| Type |
Details |
Score |
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zerial M |
| Year: |
1989 |
| Journal: |
EMBO J |
| Title: |
The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. |
| Volume: |
8 |
| Issue: |
3 |
| Pages: |
805-13 |
|
•
•
•
•
•
|
| Gene |
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•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Allele |
| Name: |
FBJ osteosarcoma oncogene; targeted mutation 1, Erwin F Wagner |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Palomer X |
| Year: |
2015 |
| Journal: |
Dis Model Mech |
| Title: |
miR-146a targets Fos expression in human cardiac cells. |
| Volume: |
8 |
| Issue: |
9 |
| Pages: |
1081-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fadel J |
| Year: |
2006 |
| Journal: |
Neurosci Lett |
| Title: |
Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice. |
| Volume: |
402 |
| Issue: |
1-2 |
| Pages: |
97-101 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kolodziejska-Akiyama KM |
| Year: |
2005 |
| Journal: |
Drug Alcohol Depend |
| Title: |
Ethanol-induced FOS immunoreactivity in the brain of mu-opioid receptor knockout mice. |
| Volume: |
80 |
| Issue: |
2 |
| Pages: |
161-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Milanovic S |
| Year: |
1998 |
| Journal: |
Brain Res |
| Title: |
Production of the Fos protein after contextual fear conditioning of C57BL/6N mice. |
| Volume: |
784 |
| Issue: |
1-2 |
| Pages: |
37-47 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huerta JJ |
| Year: |
1999 |
| Journal: |
Brain Res |
| Title: |
Spatio-temporal analysis of light-induced Fos expression in the retina of rd mutant mice. |
| Volume: |
834 |
| Issue: |
1-2 |
| Pages: |
122-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barone MV |
| Year: |
1995 |
| Journal: |
Nature |
| Title: |
Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src. |
| Volume: |
378 |
| Issue: |
6556 |
| Pages: |
509-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mukai T |
| Year: |
2013 |
| Journal: |
Neurosci Res |
| Title: |
Preferential suppression of limbic Fos expression by intermittent hypoxia in obese diabetic mice. |
| Volume: |
77 |
| Issue: |
4 |
| Pages: |
202-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu Q |
| Year: |
2008 |
| Journal: |
J Neurosci |
| Title: |
Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions. |
| Volume: |
28 |
| Issue: |
37 |
| Pages: |
9218-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Salchner P |
| Year: |
2004 |
| Journal: |
Cell Mol Life Sci |
| Title: |
Genetic functional inactivation of neuronal nitric oxide synthase affects stress-related Fos expression in specific brain regions. |
| Volume: |
61 |
| Issue: |
12 |
| Pages: |
1498-506 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Malik MT |
| Year: |
2005 |
| Journal: |
Respir Physiol Neurobiol |
| Title: |
Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B. |
| Volume: |
145 |
| Issue: |
1 |
| Pages: |
23-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aste N |
| Year: |
2003 |
| Journal: |
Brain Res Bull |
| Title: |
Forebrain Fos responses to reproductively related chemosensory cues in aromatase knockout mice. |
| Volume: |
60 |
| Issue: |
3 |
| Pages: |
191-200 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sollars PJ |
| Year: |
2006 |
| Journal: |
Neurosci Lett |
| Title: |
Light-induced Fos expression is attenuated in the suprachiasmatic nucleus of serotonin 1B receptor knockout mice. |
| Volume: |
401 |
| Issue: |
3 |
| Pages: |
209-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee HJ |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation. |
| Volume: |
103 |
| Issue: |
42 |
| Pages: |
15669-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diefenbacher M |
| Year: |
2008 |
| Journal: |
Mol Endocrinol |
| Title: |
Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1. |
| Volume: |
22 |
| Issue: |
8 |
| Pages: |
1767-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Samoriski GM |
| Year: |
1997 |
| Journal: |
Exp Neurol |
| Title: |
Differential spatial patterns of Fos induction following generalized clonic and generalized tonic seizures. |
| Volume: |
143 |
| Issue: |
2 |
| Pages: |
255-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hitzemann B |
| Year: |
1997 |
| Journal: |
Alcohol Clin Exp Res |
| Title: |
Genetics ethanol and the Fos response: a comparison of the C57BL/6J and DBA/2J inbred mouse strains. |
| Volume: |
21 |
| Issue: |
8 |
| Pages: |
1497-507 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Behrens A |
| Year: |
2000 |
| Journal: |
Oncogene |
| Title: |
Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation. |
| Volume: |
19 |
| Issue: |
22 |
| Pages: |
2657-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Canonigo-Balancio AJ |
| Year: |
2009 |
| Journal: |
J Immunol |
| Title: |
SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis. |
| Volume: |
183 |
| Issue: |
11 |
| Pages: |
7259-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Patel N |
| Year: |
1998 |
| Journal: |
Neuropsychopharmacology |
| Title: |
Genetics, haloperidol, and the Fos response in the basal ganglia: a comparison of the C57BL/6J and DBA/2J inbred mouse strains. |
| Volume: |
18 |
| Issue: |
6 |
| Pages: |
480-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kataoka K |
| Year: |
1994 |
| Journal: |
Mol Cell Biol |
| Title: |
MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun. |
| Volume: |
14 |
| Issue: |
11 |
| Pages: |
7581-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ryabinin AE |
| Year: |
1999 |
| Journal: |
Pharmacol Biochem Behav |
| Title: |
Different levels of Fos immunoreactivity after repeated handling and injection stress in two inbred strains of mice. |
| Volume: |
63 |
| Issue: |
1 |
| Pages: |
143-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tulchinsky E |
| Year: |
2000 |
| Journal: |
Histol Histopathol |
| Title: |
Fos family members: regulation, structure and role in oncogenic transformation. |
| Volume: |
15 |
| Issue: |
3 |
| Pages: |
921-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park J |
| Year: |
2014 |
| Journal: |
Neurobiol Dis |
| Title: |
Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: a Fos protein study. |
| Volume: |
64 |
|
| Pages: |
1-7 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Richard N Day |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mantella RC |
| Year: |
2004 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
Enhanced corticosterone concentrations and attenuated Fos expression in the medial amygdala of female oxytocin knockout mice exposed to psychogenic stress. |
| Volume: |
287 |
| Issue: |
6 |
| Pages: |
R1494-504 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Taylor AC |
| Year: |
2008 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia. |
| Volume: |
294 |
| Issue: |
4 |
| Pages: |
R1285-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Melko M |
| Year: |
2013 |
| Journal: |
Hum Mol Genet |
| Title: |
Loss of FMR2 further emphasizes the link between deregulation of immediate early response genes FOS and JUN and intellectual disability. |
| Volume: |
22 |
| Issue: |
15 |
| Pages: |
2984-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Radulovic J |
| Year: |
2000 |
| Journal: |
Brain Res Mol Brain Res |
| Title: |
In vivo NMDA/dopamine interaction resulting in Fos production in the limbic system and basal ganglia of the mouse brain. |
| Volume: |
75 |
| Issue: |
2 |
| Pages: |
271-80 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
380
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miyamoto S |
| Year: |
2004 |
| Journal: |
Neuropsychopharmacology |
| Title: |
Amphetamine-induced Fos is reduced in limbic cortical regions but not in the caudate or accumbens in a genetic model of NMDA receptor hypofunction. |
| Volume: |
29 |
| Issue: |
12 |
| Pages: |
2180-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Araújo-Filho HG |
| Year: |
2017 |
| Journal: |
Neuroscience |
| Title: |
D-limonene exhibits superior antihyperalgesic effects in a β-cyclodextrin-complexed form in chronic musculoskeletal pain reducing Fos protein expression on spinal cord in mice. |
| Volume: |
358 |
|
| Pages: |
158-169 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Karakaslar EO |
| Year: |
2023 |
| Journal: |
Aging Cell |
| Title: |
Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging. |
| Volume: |
22 |
| Issue: |
4 |
| Pages: |
e13792 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Geusz ME |
| Year: |
1997 |
| Journal: |
Curr Biol |
| Title: |
Long-term monitoring of circadian rhythms in c-fos gene expression from suprachiasmatic nucleus cultures. |
| Volume: |
7 |
| Issue: |
10 |
| Pages: |
758-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wada M |
| Year: |
2010 |
| Journal: |
Behav Brain Res |
| Title: |
Noninvasive bioluminescence imaging of c-fos expression in the mouse barrel cortex. |
| Volume: |
208 |
| Issue: |
1 |
| Pages: |
158-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang XJ |
| Year: |
2000 |
| Journal: |
Mol Carcinog |
| Title: |
Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis. |
| Volume: |
29 |
| Issue: |
2 |
| Pages: |
67-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lau YE |
| Year: |
2003 |
| Journal: |
Brain Res Bull |
| Title: |
Induction of Fos in the accessory olfactory system by male odors persists in female mice with a null mutation of the aromatase (cyp19) gene. |
| Volume: |
60 |
| Issue: |
1-2 |
| Pages: |
143-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lopez-RodrÃguez C |
| Year: |
1999 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. |
| Volume: |
96 |
| Issue: |
13 |
| Pages: |
7214-9 |
|
•
•
•
•
•
|
| Allele |
| Name: |
FBJ osteosarcoma oncogene; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
FBJ osteosarcoma oncogene; endonuclease-mediated mutation 6, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meijlink F |
| Year: |
1985 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene. |
| Volume: |
82 |
| Issue: |
15 |
| Pages: |
4987-91 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Douglas J Epstein |
| Allele Type: |
Transgenic |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, David P Lane |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, David P Lane |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
FBJ osteosarcoma oncogene; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
FBJ osteosarcoma oncogene; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
FBJ osteosarcoma oncogene; endonuclease-mediated mutation 5, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Giovane A |
| Year: |
1997 |
| Journal: |
Mol Cell Biol |
| Title: |
Net-b, a Ras-insensitive factor that forms ternary complexes with serum response factor on the serum response element of the fos promoter. |
| Volume: |
17 |
| Issue: |
10 |
| Pages: |
5667-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Doody KM |
| Year: |
2015 |
| Journal: |
Sci Transl Med |
| Title: |
Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. |
| Volume: |
7 |
| Issue: |
288 |
| Pages: |
288ra76 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 26, Mercedes Rincon |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
FBJ osteosarcoma oncogene; endonuclease-mediated mutation 7, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
FBJ osteosarcoma oncogene; endonuclease-mediated mutation 4, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Marcelo Rubinstein |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bozec A |
| Year: |
2010 |
| Journal: |
J Cell Biol |
| Title: |
Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production. |
| Volume: |
190 |
| Issue: |
6 |
| Pages: |
1093-106 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eferl R |
| Year: |
2004 |
| Journal: |
EMBO J |
| Title: |
The Fos-related antigen Fra-1 is an activator of bone matrix formation. |
| Volume: |
23 |
| Issue: |
14 |
| Pages: |
2789-99 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rajasekaran S |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Fra-1/AP-1 transcription factor negatively regulates pulmonary fibrosis in vivo. |
| Volume: |
7 |
| Issue: |
7 |
| Pages: |
e41611 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Transcription factor activator protein (AP)-1, comprising Jun (c-Jun, JunB, and JunD) and Fos (c-Fos, FosB, Fra1, and Fra2) family members, plays a central role in regulating gene transcription in various biological processes []. Fos protein family members are involved in rodent fibroblasts transformation []. Fos protein family members form stable heterodimers with Jun proteins and thereby enhance their DNA-bindingactivity [].This entry represents fos-related antigen 1 (Fra1). It is an activator of bone matrix formation []and can negatively regulate pulmonary fibrosis in vivo []. It is overexpressed in breast cancer cells and may be a possible biomarker for prognosis of breast cancer []. |
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| Allele |
| Name: |
transgene insertion 34, Elaine Fuchs |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
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| Strain |
| Attribute String: |
mutant stock, transgenic |
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| Allele |
| Name: |
collagen, type I, alpha 1; targeted mutation 1, Erwin F Wagner |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Inserted expressed sequence, RMCE-ready |
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| Allele |
| Name: |
engulfment and cell motility 1; targeted mutation 1, Masao Kakoki |
| Allele Type: |
Targeted |
| Attribute String: |
Hypomorph |
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| Publication |
| First Author: |
Yutsudo N |
| Year: |
2013 |
| Journal: |
Neuropsychopharmacology |
| Title: |
fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior. |
| Volume: |
38 |
| Issue: |
5 |
| Pages: |
895-906 |
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| Protein Domain |
| Type: |
Family |
| Description: |
Transcription factor activator protein (AP)-1, comprising Jun (c-Jun, JunB, and JunD) and Fos (c-Fos, FosB, Fra1, and Fra2) family members, plays a central role in regulating gene transcription in various biological processes []. Fos protein family members form stable heterodimerswith Jun proteins and thereby enhance their DNA-bindingactivity []. This entry reprsents FosB []. FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior []. |
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| Publication |
| First Author: |
Caputto BL |
| Year: |
2014 |
| Journal: |
Biochim Biophys Acta |
| Title: |
c-Fos: an AP-1 transcription factor with an additional cytoplasmic, non-genomic lipid synthesis activation capacity. |
| Volume: |
1841 |
| Issue: |
9 |
| Pages: |
1241-6 |
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| Publication |
| First Author: |
Ferrero GO |
| Year: |
2014 |
| Journal: |
Biochem J |
| Title: |
c-Fos-activated synthesis of nuclear phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)Pâ‚‚] promotes global transcriptional changes. |
| Volume: |
461 |
| Issue: |
3 |
| Pages: |
521-30 |
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| Protein Domain |
| Type: |
Family |
| Description: |
Transcription factor activator protein (AP)-1, comprising Jun (c-Jun, JunB, and JunD) and Fos (c-Fos, FosB, Fra1, and Fra2) family members, plays a central role in regulating gene transcription in various biological processes []. Fos protein family members are involved in rodent fibroblasts transformation []. Fos protein family members form stable heterodimers with Jun proteins and thereby enhance their DNA-bindingactivity [].This entry represents the c-Fos and v-Fos proteins. c-Fos is the human homologue of the retroviral oncogene v-Fos. c-Fos can regulate growth not only by its transcription-factor activity, but also through mechanisms independent of its genomic AP-1 activity. By association with particular enzymes, it can act as a cytoplasmic activator of the biosynthesis of lipids both in normal and pathological cellular processes []. In the nucleus, where lipid synthesis also occurs, it binds to PI4P5K (phosphatidylinositol-4-monophosphate 5-kinase) and activates nuclear PtdIns(4,5)P2 synthesis in response to growth signals, which, in turn, promotes transcriptional changes []. |
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| Publication |
| First Author: |
DasGupta R |
| Year: |
1999 |
| Journal: |
Development |
| Title: |
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. |
| Volume: |
126 |
| Issue: |
20 |
| Pages: |
4557-68 |
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| Allele |
| Name: |
transgene insertion 38, James S Norris |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
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| Strain |
| Attribute String: |
congenic, mutant strain, transgenic |
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| Publication |
| First Author: |
Yamagami T |
| Year: |
2018 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Transient activation of Wnt/β-catenin signaling reporter in fibrotic scar formation after compression spinal cord injury in adult mice. |
| Volume: |
496 |
| Issue: |
4 |
| Pages: |
1302-1307 |
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| Publication |
| First Author: |
Zemke AC |
| Year: |
2009 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium. |
| Volume: |
41 |
| Issue: |
5 |
| Pages: |
535-43 |
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| Publication |
| First Author: |
Xie G |
| Year: |
2017 |
| Journal: |
J Invest Dermatol |
| Title: |
E-Cadherin-Mediated Cell Contact Controls the Epidermal Damage Response in Radiation Dermatitis. |
| Volume: |
137 |
| Issue: |
8 |
| Pages: |
1731-1739 |
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