| Type |
Details |
Score |
| Publication |
| First Author: |
Baek CM |
| Year: |
2004 |
| Journal: |
Exp Mol Med |
| Title: |
Transforming variant of Met receptor confers serum independence and anti-apoptotic property and could be involved in the mouse thymic lymphomagenesis. |
| Volume: |
36 |
| Issue: |
4 |
| Pages: |
283-91 |
|
•
•
•
•
•
|
| Pathway |
|
•
•
•
•
•
|
| Pathway |
|
•
•
•
•
•
|
| Pathway |
|
•
•
•
•
•
|
| Pathway |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129 * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 1, Carmen Birchmeier |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 1, Carola Ponzetto |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 2, Carola Ponzetto |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 3, Carola Ponzetta |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; pulmonary adenoma resistance (susceptibility) |
| Allele Type: |
QTL |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 4, Carola Ponzetta |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 4.1, Carola Ponzetta |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 2, Carmen Birchmeier |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 2.1, Carmen Birchmeier |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 1, Rudiger Klein |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 2, Rudiger Klein |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 3, Rudiger Klein |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; endonuclease-mediated mutation 2, Cyagen Biosciences |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met<+> |
| Background: |
involves: 129 * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met<+> |
| Background: |
involves: 129 * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1101193 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
1999-06-29 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1640817 |
| Pattern: |
Regionally restricted |
| Stage: |
TS17 |
| Assay Id: |
MGI:1338962 |
| Age: |
embryonic day 10.5 |
| Image: |
3C |
| Note: |
Expression is in migratory cells of muscle precursors. Expression ovelaps with Met expression. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Compe E |
| Year: |
2012 |
| Journal: |
Nat Rev Mol Cell Biol |
| Title: |
TFIIH: when transcription met DNA repair. |
| Volume: |
13 |
| Issue: |
6 |
| Pages: |
343-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Somers WS |
| Year: |
1994 |
| Journal: |
Ann N Y Acad Sci |
| Title: |
The Met repressor-operator complex: DNA recognition by beta-strands. |
| Volume: |
726 |
|
| Pages: |
105-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Garvie CW |
| Year: |
2000 |
| Journal: |
Structure |
| Title: |
Direct and indirect readout in mutant Met repressor-operator complexes. |
| Volume: |
8 |
| Issue: |
9 |
| Pages: |
905-14 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met<+> |
| Background: |
involves: 129 * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met<+> |
| Background: |
involves: 129 * C57BL/6J * FVB/N |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1031
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1013
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 1, Snorri S Thorgeirsson |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 1.1, Snorri S Thorgeirsson |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 5, George Vande Woude |
| Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 1, Mouse Clinical Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 1.1, Mouse Clinical Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
met proto-oncogene; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129/Sv * C57BL/6 * CD-1 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129/Sv * C57BL/6 * CD-1 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129/Sv * C57BL/6 * CD-1 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: ICR |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129S1/Sv * 129X1/SvJ |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129P2/Ola * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
Not Specified |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
LaMonte BL |
| Year: |
2006 |
| Journal: |
Microbiology |
| Title: |
In vivo hydrolysis of S-adenosylmethionine induces the met regulon of Escherichia coli. |
| Volume: |
152 |
| Issue: |
Pt 5 |
| Pages: |
1451-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiricny J |
| Year: |
1994 |
| Journal: |
Trends Genet |
| Title: |
Colon cancer and DNA repair: have mismatches met their match? |
| Volume: |
10 |
| Issue: |
5 |
| Pages: |
164-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Somers WS |
| Year: |
1992 |
| Journal: |
Nature |
| Title: |
Crystal structure of the met repressor-operator complex at 2.8 A resolution reveals DNA recognition by beta-strands. |
| Volume: |
359 |
| Issue: |
6394 |
| Pages: |
387-93 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met<+> |
| Background: |
involves: BALB/cJ * SWR/J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
656
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim DE |
| Year: |
2020 |
| Journal: |
Aging Cell |
| Title: |
Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. |
| Volume: |
19 |
| Issue: |
3 |
| Pages: |
e13072 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stamos J |
| Year: |
2004 |
| Journal: |
EMBO J |
| Title: |
Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. |
| Volume: |
23 |
| Issue: |
12 |
| Pages: |
2325-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu X |
| Year: |
2017 |
| Journal: |
Cancer Res |
| Title: |
MET Exon 14 Mutation Encodes an Actionable Therapeutic Target in Lung Adenocarcinoma. |
| Volume: |
77 |
| Issue: |
16 |
| Pages: |
4498-4505 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shen Y |
| Year: |
2000 |
| Journal: |
Cell |
| Title: |
InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase. |
| Volume: |
103 |
| Issue: |
3 |
| Pages: |
501-10 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
620
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
718
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
653
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
436
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
507
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
252
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6118099 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2018-02-28 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1788220 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:6118110 |
| Age: |
embryonic day 12.5 |
| Image: |
2a |
| Note: |
No longer present in the round mesenchymal cells but weak to moderate intensity in the long spindle-like cells arranged radially and longitudinally to the lingual surface from the dorsal pharyngeal area. Colocalized with Met in the myogenic cells. |
| Specimen Label: |
2a |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schilperoort M |
| Year: |
2019 |
| Journal: |
Sci Rep |
| Title: |
Time-restricted feeding improves adaptation to chronically alternating light-dark cycles. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
7874 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met<+> |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met<+> |
| Background: |
involves: 129 * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met Tg(mI56i-cre,EGFP)1Kc/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J * FVB |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met Tg(Nes-cre)1Kln/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
collagen, type I, alpha 1; targeted mutation 28, The Netherlands Cancer Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
protein kinase C, alpha; endonuclease-mediated mutation 1, Alexandra C Newton |
| Allele Type: |
Endonuclease-mediated |
|
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1091
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
696
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1440
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liang TJ |
| Year: |
1996 |
| Journal: |
J Clin Invest |
| Title: |
Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors. |
| Volume: |
97 |
| Issue: |
12 |
| Pages: |
2872-7 |
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| Genotype |
| Symbol: |
Met/Met Tg(Mx1-cre)1Cgn/? |
| Background: |
involves: C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
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| Genotype |
| Symbol: |
Gab1/Gab1 Met/Met |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
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