|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1001 to 1100 out of 1557 for Tpr

<< First    < Previous  |  Next >    Last >>
0.158s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
Q9D1J2
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: false
•
•
•
•
•
Protein
F6WT10
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: true
•
•
•
•
•
Protein
A0A0U1RPT9
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
•
•
•
•
•
Protein
D3Z315
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: true
•
•
•
•
•
Protein
D3YYH2
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
•
•
•
•
•
Protein
B2X2D9
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
•
•
•
•
•
Protein
F6XIG5
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
•
•
•
•
•
Protein
Q3TV86
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: true
•
•
•
•
•
Protein
Q6ZQ91
Organism: Mus musculus/domesticus
Length: 1265  
Fragment?: true
•
•
•
•
•
Protein
F6V2A3
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
•
•
•
•
•
Protein
D3YZ32
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
•
•
•
•
•
Protein
G3X9U9
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: false
•
•
•
•
•
Protein
Q8C4W1
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
•
•
•
•
•
Protein
Q8BSI7
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
•
•
•
•
•
Protein
A0PJ46
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: true
•
•
•
•
•
Protein
Q3UK51
Organism: Mus musculus/domesticus
Length: 687  
Fragment?: false
•
•
•
•
•
Protein
Q3UZS1
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
•
•
•
•
•
Protein
Q3TXL9
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
•
•
•
•
•
Protein
A0A3Q4EGC9
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
•
•
•
•
•
Protein
A0A286YCU6
Organism: Mus musculus/domesticus
Length: 273  
Fragment?: true
•
•
•
•
•
Protein
Q3UFC2
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
•
•
•
•
•
Protein
E9QJV4
Organism: Mus musculus/domesticus
Length: 665  
Fragment?: false
•
•
•
•
•
Protein
A0A0G2JDE8
Organism: Mus musculus/domesticus
Length: 656  
Fragment?: false
•
•
•
•
•
Protein
A0A3Q4EGM1
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
•
•
•
•
•
Protein
B0QZH3
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
•
•
•
•
•
Protein
Q3U1Q7
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: true
•
•
•
•
•
Protein
E9Q6I5
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
•
•
•
•
•
Protein
Q3TGH0
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
•
•
•
•
•
Protein
Q3THU3
Organism: Mus musculus/domesticus
Length: 740  
Fragment?: false
•
•
•
•
•
Protein
A0A0A6YWQ7
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
•
•
•
•
•
Protein
Q3UCI6
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
•
•
•
•
•
Protein
G3X8X1
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
•
•
•
•
•
Publication
11523989 | -
First Author: Kang H
Year: 2001
Journal: Biochemistry
Title: Identification of amino acids in the tetratricopeptide repeat and C-terminal domains of protein phosphatase 5 involved in autoinhibition and lipid activation.
Volume: 40
Issue: 35
Pages: 10485-90
•
•
•
•
•
Publication
11504734 | -
First Author: Lubert EJ
Year: 2001
Journal: J Biol Chem
Title: Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5.
Volume: 276
Issue: 42
Pages: 38582-7
•
•
•
•
•
Publication
7925273 | -
First Author: Chen MX
Year: 1994
Journal: EMBO J
Title: A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus.
Volume: 13
Issue: 18
Pages: 4278-90
•
•
•
•
•
Publication
16407978 | -
First Author: Wandinger SK
Year: 2006
Journal: EMBO J
Title: The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90.
Volume: 25
Issue: 2
Pages: 367-76
•
•
•
•
•
Publication
9024684 | -
First Author: Cordes VC
Year: 1997
Journal: J Cell Biol
Title: Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments.
Volume: 136
Issue: 3
Pages: 515-29
•
•
•
•
•
Publication
7798308 | -
First Author: Byrd DA
Year: 1994
Journal: J Cell Biol
Title: Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex.
Volume: 127
Issue: 6 Pt 1
Pages: 1515-26
•
•
•
•
•
Publication
10085285 | -
First Author: Strambio-de-Castillia C
Year: 1999
Journal: J Cell Biol
Title: Proteins connecting the nuclear pore complex with the nuclear interior.
Volume: 144
Issue: 5
Pages: 839-55
•
•
•
•
•
Publication
12531921 | -
First Author: Green DM
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export.
Volume: 100
Issue: 3
Pages: 1010-5
•
•
•
•
•
Protein Domain
IPR012929 | TPR/MLP1
Type: Domain
Description: This domain is found in a number of proteins, including TPR protein () and yeast myosin-like protein 1 (MLP1, ). These proteins share a number of features; for example, they have coiled-coil regions and are associated with nuclear pores [, , ]. TPR is thought to be a component of nuclear pore complex- attached intranuclear filaments [], and is implicated in nuclear protein import []. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerisation of kinase domains or by targeting these kinases to the nuclear pore complex []. Mlp1 acts as a docking platform for for heterogeneous nuclear ribonucleoproteins that are required for mRNA export [].
•
•
•
•
•
Protein Domain
IPR011236 | Ser/Thr_PPase_5
Type: Family
Description: These eukaryotic serine/threonine phosphoprotein phosphatases, first described from human (PP5) and Saccharomyces cerevisiae (PPT1), are distinguished from related protein phosphatases by an N-terminal region of about 200 residues that contains three tandem tetratricopeptide repeats (TPR) []. Structurally, TPR repeats form a helical scaffold of antiparallel α-helices with an amphipathic groove that mediates protein-protein interactions []. The TPR domains contribute to regulation of PP5 activity, which is normally low but stimulated by interaction with lipid [], and to interaction with other proteins [].PPT1 specifically binds to and dephosphorylates Hsp90 and this dephosphorylation positively regulates the Hsp90 chaperone machinery []. PPP5 is involved in a wide range of processes including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response hormones, calcium, fatty acids, TGF-beta and also oxidative and genotoxic stresses [, , ].
•
•
•
•
•
Protein
Q91YW3
Organism: Mus musculus/domesticus
Length: 504  
Fragment?: false
•
•
•
•
•
Protein
Q9CX34
Organism: Mus musculus/domesticus
Length: 336  
Fragment?: false
•
•
•
•
•
Protein
Q3UFV9
Organism: Mus musculus/domesticus
Length: 504  
Fragment?: false
•
•
•
•
•
Protein
E9Q1X9
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: true
•
•
•
•
•
Publication
16000385 | -
First Author: Sadler KC
Year: 2005
Journal: Development
Title: A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.
Volume: 132
Issue: 15
Pages: 3561-72
•
•
•
•
•
Publication
23812373 | -
First Author: Li Z
Year: 2013
Journal: Nat Struct Mol Biol
Title: Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle.
Volume: 20
Issue: 8
Pages: 929-35
•
•
•
•
•
Publication
22387434 | -
First Author: Dores-Silva PR
Year: 2012
Journal: Arch Biochem Biophys
Title: Low resolution structural characterization of the Hsp70-interacting protein - Hip - from Leishmania braziliensis emphasizes its high asymmetry.
Volume: 520
Issue: 2
Pages: 88-98
•
•
•
•
•
Publication
8887650 | -
First Author: Prapapanich V
Year: 1996
Journal: Mol Cell Biol
Title: Mutational analysis of the hsp70-interacting protein Hip.
Volume: 16
Issue: 11
Pages: 6200-7
•
•
•
•
•
Publication
11599566 | -
First Author: Webb MA
Year: 2001
Journal: Cell Stress Chaperones
Title: Orthologs in Arabidopsis thaliana of the Hsp70 interacting protein Hip.
Volume: 6
Issue: 3
Pages: 247-55
•
•
•
•
•
Publication
12237855 | -
First Author: Tallada VA
Year: 2002
Journal: Yeast
Title: Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects.
Volume: 19
Issue: 13
Pages: 1139-51
•
•
•
•
•
Publication
24210908 | -
First Author: Fan JY
Year: 2013
Journal: Neuron
Title: Noncanonical FK506-binding protein BDBT binds DBT to enhance its circadian function and forms foci at night.
Volume: 80
Issue: 4
Pages: 984-96
•
•
•
•
•
Protein Domain
IPR034649 | Hip_N
Type: Domain
Description: The Hsc70/Hsp70-interacting protein (Hip, also p48 or suppressor of tumorigenicity ST13) functions as a regulator of the cyclic action of Hsp70. Hip forms homodimers, and this entry represents the N-terminal dimerization domain, which may not be directly involved in its regulatory function. A central domain of Hip that contains TPR repeats binds the ATPase domain of Hsp70 and slows the release of ADP [, , , ].
•
•
•
•
•
Protein Domain
IPR046924 | CATASP
Type: Domain
Description: This is a small, rapidly-evolving domain predicted to possess a compact, four-helix structure. Along with a gene encoding a TPR repeat region fused to a CASPASE domain and a gene encoding the CATRA module (CATRA-N CATRA-C) C-terminally fused to a diverse range of conflict effector domains, forms the three gene island making up the CATRA conflict systems. Plays a possible inhibitory role in theCATRA system which is relieved upon sensing of an invasive molecule or is directly cleaved by the CASPASE domain [].
•
•
•
•
•
Protein Domain
IPR046880 | TPR-S
Type: Repeat
Description: This entry represents a sensor domain consisting of 7 TPR repeats forming a tightly-wound solenoid structure harbouring a deep central pocket. The TPR-S binding pocket is lined with several conserved aromatic and polar residues predicted to bind a NAD -derived nucleotide in prokaryotic NAD -derived nucleotide-activated effector conflict systems. It has been acquired at the base of the choanoflagellate-animal lineage as a core component of the ASK signalosome [].
•
•
•
•
•
Protein Domain
IPR040478 | FKBP_N_2
Type: Domain
Description: This is the N-terminal domain of the beta chain found in Drosophila melanogaster protein BDBT (a FK506-Binding Protein) which stimulates the DBT circadian function. The domain contains the DBT-binding site. The domain is structurally homologous to the peptidyl prolyl isomerase (PPIase) regions of FK506-binding proteins despite low sequence homology. BDBT is structurally related to the immunophilin FKBP51 and it shares a common domain organization consisting of PPIase-like and TPR domains with noncanonical immunophilins such as FKBP38 or FKBPL [].
•
•
•
•
•
Protein Domain
IPR030965 | SagB-rel_DH_2
Type: Family
Description: Members resemble the peptide maturation dehydrogenase SagB of thiazole and oxazole modification systems, and occur in a what appears to be a new type of peptide modification system. One adjacent marker is a new type of nitrile hydratase alpha subunit-related putative precursor, , distantly related the NHLP leader peptide family . Another is a large protein, , with regions similar to adenylate cyclases and TPR proteins.
•
•
•
•
•
Protein Domain
IPR039856 | EMC2-like
Type: Family
Description: ER membrane protein complex subunit 2 (EMC2, also known as tetratricopeptide repeat protein 35) is a tetratricopeptide repeat-containing protein, and a component of the ER membrane protein complex (EMC), which is required for efficient folding of proteins in the endoplasmic reticulum (ER) []. This entry also includes TPR repeat protein Oca3 from the fission yeast Schizosaccharomyces pombe which may be involved in cell cycle regulation [].
•
•
•
•
•
Protein Domain
IPR021773 | TPC11
Type: Domain
Description: This entry represents a domain found in trafficking protein particle complex subunit 11 (Trappc11), which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage []. The C terminus of this region contains TPR repeats.In zebrafish, Trappc11 is also known as protein foie gras. It has been shown to affect development; the mutants develop large, lipid-filled hepatocytes in the liver, resembling those in individuals with fatty liver disease [].
•
•
•
•
•
Protein
Q60716
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
•
•
•
•
•
Protein
Q60715
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
•
•
•
•
•
Protein
A2A690
Organism: Mus musculus/domesticus
Length: 1994  
Fragment?: false
•
•
•
•
•
Protein
Q8CGY6
Organism: Mus musculus/domesticus
Length: 931  
Fragment?: false
•
•
•
•
•
Protein
Q91YR7
Organism: Mus musculus/domesticus
Length: 941  
Fragment?: false
•
•
•
•
•
Protein
Q80ZK9
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
•
•
•
•
•
Protein
Q99KD5
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
•
•
•
•
•
Protein
B2RT41
Organism: Mus musculus/domesticus
Length: 1992  
Fragment?: false
•
•
•
•
•
Protein
Q3UGE6
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: true
•
•
•
•
•
Protein
Q6P7T8
Organism: Mus musculus/domesticus
Length: 1014  
Fragment?: true
•
•
•
•
•
Protein
A0A6I8MWX8
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
•
•
•
•
•
Protein
A2A5E1
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
•
•
•
•
•
Protein
Q5SX75
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
•
•
•
•
•
Protein
Q3UL32
Organism: Mus musculus/domesticus
Length: 494  
Fragment?: false
•
•
•
•
•
Protein
Q6ZPZ8
Organism: Mus musculus/domesticus
Length: 620  
Fragment?: true
•
•
•
•
•
Protein
Q6A049
Organism: Mus musculus/domesticus
Length: 1638  
Fragment?: true
•
•
•
•
•
Protein
A0A6I8MWZ1
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: false
•
•
•
•
•
Protein
Q3TN84
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
•
•
•
•
•
Protein
A0A5K1VVS7
Organism: Mus musculus/domesticus
Length: 1088  
Fragment?: false
•
•
•
•
•
Protein
A0A6I8MX00
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
•
•
•
•
•
Protein
A2AE98
Organism: Mus musculus/domesticus
Length: 615  
Fragment?: false
•
•
•
•
•
Protein
Q5SX74
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
•
•
•
•
•
Protein
Q8JZZ2
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
•
•
•
•
•
Protein
Q3UF16
Organism: Mus musculus/domesticus
Length: 561  
Fragment?: false
•
•
•
•
•
Publication
8636124 | J:32101
First Author: Malek SN
Year: 1996
Journal: J Biol Chem
Title: p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains.
Volume: 271
Issue: 12
Pages: 6952-62
•
•
•
•
•
Publication
8660659 | J:43666
First Author: Smith JB
Year: 1996
Journal: Arch Biochem Biophys
Title: The glucocorticoid attenuated response genes GARG-16, GARG-39, and GARG-49/IRG2 encode inducible proteins containing multiple tetratricopeptide repeat domains.
Volume: 330
Issue: 2
Pages: 290-300
•
•
•
•
•
Publication
8077208 | J:57652
First Author: Becker W
Year: 1994
Journal: J Biol Chem
Title: Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain.
Volume: 269
Issue: 36
Pages: 22586-92
•
•
•
•
•
Publication
30158508 | J:282604
 
First Author: Shamoto N
Year: 2018
Journal: Cells
Title: CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility.
Volume: 7
Issue: 9
•
•
•
•
•
Publication
25882846 | J:224694
First Author: Clairfeuille T
Year: 2015
Journal: J Biol Chem
Title: Structure and Membrane Binding Properties of the Endosomal Tetratricopeptide Repeat (TPR) Domain-containing Sorting Nexins SNX20 and SNX21.
Volume: 290
Issue: 23
Pages: 14504-17
•
•
•
•
•
Publication
31735292 | J:289075
First Author: Lorès P
Year: 2019
Journal: Am J Hum Genet
Title: Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility.
Volume: 105
Issue: 6
Pages: 1148-1167
•
•
•
•
•
Publication
9603993 | J:48385
First Author: Tsukahara F
Year: 1998
Journal: J Biochem
Title: Molecular characterization of the mouse mtprd gene, a homologue of human TPRD: unique gene expression suggesting its critical role in the pathophysiology of Down syndrome.
Volume: 123
Issue: 6
Pages: 1055-63
•
•
•
•
•
Publication
30076146 | J:266278
First Author: Wang Q
Year: 2018
Journal: Blood
Title: Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.
Volume: 132
Issue: 12
Pages: 1279-1292
•
•
•
•
•
Publication
37726498 | J:347875
First Author: Wang L
Year: 2024
Journal: Mol Neurobiol
Title: FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat Diet.
Volume: 61
Issue: 3
Pages: 1479-1494
•
•
•
•
•
Publication
19581287 | J:152609
First Author: Echeverría PC
Year: 2009
Journal: Mol Cell Biol
Title: Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.
Volume: 29
Issue: 17
Pages: 4788-97
•
•
•
•
•
Publication
17535810 | J:177154
First Author: Bédard J
Year: 2007
Journal: J Biol Chem
Title: Functional similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein (Hip).
Volume: 282
Issue: 29
Pages: 21404-14
•
•
•
•
•
Publication
10642524 | J:60612
 
First Author: Van Der Spuy J
Year: 2000
Journal: Biochem J
Title: Heat shock cognate protein 70 chaperone-binding site in the co-chaperone murine stress-inducible protein 1 maps to within three consecutive tetratricopeptide repeat motifs.
Volume: 345 Pt 3
Pages: 645-51
•
•
•
•
•
Publication
3282234 | J:23848
First Author: Park M
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Two rearranged MET alleles in MNNG-HOS cells reveal the orientation of MET on chromosome 7 to other markers tightly linked to the cystic fibrosis locus.
Volume: 85
Issue: 8
Pages: 2667-71
•
•
•
•
•
Publication
10455184 | J:57013
First Author: Koga H
Year: 1999
Journal: J Biol Chem
Title: Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase.
Volume: 274
Issue: 35
Pages: 25051-60
•
•
•
•
•
Publication
12964006 | J:93270
First Author: Katoh M
Year: 2003
Journal: Int J Oncol
Title: Identification and characterization of TPARM gene in silico.
Volume: 23
Issue: 4
Pages: 1213-7
•
•
•
•
•
Publication
31488544 | J:282860
First Author: Yadav RP
Year: 2019
Journal: J Biol Chem
Title: Interaction of the tetratricopeptide repeat domain of aryl hydrocarbon receptor-interacting protein-like 1 with the regulatory Pγ subunit of phosphodiesterase 6.
Volume: 294
Issue: 43
Pages: 15795-15807
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom