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Search results 1101 to 1200 out of 2139 for Lck

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Type Details Score
Publication
1965144 | J:109934
First Author: Garvin AM
Year: 1990
Journal: Int Immunol
Title: Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen.
Volume: 2
Issue: 2
Pages: 173-80
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Publication
12771543 | J:128148
 
First Author: Watanabe N
Year: 2003
Journal: Int Arch Allergy Immunol
Title: Th2 immune responses in GATA-3-transgenic mice infected with Heligmosomoides polygyrus.
Volume: 131 Suppl 1
Pages: 11-4
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Publication
11739157 | J:132264
First Author: Christopherson KW 2nd
Year: 2001
Journal: Blood
Title: Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration.
Volume: 98
Issue: 13
Pages: 3562-8
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Publication
9384581 | J:201392
First Author: Iritani BM
Year: 1997
Journal: EMBO J
Title: Control of B cell development by Ras-mediated activation of Raf.
Volume: 16
Issue: 23
Pages: 7019-31
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Publication
24596147 | J:211203
 
First Author: Jenkins MR
Year: 2014
Journal: Elife
Title: Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.
Volume: 3
Pages: e01310
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Publication
9842910 | -
First Author: Millán J
Year: 1998
Journal: Eur J Immunol
Title: MAL, a novel integral membrane protein of human T lymphocytes, associates with glycosylphosphatidylinositol-anchored proteins and Src-like tyrosine kinases.
Volume: 28
Issue: 11
Pages: 3675-84
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Publication
10339572 | -
First Author: Cheong KH
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells.
Volume: 96
Issue: 11
Pages: 6241-8
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Publication
10739088 | -
First Author: Frank M
Year: 2000
Journal: Prog Neurobiol
Title: MAL, a proteolipid in glycosphingolipid enriched domains: functional implications in myelin and beyond.
Volume: 60
Issue: 6
Pages: 531-44
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Protein Domain
IPR013295 | MAL
Type: Family
Description: Myelin is a product of myelinating cells: Schawnn cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS). The processes of these myelinating cells wrap around axon segments to form a sheath. This sheath possesses insulating properties, allowing rapid propagation of action potentials (the electrical signal propagated by nerve cells) between the myelinating cell intervening nodes. Without myelin insulation, axons would need a 10-30-fold increase in diameter to achieve comparable conduction velocities. At the onset of myelination, during development, large amounts of myelin-specific lipids and proteins are synthesised and transported to the developing myelin sheath. The major protein component of PNS and CNS myelin differs between the 2 nervous systems. However, some of the minor protein components, including the 4 transmembrane (TM)-domain-containing myelin and lymphocyte protein (MAL), are found in both systems. Outside the nervous system, MAL is also found in T-cells and some epithelial cells (e.g., kidney, stomach and thyroid) []. Glycosphingolipids are enriched in both epithelial cells and myelin, and are believed to decrease the permeability of lipid membranes to small molecules and increase the ability for membrane curvature. MAL co-purifies with glycosphingolipids in detergent-insoluble domains, suggesting a possible interaction. In Madin Darby Canine Kidney (MDCK) cells, MAL is found mainly in transport vesicles, and recent studies suggest that MAL is required for efficient vesicular transport of proteins across apical cell membranes []. In myelinating cells, MAL appears to play a similar role, interacting with glycosphingolipids to decrease membrane permeability; however, here this property most likely manifests itself as an improved insulating ability of the myelin []. In lymphocytes, however, MAL appears to act as a TM-linker protein in T-cell signal transduction, linking the cell surface glycosyl phosphatidylinositol anchored protein CD59 to the intracellular tyrosine kinase Lck [].
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Protein
E9Q696
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
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Publication
30513302 | J:306277
First Author: Becher J
Year: 2018
Journal: Dev Cell
Title: AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis.
Volume: 47
Issue: 5
Pages: 592-607.e6
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Publication
9016869 | J:128694
First Author: Thomis DC
Year: 1997
Journal: J Exp Med
Title: Peripheral expression of Jak3 is required to maintain T lymphocyte function.
Volume: 185
Issue: 2
Pages: 197-206
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Publication
28424240 | J:247860
First Author: Gao B
Year: 2017
Journal: J Immunol
Title: The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.
Volume: 198
Issue: 10
Pages: 3927-3938
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Publication
11477404 | J:107212
First Author: Ioannidis V
Year: 2001
Journal: Nat Immunol
Title: The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.
Volume: 2
Issue: 8
Pages: 691-7
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Publication
18568639 | J:306776
First Author: Al-Qahtani A
Year: 2008
Journal: Autoimmunity
Title: A role for DRAK2 in the germinal center reaction and the antibody response.
Volume: 41
Issue: 5
Pages: 341-52
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Publication
11717191 | J:109858
First Author: Cancro MP
Year: 2001
Journal: Int Immunol
Title: xid mice reveal the interplay of homeostasis and Bruton's tyrosine kinase-mediated selection at multiple stages of B cell development.
Volume: 13
Issue: 12
Pages: 1501-14
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Publication
26486172 | J:259046
First Author: Jha A
Year: 2015
Journal: Sci Signal
Title: Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis.
Volume: 8
Issue: 399
Pages: ra103
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Publication
8643610 | J:78762
First Author: Weih F
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway.
Volume: 93
Issue: 11
Pages: 5533-8
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Strain
MGI:5447923 | B6.Cg-Tcra<tm1Mom> Nr3c1<tm1.1Jda> Tg(Lck-cre)548Jxm
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
15998791 | J:100651
First Author: Baldwin TA
Year: 2005
Journal: J Exp Med
Title: The timing of TCR alpha expression critically influences T cell development and selection.
Volume: 202
Issue: 1
Pages: 111-21
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Publication
19415629 | J:150024
First Author: Azhar M
Year: 2009
Journal: Genesis
Title: Generation of mice with a conditional allele for transforming growth factor beta 1 gene.
Volume: 47
Issue: 6
Pages: 423-31
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Publication
17804719 | J:124884
First Author: van de Wetering CI
Year: 2007
Journal: Cancer Res
Title: Chromosomal instability and supernumerary centrosomes represent precursor defects in a mouse model of T-cell lymphoma.
Volume: 67
Issue: 17
Pages: 8081-8
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Publication
21216893 | J:169312
First Author: Cheon EC
Year: 2011
Journal: Cancer Res
Title: Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.
Volume: 71
Issue: 5
Pages: 1627-36
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Publication
22072302 | J:321173
First Author: Cheon EC
Year: 2012
Journal: J Gastrointest Surg
Title: Genetic deletion of 5-lipoxygenase increases tumor-infiltrating macrophages in Apc(Δ468) mice.
Volume: 16
Issue: 2
Pages: 389-93
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Publication
25486566 | J:321174
First Author: Ehrlich LA
Year: 2014
Journal: Cell Cycle
Title: Tcrδ translocations that delete the Bcl11b haploinsufficient tumor suppressor gene promote atm-deficient T cell acute lymphoblastic leukemia.
Volume: 13
Issue: 19
Pages: 3076-82
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Publication
17077325 | J:145360
First Author: Matei IR
Year: 2007
Journal: Blood
Title: ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes.
Volume: 109
Issue: 5
Pages: 1887-96
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Publication
18382684 | J:134259
First Author: Cheng N
Year: 2008
Journal: PLoS One
Title: p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.
Volume: 3
Issue: 4
Pages: e1911
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Publication
18381351 | J:136172
First Author: Horino J
Year: 2008
Journal: Int Immunol
Title: Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice.
Volume: 20
Issue: 6
Pages: 753-62
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Publication
35011668 | J:317409
 
First Author: Lee JY
Year: 2021
Journal: Cells
Title: Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell Differentiation.
Volume: 11
Issue: 1
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Publication
20042587 | J:159500
First Author: Wang Y
Year: 2010
Journal: J Immunol
Title: Promoting immune responses by LIGHT in the face of abundant regulatory T cell inhibition.
Volume: 184
Issue: 3
Pages: 1589-95
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Publication
16226504 | J:113276
First Author: Choi EY
Year: 2005
Journal: Immunity
Title: Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells.
Volume: 23
Issue: 4
Pages: 387-96
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Publication
16446310 | J:106759
First Author: McPherson JP
Year: 2006
Journal: Hum Mol Genet
Title: A role for Brca1 in chromosome end maintenance.
Volume: 15
Issue: 6
Pages: 831-8
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Publication
19767771 | J:157041
First Author: Gaidarenko O
Year: 2009
Journal: Oncogene
Title: Transcription activity is required for p53-dependent tumor suppression.
Volume: 28
Issue: 49
Pages: 4397-401
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Publication
23913959 | J:205812
First Author: Tamiya T
Year: 2013
Journal: J Immunol
Title: Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.
Volume: 191
Issue: 5
Pages: 2360-71
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Publication
28049829 | J:239538
First Author: Engler JB
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.
Volume: 114
Issue: 2
Pages: E181-E190
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Publication
16025118 | J:100461
First Author: Gounari F
Year: 2005
Journal: Nat Immunol
Title: Loss of adenomatous polyposis coli gene function disrupts thymic development.
Volume: 6
Issue: 8
Pages: 800-9
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Publication
24659687 | J:209989
First Author: Davila SJ
Year: 2014
Journal: J Immunol
Title: Integrin α4β1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection.
Volume: 192
Issue: 9
Pages: 4284-93
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Publication
25627579 | J:229274
First Author: Linker RA
Year: 2015
Journal: Eur J Immunol
Title: Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage.
Volume: 45
Issue: 5
Pages: 1326-38
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Publication
16585583 | J:131156
First Author: Huang Z
Year: 2006
Journal: J Immunol
Title: Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway.
Volume: 176
Issue: 8
Pages: 4880-7
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Publication
12165504 | J:120208
First Author: Fowlkes BJ
Year: 2002
Journal: J Immunol
Title: A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development.
Volume: 169
Issue: 4
Pages: 1817-21
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Publication
11067867 | J:115112
First Author: Thompson LF
Year: 2000
Journal: J Clin Invest
Title: Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures.
Volume: 106
Issue: 9
Pages: 1149-57
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Publication
22730535 | J:189790
First Author: Yin B
Year: 2012
Journal: J Immunol
Title: Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes.
Volume: 189
Issue: 3
Pages: 1372-9
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Publication
25197064 | J:216365
First Author: Foijer F
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.
Volume: 111
Issue: 37
Pages: 13427-32
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Publication
24680824 | J:219468
First Author: Boo K
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Pontin is required for pre-TCR signaling at the β-selection checkpoint in T cell development.
Volume: 447
Issue: 1
Pages: 44-50
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Publication
15802531 | J:107444
First Author: Baumann S
Year: 2005
Journal: Blood
Title: Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer.
Volume: 106
Issue: 2
Pages: 617-25
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Publication
18523311 | J:137157
First Author: Wüst S
Year: 2008
Journal: J Immunol
Title: Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis.
Volume: 180
Issue: 12
Pages: 8434-43
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Publication
21918186 | J:179309
First Author: Schweingruber N
Year: 2011
Journal: J Immunol
Title: Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis.
Volume: 187
Issue: 8
Pages: 4310-8
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Publication
21245485 | J:170512
First Author: Liu Y
Year: 2011
Journal: Blood
Title: Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes.
Volume: 117
Issue: 12
Pages: 3257-67
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Publication
12969314 | J:85493
 
First Author: Tumanov AV
Year: 2003
Journal: Immunol Rev
Title: Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting.
Volume: 195
Pages: 106-16
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Publication
12705851 | J:83009
First Author: Chong MM
Year: 2003
Journal: Immunity
Title: Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.
Volume: 18
Issue: 4
Pages: 475-87
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Publication
19561615 | J:151652
First Author: Okamoto M
Year: 2009
Journal: Nat Immunol
Title: Mina, an Il4 repressor, controls T helper type 2 bias.
Volume: 10
Issue: 8
Pages: 872-9
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Publication
18353770 | J:137101
First Author: Lu X
Year: 2008
Journal: J Biol Chem
Title: Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice.
Volume: 283
Issue: 20
Pages: 13825-33
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Publication
14608382 | J:86605
First Author: Xu Y
Year: 2003
Journal: Nat Immunol
Title: Deletion of beta-catenin impairs T cell development.
Volume: 4
Issue: 12
Pages: 1177-82
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Publication
30201609 | J:272814
First Author: Moloughney JG
Year: 2018
Journal: J Biol Chem
Title: mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation.
Volume: 293
Issue: 42
Pages: 16464-16478
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Publication
16491076 | J:112614
First Author: Bilic I
Year: 2006
Journal: Nat Immunol
Title: Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Volume: 7
Issue: 4
Pages: 392-400
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Publication
25078620 | J:220125
First Author: Zhang XY
Year: 2014
Journal: Biochem Biophys Res Commun
Title: FADD is essential for glucose uptake and survival of thymocytes.
Volume: 451
Issue: 2
Pages: 202-7
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Publication
17785606 | J:134801
First Author: Allende ML
Year: 2008
Journal: FASEB J
Title: S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues.
Volume: 22
Issue: 1
Pages: 307-15
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Publication
18474632 | J:137138
First Author: Thompson BJ
Year: 2008
Journal: J Exp Med
Title: Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7.
Volume: 205
Issue: 6
Pages: 1395-408
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Publication
21881210 | J:178229
First Author: Hahn JN
Year: 2011
Journal: J Clin Invest
Title: Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice.
Volume: 121
Issue: 10
Pages: 4030-42
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Publication
25054639 | J:217860
First Author: Kasper LH
Year: 2014
Journal: PLoS One
Title: T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs.
Volume: 9
Issue: 7
Pages: e102076
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Publication
20937872 | J:165512
First Author: Guo F
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.
Volume: 107
Issue: 43
Pages: 18505-10
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Publication
17704296 | J:127327
First Author: Zheng L
Year: 2007
Journal: J Leukoc Biol
Title: A hCXCR1 transgenic mouse model containing a conditional color-switching system for imaging of hCXCL8/IL-8 functions in vivo.
Volume: 82
Issue: 5
Pages: 1247-56
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Publication
15027899 | J:88415
First Author: Pan L
Year: 2004
Journal: Immunology
Title: Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes.
Volume: 111
Issue: 2
Pages: 147-54
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Publication
36027914 | J:329911
First Author: Wong CK
Year: 2022
Journal: Cell Metab
Title: Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation.
Volume: 34
Issue: 10
Pages: 1514-1531.e7
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Publication
19265138 | J:145923
First Author: Wang X
Year: 2009
Journal: J Immunol
Title: MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.
Volume: 182
Issue: 6
Pages: 3597-608
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Publication
15195090 | J:91122
First Author: Bender TP
Year: 2004
Journal: Nat Immunol
Title: Critical functions for c-Myb at three checkpoints during thymocyte development.
Volume: 5
Issue: 7
Pages: 721-9
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Publication
30540939 | J:270811
First Author: Simula L
Year: 2018
Journal: Cell Rep
Title: Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
Volume: 25
Issue: 11
Pages: 3059-3073.e10
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Publication
22393458 | J:185287
First Author: Wang HC
Year: 2012
Journal: PLoS One
Title: Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice.
Volume: 7
Issue: 2
Pages: e32944
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Publication
29732501 | J:350748
First Author: Lü S
Year: 2018
Journal: J Mol Med (Berl)
Title: PKM2-dependent metabolic reprogramming in CD4(+) T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis.
Volume: 96
Issue: 6
Pages: 585-600
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Publication
30890796 | J:282432
First Author: Twohig JP
Year: 2019
Journal: Nat Immunol
Title: Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells.
Volume: 20
Issue: 4
Pages: 458-470
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Publication
21931869 | J:177688
First Author: Suliman S
Year: 2011
Journal: PLoS One
Title: Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis.
Volume: 6
Issue: 9
Pages: e24937
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Publication
21471448 | J:173095
First Author: Wang X
Year: 2011
Journal: J Immunol
Title: MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades.
Volume: 186
Issue: 10
Pages: 5791-800
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Publication
18809669 | J:142820
First Author: Mearns H
Year: 2008
Journal: Infect Immun
Title: Interleukin-4-promoted T helper 2 responses enhance Nippostrongylus brasiliensis-induced pulmonary pathology.
Volume: 76
Issue: 12
Pages: 5535-42
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Publication
8016642 | J:67942
First Author: Gu H
Year: 1994
Journal: Science
Title: Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.
Volume: 265
Issue: 5168
Pages: 103-6
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Publication
17500591 | J:143157
First Author: Radwanska M
Year: 2007
Journal: PLoS Pathog
Title: Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection.
Volume: 3
Issue: 5
Pages: e68
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Publication
23543769 | J:201209
First Author: You D
Year: 2013
Journal: J Leukoc Biol
Title: IL-4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates.
Volume: 93
Issue: 6
Pages: 933-42
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Publication
16096649 | J:100794
First Author: Drynan LF
Year: 2005
Journal: EMBO J
Title: Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis.
Volume: 24
Issue: 17
Pages: 3136-46
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Publication
18097009 | J:130898
First Author: Manicassamy S
Year: 2008
Journal: J Immunol
Title: Requirement of calcineurin a beta for the survival of naive T cells.
Volume: 180
Issue: 1
Pages: 106-12
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Publication
18684921 | J:140195
First Author: Mars LT
Year: 2008
Journal: J Immunol
Title: Invariant NKT cells regulate experimental autoimmune encephalomyelitis and infiltrate the central nervous system in a CD1d-independent manner.
Volume: 181
Issue: 4
Pages: 2321-9
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Publication
23882125 | J:203700
First Author: Chen H
Year: 2013
Journal: FASEB J
Title: Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4+ CD25+ Foxp3+ regulatory T-cell development in mice.
Volume: 27
Issue: 10
Pages: 3979-90
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Publication
30843878 | J:292606
 
First Author: Lee CG
Year: 2019
Journal: JCI Insight
Title: Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses.
Volume: 4
Issue: 5
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Publication
24076049 | J:208203
First Author: Zhang N
Year: 2013
Journal: Immunity
Title: Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention.
Volume: 39
Issue: 4
Pages: 687-96
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