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Search results 1101 to 1165 out of 1165 for Fgf15

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Type Details Score
Strain
MGI:6711270 | B6.Cg-Fgf15<tm1.1(cre)Thor>/J
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Smo/Smo<+> Tg(Fgf15-cre)1Hisa/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgf15/Fgf15<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
19854269 | J:156737
First Author: Zhao L
Year: 2010
Journal: Mech Dev
Title: Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain.
Volume: 127
Issue: 1-2
Pages: 62-72
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Genotype
Genotype
Symbol: Smo/Smo Tg(Fgf15-cre)1Hisa/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Fgf15-cre)1Bld/?
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
36719070 | J:350268
   
First Author: Sarkar A
Year: 2023
Journal: Elife
Title: Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver.
Volume: 12
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Publication
33066956 | J:303592
First Author: Wei L
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Pharyngeal epithelial deletion of Tbx1 causes caudal pharyngeal arch defect but not cardiac conotruncal anomaly.
Volume: 533
Issue: 4
Pages: 1315-1322
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Publication
29416063 | J:257903
First Author: Kim YC
Year: 2018
Journal: Nat Commun
Title: AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle.
Volume: 9
Issue: 1
Pages: 540
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Protein Domain
IPR028303 | FGF15/FGF19
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].Fibroblast growth factor 15 (FGF15) plays a key role in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis [, , ]. Mouse FGF15 has been shown to be stimulated when bile acids bind to farnesoid X receptor (FXR) [], and is therefore thought to a factor in chronic bile acid diarrhoea and in certain metabolic disorders [].FGF15 has been experimentally characterised in mouse, but has not been found in other species. However, there is an orthologous human protein, FGF19, and together they share about 50% amino acid identity and display similar endocrine functions, so are often referred to as FGF15/19 [, ]. FGF15 and FGF19 differ from other FGFs due to subtle changes in their tertiary structure, they have low heparin binding affinity enabling them to diffuse away from their site of secretion and signal to distantcells. FGF signaling through the FGF receptors is also different, as they require klotho protein cofactors rather than heparin sulfate proteoglycan [].Fibroblast growth factor 19 (FGF19) plays a key role in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis [, , ]. Human FGF19 expression has been shown to be stimulated approximately 300-fold by physiological concentrations of bile acids including chenodeoxycholic acid, glycochenodeoxycholic acid and obeticholic acid in explants of ileal mucosa []. The protein is thought to be a factor in chronic bile acid diarrhoea and in certain metabolic disorders [, ]. FGF19 has been experimentally characterised in humans and other species, but has not been found in mouse. However there is an orthologous mouse protein, FGF15, and together they share about 50% amino acid identity and display similar endocrine functions, so are often referred to as FGF15/19 [, ]. FGF15 and FGF19 differ from other FGFs due to subtle changes in their tertiary structure. They have low heparin binding affinity, enabling them to diffuse away from their site of secretion and signal to distant cells. FGF signaling through the FGF receptors is also different, as they require klotho protein cofactors rather than heparin sulfate proteoglycan []. Unlike other members of the family that can bind several FGF receptors, FGF19 is specific for FGFR4 [].
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Protein Domain
IPR035444 | FGF15/19/21
Type: Family
Description: This entry includes fibroblast growth factor 15/19/21 (FGF15/19/21).Fibroblast growth factor 15 (FGF15) plays a key role in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis [, , ]. Mouse FGF15 has been shown to be stimulated when bile acids bind to farnesoid X receptor (FXR) [], and is therefore thought to a factor in chronic bile acid diarrhoea and in certain metabolic disorders [].FGF15 has been experimentally characterised in mouse, but has not been found in other species. However, there is an orthologous human protein, FGF19, and together they share about 50% amino acid identity and display similar endocrine functions, so are often referred to as FGF15/19 [, ]. FGF15 and FGF19 differ from other FGFs due to subtle changes in their tertiary structure, they have low heparin binding affinity enabling them to diffuse away from their site of secretion and signal to distant cells. FGF signaling through the FGF receptors is also different, as they require klotho protein cofactors rather than heparin sulfate proteoglycan [].Fibroblast growth factor 19 (FGF19) plays a key role in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis [, , ]. Human FGF19 expression has been shown to be stimulated approximately 300-fold by physiological concentrations of bile acids including chenodeoxycholic acid, glycochenodeoxycholic acid and obeticholic acid in explants of ileal mucosa []. The protein is thought to be a factor in chronic bile acid diarrhoea and in certain metabolic disorders [, ]. FGF19 has been experimentally characterised in humans and other species, but has not been found in mouse. However there is an orthologous mouse protein, FGF15, and together they share about 50% amino acid identity and display similar endocrine functions, so are often referred to as FGF15/19 [, ]. FGF15 and FGF19 differ from other FGFs due to subtle changes in their tertiary structure. They have low heparin binding affinity, enabling them to diffuse away from their site of secretion and signal to distant cells. FGF signaling through the FGF receptors is also different, as they require klotho protein cofactors rather than heparin sulfate proteoglycan []. Unlike other members of the family that can bind several FGF receptors, FGF19 is specific for FGFR4 [].FGF21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression []. FGF21 has been shown to protect animals from diet-induced obesity when overexpressed in transgenic mice. It also lowers blood glucoseand triglyceride levels when administered to diabetic rodents [], suggesting it may exhibit the therapeutic characteristics necessary for effective treatment of diabetes. Treatment of animals with FGF21 results in increased energy expenditure, fat utilisation and lipid excretion []. FGF21 is most abundantly expressed in the liver, and also expressed in the thymus at lower levels [].
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Publication
22302876 | -
First Author: Potthoff MJ
Year: 2012
Journal: Genes Dev
Title: Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.
Volume: 26
Issue: 4
Pages: 312-24
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Publication
23518683 | -
First Author: Zhang JH
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids.
Volume: 304
Issue: 10
Pages: G940-8
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Publication
22396169 | -
 
First Author: Jones SA
Year: 2012
Journal: Adv Exp Med Biol
Title: Physiology of FGF15/19.
Volume: 728
Pages: 171-82
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Publication
10525310 | -
First Author: Xie MH
Year: 1999
Journal: Cytokine
Title: FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.
Volume: 11
Issue: 10
Pages: 729-35
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Protein
O35622
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q790L8
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Publication
22057115 | J:319839
First Author: Modica S
Year: 2012
Journal: Gastroenterology
Title: Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis.
Volume: 142
Issue: 2
Pages: 355-65.e1-4
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Publication
32679164 | J:301126
 
First Author: Csanaky IL
Year: 2020
Journal: Toxicol Appl Pharmacol
Title: Effects of patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice.
Volume: 403
Pages: 115136
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Publication
16284190 | J:118817
First Author: Gutierrez A
Year: 2006
Journal: Arterioscler Thromb Vasc Biol
Title: Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4.
Volume: 26
Issue: 2
Pages: 301-6
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Publication
23307639 | J:222465
First Author: Borello U
Year: 2014
Journal: Cereb Cortex
Title: Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.
Volume: 24
Issue: 6
Pages: 1409-21
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Publication
19192266 | J:160732
 
First Author: Thomson RE
Year: 2009
Journal: Neural Dev
Title: Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex.
Volume: 4
Pages: 4
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Publication
22467244 | J:293604
First Author: Kong B
Year: 2012
Journal: Hepatology
Title: Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice.
Volume: 56
Issue: 3
Pages: 1034-43
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Publication
24954587 | J:309810
First Author: Degirolamo C
Year: 2015
Journal: Hepatology
Title: Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation.
Volume: 61
Issue: 1
Pages: 161-70
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Publication
20233723 | J:164561
First Author: Schmidt DR
Year: 2010
Journal: J Biol Chem
Title: Regulation of bile acid synthesis by fat-soluble vitamins A and D.
Volume: 285
Issue: 19
Pages: 14486-94
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Publication
33895309 | J:320453
First Author: Zaufel A
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions.
Volume: 1867
Issue: 8
Pages: 166153
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Publication
17720959 | J:129978
First Author: Kim I
Year: 2007
Journal: J Lipid Res
Title: Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine.
Volume: 48
Issue: 12
Pages: 2664-72
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Publication
35105957 | J:358864
First Author: Liu S
Year: 2022
Journal: Acta Pharmacol Sin
Title: Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression.
Volume: 43
Issue: 9
Pages: 2362-2372
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Publication
29944388 | J:274393
First Author: Somm E
Year: 2018
Journal: Am J Physiol Endocrinol Metab
Title: β-Klotho deficiency shifts the gut-liver bile acid axis and induces hepatic alterations in mice.
Volume: 315
Issue: 5
Pages: E833-E847
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Publication
20194350 | J:160713
First Author: Smith DL
Year: 2010
Journal: Carcinogenesis
Title: Sodium taurocholate inhibits intestinal adenoma formation in APCMin/+ mice, potentially through activation of the farnesoid X receptor.
Volume: 31
Issue: 6
Pages: 1100-9
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Publication
23139217 | J:194692
First Author: Henkel AS
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation.
Volume: 304
Issue: 2
Pages: G221-6
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Publication
10858549 | J:63008
First Author: Nishimura T
Year: 2000
Journal: Biochim Biophys Acta
Title: Identification of a novel FGF, FGF-21, preferentially expressed in the liver.
Volume: 1492
Issue: 1
Pages: 203-6
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Publication
15902306 | J:99202
First Author: Kharitonenkov A
Year: 2005
Journal: J Clin Invest
Title: FGF-21 as a novel metabolic regulator.
Volume: 115
Issue: 6
Pages: 1627-35
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Protein
A0A140LIL5
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
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Publication
18687777 | -
First Author: Coskun T
Year: 2008
Journal: Endocrinology
Title: Fibroblast growth factor 21 corrects obesity in mice.
Volume: 149
Issue: 12
Pages: 6018-27
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Publication
17074316 | J:119950
First Author: Xu H
Year: 2007
Journal: Dev Biol
Title: Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells.
Volume: 302
Issue: 2
Pages: 670-82
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Publication
33127558 | J:315743
First Author: Yan S
Year: 2021
Journal: Cell Mol Gastroenterol Hepatol
Title: Hepatic Autophagy Deficiency Remodels Gut Microbiota for Adaptive Protection via FGF15-FGFR4 Signaling.
Volume: 11
Issue: 4
Pages: 973-997
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Publication
28756207 | J:255403
 
First Author: Zhao LY
Year: 2017
Journal: Biochem Pharmacol
Title: Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression.
Volume: 142
Pages: 194-203
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Publication
33154041 | J:344684
First Author: Weber AA
Year: 2021
Journal: Drug Metab Dispos
Title: Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation.
Volume: 49
Issue: 1
Pages: 12-19
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Publication
19608735 | J:152088
First Author: Lukovac S
Year: 2009
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice.
Volume: 297
Issue: 3
Pages: G520-31
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Publication
33769482 | J:343885
 
First Author: Nguyen JT
Year: 2021
Journal: Endocrinology
Title: Deletion of Intestinal SHP Impairs Short-term Response to Cholic Acid Challenge in Male Mice.
Volume: 162
Issue: 8
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Publication
34603061 | J:312661
 
First Author: Shu X
Year: 2021
Journal: Front Pharmacol
Title: Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation.
Volume: 12
Pages: 750826
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Protein
Q9JJN1
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
A0A7U3L6A3
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Publication
16284121 | J:102843
First Author: Zhang Z
Year: 2005
Journal: Development
Title: Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development.
Volume: 132
Issue: 23
Pages: 5307-15
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Publication
24365583 | J:323205
First Author: Chow EC
Year: 2014
Journal: Gastroenterology
Title: Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.
Volume: 146
Issue: 4
Pages: 1048-59
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Publication
28065787 | J:272089
First Author: de Boer JF
Year: 2017
Journal: Gastroenterology
Title: Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice.
Volume: 152
Issue: 5
Pages: 1126-1138.e6
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Publication
30063921 | J:279167
First Author: Pan Q
Year: 2018
Journal: Gastroenterology
Title: Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis.
Volume: 155
Issue: 5
Pages: 1578-1592.e16
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Publication
2549857 | -
 
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
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Publication
7583099 | -
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
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Publication
3072709 | -
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
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Publication
11276432 | J:67832
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
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Publication
10830168 | -
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
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Publication
8652550 | -
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
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Publication
1705486 | -
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
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Publication
8760337 | -
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
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Publication
23000357 | -
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
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Publication
15689573 | -
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
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Publication
10441498 | J:56785
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
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Publication
23108135 | -
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
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Publication
23016864 | -
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
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Publication
1649700 | -
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
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Publication
11746231 | -
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
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Publication
14745970 | -
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
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Publication
8978613 | -
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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