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Search results 1101 to 1200 out of 1224 for Grb10

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Type Details Score
Allele  
Name: GRB10 interacting GYF protein 1; gene trap W065C08, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 1; gene trap W085A05, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap AB0020, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 1; gene trap XR0137, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap XR0051, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap XS0857, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 1; gene trap W015E09, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap G026G09, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap A032B02, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap W235C01, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap A062E03, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap P016C04, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap PST2476, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 1; gene trap PST6448, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap P042E12, German Gene Trap Consortium
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap EUCE0031h01, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap EUCE0267d04, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap EUCE0016h02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap EUCE0016h01, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap EUCE0274h07, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 1; gene trap H17D, H Earl Ruley
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap EUCJ0012c07, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap EUCJ0140d03, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap EUCJ0016a02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
Allele
Name: GRB10 interacting GYF protein 2; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST13132E10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST13529A6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST13533E10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST13687C9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST13731F7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST13801G8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14117C12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14078F3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14043E10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14224B10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14533D8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14647H2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14658D8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14684E3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14909E12, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14933C10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST14979E8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST15064C8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST15076D2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele  
Name: GRB10 interacting GYF protein 2; gene trap IST15008E8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Allele
Name: GRB10 interacting GYF protein 1; targeted mutation 1, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: GRB10 interacting GYF protein 2; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: GRB10 interacting GYF protein 1; endonuclease-mediated mutation 1, Baylor College of Medicine
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: GRB10 interacting GYF protein 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: GRB10 interacting GYF protein 2; endonuclease-mediated mutation 3, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: GRB10 interacting GYF protein 2; endonuclease-mediated mutation 7, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: GRB10 interacting GYF protein 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: GRB10 interacting GYF protein 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Gigyf2/Gigyf2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Gigyf1/Gigyf1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
Publication      
First Author: Ding Z
Year: 2023
Journal: Biol Psychiatry
Title: Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice.
Publication
First Author: Huang Q
Year: 2010
Journal: J Biol Chem
Title: Structural basis for the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4.
Volume: 285
Issue: 53
Pages: 42130-9
Publication
First Author: Blagitko N
Year: 2000
Journal: Hum Mol Genet
Title: Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.
Volume: 9
Issue: 11
Pages: 1587-95
Publication
First Author: Kazi JU
Year: 2013
Journal: Mol Oncol
Title: FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.
Volume: 7
Issue: 3
Pages: 402-18
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Strain
Attribute String: coisogenic, targeted mutation
Strain
Attribute String: coisogenic
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Gigyf2/Gigyf2<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Gigyf2/Gigyf2
Background: C57BL/6N-Gigyf2/Bay
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Gigyf1/Gigyf1
Background: C57BL/6N-Gigyf1/BayMmucd
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Gigyf1/Gigyf1<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Gigyf2/Gigyf2<+>
Background: C57BL/6N-Gigyf2/Bay
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Morita M
Year: 2012
Journal: Mol Cell Biol
Title: A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Volume: 32
Issue: 17
Pages: 3585-93
Genotype
Symbol: Gigyf1/Gigyf1 Neurod6/Neurod6<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gigyf1/Gigyf1 Gad2/Gad2<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Rybiczka-Tešulov M
Year: 2024
Journal: Nat Commun
Title: Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development.
Volume: 15
Issue: 1
Pages: 6773
Protein
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: false
Publication
First Author: Lafuente EM
Year: 2004
Journal: Dev Cell
Title: RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.
Volume: 7
Issue: 4
Pages: 585-95
Protein Domain
Type: Domain
Description: This entry represents the SH2 domain of Grb10.The Grb7 (growth factor receptor-bound 7) family includes Grb7, Grb10, and Grb14. These are adapter proteins mediating signal transduction from multiple cell surface receptors to diverse downstream pathways. They are composed of an N-terminal proline-rich domain, a Ras Associating-like (RA) domain, a Pleckstrin Homology (PH) domain, a PIR (phosphorylated insulin receptor interacting region) domain (also known as the family-specific BPS region), and a C-terminal SH2 domain []. Grb10 inhibits insulin receptor kinase activity and mediates insulin-stimulated degradation of the insulin receptor []. It binds to the regulatory kinase loop of the insulin receptor (IR) via its SH2 and BPS domains []. Grb10 is directly phosphorylated by mTORC1 and may participate in a feedback inhibition of the phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways [].
Protein Domain
Type: Family
Description: Proteins in this entry consist of a Ras-associated (RA) domain, a PH domain, a family-specific BPS region, and a C-terminal SH2 domain. Grb7, Grb10 and Grb14 are paralogues that are also present in this entry []. These adapter proteins bind a variety of receptor tyrosine kinases, including the insulin and insulin-like growth factor-1 (IGF1) receptors. Grb10 and Grb14 are important tissue-specific negative regulators of insulin and IGF1 signaling based and may contribute to type 2 (non-insulin-dependent) diabetes in humans. RA-PH function as a single structural unit and is dimerized via a helical extension of the PH domain. The PH domain here are proposed to bind phosphoinositides non-cannonically and are unlikely to bind an activated GTPase []. This entry also includes APBB1IP (also known as RIAM), which functions in the signal transduction from Ras activation to actin cytoskeletal remodelling [].
Publication
First Author: Wilson MD
Year: 2001
Journal: Nucleic Acids Res
Title: Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.
Volume: 29
Issue: 6
Pages: 1352-65
Publication
First Author: Chumley MJ
Year: 2007
Journal: J Neurosci
Title: EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis.
Volume: 27
Issue: 49
Pages: 13481-90
Publication
First Author: Kojima T
Year: 2007
Journal: Am J Pathol
Title: Proangiogenic role of ephrinB1/EphB1 in basic fibroblast growth factor-induced corneal angiogenesis.
Volume: 170
Issue: 2
Pages: 764-73
Publication
First Author: Petros TJ
Year: 2009
Journal: J Neurosci
Title: Specificity and sufficiency of EphB1 in driving the ipsilateral retinal projection.
Volume: 29
Issue: 11
Pages: 3463-74
Publication
First Author: Stein E
Year: 1997
Journal: Trends Cardiovasc Med
Title: Eph family receptors and ligands in vascular cell targeting and assembly.
Volume: 7
Issue: 8
Pages: 329-34
Protein Domain
Type: Domain
Description: This entry represents the SAM (sterile alpha motif) domain of the EphB1 receptors. This domain, located in the cytoplasmic region of EphB1, is a potential C-terminal protein-protein interaction domain. In human vascular endothelial cells, it appears to mediate cell-cell initiated signal transduction via the binding of the adaptor protein GRB10 (growth factor) through its SH2 domain to a conserved tyrosine that is phosphorylated []. EphB1 receptors play a role in neurogenesis, in particular in regulation of proliferation and migration of neural progenitors in the hippocampus and in corneal neovascularization []; they are involved in converting the crossed retinal projection to ipsilateral retinal projection []. They may be potential targets in angiogenesis-related disorders [].
Protein Domain
Type: Domain
Description: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP) consists of a Ras-associated (RA) domain, a PH domain, a family-specific BPS region, and a C-terminal SH2 domain. Grb7, Grb10 and Grb14 are paralogues that are also present in this entry []. These adapter proteins bind a variety of receptor tyrosine kinases, including the insulin and insulin-like growth factor-1 (IGF1) receptors. Grb10 and Grb14 are important tissue-specific negative regulators of insulin and IGF1 signaling based and may contribute to type 2 (non-insulin-dependent) diabetes in humans. RA-PH function as a single structural unit and is dimerized via a helical extension of the PH domain. The PH domain here are proposed to bind phosphoinositides non-cannonically and are unlikely to bind an activated GTPase []. The tandem RA-PH domains are present in a second adapter-protein family, MRL proteins, Caenorhabditis elegansprotein MIG-1012, the mammalian proteins RIAM and lamellipodin and the Drosophila melanogasterprotein Pico12, all of which are Ena/VASP-binding proteins involved in actin-cytoskeleton rearrangement.PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane []. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Protein
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
Publication  
First Author: Lemmon MA
Year: 2007
Journal: Biochem Soc Symp
Title: Pleckstrin homology (PH) domains and phosphoinositides.
Issue: 74
Pages: 81-93
Publication
First Author: Desbuquois B
Year: 2013
Journal: FEBS J
Title: Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins.
Volume: 280
Issue: 3
Pages: 794-816
Protein
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1266  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 645  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: false
Publication
First Author: Dey BR
Year: 1996
Journal: Mol Endocrinol
Title: Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10.
Volume: 10
Issue: 6
Pages: 631-41
Publication
First Author: Monk D
Year: 2003
Journal: Mamm Genome
Title: Imprinted methylation profiles for proximal mouse chromosomes 11 and 7 as revealed by methylation-sensitive representational difference analysis.
Volume: 14
Issue: 12
Pages: 805-16