| Type |
Details |
Score |
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Órdenes P |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
Lactate activates hypothalamic POMC neurons by intercellular signaling. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
21644 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guan X |
| Year: |
2012 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. |
| Volume: |
303 |
| Issue: |
7 |
| Pages: |
E853-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friedman JM |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Generation of an rtTA transgene controlled by the Pomc promoter |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vong L |
| Year: |
2011 |
| Journal: |
Neuron |
| Title: |
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. |
| Volume: |
71 |
| Issue: |
1 |
| Pages: |
142-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dodd GT |
| Year: |
2018 |
| Journal: |
Elife |
| Title: |
Insulin regulates POMC neuronal plasticity to control glucose metabolism. |
| Volume: |
7 |
|
|
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
postnatal week 12 |
| Stage: |
28 |
| Structure . Name: |
hypothalamus |
| Notes: |
cells expressing Pomc |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
postnatal week 12 |
| Stage: |
28 |
| Structure . Name: |
hypothalamus |
| Notes: |
cells expressing Pomc |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
postnatal week 12 |
| Stage: |
28 |
| Structure . Name: |
hypothalamus |
| Notes: |
cells expressing Pomc |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
postnatal week 12 |
| Stage: |
28 |
| Structure . Name: |
hypothalamus |
| Notes: |
cells expressing Pomc |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoon NA |
| Year: |
2022 |
| Journal: |
Cell Rep |
| Title: |
UCP2-dependent redox sensing in POMC neurons regulates feeding. |
| Volume: |
41 |
| Issue: |
13 |
| Pages: |
111894 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim GH |
| Year: |
2018 |
| Journal: |
J Clin Invest |
| Title: |
Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. |
| Volume: |
128 |
| Issue: |
3 |
| Pages: |
1125-1140 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yi CX |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
TNFα drives mitochondrial stress in POMC neurons in obesity. |
| Volume: |
8 |
|
| Pages: |
15143 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
235
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cowley MA |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. |
| Volume: |
411 |
| Issue: |
6836 |
| Pages: |
480-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang GM |
| Year: |
2021 |
| Journal: |
Cell Metab |
| Title: |
Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism. |
| Volume: |
33 |
| Issue: |
2 |
| Pages: |
334-349.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gao Y |
| Year: |
2017 |
| Journal: |
Cell Rep |
| Title: |
TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons. |
| Volume: |
18 |
| Issue: |
3 |
| Pages: |
583-592 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
He Z |
| Year: |
2021 |
| Journal: |
JCI Insight |
| Title: |
PERK in POMC neurons connects celastrol with metabolism. |
| Volume: |
6 |
| Issue: |
18 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Varela L |
| Year: |
2017 |
| Journal: |
Diabetes |
| Title: |
Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons. |
| Volume: |
66 |
| Issue: |
6 |
| Pages: |
1511-1520 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kaushik S |
| Year: |
2012 |
| Journal: |
EMBO Rep |
| Title: |
Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. |
| Volume: |
13 |
| Issue: |
3 |
| Pages: |
258-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Silva JP |
| Year: |
2016 |
| Journal: |
Genome Med |
| Title: |
Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Paeger L |
| Year: |
2017 |
| Journal: |
Elife |
| Title: |
Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin. |
| Volume: |
6 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cui J |
| Year: |
2016 |
| Journal: |
J Clin Invest |
| Title: |
Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. |
| Volume: |
126 |
| Issue: |
9 |
| Pages: |
3192-206 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Z |
| Year: |
2018 |
| Journal: |
FEBS Lett |
| Title: |
Short-term tamoxifen treatment has long-term effects on metabolism in high-fat diet-fed mice with involvement of Nmnat2 in POMC neurons. |
| Volume: |
592 |
| Issue: |
19 |
| Pages: |
3305-3316 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang Q |
| Year: |
2022 |
| Journal: |
Diabetes |
| Title: |
MANF in POMC Neurons Promotes Brown Adipose Tissue Thermogenesis and Protects Against Diet-Induced Obesity. |
| Volume: |
71 |
| Issue: |
11 |
| Pages: |
2344-2359 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mun SH |
| Year: |
2023 |
| Journal: |
Cell Rep |
| Title: |
Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons. |
| Volume: |
42 |
| Issue: |
7 |
| Pages: |
112746 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Perissinotti PP |
| Year: |
2021 |
| Journal: |
Front Neurosci |
| Title: |
Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin. |
| Volume: |
15 |
|
| Pages: |
718464 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yuan F |
| Year: |
2020 |
| Journal: |
Mol Metab |
| Title: |
Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling. |
| Volume: |
42 |
|
| Pages: |
101084 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Coester B |
| Year: |
2020 |
| Journal: |
Diabetes |
| Title: |
Amylin/Calcitonin Receptor-Mediated Signaling in POMC Neurons Influences Energy Balance and Locomotor Activity in Chow-Fed Male Mice. |
| Volume: |
69 |
| Issue: |
6 |
| Pages: |
1110-1125 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boston BA |
| Year: |
1997 |
| Journal: |
Science |
| Title: |
Independent and additive effects of central POMC and leptin pathways on murine obesity. |
| Volume: |
278 |
| Issue: |
5343 |
| Pages: |
1641-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang SB |
| Year: |
2012 |
| Journal: |
Neuron |
| Title: |
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. |
| Volume: |
75 |
| Issue: |
3 |
| Pages: |
425-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dorfman MD |
| Year: |
2017 |
| Journal: |
Diabetes |
| Title: |
Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity. |
| Volume: |
66 |
| Issue: |
4 |
| Pages: |
920-934 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang Y |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
1718 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mercer AJ |
| Year: |
2014 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice. |
| Volume: |
306 |
| Issue: |
8 |
| Pages: |
E904-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Timper K |
| Year: |
2018 |
| Journal: |
Cell Rep |
| Title: |
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. |
| Volume: |
25 |
| Issue: |
2 |
| Pages: |
383-397.e10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lutz TA |
| Year: |
2018 |
| Journal: |
Diabetes |
| Title: |
Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus. |
| Volume: |
67 |
| Issue: |
5 |
| Pages: |
805-817 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yao T |
| Year: |
2017 |
| Journal: |
Diabetes |
| Title: |
Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia. |
| Volume: |
66 |
| Issue: |
3 |
| Pages: |
663-673 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maejima Y |
| Year: |
2014 |
| Journal: |
FEBS Lett |
| Title: |
Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. |
| Volume: |
588 |
| Issue: |
23 |
| Pages: |
4404-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin S |
| Year: |
2000 |
| Journal: |
Brain Res |
| Title: |
Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. |
| Volume: |
875 |
| Issue: |
1-2 |
| Pages: |
89-95 |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
postnatal week 12 |
| Stage: |
28 |
| Structure . Name: |
hypothalamus |
| Notes: |
ribosome pulldown from cells expressing Pomc |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
postnatal week 12 |
| Stage: |
28 |
| Structure . Name: |
hypothalamus |
| Notes: |
ribosome pulldown from cells expressing Pomc |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
postnatal week 12 |
| Stage: |
28 |
| Structure . Name: |
hypothalamus |
| Notes: |
ribosome pulldown from cells expressing Pomc |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
postnatal week 12 |
| Stage: |
28 |
| Structure . Name: |
hypothalamus |
| Notes: |
ribosome pulldown from cells expressing Pomc |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 51 |
| Stage: |
28 |
| Structure . Name: |
arcuate nucleus |
| Notes: |
sorted POMC neuron from a fed mouse |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 51 |
| Stage: |
28 |
| Structure . Name: |
arcuate nucleus |
| Notes: |
sorted POMC neuron from a fed mouse |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 55 |
| Stage: |
28 |
| Structure . Name: |
arcuate nucleus |
| Notes: |
sorted POMC neuron from a fed mouse |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 56 |
| Stage: |
28 |
| Structure . Name: |
arcuate nucleus |
| Notes: |
sorted POMC neuron from a fed mouse |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 55 |
| Stage: |
28 |
| Structure . Name: |
arcuate nucleus |
| Notes: |
sorted POMC neuron from a fed mouse |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin HV |
| Year: |
2010 |
| Journal: |
Diabetes |
| Title: |
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. |
| Volume: |
59 |
| Issue: |
2 |
| Pages: |
337-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith MA |
| Year: |
2015 |
| Journal: |
Cell Rep |
| Title: |
Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice. |
| Volume: |
11 |
| Issue: |
3 |
| Pages: |
335-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ramírez S |
| Year: |
2017 |
| Journal: |
Cell Metab |
| Title: |
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control. |
| Volume: |
25 |
| Issue: |
6 |
| Pages: |
1390-1399.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schneeberger M |
| Year: |
2013 |
| Journal: |
Cell |
| Title: |
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. |
| Volume: |
155 |
| Issue: |
1 |
| Pages: |
172-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gómez-Valadés AG |
| Year: |
2021 |
| Journal: |
Cell Metab |
| Title: |
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis. |
| Volume: |
33 |
| Issue: |
9 |
| Pages: |
1820-1835.e9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Williams KW |
| Year: |
2014 |
| Journal: |
Cell Metab |
| Title: |
Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. |
| Volume: |
20 |
| Issue: |
3 |
| Pages: |
471-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mounien L |
| Year: |
2010 |
| Journal: |
FASEB J |
| Title: |
Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons. |
| Volume: |
24 |
| Issue: |
6 |
| Pages: |
1747-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang H |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. |
| Volume: |
9 |
| Issue: |
7 |
| Pages: |
e1001112 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Claret M |
| Year: |
2007 |
| Journal: |
J Clin Invest |
| Title: |
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. |
| Volume: |
117 |
| Issue: |
8 |
| Pages: |
2325-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mandelblat-Cerf Y |
| Year: |
2015 |
| Journal: |
Elife |
| Title: |
Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales. |
| Volume: |
4 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang M |
| Year: |
2023 |
| Journal: |
Mol Metab |
| Title: |
GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity. |
| Volume: |
79 |
|
| Pages: |
101839 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Al-Massadi O |
| Year: |
2019 |
| Journal: |
Diabetes |
| Title: |
MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance. |
| Volume: |
68 |
| Issue: |
12 |
| Pages: |
2210-2222 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dodd GT |
| Year: |
2015 |
| Journal: |
Cell |
| Title: |
Leptin and insulin act on POMC neurons to promote the browning of white fat. |
| Volume: |
160 |
| Issue: |
1-2 |
| Pages: |
88-104 |
|
•
•
•
•
•
|
| Regulatory Region |
| Type: |
enhancer |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Al-Qassab H |
| Year: |
2009 |
| Journal: |
Cell Metab |
| Title: |
Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. |
| Volume: |
10 |
| Issue: |
5 |
| Pages: |
343-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marenne G |
| Year: |
2020 |
| Journal: |
Cell Metab |
| Title: |
Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. |
| Volume: |
31 |
| Issue: |
6 |
| Pages: |
1107-1119.e12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Keilhoff G |
| Year: |
2001 |
| Journal: |
Acta Histochem |
| Title: |
Lack of neuronal NOS has consequences for the expression of POMC and POMC-derived peptides in the mouse pituitary. |
| Volume: |
103 |
| Issue: |
4 |
| Pages: |
397-412 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Newton AJ |
| Year: |
2013 |
| Journal: |
Endocrinology |
| Title: |
AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice. |
| Volume: |
154 |
| Issue: |
1 |
| Pages: |
172-83 |
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| Publication |
| First Author: |
He Z |
| Year: |
2019 |
| Journal: |
Mol Metab |
| Title: |
Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons - Implications for energy balance and glucose control. |
| Volume: |
28 |
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| Pages: |
120-134 |
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| Publication |
| First Author: |
Smith ME |
| Year: |
1994 |
| Journal: |
J Neurol Sci |
| Title: |
POMC neuropeptides and their receptors in the neuromuscular system of wobbler mice. |
| Volume: |
124 Suppl |
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| Pages: |
56-8 |
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•
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| Publication |
| First Author: |
Ancans J |
| Year: |
1999 |
| Journal: |
J Invest Dermatol |
| Title: |
Human epidermal proopiomelanocortin (POMC) cDNA variant is identical to mouse POMC cDNA. |
| Volume: |
112 |
| Issue: |
4 |
| Pages: |
516-7 |
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•
•
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| Publication |
| First Author: |
Farooqui J |
| Year: |
1999 |
| Journal: |
J Invest Dermatol |
| Title: |
Human epidermal proopiomelanocortin (POMC) cDNA variant is identical to mouse POMC cDNA - Reply. |
| Volume: |
112 |
| Issue: |
4 |
| Pages: |
517 |
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| HT Experiment |
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| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
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| Publication |
| First Author: |
do Carmo JM |
| Year: |
2014 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation. |
| Volume: |
307 |
| Issue: |
12 |
| Pages: |
R1438-47 |
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•
•
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| Publication |
| First Author: |
Rau AR |
| Year: |
2020 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
Disruption of GABA or glutamate release from POMC neurons in the adult mouse does not affect metabolic end points. |
| Volume: |
319 |
| Issue: |
5 |
| Pages: |
R592-R601 |
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•
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| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
embryonic day 15.5 |
| Stage: |
23 |
| Structure . Name: |
hypothalamus |
| Notes: |
FACs sorted Pomc reporter neurons from arcuate nuclei |
| Curation Status: |
Curated |
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•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
embryonic day 15.5 |
| Stage: |
23 |
| Structure . Name: |
hypothalamus |
| Notes: |
FACs sorted Pomc reporter neurons from arcuate nuclei |
| Curation Status: |
Curated |
|
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•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
embryonic day 15.5 |
| Stage: |
23 |
| Structure . Name: |
hypothalamus |
| Notes: |
FACs sorted Pomc reporter neurons from arcuate nuclei |
| Curation Status: |
Curated |
|
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•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Not Specified |
| Age: |
embryonic day 15.5 |
| Stage: |
23 |
| Structure . Name: |
hypothalamus |
| Notes: |
FACs sorted Pomc reporter neurons from arcuate nuclei |
| Curation Status: |
Curated |
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•
•
•
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| Publication |
| First Author: |
Tse EK |
| Year: |
2018 |
| Journal: |
Mol Cell Endocrinol |
| Title: |
Palmitate induces neuroinflammation, ER stress, and Pomc mRNA expression in hypothalamic mHypoA-POMC/GFP neurons through novel mechanisms that are prevented by oleate. |
| Volume: |
472 |
|
| Pages: |
40-49 |
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•
•
•
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| Publication |
| First Author: |
Zhou Y |
| Year: |
2001 |
| Journal: |
J Neuroendocrinol |
| Title: |
Ablation of pituitary pro-opiomelanocortin (POMC) cells produces alterations in hypothalamic POMC mRNA levels and midbrain mu opioid receptor binding in a conditional transgenic mouse model. |
| Volume: |
13 |
| Issue: |
9 |
| Pages: |
808-17 |
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•
•
•
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| Publication |
| First Author: |
Tang Q |
| Year: |
2021 |
| Journal: |
FASEB J |
| Title: |
Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis. |
| Volume: |
35 |
| Issue: |
3 |
| Pages: |
e21408 |
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•
•
•
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| Publication |
| First Author: |
Shi H |
| Year: |
2008 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis. |
| Volume: |
294 |
| Issue: |
3 |
| Pages: |
E630-9 |
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•
•
•
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| Publication |
| First Author: |
Dragano NRV |
| Year: |
2024 |
| Journal: |
Mol Metab |
| Title: |
Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance. |
| Volume: |
79 |
|
| Pages: |
101840 |
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•
•
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| Publication |
| First Author: |
Leyrer-Jackson JM |
| Year: |
2022 |
| Journal: |
Brain Res |
| Title: |
Sex differences and the lack of effects of chemogenetic manipulation of pro-opiomelanocortin (POMC) neurons on alcohol consumption in male and female mice. |
| Volume: |
1786 |
|
| Pages: |
147901 |
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•
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| Publication |
| First Author: |
Long L |
| Year: |
2014 |
| Journal: |
J Clin Invest |
| Title: |
PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding. |
| Volume: |
124 |
| Issue: |
9 |
| Pages: |
4017-27 |
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•
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| Publication |
| First Author: |
Kievit P |
| Year: |
2006 |
| Journal: |
Cell Metab |
| Title: |
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. |
| Volume: |
4 |
| Issue: |
2 |
| Pages: |
123-32 |
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•
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| Publication |
| First Author: |
Xu Y |
| Year: |
2008 |
| Journal: |
Neuron |
| Title: |
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. |
| Volume: |
60 |
| Issue: |
4 |
| Pages: |
582-9 |
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| Publication |
| First Author: |
Li H |
| Year: |
2023 |
| Journal: |
Nat Commun |
| Title: |
The melanocortin action is biased toward protection from weight loss in mice. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
2200 |
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| Publication |
| First Author: |
Xu Y |
| Year: |
2010 |
| Journal: |
Nat Neurosci |
| Title: |
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. |
| Volume: |
13 |
| Issue: |
12 |
| Pages: |
1457-9 |
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| Publication |
| First Author: |
Xiao Y |
| Year: |
2017 |
| Journal: |
Diabetes |
| Title: |
ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure. |
| Volume: |
66 |
| Issue: |
5 |
| Pages: |
1146-1158 |
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| Publication |
| First Author: |
Janoschek R |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. |
| Volume: |
103 |
| Issue: |
28 |
| Pages: |
10707-12 |
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| First Author: |
Mori H |
| Year: |
2009 |
| Journal: |
Cell Metab |
| Title: |
Critical role for hypothalamic mTOR activity in energy balance. |
| Volume: |
9 |
| Issue: |
4 |
| Pages: |
362-74 |
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| First Author: |
Könner AC |
| Year: |
2007 |
| Journal: |
Cell Metab |
| Title: |
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. |
| Volume: |
5 |
| Issue: |
6 |
| Pages: |
438-49 |
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| Publication |
| First Author: |
Wang X |
| Year: |
2014 |
| Journal: |
Diabetologia |
| Title: |
Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons. |
| Volume: |
57 |
| Issue: |
1 |
| Pages: |
236-45 |
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| Publication |
| First Author: |
Shin AC |
| Year: |
2017 |
| Journal: |
Diabetes |
| Title: |
Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action. |
| Volume: |
66 |
| Issue: |
6 |
| Pages: |
1560-1571 |
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| First Author: |
Quan W |
| Year: |
2012 |
| Journal: |
Endocrinology |
| Title: |
Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response. |
| Volume: |
153 |
| Issue: |
4 |
| Pages: |
1817-26 |
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| First Author: |
Fricker LD |
| Year: |
2021 |
| Journal: |
Cell Chem Biol |
| Title: |
Neuropeptidomic Analysis of a Genetically Defined Cell Type in Mouse Brain and Pituitary. |
| Volume: |
28 |
| Issue: |
1 |
| Pages: |
105-112.e4 |
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| First Author: |
Hill JW |
| Year: |
2010 |
| Journal: |
Cell Metab |
| Title: |
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. |
| Volume: |
11 |
| Issue: |
4 |
| Pages: |
286-97 |
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| Publication |
| First Author: |
Hill JW |
| Year: |
2009 |
| Journal: |
Endocrinology |
| Title: |
Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. |
| Volume: |
150 |
| Issue: |
11 |
| Pages: |
4874-82 |
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