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Search results 1101 to 1200 out of 1552 for Erbb3

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Type Details Score
Protein Domain
IPR004545 | PA2G4
Type: Family
Description: Proteins of this family have been identified in a number of species as a nuclear protein with a cell cycle dependence. Various names have been given to members of this family which include cell cycle protein p38-2G4, also known as proliferation-associated protein PA2G4 [, ], curved DNA-binding protein [], proliferation-associated protein A, and ErbB3-binding protein 1 (Ebp1) []. They constitute the proliferation-associated PA2G4 family, which is structurally homologous to the type II methionine aminopeptidases, but without methionine aminopeptidase activity [, ]. ErbB3 binding protein-1 (Ebp1) is a potential regulator of ErbB3 signaling, and is implicated in cell growth, apoptosis and differentiation in many cell types [, ].These proteins are classified as non-peptidase homologues in the MEROPS peptidase family M24 (clan MG).
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Genotype
Genotype
Symbol: Erbb3/Erbb3 Gt(ROSA)26Sor/? Tg(Dhh-cre)1Mejr/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
10521398 | J:58105
First Author: Woldeyesus MT
Year: 1999
Journal: Genes Dev
Title: Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.
Volume: 13
Issue: 19
Pages: 2538-48
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Publication
16652155 | J:115842
First Author: Jackson-Fisher AJ
Year: 2006
Journal: Oncogene
Title: Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4.
Volume: 25
Issue: 41
Pages: 5664-72
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Publication
23365119 | J:200123
First Author: Montero-Conde C
Year: 2013
Journal: Cancer Discov
Title: Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.
Volume: 3
Issue: 5
Pages: 520-33
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Publication
22439932 | J:186090
First Author: Yamaguchi T
Year: 2012
Journal: Cancer Cell
Title: NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
Volume: 21
Issue: 3
Pages: 348-61
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Publication
12213576 | J:79090
First Author: Hulit J
Year: 2002
Journal: Biochem Pharmacol
Title: ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1.
Volume: 64
Issue: 5-6
Pages: 827-36
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Publication
12824184 | J:85420
First Author: Li BS
Year: 2003
Journal: J Biol Chem
Title: Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.
Volume: 278
Issue: 37
Pages: 35702-9
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Publication
37775182 | J:360543
First Author: Han J
Year: 2023
Journal: Genes Dev
Title: Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer.
Volume: 37
Issue: 17-18
Pages: 818-828
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Protein Coding Gene
MGI:1098246 | Nrg2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0A140LHT4
Organism: Mus musculus/domesticus
Length: 2805  
Fragment?: false
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Protein
E9PUJ3
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Publication
11447105 | -
First Author: Zesławski W
Year: 2001
Journal: EMBO J
Title: The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5.
Volume: 20
Issue: 14
Pages: 3638-44
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Publication
12154198 | -
First Author: Cho HS
Year: 2002
Journal: Science
Title: Structure of the extracellular region of HER3 reveals an interdomain tether.
Volume: 297
Issue: 5585
Pages: 1330-3
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Publication
7567962 | -
First Author: Ward CW
Year: 1995
Journal: Proteins
Title: Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor.
Volume: 22
Issue: 2
Pages: 141-53
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Protein Domain
IPR009030 | Growth_fac_rcpt_cys_sf
Type: Homologous_superfamily
Description: This growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [], the type-1 insulin-like growth-factor receptor (IGF-1R) [], and members of the epidermal growth factor (EGF) receptor family [], such as the receptor protein-tyrosine kinase Erbb-3 (ErbB3) []. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a β-hairpin with two adjacent disulphides. IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organisation, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues. IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain. ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately []. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A β-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure.
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Publication
15314180 | J:92790
First Author: Wu X
Year: 2004
Journal: Mol Cell Biol
Title: Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.
Volume: 24
Issue: 17
Pages: 7748-57
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Publication
26230680 | J:238601
First Author: Ennequin G
Year: 2015
Journal: PLoS One
Title: Neuregulin 1 Improves Glucose Tolerance in db/db Mice.
Volume: 10
Issue: 7
Pages: e0130568
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Publication
12213737 | J:78873
First Author: Rosner A
Year: 2002
Journal: Am J Pathol
Title: Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors.
Volume: 161
Issue: 3
Pages: 1087-97
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Publication
20220087 | J:160056
First Author: Porzia A
Year: 2010
Journal: J Immunol
Title: Attenuation of PI3K/Akt-mediated tumorigenic signals through PTEN activation by DNA vaccine-induced anti-ErbB2 antibodies.
Volume: 184
Issue: 8
Pages: 4170-7
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Publication
16914500 | J:112458
First Author: Rivera-Feliciano J
Year: 2006
Journal: Development
Title: Development of heart valves requires Gata4 expression in endothelial-derived cells.
Volume: 133
Issue: 18
Pages: 3607-18
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Publication
7477377 | J:29973
First Author: Lee KF
Year: 1995
Journal: Nature
Title: Requirement for neuregulin receptor erbB2 in neural and cardiac development.
Volume: 378
Issue: 6555
Pages: 394-8
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Publication
15470130 | J:132561
First Author: Stankovic K
Year: 2004
Journal: J Neurosci
Title: Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.
Volume: 24
Issue: 40
Pages: 8651-61
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Publication
23593223 | J:200032
First Author: Hodgson MC
Year: 2013
Journal: PLoS One
Title: Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice.
Volume: 8
Issue: 4
Pages: e60455
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Publication
23899604 | J:204096
First Author: Dahlhoff M
Year: 2013
Journal: Biochim Biophys Acta
Title: Increased activation of the epidermal growth factor receptor in transgenic mice overexpressing epigen causes peripheral neuropathy.
Volume: 1832
Issue: 12
Pages: 2068-76
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Publication
18358466 | J:136063
First Author: Xu B
Year: 2008
Journal: Dev Biol
Title: Cited2 is required for fetal lung maturation.
Volume: 317
Issue: 1
Pages: 95-105
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Publication
28617998 | J:243919
First Author: Logan AM
Year: 2017
Journal: Glia
Title: Schwann cell-specific deletion of the endosomal PI 3-kinase Vps34 leads to delayed radial sorting of axons, arrested myelination, and abnormal ErbB2-ErbB3 tyrosine kinase signaling.
Volume: 65
Issue: 9
Pages: 1452-1470
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Publication
29410073 | J:261978
First Author: Hoesl C
Year: 2018
Journal: Biochim Biophys Acta
Title: The receptor tyrosine kinase ERBB4 is expressed in skin keratinocytes and influences epidermal proliferation.
Volume: 1862
Issue: 4
Pages: 958-966
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Publication
10980598 | J:64524
First Author: Kiguchi K
Year: 2000
Journal: Oncogene
Title: Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development.
Volume: 19
Issue: 37
Pages: 4243-54
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Publication
25401691 | J:227798
First Author: Wang GX
Year: 2014
Journal: Nat Med
Title: The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis.
Volume: 20
Issue: 12
Pages: 1436-1443
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Publication
15958580 | J:99382
First Author: Liu M
Year: 2005
Journal: Cancer Res
Title: Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer.
Volume: 65
Issue: 12
Pages: 5325-36
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Publication
17145873 | J:116215
First Author: Yen L
Year: 2006
Journal: Cancer Res
Title: Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth.
Volume: 66
Issue: 23
Pages: 11279-86
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Publication
28218289 | J:274547
 
First Author: Arai T
Year: 2017
Journal: Sci Rep
Title: Type I neuregulin1α is a novel local mediator to suppress hepatic gluconeogenesis in mice.
Volume: 7
Pages: 42959
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Publication
12466964 | J:314758
First Author: Hobbs SS
Year: 2002
Journal: Oncogene
Title: Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation.
Volume: 21
Issue: 55
Pages: 8442-52
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Publication
23637177 | J:325503
First Author: Fleck D
Year: 2013
Journal: J Neurosci
Title: Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.
Volume: 33
Issue: 18
Pages: 7856-69
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Publication
9168114 | J:317052
First Author: Chang H
Year: 1997
Journal: Nature
Title: Ligands for ErbB-family receptors encoded by a neuregulin-like gene.
Volume: 387
Issue: 6632
Pages: 509-12
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Publication
7816098 | J:22296
First Author: Jo SA
Year: 1995
Journal: Nature
Title: Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression.
Volume: 373
Issue: 6510
Pages: 158-61
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Publication
27353365 | J:240367
First Author: Hatakeyama J
Year: 2016
Journal: Sci Signal
Title: The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3.
Volume: 9
Issue: 434
Pages: ra65
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Publication
11135307 | J:66822
First Author: Halford MM
Year: 2001
Journal: Bioessays
Title: Revelations of the RYK receptor.
Volume: 23
Issue: 1
Pages: 34-45
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Publication
12154062 | J:78113
First Author: Li H
Year: 2002
Journal: Cancer Res
Title: Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the Nf1:p53 mouse tumor model.
Volume: 62
Issue: 15
Pages: 4507-13
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Publication
10531446 | J:119902
First Author: Tanowitz M
Year: 1999
Journal: J Neurosci
Title: Regulation of neuregulin-mediated acetylcholine receptor synthesis by protein tyrosine phosphatase SHP2.
Volume: 19
Issue: 21
Pages: 9426-35
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Publication
19293185 | J:147358
First Author: Hernandez L
Year: 2009
Journal: Cancer Res
Title: The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12.
Volume: 69
Issue: 7
Pages: 3221-7
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Publication
17555517 | J:147689
First Author: Fisher MC
Year: 2007
Journal: Dev Growth Differ
Title: Requirement for ErbB2/ErbB signaling in developing cartilage and bone.
Volume: 49
Issue: 6
Pages: 503-13
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Publication
23769722 | J:214029
 
First Author: Yamada A
Year: 2013
Journal: Mol Cell Neurosci
Title: Necl-2/CADM1 interacts with ErbB4 and regulates its activity in GABAergic neurons.
Volume: 56
Pages: 234-43
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Publication
27118868 | J:245070
First Author: Karlsson T
Year: 2016
Journal: Biochem J
Title: A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction.
Volume: 473
Issue: 14
Pages: 2033-47
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Publication
37155852 | J:342348
First Author: Kim YS
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation.
Volume: 120
Issue: 20
Pages: e2302937120
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Publication
10353604 | J:54899
First Author: Elenius K
Year: 1999
Journal: Oncogene
Title: Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase.
Volume: 18
Issue: 16
Pages: 2607-15
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Publication
18495327 | J:141681
First Author: Jing X
Year: 2008
Journal: Exp Hematol
Title: E3 ligase FLRF (Rnf41) regulates differentiation of hematopoietic progenitors by governing steady-state levels of cytokine and retinoic acid receptors.
Volume: 36
Issue: 9
Pages: 1110-20
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Publication
15750185 | J:97216
First Author: Weninger WJ
Year: 2005
Journal: Development
Title: Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development.
Volume: 132
Issue: 6
Pages: 1337-48
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Publication
26474499 | J:226975
First Author: Gilbert MA
Year: 2015
Journal: Gene Expr Patterns
Title: Neuregulin1 and ErbB expression in the uninjured and regenerating olfactory mucosa.
Volume: 19
Issue: 1-2
Pages: 108-19
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Publication
10824084 | J:62758
First Author: Stein RA
Year: 2000
Journal: J Mol Evol
Title: Evolutionary analysis of the ErbB receptor and ligand families.
Volume: 50
Issue: 5
Pages: 397-412
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Publication
8622899 | J:79534
First Author: Krane IM
Year: 1996
Journal: Oncogene
Title: NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice.
Volume: 12
Issue: 8
Pages: 1781-8
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Protein
Q8BR76
Organism: Mus musculus/domesticus
Length: 992  
Fragment?: false
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Protein
A2AJP5
Organism: Mus musculus/domesticus
Length: 1061  
Fragment?: false
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Protein
Q8C4U4
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Protein
Q99PK1
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
D6RGQ2
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Protein
E9QNI1
Organism: Mus musculus/domesticus
Length: 995  
Fragment?: false
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Protein
Q5SVE7
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
O88459
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
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Protein
A0A0U1RNZ6
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: true
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Protein
Q8BT65
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Publication
12821646 | J:84095
First Author: Bao J
Year: 2003
Journal: J Cell Biol
Title: Back signaling by the Nrg-1 intracellular domain.
Volume: 161
Issue: 6
Pages: 1133-41
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Protein Domain
IPR002154 | Neuregulin_C
Type: Domain
Description: Neuregulins are a sub-family of EGF-like molecules that have been shown to play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses [, ]. Included in the family are heregulin; neu differentiation factor; acetylcholine receptor synthesis stimulator; glial growth factor; and sensory and motor-neuron derived factor []. Multiple family members are generated by alternate splicing or by use of several cell type-specific transcription initiation sites. In general, they bind to and activate the erbB family of receptor tyrosine kinases (erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4)), functioning both as heterodimers and homodimers.The transmembrane forms of neuregulin 1 (NRG1) are present within synaptic vesicles, including those containing glutamate []. After exocytosis, NRG1 is in the presynaptic membrane, where the ectodomain of NRG1 may be cleaved off. The ectodomain then migrates across the synaptic cleft and binds to and activates a member of the EGF-receptor family on the postsynaptic membrane. This has been shown to increase the expression of certain glutamate-receptor subunits. NRG1 appears to signal for glutamate-receptor subunit expression, localisation, and /or phosphorylation facilitating subsequent glutamate transmission. The NRG1 gene has been identified as a potential gene determining susceptibility to schizophrenia by a combination of genetic linkage and association approaches []. Membrane-anchored Nrg-1 isoforms consist of a variable N-terminal extracellular domain and a conserved transmembrane and C-terminal cytoplasmic domains []. This entry represents the C-terminal, intracellular domain.
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Protein Domain
IPR018250 | NRG1
Type: Family
Description: Neuregulins are a sub-family of EGF-like molecules that have been shown to play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses [, ]. Included in the family are heregulin; neu differentiation factor; acetylcholine receptor synthesis stimulator; glial growth factor; and sensory and motor-neuron derived factor []. Multiple family members are generated by alternate splicing or by use of several cell type-specific transcription initiation sites. In general, they bind to and activate the erbB family of receptor tyrosine kinases (erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4)), functioning both as heterodimers and homodimers.The transmembrane forms of neuregulin 1 (NRG1) are present within synaptic vesicles, including those containing glutamate []. After exocytosis, NRG1 is in the presynaptic membrane, where the ectodomain of NRG1 may be cleaved off. The ectodomain then migrates across the synaptic cleft and binds to and activates a member of the EGF-receptor family on the postsynaptic membrane. This has been shown to increase the expression of certain glutamate-receptor subunits. NRG1 appears to signal for glutamate-receptor subunit expression, localisation, and /or phosphorylation facilitating subsequent glutamate transmission. The NRG1 gene has been identified as a potential gene determining susceptibility to schizophrenia by a combination of genetic linkage and association approaches [].
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Protein Coding Gene
MGI:1202864 | Myoc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98354 | Sos1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18700973 | J:142118
First Author: Young CD
Year: 2008
Journal: Breast Cancer Res
Title: Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3.
Volume: 10
Issue: 4
Pages: R70
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Publication
32531343 | J:292709
 
First Author: Mitchell R
Year: 2020
Journal: Neurobiol Dis
Title: ErbB1-dependent signalling and vesicular trafficking in primary afferent nociceptors associated with hypersensitivity in neuropathic pain.
Volume: 142
Pages: 104961
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Protein
A2AFS3
Organism: Mus musculus/domesticus
Length: 1009  
Fragment?: false
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Protein
Q3UZV7
Organism: Mus musculus/domesticus
Length: 1028  
Fragment?: false
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Protein
Q8CIY1
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: true
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Protein
Q9WVF5
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
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Protein
B2KGF7
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: true
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Protein
O35171
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: true
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Protein
A0A0A0MQC6
Organism: Mus musculus/domesticus
Length: 1013  
Fragment?: false
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Protein
Q8C4P9
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
Q99LE4
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
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Protein
Q9ERV6
Organism: Mus musculus/domesticus
Length: 643  
Fragment?: false
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Protein
B9EHI9
Organism: Mus musculus/domesticus
Length: 1028  
Fragment?: false
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Protein
Q3V313
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
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Protein
Q8R0Y1
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: true
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Protein
Q80Y89
Organism: Mus musculus/domesticus
Length: 711  
Fragment?: false
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Publication
9690478 | -
First Author: Garrett TP
Year: 1998
Journal: Nature
Title: Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor.
Volume: 394
Issue: 6691
Pages: 395-9
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Publication
9804837 | -
First Author: Schroering A
Year: 1998
Journal: J Biol Chem
Title: Sensory and motor neuron-derived factor is a transmembrane heregulin that is expressed on the plasma membrane with the active domain exposed to the extracellular environment.
Volume: 273
Issue: 46
Pages: 30643-50
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Publication
9208852 | -
First Author: Burden S
Year: 1997
Journal: Neuron
Title: Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis.
Volume: 18
Issue: 6
Pages: 847-55
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Publication
9892702 | J:52282
First Author: Vartanian T
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Failure of spinal cord oligodendrocyte development in mice lacking neuregulin.
Volume: 96
Issue: 2
Pages: 731-5
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Publication
12145742 | J:81106
First Author: Stefansson H
Year: 2002
Journal: Am J Hum Genet
Title: Neuregulin 1 and susceptibility to schizophrenia.
Volume: 71
Issue: 4
Pages: 877-92
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Protein Coding Gene
MGI:1346867 | Map2k2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95805 | Grb2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96224 | Hras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q810X0
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
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Protein
Q499E0
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
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Protein
Q9JI71
Organism: Mus musculus/domesticus
Length: 686  
Fragment?: false
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Protein
Q8VIK5
Organism: Mus musculus/domesticus
Length: 1034  
Fragment?: false
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Protein
O88516
Organism: Mus musculus/domesticus
Length: 592  
Fragment?: false
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Protein
Q9QYY7
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q5ND28
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
P59222
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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Protein
P19467
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
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