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Search results 1101 to 1156 out of 1156 for Mapk8

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Type Details Score
UniProt Feature
UniProt Feature
Begin: 232
Description: Phosphoserine; by MAPK8
Type: modified residue
End: 232
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UniProt Feature
UniProt Feature
Begin: 120
Description: Phosphoserine; by MAPK8
Type: modified residue
End: 120
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UniProt Feature
UniProt Feature
Begin: 148
Description: Phosphothreonine; by MAPK8
Type: modified residue
End: 148
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UniProt Feature
UniProt Feature
Begin: 183
Description: Phosphothreonine; by MAPK8
Type: modified residue
End: 183
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UniProt Feature
UniProt Feature
Begin: 135
Description: Phosphoserine; by MAPK8
Type: modified residue
End: 135
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UniProt Feature
UniProt Feature
Begin: 706
Description: Phosphothreonine; by MAPK8
Type: modified residue
End: 706
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UniProt Feature
UniProt Feature
Begin: 696
Description: Phosphoserine; by MAPK8
Type: modified residue
End: 696
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UniProt Feature
UniProt Feature
Begin: 46
Description: Phosphoserine; by MAPK8
Type: modified residue
End: 46
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UniProt Feature
UniProt Feature
Begin: 280
Description: Phosphothreonine; by MAPK8
Type: modified residue
End: 280
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UniProt Feature
UniProt Feature
Begin: 384
Description: Phosphoserine; by MAPK1 and MAPK8
Type: modified residue
End: 384
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UniProt Feature
UniProt Feature
Begin: 213
Description: Phosphoserine; by MAPK8 and MAPK9
Type: modified residue
End: 213
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UniProt Feature
UniProt Feature
Begin: 217
Description: Phosphoserine; by MAPK8 and MAPK9
Type: modified residue
End: 217
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UniProt Feature
UniProt Feature
Begin: 73
Description: Phosphoserine; by MAPK8 and PLK3
Type: modified residue
End: 73
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UniProt Feature
UniProt Feature
Begin: 308
Description: Phosphoserine; by MAPK8 and MAPK9
Type: modified residue
End: 308
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UniProt Feature
UniProt Feature
Begin: 70
Description: Phosphoserine; by MAPK8 and PKC
Type: modified residue
End: 70
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UniProt Feature
UniProt Feature
Begin: 265
Description: Phosphoserine; by MAPK8 and MAPK9
Type: modified residue
End: 265
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UniProt Feature
UniProt Feature
Begin: 87
Description: Phosphothreonine; by MAPK8 and MAPK9
Type: modified residue
End: 87
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UniProt Feature
UniProt Feature
Begin: 75
Description: Phosphoserine; by MAPK8 and MAPK9
Type: modified residue
End: 75
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UniProt Feature
UniProt Feature
Begin: 61
Description: Phosphoserine; by MAPK8 and MAPK9
Type: modified residue
End: 61
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UniProt Feature
UniProt Feature
Begin: 347
Description: Phosphoserine; by MAPK8 and MAPK9
Type: modified residue
End: 347
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UniProt Feature
UniProt Feature
Begin: 863
Description: Phosphoserine; by MAPK8 and MTOR
Type: modified residue
End: 863
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UniProt Feature
UniProt Feature
Begin: 397
Description: Phosphothreonine; by MAPK8 and MAPK9
Type: modified residue
End: 397
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UniProt Feature
UniProt Feature
Begin: 352
Description: Phosphoserine; by MAPK8 and MAPK9
Type: modified residue
End: 352
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UniProt Feature
UniProt Feature
Begin: 104
Description: Phosphothreonine; by MAPK8 and MAPK9
Type: modified residue
End: 104
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UniProt Feature
UniProt Feature
Begin: 307
Description: Phosphoserine; by IKKB, MAPK8 and RPS6KB1
Type: modified residue
End: 307
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UniProt Feature
UniProt Feature
Begin: 522
Description: Phosphothreonine; by DYRK1A, DYRK3 and MAPK8
Type: modified residue
End: 522
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UniProt Feature
UniProt Feature
Begin: 738
Description: Phosphothreonine; by MAPK1, MAPK3 and MAPK8
Type: modified residue
End: 738
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Allele
Mapk8<em1Smoc> | MGI:7290970
Name: mitogen-activated protein kinase 8; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6429152 | C57BL/6JSmoc-Mapk8<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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GO Term
GO:0007254 | JNK cascade
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Allele
Gt(ROSA)26Sor<tm17(MAP2K7/MAPK8)Jhai> | MGI:5575397
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 17, Jody Haigh
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Tg(Mapk8-EGFP)FV33Gsat | MGI:4847220
Name: transgene insertion FV33, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Protein
Q8BVZ5
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
H3BKB5
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Protein
D3Z6T7
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Protein
E9M2E8
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: true
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Protein
H3BLN5
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: true
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Publication
17185418 | -
First Author: Carriere V
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo.
Volume: 104
Issue: 1
Pages: 282-7
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Publication
22215666 | -
First Author: Kakkar R
Year: 2012
Journal: J Biol Chem
Title: Interleukin 33 as a mechanically responsive cytokine secreted by living cells.
Volume: 287
Issue: 9
Pages: 6941-8
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Protein Domain
IPR026145 | IL-33
Type: Family
Description: This entry represents interleukin-33 (IL33), which that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 [, ]. It also serves as a warning signal between cells at times of injury or cell death [].
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Strain
MGI:5003652 | STOCK Tg(Mapk8-EGFP)FV33Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Gt(ROSA)26Sor<tm1(CAG-MAP2K7*/MAPK8,-EGFP)Ftw> | MGI:5494696
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, F Thomas Wunderlich
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter
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Publication
31533924 | J:284125
 
First Author: Qin Y
Year: 2019
Journal: Development
Title: WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis.
Volume: 146
Issue: 20
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Protein Domain
IPR038498 | OspF/SpvC_sf
Type: Homologous_superfamily
Description: This entry includes the virulence protein SpvC and the phosphothreonine lyase OspF. OspF catalyses the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3. This epigenetic modification results in inhibition of the transcription of a specific subset of proinflammatory genes, and ultimately to a reduced immune response against the invading pathogen. The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host [, , ].The spv region of the Salmonella virulence plasmids consists of five genes located on an 8-kb fragment, shown to be essential for virulence in mice []. SpvC (also known as mkfA and VirA []) is part of this gene cluster and is utilised by the microbe upon entry into macrophages, although the exact mechanism is unclear.
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Protein Domain
IPR003519 | OspF/SpvC
Type: Family
Description: This entry includes the virulence protein SpvC and the phosphothreonine lyase OspF. OspF catalyses the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3. This epigenetic modification results in inhibition of the transcription of a specific subset of proinflammatory genes, and ultimately to a reduced immune response against the invading pathogen. The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host [, , ].The spv region of the Salmonella virulence plasmids consists of five genes located on an 8-kb fragment, shown to be essential for virulence in mice []. SpvC (also known as mkfA and VirA []) is part of this gene cluster and is utilised by the microbe upon entry into macrophages, although the exact mechanism is unclear.
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Ckmm-cre)5Khn/?
Background: involves: C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Publication
17159983 | -
First Author: Arbibe L
Year: 2007
Journal: Nat Immunol
Title: An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses.
Volume: 8
Issue: 1
Pages: 47-56
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Publication
17305427 | -
First Author: Kramer RW
Year: 2007
Journal: PLoS Pathog
Title: Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation.
Volume: 3
Issue: 2
Pages: e21
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Publication
17303758 | -
First Author: Li H
Year: 2007
Journal: Science
Title: The phosphothreonine lyase activity of a bacterial type III effector family.
Volume: 315
Issue: 5814
Pages: 1000-3
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Publication
1400193 | -
First Author: Roudier C
Year: 1992
Journal: J Bacteriol
Title: Characterization of translation termination mutations in the spv operon of the Salmonella virulence plasmid pSDL2.
Volume: 174
Issue: 20
Pages: 6418-23
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Publication
1378053 | -
First Author: Krause M
Year: 1992
Journal: J Bacteriol
Title: Regulation of plasmid virulence gene expression in Salmonella dublin involves an unusual operon structure.
Volume: 174
Issue: 13
Pages: 4482-9
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Publication
29749399 | J:269488
     
First Author: Heaton WL
Year: 2018
Journal: Leukemia
Title: Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion.
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Publication
15254788 | J:96648
First Author: Katoh M
Year: 2004
Journal: Int J Mol Med
Title: Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico.
Volume: 14
Issue: 2
Pages: 333-8
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Publication
28218919 | J:251277
First Author: Wang PX
Year: 2017
Journal: Nat Med
Title: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.
Volume: 23
Issue: 4
Pages: 439-449
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Publication
29106399 | J:252611
First Author: Awazawa M
Year: 2017
Journal: Nat Med
Title: A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle.
Volume: 23
Issue: 12
Pages: 1466-1473
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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