| Type |
Details |
Score |
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3056767 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-01-31 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1716823 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:7578959 |
| Age: |
embryonic day 15.5 |
| Image: |
1A |
| Note: |
Extensive co-localized immunostaining with Tfap2b was detected. |
| Specimen Label: |
1A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1934791 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-01-31 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1716823 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:7578988 |
| Age: |
embryonic day 15.5 |
| Image: |
1C |
| Note: |
Immunopositive retinal progenitor cells colocalized with Tfap2b labeling. |
| Specimen Label: |
1C |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5697711 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-01-31 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1716824 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:7579054 |
| Age: |
embryonic day 16.5 |
|
| Note: |
The vast majority (>98%) of Tfap2b immunopositive cells did not co-express Ki67. |
| Specimen Label: |
not shown |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7614276 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-03-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1683917 |
| Pattern: |
Regionally restricted |
| Stage: |
TS17 |
| Assay Id: |
MGI:7615297 |
| Age: |
embryonic day 10.5 |
| Image: |
7H |
| Note: |
Expression was located at the oral surface, but boundary cells co-expressing Tfap2b remain broadly distributed. |
| Specimen Label: |
7H |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3056767 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2023-08-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1707420 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:7520310 |
| Age: |
embryonic day 12.5 |
| Image: |
3D/F |
| Note: |
Coexpressed with Tfap2b in the ventricular zone. Some Tfap2b+ cells did not express Tfap2a. |
| Specimen Label: |
3D/F |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7614276 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-03-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3826220 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:7615297 |
| Age: |
embryonic day 12.0 |
| Image: |
7J |
| Note: |
Expression was detected in the dental epithelium. Some overlap with Tfap2b expression was observed at the anterior boundary. |
| Specimen Label: |
7J |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3056767 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-01-31 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1859027 |
| Pattern: |
Regionally restricted |
| Stage: |
TS27 |
| Assay Id: |
MGI:7578959 |
| Age: |
postnatal day 0 |
| Image: |
2D |
| Note: |
Extensive overlap between Tfap2a and Tfap2b expression was observed (80% of immunopositive cells). In the outer retina, putative horizontal cells exhibiting strong Tfap2b signal were weakly stained for Tfap2a. |
| Specimen Label: |
2D |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| CL Term |
|
•
•
•
•
•
|
| CL Term |
|
•
•
•
•
•
|
| CL Term |
|
•
•
•
•
•
|
| CL Term |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smaldone G |
| Year: |
2016 |
| Journal: |
FEBS Lett |
| Title: |
The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states. |
| Volume: |
590 |
| Issue: |
11 |
| Pages: |
1663-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marneros AG |
| Year: |
2013 |
| Journal: |
Am J Hum Genet |
| Title: |
Mutations in KCTD1 cause scalp-ear-nipple syndrome. |
| Volume: |
92 |
| Issue: |
4 |
| Pages: |
621-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang X |
| Year: |
2017 |
| Journal: |
J Dent Res |
| Title: |
MicroRNA-155-3p Mediates TNF-?-Inhibited Cementoblast Differentiation. |
| Volume: |
96 |
| Issue: |
12 |
| Pages: |
1430-1437 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mei F |
| Year: |
2012 |
| Journal: |
Biochemistry (Mosc) |
| Title: |
Expression, purification, and secondary structure characterization of recombinant KCTD1. |
| Volume: |
77 |
| Issue: |
8 |
| Pages: |
941-5 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in the human potassium channel tetramerization domain-containing protein 1 (KCTD1) (, ) and similar sequences from vertebrates. This domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerisation or heterodimerisation. KCTD family BTB domains can adopt a wide range of oligomerisation geometries, including homodimerisation, tetramerisation, and pentamerisation. The KCTD1 BTB domains form pentamers [].KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signalling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome [, , , , ]. |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ji AX |
| Year: |
2016 |
| Journal: |
J Mol Biol |
| Title: |
Structural Insights into KCTD Protein Assembly and Cullin3 Recognition. |
| Volume: |
428 |
| Issue: |
1 |
| Pages: |
92-107 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoldi G |
| Year: |
2016 |
| Journal: |
Cancer Res |
| Title: |
RANK Signaling Blockade Reduces Breast Cancer Recurrence by Inducing Tumor Cell Differentiation. |
| Volume: |
76 |
| Issue: |
19 |
| Pages: |
5857-5869 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barzago MM |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Generation of a new mouse model of glaucoma characterized by reduced expression of the AP-2? and AP-2? proteins. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
11140 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
257
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
180
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pinkas DM |
| Year: |
2017 |
| Journal: |
Biochem J |
| Title: |
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases. |
| Volume: |
474 |
| Issue: |
22 |
| Pages: |
3747-3761 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
861
 |
| Fragment?: |
false |
|
•
•
•
•
•
|