| Type |
Details |
Score |
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST13993D9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14162B2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14190E7, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14202A2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune homolog 2; gene trap IST14203G3, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14220F9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14258E2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14252D6, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14288G5, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune homolog 2; gene trap IST14367G5, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune homolog 2; gene trap IST14349D5, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14391G4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14394C10, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune homolog 2; gene trap IST14416E4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14485F12, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14488A2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14498D8, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14562B12, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune homolog 2; gene trap IST14580C8, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14644G4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14686A12, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14667C9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune homolog 2; gene trap IST14675F6, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14753B9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14704D2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST14900G7, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune homolog 2; gene trap IST14860G1, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune homolog 2; gene trap IST15026G1, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST15066A10, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
prune exopolyphosphatase; gene trap IST15069C2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Prune1/Prune1 |
| Background: |
FVB/N-Prune1 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Prune2/Prune2 |
| Background: |
involves: C57BL * DBA |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Prune1/Prune1<+> |
| Background: |
C57BL/6N-Prune1/Ucd |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Prune2/Prune2 |
| Background: |
C57BL/6N-Prune2/Wtsi |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Prune1/Prune1<+> |
| Background: |
C57BL/6N-Prune1/MbpMmucd |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
chemically induced mutation, coisogenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
chemically induced mutation, coisogenic, mutant strain |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Siggs OM |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Record for "prune", updated 2nd of September, 2008. |
|
|
|
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hr/Hr |
| Background: |
C57BL/6J-Hr |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
263
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo D |
| Year: |
1995 |
| Journal: |
J Gen Virol |
| Title: |
Prunus necrotic ringspot ilarvirus: nucleotide sequence of RNA3 and the relationship to other ilarviruses based on coat protein comparison. |
| Volume: |
76 ( Pt 5) |
|
| Pages: |
1073-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamagata A |
| Year: |
2002 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The crystal structure of exonuclease RecJ bound to Mn2+ ion suggests how its characteristic motifs are involved in exonuclease activity. |
| Volume: |
99 |
| Issue: |
9 |
| Pages: |
5908-12 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family consists of various coat proteins from the Ilarviruses which belong to the Bromoviridae, members include Apple mosaic virus and Prune dwarf virus. The Ilarvirus coat protein is required to initiate replication of the viral genome in host plants []. Members of the Bromoviridae have a positive stand ssRNA genome with no DNA stage in their replication. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
DHH phosphoesterase superfamily includes manganese-dependent inorganic pyrophosphatase (family II), Drosophila prune protein and bacterial RecJ exonuclease []. Typically, its members consist of two non-similar domains:domain 1 with parallel sheet of 6 strands and domain 2 with mixed sheet of 5 strands. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rajman LA |
| Year: |
2000 |
| Journal: |
J Bacteriol |
| Title: |
A thermostable single-strand DNase from Methanococcus jannaschii related to the RecJ recombination and repair exonuclease from Escherichia coli. |
| Volume: |
182 |
| Issue: |
3 |
| Pages: |
607-12 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This is a domain of predicted phosphoesterases, including Drosophila prune protein and bacterial RecJ exonuclease []. The RecJ protein of Escherichia coli plays an important role in a number of DNA repair and recombination pathways. RecJ catalyzes processive degradation of single-stranded DNA in a 5'-to-3' direction. Sequences highly related to those encoding RecJ can be found in many of the eubacterial genomes sequenced to date []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and ICS/MCI |
| Year: |
2024 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) Generated by ICS/MCI |
|
|
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
800
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takahashi M |
| Year: |
2020 |
| Journal: |
Dev Biol |
| Title: |
Macrophages fine-tune pupil shape during development. |
| Volume: |
464 |
| Issue: |
2 |
| Pages: |
137-144 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiang D |
| Year: |
2022 |
| Journal: |
Immunity |
| Title: |
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina. |
| Volume: |
55 |
| Issue: |
12 |
| Pages: |
2318-2335.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hong S |
| Year: |
2016 |
| Journal: |
Science |
| Title: |
Complement and microglia mediate early synapse loss in Alzheimer mouse models. |
| Volume: |
352 |
| Issue: |
6286 |
| Pages: |
712-716 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fujimoto S |
| Year: |
2023 |
| Journal: |
Dev Cell |
| Title: |
Activity-dependent local protection and lateral inhibition control synaptic competition in developing mitral cells in mice. |
| Volume: |
58 |
| Issue: |
14 |
| Pages: |
1221-1236.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kostadinov D |
| Year: |
2015 |
| Journal: |
Elife |
| Title: |
Protocadherin-dependent dendritic self-avoidance regulates neural connectivity and circuit function. |
| Volume: |
4 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guedes JR |
| Year: |
2023 |
| Journal: |
Neuron |
| Title: |
IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development. |
| Volume: |
111 |
| Issue: |
21 |
| Pages: |
3435-3449.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen M |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
Spatially coordinated kinase signaling regulates local axon degeneration. |
| Volume: |
32 |
| Issue: |
39 |
| Pages: |
13439-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun C |
| Year: |
2023 |
| Journal: |
J Exp Med |
| Title: |
Maternal diet during early gestation influences postnatal taste activity-dependent pruning by microglia. |
| Volume: |
220 |
| Issue: |
12 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng TW |
| Year: |
2009 |
| Journal: |
Eur J Neurosci |
| Title: |
Secreted TARSH regulates olfactory mitral cell dendritic complexity. |
| Volume: |
29 |
| Issue: |
6 |
| Pages: |
1083-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kesler CT |
| Year: |
2015 |
| Journal: |
FASEB J |
| Title: |
Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation. |
| Volume: |
29 |
| Issue: |
9 |
| Pages: |
3668-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chu Y |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Enhanced synaptic connectivity and epilepsy in C1q knockout mice. |
| Volume: |
107 |
| Issue: |
17 |
| Pages: |
7975-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bodnar RJ |
| Year: |
2009 |
| Journal: |
J Cell Sci |
| Title: |
IP-10 induces dissociation of newly formed blood vessels. |
| Volume: |
122 |
| Issue: |
Pt 12 |
| Pages: |
2064-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
DeFalco T |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. |
| Volume: |
111 |
| Issue: |
23 |
| Pages: |
E2384-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang Y |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. |
| Volume: |
109 |
| Issue: |
43 |
| Pages: |
17561-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rogerson-Wood L |
| Year: |
2023 |
| Journal: |
eNeuro |
| Title: |
An Early Enriched Experience Drives an Activated Microglial Profile at Site of Corrective Neuroplasticity in Ten-m3 Knock-Out Mice. |
| Volume: |
10 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li T |
| Year: |
2020 |
| Journal: |
EMBO J |
| Title: |
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding. |
| Volume: |
39 |
| Issue: |
16 |
| Pages: |
e104136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Overbeek PA |
| Year: |
2011 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Direct Data Submission for Overbeek Lentiviral Transgenic Lines |
|
|
|
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gautam D |
| Year: |
2006 |
| Journal: |
Cell Metab |
| Title: |
A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. |
| Volume: |
3 |
| Issue: |
6 |
| Pages: |
449-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsui M |
| Year: |
2000 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. |
| Volume: |
97 |
| Issue: |
17 |
| Pages: |
9579-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aihara T |
| Year: |
2003 |
| Journal: |
Gastroenterology |
| Title: |
Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice. |
| Volume: |
125 |
| Issue: |
6 |
| Pages: |
1774-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zawalich WS |
| Year: |
2004 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Effects of muscarinic receptor type 3 knockout on mouse islet secretory responses. |
| Volume: |
315 |
| Issue: |
4 |
| Pages: |
872-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao CM |
| Year: |
2014 |
| Journal: |
Sci Transl Med |
| Title: |
Denervation suppresses gastric tumorigenesis. |
| Volume: |
6 |
| Issue: |
250 |
| Pages: |
250ra115 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li JH |
| Year: |
2009 |
| Journal: |
Diabetes |
| Title: |
Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice. |
| Volume: |
58 |
| Issue: |
12 |
| Pages: |
2776-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gericke A |
| Year: |
2014 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Role of the M3 muscarinic acetylcholine receptor subtype in murine ophthalmic arteries after endothelial removal. |
| Volume: |
55 |
| Issue: |
1 |
| Pages: |
625-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Duttaroy A |
| Year: |
2004 |
| Journal: |
Diabetes |
| Title: |
Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. |
| Volume: |
53 |
| Issue: |
7 |
| Pages: |
1714-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stengel PW |
| Year: |
2002 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
M(3)-receptor knockout mice: muscarinic receptor function in atria, stomach fundus, urinary bladder, and trachea. |
| Volume: |
282 |
| Issue: |
5 |
| Pages: |
R1443-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gericke A |
| Year: |
2011 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Identification of the muscarinic acetylcholine receptor subtype mediating cholinergic vasodilation in murine retinal arterioles. |
| Volume: |
52 |
| Issue: |
10 |
| Pages: |
7479-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Musayeva A |
| Year: |
2021 |
| Journal: |
Int J Mol Sci |
| Title: |
Aged Mice Devoid of the M3 Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease. |
| Volume: |
22 |
| Issue: |
11 |
|
|
•
•
•
•
•
|