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Search results 1101 to 1200 out of 2229 for Fgfr3

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Type Details Score
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
29652901 | J:261370
First Author: Saint-Laurent C
Year: 2018
Journal: PLoS One
Title: Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia.
Volume: 13
Issue: 4
Pages: e0195876
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GXD Expression
GXD Expression
 
Probe: MGI:6363656
Assay Type: RNA in situ
Annotation Date: 2019-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6363685
Age: embryonic day 12.5
Note: Expression unchanged compared to control.
Specimen Label: Fgfr3 -/- not shown
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6363678
Assay Type: RNA in situ
Annotation Date: 2019-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6363712
Age: embryonic day 12.5
Note: Expression unchanged compared to control.
Specimen Label: Fgfr3 -/- not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6363679
Assay Type: RNA in situ
Annotation Date: 2019-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6363713
Age: embryonic day 12.5
Note: Expression unchanged compared to control.
Specimen Label: Fgfr3 -/- not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6363680
Assay Type: RNA in situ
Annotation Date: 2019-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6363714
Age: embryonic day 12.5
Note: Expression unchanged compared to control.
Specimen Label: Fgfr3 -/- not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6363676
Assay Type: RNA in situ
Annotation Date: 2019-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6363710
Age: embryonic day 12.5
Note: Expression unchanged compared to control.
Specimen Label: Fgfr3 -/- not shown
Detected: true
Specimen Num: 3
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Publication
25456072 | J:220760
First Author: Matsushita M
Year: 2015
Journal: Endocrinology
Title: Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene.
Volume: 156
Issue: 2
Pages: 548-54
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Publication
19401440 | J:173030
First Author: Sun F
Year: 2009
Journal: Nucleic Acids Res
Title: Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression.
Volume: 37
Issue: 12
Pages: 3897-911
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Publication
20393505 | J:160845
First Author: Zingone A
Year: 2010
Journal: Leukemia
Title: Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms.
Volume: 24
Issue: 6
Pages: 1171-8
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Pathway
R-MMU-5654706 | FRS-mediated FGFR3 signaling
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Pathway
R-MMU-5654741 | Signaling by FGFR3
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Pathway
R-MMU-5654227 | Phospholipase C-mediated cascade; FGFR3
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Pathway
R-MMU-5654708 | Downstream signaling of activated FGFR3
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Pathway
R-MMU-5654732 | Negative regulation of FGFR3 signaling
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Pathway
R-MMU-190239 | FGFR3 ligand binding and activation
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HT Experiment
E-GEOD-15452 | Expression data from lung of mice bearing mutations of FGFR3 and FGFR4
Series Id: GSE15452
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Interaction Experiment
Tan CC (2010)
Description: Fgfr3 is a transcriptional target of Ap2delta and Ash2l-containing histone methyltransferase complexes.
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Interaction Experiment
Guo C (2008)
Description: Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia.
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Allele
Fgfr3<tm3.1Llm> | MGI:7516790
Name: fibroblast growth factor receptor 3; targeted mutation 3.1, Laurence Legeai-Mallet
Allele Type: Targeted
Attribute String: Constitutively active, Humanized sequence
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Allele
Fgfr3<tm1(FGFR3*)Smoc> | MGI:7786857
Name: fibroblast growth factor receptor 3; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Fgfr3/Fgfr3<+>
Background: involves: C57BL/6N
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0080041 | hypochondroplasia
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Publication
20046871 | -
First Author: Tan CC
Year: 2009
Journal: PLoS One
Title: Fgfr3 is a transcriptional target of Ap2delta and Ash2l-containing histone methyltransferase complexes.
Volume: 4
Issue: 12
Pages: e8535
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Publication
18485666 | -
First Author: Guo C
Year: 2008
Journal: Cell Signal
Title: Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia.
Volume: 20
Issue: 8
Pages: 1471-7
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Strain
MGI:7788688 | C57BL/6JSmoc-Fgfr3<tm1(FGFR3*)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Fgfr3<tm1.1Aomw> | MGI:3831364
Name: fibroblast growth factor receptor 3; targeted mutation 1.1, Andrew O M Wilkie
Allele Type: Targeted
Attribute String: Humanized sequence
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DO Term
DOID:0111158 | SADDAN
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DO Term
DOID:0111160 | camptodactyly-tall stature-scoliosis-hearing loss syndrome
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DO Term
DOID:0111161 | Crouzon syndrome-acanthosis nigricans syndrome
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Publication
17785202 | -
First Author: Kang S
Year: 2007
Journal: Cancer Cell
Title: FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.
Volume: 12
Issue: 3
Pages: 201-14
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Allele
Tg(Fgfr3-icre/ERT2)4-2Wdr | MGI:3832576
Name: transgene insertion 4-2, William D Richardson
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Genotype
Genotype
Symbol: Fgfr3/Fgfr3
Background: CBACa.129P2-Fgfr3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgfr3/Fgfr3<+>
Background: B6.129P2-Fgfr3
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgfr3/Fgfr3<+>
Background: CBACa.129P2-Fgfr3
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgfr3/Fgfr3
Background: 129S6.129P2-Fgfr3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgfr3/Fgfr3
Background: B6.129P2-Fgfr3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgfr3/Fgfr3<+>
Background: 129S6.129P2-Fgfr3
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0060703 | Muenke Syndrome
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DO Term
DOID:0081371 | lacrimoauriculodentodigital syndrome 2
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Publication
19088846 | -
First Author: Krejci P
Year: 2008
Journal: PLoS One
Title: Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage.
Volume: 3
Issue: 12
Pages: e3961
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Strain
MGI:5603119 | B6;CBA-Tg(Fgfr3-icre/ERT2)4-2Wdr/J
Attribute String: mutant stock, transgenic
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Publication
31495587 | J:286149
First Author: Slezak M
Year: 2019
Journal: Curr Biol
Title: Distinct Mechanisms for Visual and Motor-Related Astrocyte Responses in Mouse Visual Cortex.
Volume: 29
Issue: 18
Pages: 3120-3127.e5
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Publication
28785080 | J:256579
First Author: Matsushita M
Year: 2017
Journal: Sci Rep
Title: Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia.
Volume: 7
Issue: 1
Pages: 7371
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Protein Coding Gene
MGI:894695 | Galnt3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P70419
Organism: Mus musculus/domesticus
Length: 633  
Fragment?: false
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Allele
Tg(Fgfr3-EGFP)KB81Gsat | MGI:4847050
Name: transgene insertion KB81, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb | MGI:6108317
Name: transgene insertion 10, Jean Hebert
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Allele
Fgfr3<tm1.1(FGFR3*)Ytc> | MGI:6416441
Name: fibroblast growth factor receptor 3; targeted mutation 1.1, Yuan-Tsong Chen
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
33952673 | J:322301
 
First Author: Kimura T
Year: 2021
Journal: Sci Transl Med
Title: An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice.
Volume: 13
Issue: 592
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Publication
33262386 | J:299598
First Author: Ozaki T
Year: 2020
Journal: Sci Rep
Title: Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia.
Volume: 10
Issue: 1
Pages: 20915
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Protein Coding Gene
MGI:1345138 | Spry2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:894316 | Mknk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O08605
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
Q9QXV8
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Allele
Fgfr3<tm1Wei> | MGI:2135635
 
Name: fibroblast growth factor receptor 3; targeted mutation 1, Weizmann Institute of Science
Allele Type: Targeted
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Allele
Tg(Col2a1-Fgfr3/GH)ADor | MGI:2181545
Name: transgene insertion A, David M Ornitz
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5632519 | FVB/N-Tg(Col2a1-Fgfr3/GH)ADor
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Tg(Col2a1-Fgfr3/GH)BDor | MGI:2181547
Name: transgene insertion B, David M Ornitz
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5632521 | FVB/N-Tg(Col2a1-Fgfr3/GH)BDor
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Tg(FGFR3-G380R)7Aya | MGI:2386939
Name: transgene insertion 7, Avner Yayon
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5004152 | STOCK Tg(Fgfr3-EGFP)KB81Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor | MGI:5604241
Name: transgene insertion, David M Ornitz
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Strain
MGI:6108320 | STOCK Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb/J
Attribute String: transgenic, mutant stock
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Genotype
Genotype
Symbol: Tg(Col2a1-Fgfr3/GH)ADor/Tg(Col2a1-Fgfr3/GH)ADor
Background: FVB/N-Tg(Col2a1-Fgfr3/GH)ADor
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Col2a1-Fgfr3/GH)BDor/?
Background: FVB/N-Tg(Col2a1-Fgfr3/GH)BDor
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgfr3/Fgfr3
Background: involves: 129
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgfr3/Fgfr3<+>
Background: involves: 129
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgfr3/Fgfr3
Background: involves: 129S1/Sv * 129X1/SvJ * MF1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(FGFR3-G380R)7Aya/?
Background: involves: BALB/c * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(FGFR3-G380R)7Aya/Tg(FGFR3-G380R)7Aya
Background: involves: BALB/c * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Protein
Q61851
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: false
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Protein
P54130
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
P15655
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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Publication
8428519 | J:3992
First Author: Keegan K
Year: 1993
Journal: Cytogenet Cell Genet
Title: The fibroblast growth factor receptor 3 gene (FGFR3) is assigned to human chromosome 4.
Volume: 62
Issue: 2-3
Pages: 172-5
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Publication
35659742 | J:354961
First Author: Xu M
Year: 2022
Journal: Stem Cell Res Ther
Title: Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration.
Volume: 13
Issue: 1
Pages: 227
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Protein Coding Gene
MGI:2135965 | Frs3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88190 | Braf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P28028
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q91WJ0
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Publication
28929130 | J:255285
 
First Author: Anttonen T
Year: 2017
Journal: eNeuro
Title: Cytoskeletal Stability in the Auditory Organ In Vivo: RhoA Is Dispensable for Wound Healing but Essential for Hair Cell Development.
Volume: 4
Issue: 5
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Protein
P37237
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Publication
19286672 | -
First Author: Salazar L
Year: 2009
Journal: Hum Mol Genet
Title: A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells.
Volume: 18
Issue: 11
Pages: 1951-61
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Protein Domain
IPR035591 | PI3K_p85alpha_SH3
Type: Domain
Description: This entry represents the SH3 domain of PI3K (phosphoinositide-3-kinase) subunit alpha (also known as subunit p85-alpha). Class I PI3Ks convert PtdIns(4,5)P2 to the critical second messenger PtdIns(3,4,5)P3. Class IA PI3Ks consist of a p110 catalytic subunit bound to one of five regulatory subunits, generated by alternative splicing of three different genes: p85alpha, p85beta, and p55gamma [, ]. The p85 subunits contain the SH3, RhoGAP, and SH2 domains. They recruit the p110 subunit to the membrane, where p110 phosphorylates inositol lipids []. Vertebrates contain two p85 isoforms, alpha and beta. In addition to regulating the p110 subunit, p85alpha interacts with activated FGFR3 [].
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Publication
25242323 | J:243534
First Author: Zhang Y
Year: 2014
Journal: Cell Rep
Title: H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm.
Volume: 8
Issue: 6
Pages: 1989-2002
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Publication
9254852 | J:42225
First Author: Wüchner C
Year: 1997
Journal: Hum Genet
Title: Human fibroblast growth factor receptor 3 gene (FGFR3): genomic sequence and primer set information for gene analysis.
Volume: 100
Issue: 2
Pages: 215-9
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Publication
37640697 | J:340561
First Author: Gong Z
Year: 2023
Journal: Nat Commun
Title: CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications.
Volume: 14
Issue: 1
Pages: 5242
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Protein Coding Gene
MGI:108088 | Gab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88279 | Cbl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P22682
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q9QYY0
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Publication
14702637 | J:87203
First Author: Yasoda A
Year: 2004
Journal: Nat Med
Title: Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.
Volume: 10
Issue: 1
Pages: 80-6
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Publication
36757814 | J:335016
 
First Author: Fan J
Year: 2023
Journal: J Clin Invest
Title: O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission.
Volume: 133
Issue: 7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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