Type |
Details |
Score |
Publication |
First Author: |
Sun J |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts. |
Volume: |
12 |
Issue: |
1 |
Pages: |
4611 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khan M |
Year: |
2007 |
Journal: |
Gene Expr Patterns |
Title: |
Hedgehog pathway gene expression during early development of the molar tooth root in the mouse. |
Volume: |
7 |
Issue: |
3 |
Pages: |
239-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tukachinsky H |
Year: |
2010 |
Journal: |
J Cell Biol |
Title: |
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. |
Volume: |
191 |
Issue: |
2 |
Pages: |
415-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teperino R |
Year: |
2012 |
Journal: |
Cell |
Title: |
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. |
Volume: |
151 |
Issue: |
2 |
Pages: |
414-26 |
|
•
•
•
•
•
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Publication |
First Author: |
Jiang K |
Year: |
2016 |
Journal: |
PLoS Biol |
Title: |
PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. |
Volume: |
14 |
Issue: |
2 |
Pages: |
e1002375 |
|
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•
•
•
•
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Publication |
First Author: |
Hyun J |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression. |
Volume: |
7 |
|
Pages: |
10993 |
|
•
•
•
•
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Publication |
First Author: |
Schou KB |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling. |
Volume: |
8 |
|
Pages: |
14177 |
|
•
•
•
•
•
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Publication |
First Author: |
Shi X |
Year: |
2017 |
Journal: |
Nat Cell Biol |
Title: |
Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. |
Volume: |
19 |
Issue: |
10 |
Pages: |
1178-1188 |
|
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•
•
•
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Publication |
First Author: |
Li XY |
Year: |
2018 |
Journal: |
Cancer Lett |
Title: |
Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli. |
Volume: |
420 |
|
Pages: |
195-207 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu W |
Year: |
2018 |
Journal: |
Blood |
Title: |
Smoothened signaling in the mouse osteoblastoid lineage is required for efficient B lymphopoiesis. |
Volume: |
131 |
Issue: |
3 |
Pages: |
323-327 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chahal KK |
Year: |
2019 |
Journal: |
PLoS One |
Title: |
Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. |
Volume: |
14 |
Issue: |
9 |
Pages: |
e0214901 |
|
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•
•
•
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Publication |
First Author: |
Kothandapani A |
Year: |
2021 |
Journal: |
Mol Cell Endocrinol |
Title: |
Distinctive functioning of STARD1 in the fetal Leydig cells compared to adult Leydig and adrenal cells. Impact of Hedgehog signaling via the primary cilium. |
Volume: |
531 |
|
Pages: |
111265 |
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•
•
•
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Publication |
First Author: |
Shao F |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis. |
Volume: |
12 |
Issue: |
1 |
Pages: |
6540 |
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•
•
•
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Publication |
First Author: |
Lv B |
Year: |
2022 |
Journal: |
J Cell Sci |
Title: |
Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation. |
Volume: |
135 |
Issue: |
16 |
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•
•
•
•
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Publication |
First Author: |
Dey J |
Year: |
2013 |
Journal: |
Cancer Res |
Title: |
MyoD is a tumor suppressor gene in medulloblastoma. |
Volume: |
73 |
Issue: |
22 |
Pages: |
6828-37 |
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•
•
•
•
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Publication |
First Author: |
Bassett EA |
Year: |
2016 |
Journal: |
Elife |
Title: |
Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation. |
Volume: |
5 |
|
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|
•
•
•
•
•
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Publication |
First Author: |
Colvin Wanshura LE |
Year: |
2011 |
Journal: |
Cancer Res |
Title: |
Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells. |
Volume: |
71 |
Issue: |
15 |
Pages: |
5336-45 |
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•
•
•
•
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Publication |
First Author: |
Pokrajac NT |
Year: |
2023 |
Journal: |
Dev Cell |
Title: |
Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation. |
Volume: |
58 |
Issue: |
20 |
Pages: |
2015-2031.e8 |
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Publication |
First Author: |
Sengupta R |
Year: |
2012 |
Journal: |
Cancer Res |
Title: |
CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. |
Volume: |
72 |
Issue: |
1 |
Pages: |
122-32 |
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•
•
•
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Publication |
First Author: |
Sankar S |
Year: |
2017 |
Journal: |
Genes Cancer |
Title: |
Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors. |
Volume: |
8 |
Issue: |
9-10 |
Pages: |
725-744 |
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•
•
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Publication |
First Author: |
Milla LA |
Year: |
2014 |
Journal: |
Int J Cancer |
Title: |
Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. |
Volume: |
134 |
Issue: |
1 |
Pages: |
21-31 |
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•
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Publication |
First Author: |
Lindsey JC |
Year: |
2015 |
Journal: |
Oncogene |
Title: |
Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance. |
Volume: |
34 |
Issue: |
36 |
Pages: |
4746-57 |
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•
•
•
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Publication |
First Author: |
Gershon TR |
Year: |
2013 |
Journal: |
Cancer Metab |
Title: |
Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma. |
Volume: |
1 |
Issue: |
1 |
Pages: |
2 |
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•
•
•
•
•
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Publication |
First Author: |
Bay SN |
Year: |
2018 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation. |
Volume: |
115 |
Issue: |
7 |
Pages: |
1570-1575 |
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Publication |
First Author: |
Pallavicini G |
Year: |
2018 |
Journal: |
Cancer Res |
Title: |
Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence. |
Volume: |
78 |
Issue: |
16 |
Pages: |
4599-4612 |
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Publication |
First Author: |
Wu C |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse. |
Volume: |
26 |
Issue: |
13 |
Pages: |
2386-2397 |
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Publication |
First Author: |
Ruiz-Perez VL |
Year: |
2007 |
Journal: |
Development |
Title: |
Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia. |
Volume: |
134 |
Issue: |
16 |
Pages: |
2903-12 |
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Publication |
First Author: |
Park JY |
Year: |
2016 |
Journal: |
Development |
Title: |
The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. |
Volume: |
143 |
Issue: |
1 |
Pages: |
133-46 |
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First Author: |
Cervelli M |
Year: |
2004 |
Journal: |
Eur J Biochem |
Title: |
Mouse spermine oxidase gene splice variants. Nuclear subcellular localization of a novel active isoform. |
Volume: |
271 |
Issue: |
4 |
Pages: |
760-70 |
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Publication |
First Author: |
Cooper AF |
Year: |
2005 |
Journal: |
Development |
Title: |
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. |
Volume: |
132 |
Issue: |
19 |
Pages: |
4407-17 |
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Publication |
First Author: |
Yang N |
Year: |
2015 |
Journal: |
Development |
Title: |
Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. |
Volume: |
142 |
Issue: |
12 |
Pages: |
2194-202 |
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Publication |
First Author: |
Yang N |
Year: |
2017 |
Journal: |
Oncogene |
Title: |
INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. |
Volume: |
36 |
Issue: |
35 |
Pages: |
4997-5005 |
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Publication |
First Author: |
Goodwin AC |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. |
Volume: |
108 |
Issue: |
37 |
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15354-9 |
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First Author: |
Chang H |
Year: |
2012 |
Journal: |
Dev Biol |
Title: |
Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1. |
Volume: |
370 |
Issue: |
2 |
Pages: |
187-97 |
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First Author: |
Okolowsky N |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland. |
Volume: |
391 |
Issue: |
2 |
Pages: |
219-29 |
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First Author: |
Yang F |
Year: |
2022 |
Journal: |
Mol Cancer Res |
Title: |
A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth. |
Volume: |
20 |
Issue: |
11 |
Pages: |
1598-1610 |
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First Author: |
Dijkgraaf GJ |
Year: |
2011 |
Journal: |
Cancer Res |
Title: |
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. |
Volume: |
71 |
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First Author: |
Li B |
Year: |
2014 |
Journal: |
Cancer Res |
Title: |
Pyrvinium attenuates Hedgehog signaling downstream of smoothened. |
Volume: |
74 |
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First Author: |
Moraes RC |
Year: |
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Journal: |
Development |
Title: |
Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia. |
Volume: |
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Rajurkar M |
Year: |
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Journal: |
Oncogene |
Title: |
Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. |
Volume: |
33 |
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46 |
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First Author: |
Atwood SX |
Year: |
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Journal: |
Nature |
Title: |
GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas. |
Volume: |
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First Author: |
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Year: |
2017 |
Journal: |
Oncogene |
Title: |
The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer. |
Volume: |
36 |
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Tang Y |
Year: |
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Journal: |
Nat Med |
Title: |
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. |
Volume: |
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J Biol Chem |
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Blassberg R |
Year: |
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Hum Mol Genet |
Title: |
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome. |
Volume: |
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First Author: |
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Year: |
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Journal: |
Exp Lung Res |
Title: |
The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis. |
Volume: |
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Year: |
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Proc Natl Acad Sci U S A |
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Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. |
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Proc Natl Acad Sci U S A |
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Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation. |
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Biol Reprod |
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Med12 regulates ovarian steroidogenesis, uterine development and maternal effects in the mammalian egg. |
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Am J Physiol Cell Physiol |
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The role of spermidine/spermine N1-acetyltransferase in endotoxin-induced acute kidney injury. |
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Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea. |
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Sci Signal |
Title: |
G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog. |
Volume: |
11 |
Issue: |
516 |
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•
•
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Publication |
First Author: |
Zhang L |
Year: |
2022 |
Journal: |
J Bone Miner Res |
Title: |
Hedgehog Signaling Controls Bone Homeostasis by Regulating Osteogenic/Adipogenic Fate of Skeletal Stem/Progenitor Cells in Mice. |
Volume: |
37 |
Issue: |
3 |
Pages: |
559-576 |
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•
•
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•
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Publication |
First Author: |
Saeki N |
Year: |
2022 |
Journal: |
Exp Cell Res |
Title: |
Pregnane X receptor (PXR) represses osteoblast differentiation through repression of the Hedgehog signaling pathway. |
Volume: |
416 |
Issue: |
1 |
Pages: |
113156 |
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Publication |
First Author: |
Xiu C |
Year: |
2022 |
Journal: |
Front Cell Dev Biol |
Title: |
Suppressor of fused-restrained Hedgehog signaling in chondrocytes is critical for epiphyseal growth plate maintenance and limb elongation in juvenile mice. |
Volume: |
10 |
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Pages: |
997838 |
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•
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Publication |
First Author: |
Morimoto Y |
Year: |
2022 |
Journal: |
Neurochem Res |
Title: |
TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF). |
Volume: |
47 |
Issue: |
9 |
Pages: |
2741-2756 |
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•
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Publication |
First Author: |
Xu J |
Year: |
2022 |
Journal: |
Development |
Title: |
The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis. |
Volume: |
149 |
Issue: |
21 |
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Publication |
First Author: |
Tsiami F |
Year: |
2024 |
Journal: |
Acta Neuropathol Commun |
Title: |
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma. |
Volume: |
12 |
Issue: |
1 |
Pages: |
125 |
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•
•
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•
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Publication |
First Author: |
Yoshida S |
Year: |
2024 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase. |
Volume: |
121 |
Issue: |
28 |
Pages: |
e2320070121 |
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Publication |
First Author: |
Crowther AJ |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. |
Volume: |
33 |
Issue: |
46 |
Pages: |
18098-108 |
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•
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Publication |
First Author: |
Blair HJ |
Year: |
2011 |
Journal: |
BMC Biol |
Title: |
Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus. |
Volume: |
9 |
|
Pages: |
14 |
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•
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•
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Publication |
First Author: |
Paudel S |
Year: |
2022 |
Journal: |
Carcinogenesis |
Title: |
Chemopreventive efficacy of silibinin against basal cell carcinoma growth and progression in UVB-irradiated Ptch+/- mice. |
Volume: |
43 |
Issue: |
6 |
Pages: |
557-570 |
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Publication |
First Author: |
Braune J |
Year: |
2017 |
Journal: |
Diabetologia |
Title: |
Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism. |
Volume: |
60 |
Issue: |
5 |
Pages: |
889-899 |
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•
•
•
•
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Publication |
First Author: |
Kimi K |
Year: |
2003 |
Journal: |
J Oral Pathol Med |
Title: |
Immunohistochemical and genetic analysis of mandibular cysts in heterozygous ptc knockout mice. |
Volume: |
32 |
Issue: |
2 |
Pages: |
108-13 |
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•
•
•
•
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Publication |
First Author: |
Cervelli M |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e64810 |
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•
•
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•
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Publication |
First Author: |
Franco A |
Year: |
2018 |
Journal: |
J Mol Cell Cardiol |
Title: |
G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts. |
Volume: |
121 |
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Pages: |
60-68 |
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•
•
•
•
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Publication |
First Author: |
Liu X |
Year: |
2017 |
Journal: |
Bone |
Title: |
Exogenous hedgehog antagonist delays but does not prevent fracture healing in young mice. |
Volume: |
103 |
|
Pages: |
241-251 |
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•
•
•
•
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Publication |
First Author: |
Chapouly C |
Year: |
2020 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes). |
Volume: |
40 |
Issue: |
12 |
Pages: |
e336-e349 |
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•
•
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•
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Publication |
First Author: |
Vujcic S |
Year: |
2003 |
Journal: |
Biochem J |
Title: |
Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. |
Volume: |
370 |
Issue: |
Pt 1 |
Pages: |
19-28 |
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•
•
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•
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Publication |
First Author: |
Hor CHH |
Year: |
2021 |
Journal: |
J Neurosci |
Title: |
Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation. |
Volume: |
41 |
Issue: |
32 |
Pages: |
6850-6863 |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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Publication |
First Author: |
Williams SE |
Year: |
2015 |
Journal: |
Development |
Title: |
Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice. |
Volume: |
142 |
Issue: |
22 |
Pages: |
3921-32 |
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•
•
•
•
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Publication |
First Author: |
Diede SJ |
Year: |
2013 |
Journal: |
Epigenetics |
Title: |
Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer. |
Volume: |
8 |
Issue: |
12 |
Pages: |
1254-60 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
372
 |
Fragment?: |
false |
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•
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•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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•
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Publication |
First Author: |
Zhou X |
Year: |
2016 |
Journal: |
Exp Neurol |
Title: |
Effect of the sonic hedgehog receptor smoothened on the survival and function of dopaminergic neurons. |
Volume: |
283 |
Issue: |
Pt A |
Pages: |
235-45 |
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•
•
•
•
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Publication |
First Author: |
Niu C |
Year: |
2019 |
Journal: |
Autophagy |
Title: |
Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway. |
Volume: |
15 |
Issue: |
5 |
Pages: |
843-870 |
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•
•
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•
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Publication |
First Author: |
Huse JT |
Year: |
2009 |
Journal: |
Brain Pathol |
Title: |
Genetically engineered mouse models of brain cancer and the promise of preclinical testing. |
Volume: |
19 |
Issue: |
1 |
Pages: |
132-43 |
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•
•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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