development.
Volume: 69
Issue: 2
Pages: 678-86
Publication
First Author: Yang R
Year: 2015
Journal: Immunity
Title: Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis.
Volume: 43
Issue: 2
Pages: 251-63
Publication
First Author: Saito K
Year: 2020
Journal: iScience
Title: Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ.
Volume: 23
Issue: 7
Pages: 101329
Publication
First Author: Kim SS
Year: 2006
Journal: Biochem Biophys Res Commun
Title: TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF.
Volume: 344
Issue: 4
Pages: 1216-23
Publication
First Author: Vijayachandra K
Year: 2009
Journal: Mol Carcinog
Title: Induction of p16ink4a and p19ARF by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes.
Volume: 48
Issue: 3
Pages: 181-186
Publication  
First Author: Arnò B
Year: 2019
Journal: J Cell Sci
Title: TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.
Volume: 132
Issue: 15
Publication
First Author: Reynolds LE
Year: 2005
Journal: Nat Med
Title: Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.
Volume: 11
Issue: 2
Pages: 167-74