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Search results 1101 to 1200 out of 1428 for Sirt1

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Type Details Score
Interaction Experiment
Kang H (2009)
Description: CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
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Interaction Experiment
Dobbin MM (2013)
Description: SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.
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Publication
31591441 | J:284242
First Author: Santos L
Year: 2019
Journal: Sci Rep
Title: A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo.
Volume: 9
Issue: 1
Pages: 14381
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Publication
28099528 | J:246363
First Author: Nakazawa H
Year: 2017
Journal: PLoS One
Title: iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53.
Volume: 12
Issue: 1
Pages: e0170391
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Interaction Experiment
Senawong T (2005)
Description: BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression.
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Interaction Experiment
Kemper JK (2009)
Description: FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.
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Interaction Experiment
Law IK (2009)
Description: Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.
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Interaction Experiment
Bouras T (2005)
Description: SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
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Allele
Col1a1<tm1(tetO-GFP/RNAi:Sirt1)Pyc> | MGI:5646012
Name: collagen, type I, alpha 1; targeted mutation 1, Peter Y Chuang
Allele Type: Targeted
Attribute String: Knockdown, Reporter, RMCE-ready
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Allele
Sirt1<tm1Smoc> | MGI:7292330
Name: sirtuin 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh | MGI:7520423
Name: transgene insertion 1, Makoto Kinoshita
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Publication
18235502 | -
First Author: Zhao W
Year: 2008
Journal: Nature
Title: Negative regulation of the deacetylase SIRT1 by DBC1.
Volume: 451
Issue: 7178
Pages: 587-90
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Interaction Experiment
Kong S (2011)
Description: The type III histone deacetylase Sirt1 suppresses p300- mediated histone H3 Lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation.
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Interaction Experiment
Dey S (2008)
Description: Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells.
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Interaction Experiment
Kang MR (2010)
Description: Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells.
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Publication
28883095 | -
First Author: Lai Y
Year: 2017
Journal: J Cell Sci
Title: Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron.
Volume: 130
Issue: 20
Pages: 3578-3587
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Publication
16166628 | -
First Author: Zhao X
Year: 2005
Journal: Mol Cell Biol
Title: Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.
Volume: 25
Issue: 19
Pages: 8456-64
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Publication
19478080 | -
First Author: Zhang T
Year: 2009
Journal: J Biol Chem
Title: Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters.
Volume: 284
Issue: 30
Pages: 20408-17
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Publication
36561976 | -
First Author: Zhang H
Year: 2022
Journal: Exp Ther Med
Title: miR‑141 impairs mitochondrial function in cardiomyocytes subjected to hypoxia/reoxygenation by targeting Sirt1 and MFN2.
Volume: 24
Issue: 6
Pages: 763
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Publication
31092012 | J:340179
First Author: Ding Y
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Peroxynitrite-Mediated SIRT (Sirtuin)-1 Inactivation Contributes to Nicotine-Induced Arterial Stiffness in Mice.
Volume: 39
Issue: 7
Pages: 1419-1431
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Allele
Tg(Sirt1)ASrn | MGI:5529482
Name: transgene insertion A, Manuel Serrano
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6355184 | C57BL/6JSmoc-Sirt1<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6146868 | C57BL/6-Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh/HshRbrc
Attribute String: mutant strain, coisogenic, transgenic
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Publication
12930829 | -
First Author: Senawong T
Year: 2003
Journal: J Biol Chem
Title: Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression.
Volume: 278
Issue: 44
Pages: 43041-50
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Publication
15639232 | -
First Author: Senawong T
Year: 2005
Journal: Arch Biochem Biophys
Title: BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression.
Volume: 434
Issue: 2
Pages: 316-25
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Publication
21775285 | -
First Author: Sundaresan NR
Year: 2011
Journal: Sci Signal
Title: The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
Volume: 4
Issue: 182
Pages: ra46
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HT Experiment
E-GEOD-22530 | Sirt1-microRNA profile
Series Id: GSE22530
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-13120 | Transcription profiling of mouse neocortex to investigate age-related gene expression changes
Series Id: GSE13120
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Protein Domain
IPR028811 | CCAR2
Type: Family
Description: Cell cycle and apoptosis regulator protein 2 (CCAR2, also known as DBC-1) regulates biological processes such as transcription, heterochromatin formation, metabolism, mRNA splicing, apoptosis, and cell proliferation []. It is a core component of the DBIRD complex, which affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions []. It binds to SIRT1 and is a negative regulator of SIRT1 []. DBC-1 has been implicated in tumorigenesis [].
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Publication
32538779 | -
   
First Author: Meng F
Year: 2020
Journal: Elife
Title: Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
Volume: 9
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Publication
18676681 | -
First Author: Dey S
Year: 2008
Journal: Carcinogenesis
Title: Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells.
Volume: 29
Issue: 10
Pages: 1920-9
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Strain
MGI:5529364 | B6.Cg-Tg(Sirt1)ASrn/J
Attribute String: congenic, mutant strain, transgenic
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Allele
Sirt1<em1Dahe> | MGI:7518811
Name: sirtuin 1; endonuclease-mediated mutation 1, Daniel Herranz
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Strain
MGI:7518812 | C57BL/6-Sirt1<em1Dahe>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Tg(Sirt1)ASrn/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Allele
Sirt1<tm3.1Mcby> | MGI:5903422
Name: sirtuin 1; targeted mutation 3.1,Michael W McBurney
Allele Type: Targeted
Attribute String: Hypomorph, Inducible
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HT Experiment
E-GEOD-62194 | A High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Series Id: GSE62194
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
18235501 | -
First Author: Kim JE
Year: 2008
Journal: Nature
Title: DBC1 is a negative regulator of SIRT1.
Volume: 451
Issue: 7178
Pages: 583-6
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Publication
23352644 | -
First Author: Kim W
Year: 2013
Journal: Cancer Lett
Title: Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis of breast cancer cells through impaired responses to UV-induced DNA damage.
Volume: 333
Issue: 2
Pages: 180-6
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Publication
19657230 | -
First Author: Kim JE
Year: 2009
Journal: Cell Cycle
Title: p30 DBC is a potential regulator of tumorigenesis.
Volume: 8
Issue: 18
Pages: 2932-5
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Strain
MGI:5903423 | 129-Sirt1<tm3.1Mcby>/Mmjax
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Sirt1/Sirt1
Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
E-GEOD-17067 | A quantitative model of transcription regulation reveals the role of non-conserved enhancers
Series Id: GSE17067
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
GSE155898 | LARP7, a new ROS sensor, protects against heart failure by enhancing mitochondrial biogenesis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-67239 | Pancreas-specific Sirt1-deficiency in mice compromises beta-cell function without development of hyperglycemia
Series Id: GSE67239
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
20154726 | J:168266
First Author: Zhang W
Year: 2010
Journal: Oncogene
Title: A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Volume: 29
Issue: 17
Pages: 2467-76
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Publication
19525223 | -
First Author: Van Rechem C
Year: 2009
Journal: J Biol Chem
Title: Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).
Volume: 284
Issue: 31
Pages: 20927-35
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Publication
15231840 | -
First Author: Pinte S
Year: 2004
Journal: J Biol Chem
Title: The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.
Volume: 279
Issue: 37
Pages: 38313-24
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Publication
20547755 | -
First Author: Van Rechem C
Year: 2010
Journal: Mol Cell Biol
Title: Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.
Volume: 30
Issue: 16
Pages: 4045-59
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Protein Domain
IPR028424 | HIC1
Type: Family
Description: Hypermethylated in cancer 1 (HIC1) is a transcriptional repressor that modulates P53-dependent and E2F1-dependent cell growth control and is epigenetically inactivated in various human cancers []. It recognises and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' []. It is a direct transcriptional repressor of ephrin-A1 and CXCR7, which are implicated in the pathogenesis of different cancers [, ]. HIC1 is also involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses []. HIC1 interacts with several different corepressors such as CTBP1, CTBP2 and MTA1 (a subunit of the NuRD complex) [].
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Protein Domain
IPR021171 | Core_histone_macro-H2A
Type: Family
Description: This group represents a core histone macro-H2A.MacroH2A is a variant of the major-type core histone H2A which contains an N-terminal H2A domain and a C-terminal nonhistone macro domain. Histone macroH2A is enriched on the inactive X chromosome of mammalian female cells []. It does not bind poly ADP-ribose, but does bind the monomeric SirT1 metabolite O-acetyl-ADP-ribose (OAADPR) with high affinity through its macro domain []. In addition, the macro domain of macroH2A associates with histone deacetylases and affects the acetylation status of nucleosomes. MacroH2A-containing nucleosomes are repressive toward transcription [].
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Publication
18722177 | J:138820
First Author: Kim JH
Year: 2008
Journal: Mol Cell
Title: CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes.
Volume: 31
Issue: 4
Pages: 510-9
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Protein
A0A1W2P6V0
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
A0A1W2P7Q7
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
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Protein Domain
IPR025224 | CCAR1/CCAR2
Type: Family
Description: Cell division cycle and apoptosis regulator protein 1 (CCAR1) associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery. CCAR1 also functions as a p53 coactivator and regulates expression of key proliferation-inducing genes [].Cell cycle and apoptosis regulator protein 2 (CCAR2, also known as DBC-1) regulates biological processes such as transcription, heterochromatin formation, metabolism, mRNA splicing, apoptosis, and cell proliferation []. It is a core component of the DBIRD complex, which affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions []. It binds to SIRT1 and is a negative regulator of SIRT1 []. DBC-1 has been implicated in tumorigenesis [].This entry also includes protein SHORT ROOT IN SALT MEDIUM 1 (RSA1, also known as EMB1579) from Arabidopsis. It regulates the transcription of several genes involved in the detoxification of reactive oxygen species generated by salt stress and the SOS1 gene that encodes a plasma membrane Na(+)/H(+) antiporter essential for salt tolerance []. RSA1 is localised to the nucleus and the loss of function of RSA1 affects global transcription and mRNA splicing [].
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Publication
24463520 | J:205556
First Author: Christophorou MA
Year: 2014
Journal: Nature
Title: Citrullination regulates pluripotency and histone H1 binding to chromatin.
Volume: 507
Issue: 7490
Pages: 104-8
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Publication
22340585 | J:181467
First Author: Ito T
Year: 2012
Journal: Cancer Cell
Title: aSIRTing control over cancer stem cells.
Volume: 21
Issue: 2
Pages: 140-2
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Protein
A9C477
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein Domain
IPR028318 | DYRK1A/B_MNB
Type: Family
Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny [].
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Protein Domain
IPR044131 | PKc_DYR1A/1B
Type: Domain
Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny [].This entry represents the catalytic domain found in DYRK1A and DYRK1B.
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Publication
20123978 | J:161722
First Author: Kurabayashi N
Year: 2010
Journal: Mol Cell Biol
Title: DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.
Volume: 30
Issue: 7
Pages: 1757-68
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Publication
16107708 | -
First Author: Chakravarthy S
Year: 2005
Journal: Mol Cell Biol
Title: Structural characterization of the histone variant macroH2A.
Volume: 25
Issue: 17
Pages: 7616-24
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Publication
11433014 | -
First Author: Chadwick BP
Year: 2001
Journal: Nucleic Acids Res
Title: Histone variant macroH2A contains two distinct macrochromatin domains capable of directing macroH2A to the inactive X chromosome.
Volume: 29
Issue: 13
Pages: 2699-705
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Publication
8769099 | -
First Author: Shindoh N
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21.
Volume: 225
Issue: 1
Pages: 92-9
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Publication
21156027 | -
First Author: Tejedor FJ
Year: 2011
Journal: FEBS J
Title: MNB/DYRK1A as a multiple regulator of neuronal development.
Volume: 278
Issue: 2
Pages: 223-35
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Publication
19685005 | -
First Author: Park J
Year: 2009
Journal: Cell Mol Life Sci
Title: Function and regulation of Dyrk1A: towards understanding Down syndrome.
Volume: 66
Issue: 20
Pages: 3235-40
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Publication
23809146 | -
First Author: Walte A
Year: 2013
Journal: FEBS J
Title: Mechanism of dual specificity kinase activity of DYRK1A.
Volume: 280
Issue: 18
Pages: 4495-511
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Publication
8631952 | -
First Author: Kentrup H
Year: 1996
Journal: J Biol Chem
Title: Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII.
Volume: 271
Issue: 7
Pages: 3488-95
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Publication
22876196 | -
First Author: Hong SH
Year: 2012
Journal: PLoS Genet
Title: Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals.
Volume: 8
Issue: 8
Pages: e1002857
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Publication
7857639 | J:37070
First Author: Tejedor F
Year: 1995
Journal: Neuron
Title: minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila.
Volume: 14
Issue: 2
Pages: 287-301
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Publication
11980910 | -
First Author: Lim S
Year: 2002
Journal: J Biol Chem
Title: Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.
Volume: 277
Issue: 28
Pages: 25040-6
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Publication
14500717 | -
First Author: Zou Y
Year: 2003
Journal: J Biol Chem
Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
Volume: 278
Issue: 49
Pages: 49573-81
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Publication
10910078 | -
First Author: Lee K
Year: 2000
Journal: Cancer Res
Title: Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
Volume: 60
Issue: 13
Pages: 3631-7
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Publication
16783373 | J:245271
First Author: Wang T
Year: 2006
Journal: Nat Struct Mol Biol
Title: Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.
Volume: 13
Issue: 7
Pages: 661-2
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HT Experiment
E-GEOD-49000 | SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Series Id: GSE49000
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
E-GEOD-40511 | MiR-34a is dispensable for normal development but its loss accelerates medulloblastoma formation
Series Id: GSE40511
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
A0A1W2P765
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
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Publication
30782483 | J:291806
First Author: Sun S
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Sirt6 deacetylase activity regulates circadian rhythms via Per2.
Volume: 511
Issue: 2
Pages: 234-238
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Protein
Q8VDP4
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: false
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Publication
9388184 | J:52872
First Author: Chung CD
Year: 1997
Journal: Science
Title: Specific inhibition of Stat3 signal transduction by PIAS3.
Volume: 278
Issue: 5344
Pages: 1803-5
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Publication
11060035 | J:175118
First Author: Rödel B
Year: 2000
Journal: EMBO J
Title: The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.
Volume: 19
Issue: 21
Pages: 5845-55
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Publication
11709556 | -
First Author: Levy C
Year: 2002
Journal: J Biol Chem
Title: A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor.
Volume: 277
Issue: 3
Pages: 1962-6
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Protein
Q3TM95
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
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Publication
25406032 | -
 
First Author: Park JH
Year: 2014
Journal: Nat Commun
Title: Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.
Volume: 5
Pages: 5483
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Publication
24651376 | -
First Author: Sun X
Year: 2014
Journal: PLoS One
Title: Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells.
Volume: 9
Issue: 3
Pages: e92746
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Protein Domain
IPR035796 | Macro_H2A
Type: Domain
Description: MacroH2A is a variant of the major-type core histone H2A which contains an N-terminal H2A domain and a C-terminal nonhistone macro domain. Histone macroH2A is enriched on the inactive X chromosome of mammalian female cells []. It does not bind poly ADP-ribose, but does bind the monomeric SirT1 metabolite O-acetyl-ADP-ribose (OAADPR) with high affinity through its macro domain []. In addition, the macro domain of macroH2A associates with histone deacetylases and affects the acetylation status of nucleosomes. MacroH2A-containing nucleosomes are repressive toward transcription [].The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ADP-ribose as a ligand. Previously identified as displaying an Appr-1"-p (ADP-ribose-1"-monophosphate) processing activity, the macro domain may play roles in distinct ADP-ribose pathways, such as the ADP-ribosylation of proteins, an important post-translational modification which occurs in DNA repair, transcription, chromatin biology, and long-term memory formation, among other processes [].
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Protein Domain
IPR027226 | PIAS3
Type: Family
Description: PIAS3 is an E3-type small ubiquitin-like modifier (SUMO) ligases, stabilising the interaction between UBE2I and Ubc9 respectively and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway [, , , ].PIAS3 sumoylates CCAR2, promoting its interaction with SIRT1 []and diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus [].SUMO proteins are ubiquitin like proteins that are covalently attached to and detached from other proteins in cells to modify their function. SUMO is first activated in an ATP-dependent reaction by formation of a thioester bond with an E1 (SUMO-activating) enzyme and then transferred to the SUMO conjugating (E2) enzyme Ubc9. Ubc9 catalyses the formation of an isopeptide bond between the C-terminal of SUMO and the amino group of lysine in the target protein. Sumoylated proteins can be targeted for different cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability [].
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Publication
24009530 | -
First Author: Guan Q
Year: 2013
Journal: PLoS Genet
Title: A nuclear calcium-sensing pathway is critical for gene regulation and salt stress tolerance in Arabidopsis.
Volume: 9
Issue: 8
Pages: e1003755
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Publication
32692742 | -
First Author: Zhang Y
Year: 2020
Journal: PLoS Biol
Title: Phase separation of Arabidopsis EMB1579 controls transcription, mRNA splicing, and development.
Volume: 18
Issue: 7
Pages: e3000782
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Protein
A9C478
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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Protein
Q80ZK5
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: true
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Publication
19218236 | J:149260
First Author: Li Z
Year: 2009
Journal: J Biol Chem
Title: Inhibition of SUV39H1 methyltransferase activity by DBC1.
Volume: 284
Issue: 16
Pages: 10361-6
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Publication
22274616 | J:181918
First Author: Miki T
Year: 2012
Journal: EMBO J
Title: PML regulates PER2 nuclear localization and circadian function.
Volume: 31
Issue: 6
Pages: 1427-39
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Publication
29765047 | J:262920
First Author: Li TY
Year: 2018
Journal: Nat Commun
Title: Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.
Volume: 9
Issue: 1
Pages: 1916
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Publication
22076378 | J:177830
First Author: Du J
Year: 2011
Journal: Science
Title: Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Volume: 334
Issue: 6057
Pages: 806-9
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Publication
23416070 | J:198161
First Author: von Meyenn F
Year: 2013
Journal: Cell Metab
Title: Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism.
Volume: 17
Issue: 3
Pages: 436-47
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Publication
32935380 | J:297488
First Author: Sun C
Year: 2020
Journal: EMBO J
Title: Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
Volume: 39
Issue: 21
Pages: e103420
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Publication
25490446 | J:217685
First Author: Tiberi L
Year: 2014
Journal: Cancer Cell
Title: A BCL6/BCOR/SIRT1 complex triggers neurogenesis and suppresses medulloblastoma by repressing Sonic Hedgehog signaling.
Volume: 26
Issue: 6
Pages: 797-812
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Publication
34363018 | J:333647
First Author: Yang K
Year: 2022
Journal: Cell Death Differ
Title: Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis.
Volume: 29
Issue: 1
Pages: 133-146
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Publication
16154098 | J:129682
First Author: Kitamura YI
Year: 2005
Journal: Cell Metab
Title: FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Volume: 2
Issue: 3
Pages: 153-63
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