Type |
Details |
Score |
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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•
•
•
•
•
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Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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•
•
•
•
•
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Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
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•
•
•
•
•
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Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
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Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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•
•
•
•
•
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Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
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•
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
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•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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•
•
•
•
•
|
Allele |
Name: |
intergenic site 2; endonuclease-mediated mutation 2, Axel Visel |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Reporter |
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•
•
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•
|
GXD Expression |
Probe: |
MGI:2149733 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-08-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3573926 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:7708043 |
Age: |
embryonic day 18.5 |
Image: |
3a |
Note: |
Expression was detected in postmitotic retinal ganglion cells in the ventrotemporal retina. Co-label with Isl2 was seen in contralateral RGC's. Some RGC's were co-labeled with EdU when injected at E13. |
Specimen Label: |
3a |
Detected: |
true |
Specimen Num: |
7 |
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•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149733 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-08-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3573926 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:7708043 |
Age: |
embryonic day 18.5 |
Image: |
3b |
Note: |
Expression was detected in postmitotic retinal ganglion cells in the ventrotemporal retina. Co-label with Isl2 was seen in contralateral RGC's. The number of RGC's co-labeled with EdU was higher when injected at E14 than when injected at E13. |
Specimen Label: |
3b |
Detected: |
true |
Specimen Num: |
8 |
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•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149733 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-08-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3573926 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:7708043 |
Age: |
embryonic day 18.5 |
Image: |
3c |
Note: |
Expression was detected in postmitotic retinal ganglion cells in the ventrotemporal retina. Co-label with Isl2 was seen in contralateral RGC's. RGC proliferation, as determined by co-label with EdU, during late development was substantial until E15 and decreased thereafter. |
Specimen Label: |
3c |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2149733 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-08-11 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3573926 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:7708043 |
Age: |
embryonic day 18.5 |
Image: |
3d |
Note: |
Expression was detected in postmitotic retinal ganglion cells in the ventrotemporal retina. Co-label with Isl2 was seen in contralateral RGC's. RGC proliferation, as determined by co-label with EdU, was decreased when injected at E16 than when injected at previous ages. |
Specimen Label: |
3d |
Detected: |
true |
Specimen Num: |
10 |
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•
•
•
•
•
|
Allele |
Name: |
transgene insertion LW124, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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•
•
•
•
•
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Publication |
First Author: |
Sweeney NT |
Year: |
2019 |
Journal: |
J Comp Neurol |
Title: |
Expression of transcription factors divides retinal ganglion cells into distinct classes. |
Volume: |
527 |
Issue: |
1 |
Pages: |
225-235 |
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•
•
•
•
•
|
Allele |
Name: |
insulin related protein 2 (islet 2); targeted mutation 1, Greg Lemke |
Allele Type: |
Targeted |
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•
•
•
•
•
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Strain |
Attribute String: |
mutant stock, transgenic |
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•
•
•
•
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Publication |
First Author: |
Zhang P |
Year: |
2023 |
Journal: |
Biomed Opt Express |
Title: |
Evaluating the performance of OCT in assessing static and potential dynamic properties of the retinal ganglion cells and nerve fiber bundles in the living mouse eye. |
Volume: |
14 |
Issue: |
12 |
Pages: |
6422-6441 |
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•
•
•
•
•
|
Genotype |
Symbol: |
Isl2/Isl2 |
Background: |
involves: C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Publication |
First Author: |
Gadd MS |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions. |
Volume: |
288 |
Issue: |
30 |
Pages: |
21924-35 |
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•
•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4 []. |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
373
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
371
 |
Fragment?: |
false |
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•
•
•
•
•
|
Publication |
First Author: |
Shanks JA |
Year: |
2016 |
Journal: |
J Neurosci |
Title: |
Corticothalamic Axons Are Essential for Retinal Ganglion Cell Axon Targeting to the Mouse Dorsal Lateral Geniculate Nucleus. |
Volume: |
36 |
Issue: |
19 |
Pages: |
5252-63 |
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•
•
•
•
•
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Publication |
First Author: |
Kim T |
Year: |
2015 |
Journal: |
Elife |
Title: |
An excitatory amacrine cell detects object motion and provides feature-selective input to ganglion cells in the mouse retina. |
Volume: |
4 |
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
411
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
373
 |
Fragment?: |
false |
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•
•
•
•
•
|
Publication |
First Author: |
Rajderkar SS |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
Dynamic enhancer landscapes in human craniofacial development. |
Volume: |
15 |
Issue: |
1 |
Pages: |
2030 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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|
|
|
•
•
•
•
•
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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•
•
•
•
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