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Search results 1101 to 1160 out of 1160 for Notch3

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Hits by Strain

Type Details Score
Protein
E9Q6E8
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q69Z97
Organism: Mus musculus/domesticus
Length: 826  
Fragment?: true
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Protein
F6UY95
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: true
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Protein
Q8BMG4
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q5U409
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
Q6ZPH8
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: true
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Protein
Q3TZA9
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: true
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Protein
Q810L0
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
E9Q7L5
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Publication
12050117 | -
First Author: Fryer CJ
Year: 2002
Journal: Genes Dev
Title: Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.
Volume: 16
Issue: 11
Pages: 1397-411
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Protein Domain
IPR046370 | MAML_N_sf
Type: Homologous_superfamily
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR046369 | MAML1-3
Type: Family
Description: This family includes the neurogenic mastermind-like proteins 1-3 (MAML1-3) from chordates, which act as critical transcriptional co-activators for Notch signaling [, ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.They consist of an N-terminal domain which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors [, ]]. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR019082 | Mastermind-like_N
Type: Domain
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Coding Gene
MGI:95294 | Egfr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q01279
Organism: Mus musculus/domesticus
Length: 1210  
Fragment?: false
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Publication
33875602 | J:325198
 
First Author: Dabertrand F
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity.
Volume: 118
Issue: 17
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Publication
35202003 | J:323882
 
First Author: Oka F
Year: 2022
Journal: J Clin Invest
Title: CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis.
Volume: 132
Issue: 8
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Notch3/Notch3<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Publication
37318881 | J:339975
 
First Author: Sugiura K
Year: 2023
Journal: JCI Insight
Title: LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3.
Volume: 8
Issue: 14
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Publication
21118965 | J:166963
First Author: Sullivan JP
Year: 2010
Journal: Cancer Res
Title: Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
Volume: 70
Issue: 23
Pages: 9937-48
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Publication
31704879 | J:282061
First Author: Kumar P
Year: 2019
Journal: J Immunol
Title: OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling.
Volume: 203
Issue: 12
Pages: 3225-3236
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Publication
23630352 | J:204776
First Author: Gopisetty A
Year: 2013
Journal: J Immunol
Title: OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells.
Volume: 190
Issue: 11
Pages: 5516-25
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Publication
30502484 | J:282276
 
First Author: Papadakos KS
Year: 2019
Journal: Matrix Biol
Title: Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling.
Volume: 81
Pages: 107-121
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Publication
21994468 | J:205398
First Author: Osanyingbemi-Obidi J
Year: 2011
Journal: Mol Cancer Res
Title: Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo.
Volume: 9
Issue: 12
Pages: 1746-54
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Publication
30226866 | J:266199
First Author: Huang S
Year: 2018
Journal: PLoS Biol
Title: Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.
Volume: 16
Issue: 9
Pages: e2005233
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Publication
21743488 | J:181067
First Author: Pradeep CR
Year: 2012
Journal: Oncogene
Title: Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.
Volume: 31
Issue: 7
Pages: 907-17
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Publication
23530123 | J:198219
First Author: Van de Walle I
Year: 2013
Journal: J Exp Med
Title: Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
Volume: 210
Issue: 4
Pages: 683-97
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Publication
27613846 | J:274430
First Author: Wang S
Year: 2016
Journal: Oncotarget
Title: Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling.
Volume: 7
Issue: 37
Pages: 58848-58861
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Publication
28266128 | J:271834
First Author: Wang S
Year: 2017
Journal: J Cell Mol Med
Title: Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice.
Volume: 21
Issue: 9
Pages: 1967-1978
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Publication
28752390 | J:263753
First Author: Cuervo H
Year: 2017
Journal: Angiogenesis
Title: PDGFRβ-P2A-CreERT2 mice: a genetic tool to target pericytes in angiogenesis.
Volume: 20
Issue: 4
Pages: 655-662
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Publication
26868537 | J:263576
 
First Author: Zeng H
Year: 2016
Journal: Sci Rep
Title: LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways.
Volume: 6
Pages: 20931
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Publication
38907003 | J:353563
First Author: Sergio I
Year: 2024
Journal: Oncogene
Title: Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL.
Volume: 43
Issue: 34
Pages: 2535-2547
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Publication
31796853 | J:297963
First Author: Klose R
Year: 2019
Journal: Sci Rep
Title: Loss of the serine protease HTRA1 impairs smooth muscle cells maturation.
Volume: 9
Issue: 1
Pages: 18224
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Publication
36645109 | J:338757
First Author: Li X
Year: 2023
Journal: FASEB J
Title: Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration.
Volume: 37
Issue: 2
Pages: e22743
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Publication
19688092 | J:152461
First Author: Dudley DD
Year: 2009
Journal: PLoS One
Title: Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.
Volume: 4
Issue: 8
Pages: e6678
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Publication
20804727 | J:165587
First Author: Bargo S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
Volume: 400
Issue: 4
Pages: 606-12
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Publication
29206900 | J:261096
First Author: Zhang C
Year: 2018
Journal: Cardiovasc Res
Title: Cbx3 inhibits vascular smooth muscle cell proliferation, migration, and neointima formation.
Volume: 114
Issue: 3
Pages: 443-455
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Publication
39548190 | J:361508
First Author: Chung WC
Year: 2025
Journal: Oncogene
Title: Lfng-expressing centroacinar cell is a unique cell-of-origin for p53 deficient pancreatic cancer.
Volume: 44
Issue: 6
Pages: 348-362
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Protein Domain
IPR022331 | Notch_3
Type: Family
Description: Notch cell surface receptors are large, single-pass type-1 transmembrane proteins found in a diverse range of metazoan species, from human to Caenorhabditis species. The fruit fly, Drosophila melanogaster, possesses only one Notch protein, whereas in C.elegans, two receptors have been found; by contrast, four Notch paralogues (designated N1-4) have been identified in mammals, playing both unique and redundant roles. The hetero-oligomer Notch comprises a large extracellular domain (ECD), containing 10-36 tandem Epidermal Growth Factor (EFG)-like repeats, which are involved in ligand interactions; a negative regulatory region, including three cysteine-rich Lin12-Notch Repeats (LNR); a single trans-membrane domain (TM); a small intracellular domain (ICD), which includes a RAM (RBPjk-association module) domain; six ankyrin repeats (ANK), which are involved in protein-protein interactions; and a PEST domain. Drosophila Notch also contains an OPA domain []. Notch signalling is an evolutionarily conserved pathway involved in a wide variety of developmental processes, including adult homeostasis and stem cell maintenance, cell proliferation and apoptosis []. Notch is activated by a range of ligands -the so-called DSL ligands (Delta/Seratte/LAG-2). Activation is also mediated by a sequence of proteolytic events: ligand binding leads to cleavage of Notch by ADAM proteases []at site 2 (S2) and presenilin-1/g-secretase at sites 3 (S3)and 4 (S4) [].The last cleavage releases the Notch intracellular part of the protein (NICD) from the membrane and, upon release, the NICD translocates to the nucleus where it associates with a CBF1/RBJk/Su(H)/Lag1 (CSL) family of DNA-binding proteins. The subsequent recruitment of a co-activator mastermind like (MAML1) protein []promotes transcriptional activation of Notch target genes: well established Notch targets are the Hes and Hey gene families. Aberrant Notch function and signalling has been associated with a number of human disorders, including Allagile syndrome, spondylocostal dysostosis, aortic valve disease, CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), and T-cell Acute Lympho-blastic Leukemia (T-ALL); it has also been implicated in various human carcinomas [, ]. Notch3 displays a more restrictive distribution than the rest of the Notch subtypes, being expressed predominantly in vascular smooth muscle cells, the central nervous system, certain thymocytes subsets, and in regulatory T cells [].
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Publication
26279302 | J:309335
First Author: Zhang S
Year: 2016
Journal: Oncogene
Title: Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Volume: 35
Issue: 19
Pages: 2485-95
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Publication
35792302 | J:341865
 
First Author: Breikaa RM
Year: 2022
Journal: Vascul Pharmacol
Title: Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes.
Volume: 145
Pages: 107087
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Publication
24039710 | J:225185
First Author: Li L
Year: 2013
Journal: PLoS One
Title: Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction.
Volume: 8
Issue: 9
Pages: e71041
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Publication
32325086 | J:314302
First Author: Kunze B
Year: 2020
Journal: Gastroenterology
Title: Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma.
Volume: 159
Issue: 2
Pages: 575-590
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Publication
29162437 | J:277897
First Author: Andersson ER
Year: 2018
Journal: Gastroenterology
Title: Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.
Volume: 154
Issue: 4
Pages: 1080-1095
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Publication
36107978 | J:329263
First Author: Alexander GM
Year: 2022
Journal: PLoS One
Title: Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease.
Volume: 17
Issue: 9
Pages: e0274615
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Publication
19379690 | -
First Author: Kopan R
Year: 2009
Journal: Cell
Title: The canonical Notch signaling pathway: unfolding the activation mechanism.
Volume: 137
Issue: 2
Pages: 216-33
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Publication
12354787 | J:94943
First Author: Hartmann D
Year: 2002
Journal: Hum Mol Genet
Title: The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Volume: 11
Issue: 21
Pages: 2615-24
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Publication
11101851 | -
First Author: Wu L
Year: 2000
Journal: Nat Genet
Title: MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Volume: 26
Issue: 4
Pages: 484-9
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Publication
12668592 | J:82719
 
First Author: Gridley T
Year: 2003
Journal: Hum Mol Genet
Title: Notch signaling and inherited disease syndromes.
Volume: 12 Spec No 1
Pages: R9-13
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Publication
16429119 | -
First Author: Louvi A
Year: 2006
Journal: Nat Rev Neurosci
Title: Notch signalling in vertebrate neural development.
Volume: 7
Issue: 2
Pages: 93-102
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Publication
10206645 | J:54336
First Author: De Strooper B
Year: 1999
Journal: Nature
Title: A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Volume: 398
Issue: 6727
Pages: 518-22
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Protein Coding Gene
MGI:1925544 | Rps27a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98887 | Uba52
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98888 | Ubb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98889 | Ubc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62984
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
P0CG50
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P62983
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
P0CG49
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Publication
10221902 | -
First Author: Artavanis-Tsakonas S
Year: 1999
Journal: Science
Title: Notch signaling: cell fate control and signal integration in development.
Volume: 284
Issue: 5415
Pages: 770-6
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