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Search results 1101 to 1135 out of 1135 for Mapk14

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Type Details Score
UniProt Feature
UniProt Feature
Begin: 727
Description: Phosphoserine; by MAPK14
Type: modified residue
End: 727
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UniProt Feature
UniProt Feature
Begin: 24
Description: Phosphothreonine; by MAPK14
Type: modified residue
End: 24
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UniProt Feature
UniProt Feature
Begin: 149
Description: Phosphoserine; by MAPK14
Type: modified residue
End: 149
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UniProt Feature
UniProt Feature
Begin: 173
Description: Phosphoserine; by MAPK14
Type: modified residue
End: 173
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UniProt Feature
UniProt Feature
Begin: 187
Description: Phosphoserine; by MAPK14
Type: modified residue
End: 187
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UniProt Feature
UniProt Feature
Begin: 163
Description: Phosphoserine; by MAPK14
Type: modified residue
End: 163
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UniProt Feature
UniProt Feature
Begin: 170
Description: Phosphoserine; by MAPK7 and MAPK14
Type: modified residue
End: 170
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UniProt Feature
UniProt Feature
Begin: 168
Description: Phosphoserine; by MAPK7 and MAPK14
Type: modified residue
End: 168
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UniProt Feature
UniProt Feature
Begin: 372
Description: Phosphoserine; by BRSK1 and MAPK14
Type: modified residue
End: 372
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UniProt Feature
UniProt Feature
Begin: 321
Description: Phosphoserine; by MELK and MAPK14
Type: modified residue
End: 321
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UniProt Feature
UniProt Feature
Begin: 29
Description: Phosphoserine; by DYRK2 and MAPK14
Type: modified residue
End: 29
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UniProt Feature
UniProt Feature
Begin: 51
Description: Phosphothreonine; by MAPK11 and MAPK14
Type: modified residue
End: 51
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UniProt Feature
UniProt Feature
Begin: 103
Description: Phosphothreonine; by MAPK11 and MAPK14
Type: modified residue
End: 103
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UniProt Feature
UniProt Feature
Begin: 350
Description: Phosphoserine; by MAPK11 and MAPK14
Type: modified residue
End: 350
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UniProt Feature
UniProt Feature
Begin: 359
Description: Phosphoserine; by MAPK1, MAPK3 and MAPK14
Type: modified residue
End: 359
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UniProt Feature
UniProt Feature
Begin: 645
Description: Phosphothreonine; by MAPK1, MAPK3 and MAPK14
Type: modified residue
End: 645
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UniProt Feature
UniProt Feature
Begin: 343
Description: Phosphoserine; by MAPK1, MAPK3 and MAPK14
Type: modified residue
End: 343
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UniProt Feature
UniProt Feature
Begin: 568
Description: Phosphothreonine; by MAPK1, MAPK3 and MAPK14
Type: modified residue
End: 568
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GO Term
GO:0038066 | p38MAPK cascade
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UniProt Feature
UniProt Feature
Begin: 53
Description: Phosphothreonine; by MAPK1, MAPK3, MAPK11, MAPK12, MAPK14 and PLK3
Type: modified residue
End: 53
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Allele
Mapk14<em1Smoc> | MGI:7290968
Name: mitogen-activated protein kinase 14; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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GO Term
GO:0051403 | stress-activated MAPK cascade
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Strain
MGI:7718144 | C57BL/6JSmoc-Mapk14<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein Domain
IPR038498 | OspF/SpvC_sf
Type: Homologous_superfamily
Description: This entry includes the virulence protein SpvC and the phosphothreonine lyase OspF. OspF catalyses the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3. This epigenetic modification results in inhibition of the transcription of a specific subset of proinflammatory genes, and ultimately to a reduced immune response against the invading pathogen. The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host [, , ].The spv region of the Salmonella virulence plasmids consists of five genes located on an 8-kb fragment, shown to be essential for virulence in mice []. SpvC (also known as mkfA and VirA []) is part of this gene cluster and is utilised by the microbe upon entry into macrophages, although the exact mechanism is unclear.
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Protein Domain
IPR003519 | OspF/SpvC
Type: Family
Description: This entry includes the virulence protein SpvC and the phosphothreonine lyase OspF. OspF catalyses the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3. This epigenetic modification results in inhibition of the transcription of a specific subset of proinflammatory genes, and ultimately to a reduced immune response against the invading pathogen. The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host [, , ].The spv region of the Salmonella virulence plasmids consists of five genes located on an 8-kb fragment, shown to be essential for virulence in mice []. SpvC (also known as mkfA and VirA []) is part of this gene cluster and is utilised by the microbe upon entry into macrophages, although the exact mechanism is unclear.
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Publication
17159983 | -
First Author: Arbibe L
Year: 2007
Journal: Nat Immunol
Title: An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses.
Volume: 8
Issue: 1
Pages: 47-56
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Publication
17305427 | -
First Author: Kramer RW
Year: 2007
Journal: PLoS Pathog
Title: Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation.
Volume: 3
Issue: 2
Pages: e21
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Publication
17303758 | -
First Author: Li H
Year: 2007
Journal: Science
Title: The phosphothreonine lyase activity of a bacterial type III effector family.
Volume: 315
Issue: 5814
Pages: 1000-3
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Publication
1400193 | -
First Author: Roudier C
Year: 1992
Journal: J Bacteriol
Title: Characterization of translation termination mutations in the spv operon of the Salmonella virulence plasmid pSDL2.
Volume: 174
Issue: 20
Pages: 6418-23
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Publication
1378053 | -
First Author: Krause M
Year: 1992
Journal: J Bacteriol
Title: Regulation of plasmid virulence gene expression in Salmonella dublin involves an unusual operon structure.
Volume: 174
Issue: 13
Pages: 4482-9
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Publication
24405637 | J:355161
 
First Author: Hadwen J
Year: 2014
Journal: Orphanet J Rare Dis
Title: VPAC2 receptor agonist BAY 55-9837 increases SMN protein levels and moderates disease phenotype in severe spinal muscular atrophy mouse models.
Volume: 9
Pages: 4
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Publication
32848861 | J:341837
 
First Author: Said R
Year: 2020
Journal: Front Physiol
Title: Calcium Sets the Clock in Ameloblasts.
Volume: 11
Pages: 920
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Publication
33691379 | J:333818
First Author: Madan V
Year: 2022
Journal: Haematologica
Title: ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.
Volume: 107
Issue: 3
Pages: 680-689
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Publication
33667992 | J:346269
 
First Author: Gao P
Year: 2021
Journal: Redox Biol
Title: MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm.
Volume: 41
Pages: 101903
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Publication
17611063 | J:126571
First Author: Dhahbi J
Year: 2007
Journal: Exp Gerontol
Title: Circulating blood leukocyte gene expression profiles: effects of the Ames dwarf mutation on pathways related to immunity and inflammation.
Volume: 42
Issue: 8
Pages: 772-88
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