Type |
Details |
Score |
Publication |
First Author: |
Stevens JD |
Year: |
2008 |
Journal: |
Differentiation |
Title: |
Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation. |
Volume: |
76 |
Issue: |
9 |
Pages: |
1006-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Campbell GR |
Year: |
2011 |
Journal: |
Mol Cell Neurosci |
Title: |
Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. |
Volume: |
46 |
Issue: |
2 |
Pages: |
548-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Taconic |
Year: |
2006 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from Taconic website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Willnow T |
Year: |
2005 |
Journal: |
Organogenesis |
Title: |
The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. |
Volume: |
2 |
Issue: |
2 |
Pages: |
42-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Collin GB |
Year: |
2020 |
Journal: |
Cells |
Title: |
Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. |
Volume: |
9 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Memic F |
Year: |
2018 |
Journal: |
Gastroenterology |
Title: |
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. |
Volume: |
154 |
Issue: |
3 |
Pages: |
624-636 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wiese CB |
Year: |
2012 |
Journal: |
Front Neurosci |
Title: |
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. |
Volume: |
6 |
|
Pages: |
130 |
|
•
•
•
•
•
|
Publication |
First Author: |
University of California, Davis |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the University of California, Davis |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Guo G |
Year: |
2010 |
Journal: |
Dev Cell |
Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
Volume: |
18 |
Issue: |
4 |
Pages: |
675-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama S |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
Volume: |
17 |
Issue: |
6 |
Pages: |
836-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Xia P |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
WASH maintains NKp46+ ILC3 cells by promoting AHR expression. |
Volume: |
8 |
|
Pages: |
15685 |
|
•
•
•
•
•
|
Allele |
Name: |
aryl-hydrocarbon receptor; targeted mutation 1, Yoshiaki Fujii-Kuriyama |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Villard PH |
Year: |
2007 |
Journal: |
Biochem Biophys Res Commun |
Title: |
PPARalpha transcriptionally induces AhR expression in Caco-2, but represses AhR pro-inflammatory effects. |
Volume: |
364 |
Issue: |
4 |
Pages: |
896-901 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sadik A |
Year: |
2020 |
Journal: |
Cell |
Title: |
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. |
Volume: |
182 |
Issue: |
5 |
Pages: |
1252-1270.e34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2018 |
Journal: |
Cancer Cell |
Title: |
Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation. |
Volume: |
33 |
Issue: |
3 |
Pages: |
480-494.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hosoya T |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice. |
Volume: |
365 |
Issue: |
3 |
Pages: |
562-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goettel JA |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. |
Volume: |
17 |
Issue: |
5 |
Pages: |
1318-1329 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giovannoni F |
Year: |
2020 |
Journal: |
Nat Neurosci |
Title: |
AHR is a Zika virus host factor and a candidate target for antiviral therapy. |
Volume: |
23 |
Issue: |
8 |
Pages: |
939-951 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borchers MT |
Year: |
2001 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling. |
Volume: |
281 |
Issue: |
3 |
Pages: |
L653-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khanal T |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. |
Volume: |
7 |
Issue: |
1 |
Pages: |
10662 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang F |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Structure and expression of the mouse AhR nuclear translocator (mArnt) gene. |
Volume: |
273 |
Issue: |
38 |
Pages: |
24867-73 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
701
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kerzee JK |
Year: |
2001 |
Journal: |
Circ Res |
Title: |
Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells: role of the Ahr bHLH/PAS transcription factor. |
Volume: |
89 |
Issue: |
7 |
Pages: |
573-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blümel J |
Year: |
1999 |
Journal: |
Eur Cytokine Netw |
Title: |
Primary immune response in skin and skin-associated lymphoid tissue of interleukin-4 transgenic mice. |
Volume: |
10 |
Issue: |
4 |
Pages: |
515-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qian C |
Year: |
2021 |
Journal: |
Theranostics |
Title: |
Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin. |
Volume: |
11 |
Issue: |
18 |
Pages: |
8797-8812 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2022 |
Journal: |
J Biol Chem |
Title: |
Protein phosphatase 2A regulates cytotoxicity and drug resistance by dephosphorylating AHR and MDR1. |
Volume: |
298 |
Issue: |
5 |
Pages: |
101918 |
|
•
•
•
•
•
|
Publication |
First Author: |
Biagioli M |
Year: |
2021 |
Journal: |
Biochem Pharmacol |
Title: |
Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction. |
Volume: |
188 |
|
Pages: |
114564 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
573
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
299
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Nebert DW |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology. |
Volume: |
283 |
Issue: |
52 |
Pages: |
36061-5 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Nerurkar PV |
Year: |
1996 |
Journal: |
Mol Pharmacol |
Title: |
Ahr locus phenotype in congenic mice influences hepatic and pulmonary DNA adduct levels of 2-amino-3-methylimidazo[4,5-f]quinoline in the absence of cytochrome P450 induction. |
Volume: |
49 |
Issue: |
5 |
Pages: |
874-81 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4+CD8+ DPK thymocytes differentiation. |
|
•
•
•
•
•
|
Publication |
First Author: |
Morales JL |
Year: |
2007 |
Journal: |
Biochemistry |
Title: |
Carboxyl terminus of hsc70-interacting protein (CHIP) can remodel mature aryl hydrocarbon receptor (AhR) complexes and mediate ubiquitination of both the AhR and the 90 kDa heat-shock protein (hsp90) in vitro. |
Volume: |
46 |
Issue: |
2 |
Pages: |
610-21 |
|
•
•
•
•
•
|
Allele |
Name: |
aryl-hydrocarbon receptor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
aryl-hydrocarbon receptor; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Abbott BD |
Year: |
2003 |
Journal: |
Toxicol Sci |
Title: |
EGF and TGF-alpha expression influence the developmental toxicity of TCDD: dose response and AhR phenotype in EGF, TGF-alpha, and EGF + TGF-alpha knockout mice. |
Volume: |
71 |
Issue: |
1 |
Pages: |
84-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bermejo DA |
Year: |
2013 |
Journal: |
Nat Immunol |
Title: |
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells. |
Volume: |
14 |
Issue: |
5 |
Pages: |
514-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thomas RS |
Year: |
2002 |
Journal: |
Pharmacogenetics |
Title: |
Sequence variation and phylogenetic history of the mouse Ahr gene. |
Volume: |
12 |
Issue: |
2 |
Pages: |
151-63 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE56983 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuo PY |
Year: |
2018 |
Journal: |
Blood |
Title: |
SOX11 augments BCR signaling to drive MCL-like tumor development. |
Volume: |
131 |
Issue: |
20 |
Pages: |
2247-2255 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-76276 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Oshima M |
Year: |
2007 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. |
Volume: |
364 |
Issue: |
2 |
Pages: |
276-82 |
|
•
•
•
•
•
|
Allele |
Name: |
aryl-hydrocarbon receptor; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee DM |
Year: |
2012 |
Journal: |
Environ Toxicol Pharmacol |
Title: |
SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4+CD8+ DPK thymocytes differentiation. |
Volume: |
34 |
Issue: |
3 |
Pages: |
858-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wejheden C |
Year: |
2010 |
Journal: |
Toxicol Sci |
Title: |
Transgenic mice with a constitutively active aryl hydrocarbon receptor display a gender-specific bone phenotype. |
Volume: |
114 |
Issue: |
1 |
Pages: |
48-58 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Lorenz Poellinger |
Allele Type: |
Transgenic |
Attribute String: |
Constitutively active, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
aryl-hydrocarbon receptor; targeted mutation 1, Masayuki Yamamoto |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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•
•
•
•
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Allele |
Name: |
aryl-hydrocarbon receptor; targeted mutation 1, Liang Zhou |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Constitutively active, Epitope tag, Reporter |
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Allele |
Name: |
aryl-hydrocarbon receptor; targeted mutation 1.1, Liang Zhou |
Allele Type: |
Targeted |
Attribute String: |
Constitutively active, Epitope tag, Reporter |
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Publication |
First Author: |
Marigo I |
Year: |
2016 |
Journal: |
Cancer Cell |
Title: |
T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells. |
Volume: |
30 |
Issue: |
3 |
Pages: |
377-390 |
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Publication |
First Author: |
Andersson P |
Year: |
2005 |
Journal: |
Anticancer Res |
Title: |
Gastric hamartomatous tumours in a transgenic mouse model expressing an activated dioxin/Ah receptor. |
Volume: |
25 |
Issue: |
2A |
Pages: |
903-11 |
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•
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Strain |
Attribute String: |
congenic, targeted mutation |
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•
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•
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Strain |
Attribute String: |
mutant stock, targeted mutation |
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Allele |
Name: |
intergenic site 2; endonuclease-mediated mutation 68, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Inducible, Reporter |
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•
•
•
•
•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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Allele |
Name: |
regulatory region 50; endonuclease-mediated mutation 1, Axel Visel |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Modified regulatory region |
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Genotype |
Symbol: |
Tg(SV40-Ahr)1Poe/? |
Background: |
involves: C57BL/6 * CBA |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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•
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Genotype |
Symbol: |
Ahr/Ahr |
Background: |
B6.129P2-Ahr |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Protein Domain |
Type: |
Family |
Description: |
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the biological and toxic effects of dioxin-like compounds []. Upon ligand binding, the receptor translocates into the nucleus where it heterodimerises with ARNT (AHR nuclear translocator) []. The aryl hydrocarbon receptor repressor (AHRR) competes with AHR for the binding of ARNT, and thereby repressing AHR's transcription activity []. |
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•
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Protein Domain |
Type: |
Family |
Description: |
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the biological and toxic effects of dioxin-like compounds []. Upon ligand binding, the receptor translocates into the nucleus where it heterodimerises with ARNT (AHR nuclear translocator) []. The aryl hydrocarbon receptor repressor (AHRR) competes with AHR for the binding of ARNT, and thereby repressing AHR's transcription activity []. |
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Strain |
Attribute String: |
mutant strain, coisogenic, endonuclease-mediated mutation |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Genotype |
Symbol: |
Rr50/Rr50 |
Background: |
FVB-Rr50 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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