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Search results 1101 to 1200 out of 3906 for Cd40

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Cd40/Cd40 Traf3ip2/Traf3ip2
Background: involves: 129 * 129P2/OlaHsd * BALB/c
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd28/Cd28 Cd40lg/Cd40lg
Background: NOD.Cg-Cd40lg Cd28
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/Cd40lg Tg(APPSWE)2576Kha/?
Background: involves: 129S2/SvPas * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40/Cd40 Tg(Tnfsf13b)1Fma/?
Background: B6.Cg-Cd40 Tg(Tnfsf13b)1Fma
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40/Cd40 Tg(Igh-V-CD40lg)#Tsub/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/? Fas/Fas
Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/Cd40lg Fas/Fas
Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40/Cd40 Ltbr/Ltbr
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/? Tg(Tek-cre)1Ywa/?
Background: involves: 129 * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/Cd40lg Tg(Tek-cre)1Ywa/?
Background: involves: 129 * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/? Tg(Cd4-cre)1Cwi/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/Cd40lg Tg(Cd4-cre)1Cwi/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40/Cd40<+>
Background: C57BL/6N-Cd40/Ucd
Zygosity: ht
Has Mutant Allele: true
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Allele
Gt(ROSA)26Sor<tm1Uzs> | MGI:3776037
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ursula Zimber-Strobl
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, No functional change
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Publication
29521626 | J:264188
   
First Author: Noviski M
Year: 2018
Journal: Elife
Title: IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.
Volume: 7
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Protein Coding Gene
MGI:101835 | Traf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108041 | Traf3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10673339 | J:60550
First Author: Gardner HP
Year: 2000
Journal: Genomics
Title: Cloning, characterization, and chromosomal localization of Pnck, a Ca(2+)/calmodulin-dependent protein kinase.
Volume: 63
Issue: 2
Pages: 279-88
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Publication
11403253 | J:69798
First Author: Guo Z
Year: 2001
Journal: Transplantation
Title: CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Volume: 71
Issue: 9
Pages: 1351-4
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Publication
24106272 | J:319029
First Author: Crist SA
Year: 2013
Journal: J Biol Chem
Title: Early growth response-1 (EGR-1) and nuclear factor of activated T cells (NFAT) cooperate to mediate CD40L expression in megakaryocytes and platelets.
Volume: 288
Issue: 47
Pages: 33985-33996
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Protein Coding Gene
MGI:1928676 | Htra2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913331 | Sharpin
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2448480 | Fancd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
34852236 | J:316085
First Author: Cui C
Year: 2021
Journal: Cell
Title: Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses.
Volume: 184
Issue: 25
Pages: 6101-6118.e13
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Protein Coding Gene
MGI:99484 | Chuk
Type: protein_coding_gene
Organism: mouse, laboratory
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Strain
MGI:4418900 | B10JAnu.Cg-H2<k2> Cd40lg<tm1Flv> Tg(TcrHEL3A9)1Mmd/AnuApb
Attribute String: major histocompatibility congenic, mutant strain, targeted mutation, congenic
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Genotype
Genotype
Symbol: Btk/Btk Cd40/Cd40
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bank1/Bank1 Cd40/Cd40
Background: involves: 129P2/OlaHsd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40/Cd40 Tnfsf11/Tnfsf11
Background: involves: 129P2/OlaHsd
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:2386643 | Tnip2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12496377 | -
First Author: Lee JR
Year: 2003
Journal: J Immunol
Title: Cutting edge: induced expression of a RhoA-specific guanine nucleotide exchange factor, p190RhoGEF, following CD40 stimulation and WEHI 231 B cell activation.
Volume: 170
Issue: 1
Pages: 19-23
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Publication
8898945 | -
First Author: Ning ZQ
Year: 1996
Journal: Eur J Immunol
Title: Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36.
Volume: 26
Issue: 10
Pages: 2356-63
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Publication
14963650 | -
First Author: Yngen M
Year: 2004
Journal: Diabetologia
Title: Enhanced P-selectin expression and increased soluble CD40 Ligand in patients with Type 1 diabetes mellitus and microangiopathy: evidence for platelet hyperactivity and chronic inflammation.
Volume: 47
Issue: 3
Pages: 537-540
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Publication
26646413 | -
First Author: Premzl M
Year: 2016
Journal: Immunogenetics
Title: Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Volume: 68
Issue: 2
Pages: 125-32
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Publication
17507094 | J:123603
First Author: Loniewski KJ
Year: 2007
Journal: Mol Immunol
Title: Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
Volume: 44
Issue: 15
Pages: 3715-23
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Publication
7896266 | J:21468
First Author: Fletcher FA
Year: 1994
Journal: Genomics
Title: Genomic organization and chromosomal localization of mouse Eplg2, a gene encoding a binding protein for the receptor tyrosine kinase elk.
Volume: 24
Issue: 1
Pages: 127-32
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Publication
14647274 | J:87846
First Author: Hasbold J
Year: 2004
Journal: Nat Immunol
Title: Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation.
Volume: 5
Issue: 1
Pages: 55-63
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Protein Coding Gene
MGI:1197009 | Birc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
32632165 | J:294172
First Author: Kawabe T
Year: 2020
Journal: Nat Commun
Title: Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Volume: 11
Issue: 1
Pages: 3366
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Protein Coding Gene
MGI:2673064 | Tnfsf18
Type: protein_coding_gene
Organism: mouse, laboratory
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Strain
MGI:5659429 | NOD.Cg-Cd28<tm1Mak> Cd40<tm1Kik> Ifng<tm1Ts> H2<h4>/HbmMmmh
Attribute String: mutant strain, congenic, targeted mutation
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Strain
MGI:5616251 | NOD.Cg-Cd40<tm1Kik> Ifng<tm1Ts> H2<h4> Tg(tetO-Tcra)1Doi/HbmMmmh
Attribute String: targeted mutation, transgenic, variant allele, congenic
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Strain
MGI:5586678 | STOCK Rag2<tm1Fwa> Cd40<tm1Kik> Tg(TcraH-Y,TcrbH-Y)71Vbo/Orl
Attribute String: transgenic, targeted mutation, mutant stock
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Strain
MGI:4441419 | C.129-Cd40<tm1Kik> Cd86<tm2Shr> Cd80<tm1Shr>/Mmnc
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:7382579 | BALB/cJGpt-Pdcd1<em2(PDCD1)Gpt> Cd40<em3(CD40)Gpt> Cd274<tm2(CD274)Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Cd40lg/? Fas/Fas Tcra/Tcra
Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/Cd40lg Fas/Fas Tcra/Tcra
Background: involves: 129P2/OlaHsd * 129S2/SvPas * MRL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/? Commd10/Commd10<+>
Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/Cd40lg Commd10/Commd10<+>
Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40/Cd40<+> Mir146/Mir146 Tg(Cr2-cre)3Cgn/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/? Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129X1/SvJ * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd40lg/Cd40lg Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129X1/SvJ * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:1338071 | Ikbkb
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15169888 | -
First Author: Lang V
Year: 2004
Journal: Mol Cell Biol
Title: ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
Volume: 24
Issue: 12
Pages: 5235-48
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Publication
15670770 | -
First Author: Chan H
Year: 2005
Journal: Biochem Biophys Res Commun
Title: TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40.
Volume: 328
Issue: 1
Pages: 198-205
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Protein Domain
IPR017424 | MAPKKK8
Type: Family
Description: This entry represents mitogen-activated protein kinase kinase kinase 8 (MAP3K8 or COT or TPL2) (), which plays a role in the cell cycle. MAP3K8 is required for TLR4 activation of the MEK/ERK pathway. MAP3K8 is able to activate NF-kappa-B 1 (NFKB1) by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105 []. MAP3K8 forms a ternary complex with NFKB1 and TNIP2 []. MAP3K8 is recruited to the CD40 complex via a mechanism dependent on TRAF-binding sites in CD40 [].
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Protein Coding Gene
MGI:108072 | Traf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1351314 | Slamf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18097035 | J:130932
First Author: Brem-Exner BG
Year: 2008
Journal: J Immunol
Title: Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.
Volume: 180
Issue: 1
Pages: 335-49
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Publication
11178743 | J:68683
First Author: Elliott RW
Year: 2001
Journal: Mamm Genome
Title: Genetic analysis of testis weight and fertility in an interspecies hybrid congenic strain for Chromosome X.
Volume: 12
Issue: 1
Pages: 45-51
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Publication
26110994 | J:233792
First Author: Hillen MR
Year: 2015
Journal: PLoS One
Title: The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade.
Volume: 10
Issue: 6
Pages: e0130830
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HT Experiment
GSE73077 | Expression analysis of TCRgd+LAP+ versus TCRgd+LAP- cells
Series Id: E-GEOD-73077
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Allele
Tg(Igh-CD40)1Kik | MGI:3687555
Name: transgene insertion 1, Hitoshi Kikutani
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Gt(ROSA)26Sor<tm1(CAG-Thy1,-srta)Vic> | MGI:7464413
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Gabriel Victora
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence
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Protein Coding Gene
MGI:96604 | Itga5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22509320 | J:307941
First Author: Zuo B
Year: 2012
Journal: PLoS One
Title: Analysis of microsatellite polymorphism in inbred knockout mice.
Volume: 7
Issue: 4
Pages: e34555
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Genotype
Genotype
Symbol: Cd40lg/Cd40lg<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129X1/SvJ * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Publication
15539150 | J:93890
First Author: Grech AP
Year: 2004
Journal: Immunity
Title: TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells.
Volume: 21
Issue: 5
Pages: 629-42
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Publication
8710854 | J:34830
First Author: Rothe M
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.
Volume: 93
Issue: 16
Pages: 8241-6
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Publication
19494299 | -
First Author: Gong YF
Year: 2009
Journal: J Immunol
Title: CD154-CD40 interactions are essential for thymus-dependent antibody production in zebrafish: insights into the origin of costimulatory pathway in helper T cell-regulated adaptive immunity in early vertebrates.
Volume: 182
Issue: 12
Pages: 7749-62
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Publication
22889889 | -
First Author: Lagos LX
Year: 2012
Journal: Dev Comp Immunol
Title: CD40L--a costimulatory molecule involved in the maturation of antigen presenting cells in Atlantic salmon (Salmo salar).
Volume: 38
Issue: 3
Pages: 416-30
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Publication
17562706 | -
First Author: Hoffmann SC
Year: 2007
Journal: J Biol Chem
Title: Identification of CLEC12B, an inhibitory receptor on myeloid cells.
Volume: 282
Issue: 31
Pages: 22370-5
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Publication
16239426 | -
First Author: Chen CH
Year: 2006
Journal: Blood
Title: Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production.
Volume: 107
Issue: 4
Pages: 1459-67
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Protein Domain
IPR034053 | TNFRSF5_N_teleost
Type: Domain
Description: Tumor necrosis factor receptor superfamily member 5 (TNFRSF5), commonly known as CD40 and also as CDW40, p50 or Bp50, is widely expressed in diverse cell types including B lymphocytes, dendritic cells, platelets, monocytes, endothelial cells, and fibroblasts []. It is essential in mediating a wide variety of immune and inflammatory responses, including T cell-dependentimmunoglobulin class switching, memory B cell development, and germinal centre formation [, , , ]. Its natural immunomodulating ligand is CD40L, and a primary defect in the CD40/CD40L system is associated with X-linked hyper-IgM (XHIM) syndrome []. It is also involved in tumorigenesis. The CD40/CD40L system serves as a link between tumorigenesis, atherosclerosis, and the immune system, and offers a potential target for drug therapy for related diseases, such as cancer, atherosclerosis, diabetes mellitus, and immunological rejection [].TNFRSF5/CD40 homologues have been identified in teleosts. The zebrafish CD40 is a type I membrane-bound protein with a sequence pattern of four cysteine-rich domains in its extracellular N-terminal region. The consensus TNFR-associated factor (TRAF)2- and TRAF6-binding motifs in mammalian CD40 are found in the cytoplasmic tail of zebrafish CD40, which indicates similar signal transduction mechanisms to higher vertebrates []. Salmon CD40 and CD40L are widely expressed, particularly in immune tissues, and their importance for the immune response is indicated by their relatively high expression in salmon lymphoid organs and gills [].This entry represents the N-terminal domain of TNFRSF5 from teleosts.
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Protein Domain
IPR042916 | CLEC12A/B
Type: Family
Description: C-type lectin domain family 12 member B (CLEC12B) is a lectin C-type inhibitory receptor that plays a role in myeloid cell function []. CLEC12A (also known as MICL or DCAL-2) is expressed in monocytes, macrophages, and dendritic-cells (DCs). It serves as a functional receptor on DCs and can internalize and collaborate with TLR or CD40 signaling and regulate immune responses [].
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Publication
22761313 | J:185495
First Author: Arnold CN
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.
Volume: 109
Issue: 31
Pages: 12286-93
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Publication
12829028 | J:115677
First Author: TeKippe M
Year: 2003
Journal: Exp Hematol
Title: Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice.
Volume: 31
Issue: 6
Pages: 521-7
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Strain
MGI:7464417 | C57BL/6-Gt(ROSA)26Sor<tm1(CAG-Thy1,-srta)Vic>/J
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Cd19/Cd19<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * BALB/c
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
E-GEOD-11005 | Transcription profiling by array of CD40L-knockout and wild-type mice with or without exposure to Pneumocystis murina for different duration
Series Id: GSE11005
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
8790420 | J:41070
First Author: Smallwood PM
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.
Volume: 93
Issue: 18
Pages: 9850-7
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Publication
12860530 | J:84635
First Author: Collette Y
Year: 2003
Journal: Trends Immunol
Title: A co-evolution perspective of the TNFSF and TNFRSF families in the immune system.
Volume: 24
Issue: 7
Pages: 387-94
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Protein Coding Gene
MGI:2143599 | Traf3ip2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18997792 | J:143169
First Author: Vallabhapurapu S
Year: 2008
Journal: Nat Immunol
Title: Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
Volume: 9
Issue: 12
Pages: 1364-70
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Publication
28062921 | J:240419
First Author: Villanueva JE
Year: 2017
Journal: Diabetologia
Title: Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice.
Volume: 60
Issue: 4
Pages: 679-689
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Publication
22711886 | J:189536
First Author: Pérez-Chacón G
Year: 2012
Journal: J Immunol
Title: TNFR-associated factor 2 deficiency in B lymphocytes predisposes to chronic lymphocytic leukemia/small lymphocytic lymphoma in mice.
Volume: 189
Issue: 2
Pages: 1053-61
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Publication
8934568 | J:37065
First Author: Xu Y
Year: 1996
Journal: Immunity
Title: Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.
Volume: 5
Issue: 5
Pages: 407-15
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Publication
10215628 | J:54467
First Author: Lomaga MA
Year: 1999
Journal: Genes Dev
Title: TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Volume: 13
Issue: 8
Pages: 1015-24
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Protein Coding Gene
MGI:1196377 | Tnfaip3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23942237 | J:201885
First Author: Sasaki Y
Year: 2013
Journal: EMBO J
Title: Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells.
Volume: 32
Issue: 18
Pages: 2463-76
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Publication
36993443 | J:334846
     
First Author: Nakandakari-Higa S
Year: 2023
Journal: bioRxiv
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