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Search results 1001 to 1100 out of 1167 for Smad4

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Type Details Score
Publication
9689088 | J:49084
First Author: Weinstein M
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.
Volume: 95
Issue: 16
Pages: 9378-83
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Publication
15378062 | J:93850
First Author: He XC
Year: 2004
Journal: Nat Genet
Title: BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling.
Volume: 36
Issue: 10
Pages: 1117-21
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Publication
18543301 | J:137219
First Author: Kim J
Year: 2008
Journal: Genesis
Title: Generation of mice with a conditional allele for Trim33.
Volume: 46
Issue: 6
Pages: 329-33
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Publication
15654327 | J:96049
First Author: Reynolds LE
Year: 2005
Journal: Nat Med
Title: Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.
Volume: 11
Issue: 2
Pages: 167-74
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Publication
37301920 | J:353924
First Author: Yang TT
Year: 2023
Journal: Commun Biol
Title: SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis.
Volume: 6
Issue: 1
Pages: 629
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Publication
27089513 | J:235172
First Author: Laklai H
Year: 2016
Journal: Nat Med
Title: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.
Volume: 22
Issue: 5
Pages: 497-505
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Publication
32049050 | J:288413
First Author: Wang X
Year: 2020
Journal: Immunity
Title: Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells.
Volume: 52
Issue: 2
Pages: 328-341.e5
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Publication
20667820 | J:166380
First Author: Martinez GJ
Year: 2010
Journal: J Biol Chem
Title: Smad2 positively regulates the generation of Th17 cells.
Volume: 285
Issue: 38
Pages: 29039-43
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Publication
23583181 | J:273981
First Author: Simic P
Year: 2013
Journal: Cell Rep
Title: SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.
Volume: 3
Issue: 4
Pages: 1175-86
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Publication
19557177 | J:150186
First Author: Fulcoli FG
Year: 2009
Journal: PLoS One
Title: Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner.
Volume: 4
Issue: 6
Pages: e6049
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Publication
38733994 | J:349437
First Author: Adkins-Threats M
Year: 2024
Journal: Cell Stem Cell
Title: Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells.
Volume: 31
Issue: 6
Pages: 886-903.e8
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Publication
31409781 | J:279390
First Author: Stone AEL
Year: 2019
Journal: Nat Commun
Title: RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection.
Volume: 10
Issue: 1
Pages: 3649
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Publication
12924153 | J:101820
First Author: Mao CM
Year: 2003
Journal: Yi Chuan Xue Bao
Title: [Establishment of keratinocyte-specific Cre recombinase transgenic mice].
Volume: 30
Issue: 5
Pages: 407-13
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Publication
26898331 | J:230802
First Author: David CJ
Year: 2016
Journal: Cell
Title: TGF-β Tumor Suppression through a Lethal EMT.
Volume: 164
Issue: 5
Pages: 1015-30
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Publication
16007227 | J:100785
First Author: Sun Y
Year: 2005
Journal: Oncogene
Title: Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling.
Volume: 24
Issue: 34
Pages: 5365-74
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Publication
23251777 | J:193530
 
First Author: Badugu A
Year: 2012
Journal: Sci Rep
Title: Digit patterning during limb development as a result of the BMP-receptor interaction.
Volume: 2
Pages: 991
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Publication
25378163 | J:217413
First Author: Choe Y
Year: 2014
Journal: J Neurosci
Title: Migration of oligodendrocyte progenitor cells is controlled by transforming growth factor β family proteins during corticogenesis.
Volume: 34
Issue: 45
Pages: 14973-83
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Publication
29234012 | J:263292
First Author: Martin-Malpartida P
Year: 2017
Journal: Nat Commun
Title: Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
Volume: 8
Issue: 1
Pages: 2070
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Publication
30206204 | J:311921
First Author: Xu Y
Year: 2018
Journal: Cell Death Dis
Title: Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling.
Volume: 9
Issue: 9
Pages: 924
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Publication
37059312 | J:340602
First Author: Zhao Y
Year: 2023
Journal: Biochim Biophys Acta Mol Basis Dis
Title: USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Volume: 1869
Issue: 6
Pages: 166713
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Publication
37192007 | J:345556
 
First Author: Ge J
Year: 2023
Journal: JCI Insight
Title: MiR-431 attenuates synaptic plasticity and memory deficits in APPswe/PS1dE9 mice.
Volume: 8
Issue: 12
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Protein
O35382
Organism: Mus musculus/domesticus
Length: 975  
Fragment?: false
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Protein
Q8C391
Organism: Mus musculus/domesticus
Length: 506  
Fragment?: false
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Protein
Q9CXE1
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
Q8CAQ9
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
Q9CWI0
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
Q69ZD1
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: true
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Protein
Q8CA11
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: false
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Publication
14631647 | -
First Author: Stefancsik R
Year: 2003
Journal: DNA Seq
Title: Relationship between the DNA binding domains of SMAD and NFI/CTF transcription factors defines a new superfamily of genes.
Volume: 14
Issue: 4
Pages: 233-9
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Publication
17507407 | -
First Author: Zeng YA
Year: 2007
Journal: Development
Title: Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation.
Volume: 134
Issue: 11
Pages: 2061-71
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Protein Domain
IPR001132 | SMAD_dom_Dwarfin-type
Type: Domain
Description: Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth [, ]. The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Dpp [, ]. This domain is also found in nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [].This entry represents the SMAD (Mothers against decapentaplegic (MAD) homologue) (also called MH2 for MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 iscomposed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C terminus of MH2 [, , ].
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Protein
Q8BUN5
Organism: Mus musculus/domesticus
Length: 425  
Fragment?: false
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Protein
Q9JIW5
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
Q62432
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
P70340
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
P97454
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
O35253
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: false
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Protein
O35182
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: false
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Protein
E3SRG8
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: false
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Protein
Q9CRR7
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: true
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Protein
B2RPW6
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: false
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Protein
Q811W8
Organism: Mus musculus/domesticus
Length: 545  
Fragment?: false
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Protein
E3SRH0
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
G3UX42
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: true
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Protein
Q0VER3
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q80ZV9
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: false
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Protein
Q3V3E0
Organism: Mus musculus/domesticus
Length: 371  
Fragment?: true
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Protein
E3SRG7
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: false
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Protein
E9Q3M0
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: false
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Protein
A2CG44
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
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Protein
Q3UVC6
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
Q8C3Y6
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Publication
19218245 | J:149064
First Author: Wang G
Year: 2009
Journal: J Biol Chem
Title: Transforming growth factor-{beta}-inducible phosphorylation of Smad3.
Volume: 284
Issue: 15
Pages: 9663-73
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Publication
11546807 | -
First Author: Seet LF
Year: 2001
Journal: J Biol Chem
Title: Endofin, an endosomal FYVE domain protein.
Volume: 276
Issue: 45
Pages: 42445-54
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Publication
22155034 | J:185675
First Author: Matsumoto Y
Year: 2012
Journal: Mol Cell Endocrinol
Title: Bone morphogenetic protein-3b (BMP-3b) inhibits osteoblast differentiation via Smad2/3 pathway by counteracting Smad1/5/8 signaling.
Volume: 350
Issue: 1
Pages: 78-86
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Publication
9858566 | J:51700
First Author: Liu B
Year: 1999
Journal: Mol Cell Biol
Title: FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals.
Volume: 19
Issue: 1
Pages: 424-30
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Publication
11836524 | J:75392
First Author: Bai RY
Year: 2002
Journal: Nat Cell Biol
Title: SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling.
Volume: 4
Issue: 3
Pages: 181-90
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Publication
17292623 | J:123207
First Author: Arndt S
Year: 2007
Journal: Mol Cell Neurosci
Title: Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.
Volume: 34
Issue: 4
Pages: 603-11
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Publication
12393497 | J:81926
First Author: Warming S
Year: 2003
Journal: Blood
Title: Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein.
Volume: 101
Issue: 5
Pages: 1934-40
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Publication
11278805 | J:68941
First Author: Puente E
Year: 2001
Journal: J Biol Chem
Title: Transcriptional activation of mouse sst2 somatostatin receptor promoter by transforming growth factor-beta. Involvement of Smad4.
Volume: 276
Issue: 16
Pages: 13461-8
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Publication
9335505 | J:43279
First Author: Imamura T
Year: 1997
Journal: Nature
Title: Smad6 inhibits signalling by the TGF-beta superfamily.
Volume: 389
Issue: 6651
Pages: 622-6
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Publication
15048087 | J:89735
First Author: Warming S
Year: 2004
Journal: Oncogene
Title: Early B-cell factor-associated zinc-finger gene is a frequent target of retroviral integration in murine B-cell lymphomas.
Volume: 23
Issue: 15
Pages: 2727-31
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Publication
11726399 | J:114419
First Author: Kelley TJ
Year: 2001
Journal: Am J Respir Cell Mol Biol
Title: Reduced Smad3 protein expression and altered transforming growth factor-beta1-mediated signaling in cystic fibrosis epithelial cells.
Volume: 25
Issue: 6
Pages: 732-8
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Publication
24485922 | J:207413
First Author: Qu X
Year: 2014
Journal: Am J Pathol
Title: Regulation of renal fibrosis by Smad3 Thr388 phosphorylation.
Volume: 184
Issue: 4
Pages: 944-52
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Publication
12183405 | J:78501
First Author: Takaku K
Year: 2002
Journal: Cancer Res
Title: No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice.
Volume: 62
Issue: 16
Pages: 4558-61
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Publication
17967875 | J:128934
First Author: Pangas SA
Year: 2008
Journal: Mol Cell Biol
Title: Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.
Volume: 28
Issue: 1
Pages: 248-57
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Publication
24859528 | J:227613
First Author: Li X
Year: 2014
Journal: Nat Med
Title: Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture.
Volume: 20
Issue: 7
Pages: 769-77
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Publication
27247403 | J:234095
First Author: Alonso-Merino E
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Thyroid hormones inhibit TGF-β signaling and attenuate fibrotic responses.
Volume: 113
Issue: 24
Pages: E3451-60
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Publication
18981480 | J:140928
First Author: Furtado MB
Year: 2008
Journal: Genes Dev
Title: BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.
Volume: 22
Issue: 21
Pages: 3037-49
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Publication
27893715 | J:241235
First Author: Huang PH
Year: 2017
Journal: Oncogene
Title: TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1.
Volume: 36
Issue: 16
Pages: 2202-2214
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Publication
22750848 | J:193159
First Author: Genovese G
Year: 2012
Journal: Cancer Discov
Title: microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma.
Volume: 2
Issue: 8
Pages: 736-49
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Publication
15292180 | J:118580
First Author: Yu J
Year: 2004
Journal: J Biol Chem
Title: Altered expression of genes of the Bmp/Smad and Wnt/calcium signaling pathways in the cone-only Nrl-/- mouse retina, revealed by gene profiling using custom cDNA microarrays.
Volume: 279
Issue: 40
Pages: 42211-20
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Publication
17699601 | J:145254
First Author: Raymond K
Year: 2007
Journal: Mol Biol Cell
Title: Dual Role of alpha6beta4 integrin in epidermal tumor growth: tumor-suppressive versus tumor-promoting function.
Volume: 18
Issue: 11
Pages: 4210-21
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Publication
18334556 | J:138475
First Author: Alcorn JF
Year: 2008
Journal: J Cell Sci
Title: Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1.
Volume: 121
Issue: Pt 7
Pages: 1036-45
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Publication
25488669 | J:235118
First Author: Sun C
Year: 2015
Journal: J Biol Chem
Title: The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis.
Volume: 290
Issue: 4
Pages: 2007-23
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Publication
10655064 | J:60214
First Author: Galvin KM
Year: 2000
Journal: Nat Genet
Title: A role for smad6 in development and homeostasis of the cardiovascular system.
Volume: 24
Issue: 2
Pages: 171-4
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Publication
31394426 | J:281625
 
First Author: Meroni M
Year: 2019
Journal: Neurobiol Aging
Title: Transforming growth factor beta 1 signaling is altered in the spinal cord and muscle of amyotrophic lateral sclerosis mice and patients.
Volume: 82
Pages: 48-59
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Publication
30786277 | J:271683
First Author: Tiwari A
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27.
Volume: 60
Issue: 2
Pages: 731-740
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Publication
28475592 | J:247139
First Author: Ma L
Year: 2017
Journal: PLoS One
Title: LSL-KrasG12D; LSL-Trp53R172H/+; Ink4flox/+; Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer.
Volume: 12
Issue: 5
Pages: e0176844
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Publication
32326436 | J:302420
 
First Author: Chleilat E
Year: 2020
Journal: Int J Mol Sci
Title: TGF-β Signaling Regulates SLC8A3 Expression and Prevents Oxidative Stress in Developing Midbrain Dopaminergic and Dorsal Raphe Serotonergic Neurons.
Volume: 21
Issue: 8
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Publication
29556203 | J:275019
 
First Author: Layoun A
Year: 2018
Journal: Front Physiol
Title: MyD88 Adaptor Protein Is Required for Appropriate Hepcidin Induction in Response to Dietary Iron Overload in Mice.
Volume: 9
Pages: 159
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Publication
23749643 | J:199471
First Author: Criscimanna A
Year: 2013
Journal: Cancer Res
Title: PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesis.
Volume: 73
Issue: 15
Pages: 4781-90
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Publication
23552743 | J:205461
First Author: Su HT
Year: 2013
Journal: Mol Cancer Res
Title: Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancer.
Volume: 11
Issue: 7
Pages: 768-79
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Publication
16884701 | J:112569
First Author: Golestaneh N
Year: 2006
Journal: Brain Res
Title: Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-beta adaptor elf-/- mouse brain.
Volume: 1108
Issue: 1
Pages: 45-53
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Publication
26987815 | J:245447
First Author: Nahomi RB
Year: 2016
Journal: Biochem J
Title: αB-crystallin is essential for the TGF-β2-mediated epithelial to mesenchymal transition of lens epithelial cells.
Volume: 473
Issue: 10
Pages: 1455-69
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Publication
26878210 | J:231525
First Author: Ishikawa K
Year: 2016
Journal: Am J Pathol
Title: αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition.
Volume: 186
Issue: 4
Pages: 859-73
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Publication
25032514 | J:232218
First Author: Bellaye PS
Year: 2015
Journal: Am J Respir Cell Mol Biol
Title: Antifibrotic role of αB-crystallin inhibition in pleural and subpleural fibrosis.
Volume: 52
Issue: 2
Pages: 244-52
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Publication
20427289 | J:348806
First Author: Bergström R
Year: 2010
Journal: J Biol Chem
Title: Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
Volume: 285
Issue: 26
Pages: 19727-37
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Publication
25105693 | J:216309
First Author: Roybal LL
Year: 2014
Journal: Mol Endocrinol
Title: Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ.
Volume: 28
Issue: 10
Pages: 1640-55
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Publication
25942106 | J:232831
First Author: Fortin J
Year: 2015
Journal: Mol Endocrinol
Title: Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?
Volume: 29
Issue: 7
Pages: 963-77
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Publication
29458012 | J:261103
First Author: DiMario JX
Year: 2018
Journal: Am J Pathol
Title: KLF10 Gene Expression Modulates Fibrosis in Dystrophic Skeletal Muscle.
Volume: 188
Issue: 5
Pages: 1263-1275
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Publication
30545632 | J:290248
First Author: Nam SA
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Autophagy in FOXD1 stroma-derived cells regulates renal fibrosis through TGF-β and NLRP3 inflammasome pathway.
Volume: 508
Issue: 3
Pages: 965-972
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Publication
21836474 | J:281893
First Author: Gong K
Year: 2011
Journal: J Hypertens
Title: Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in mice.
Volume: 29
Issue: 9
Pages: 1810-9
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Publication
34769168 | J:317931
 
First Author: Huang TH
Year: 2021
Journal: Int J Mol Sci
Title: Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway.
Volume: 22
Issue: 21
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Publication
26392315 | J:232941
First Author: Bak Y
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Hepatitis B virus X promotes hepatocellular carcinoma development via nuclear protein 1 pathway.
Volume: 466
Issue: 4
Pages: 676-81
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Publication
29247407 | J:302014
First Author: Zhao X
Year: 2018
Journal: Front Med
Title: Zfyve16 regulates the proliferation of B-lymphoid cells.
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