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Search results 1101 to 1200 out of 1243 for Tnnt2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:5588175 | B6;SJL-Tg(Tnnt2-lacZ)497Jl/J
Attribute String: mutant stock, transgenic
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Allele
Tnnt2<tm2.2Ccai> | MGI:5818511
Name: troponin T2, cardiac; targeted mutation 2.2, Chen-Leng Cai
Allele Type: Targeted
Attribute String: Reporter
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Allele
Tg(Myh6-Tnnt2*R92Q)1Lnwd | MGI:3692448
Name: transgene insertion 1, Leslie A Leinwand
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Myh6-Tnnt2*R92Q)2Lnwd | MGI:3692450
Name: transgene insertion 2, Leslie A Leinwand
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Myh6-Tnnt2*R92Q)3Lnwd | MGI:3692451
Name: transgene insertion 3, Leslie A Leinwand
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Myh6-Tnnt2)117Lnwd | MGI:3692598
Name: transgene insertion 117, Leslie A Leinwand
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Myh6-Tnnt2*R92W)1Jcf | MGI:3693250
Name: transgene insertion 1, Jil C Tardiff
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Myh6-Tnnt2*R92L)1Jcf | MGI:3693255
Name: transgene insertion 1, Jil C Tardiff
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Myh6-TNNT2)3Jdp | MGI:3793475
Name: transgene insertion 3, James D Potter
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Myh6-TNNT2*I79N)8Jdp | MGI:3793476
Name: transgene insertion 8, James D Potter
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Myh6-TNNT2*I79N)9Jdp | MGI:3793478
Name: transgene insertion 9, James D Potter
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Myh6-Tnnt2*)1Feah | MGI:3805021
Name: transgene insertion 1, Fehaan Ahmad
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Tnnt2-TNNT2*R92Q)#Ajm | MGI:4819718
Name: transgene insertion, Ali J Marian
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
11171784 | J:162685
First Author: Lim DS
Year: 2001
Journal: Circulation
Title: Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy.
Volume: 103
Issue: 6
Pages: 789-91
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Allele
Tnnt2<tm1(cre/Esr1*)Ccai> | MGI:5818273
Name: troponin T2, cardiac; targeted mutation 1, Chen-Leng Cai
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Recombinase
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Allele
Tnnt2<tm1.1(cre/Esr1*)Ccai> | MGI:5818274
Name: troponin T2, cardiac; targeted mutation 1.1, Chen-Leng Cai
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Recombinase
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Genotype
Genotype
Symbol: Tg(Myh6-TNNT2*R92Q)#Ajm/?
Background: involves: C3H * C57BL/6 * ICR
Zygosity: ot
Has Mutant Allele: true
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Publication
12952925 | J:150560
First Author: Javadpour MM
Year: 2003
Journal: J Clin Invest
Title: Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T.
Volume: 112
Issue: 5
Pages: 768-75
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Publication
21131475 | J:167218
First Author: Jimenez J
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Abnormal heart rate regulation in murine hearts with familial hypertrophic cardiomyopathy-related cardiac troponin T mutations.
Volume: 300
Issue: 2
Pages: H627-35
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Publication
28255011 | J:308140
 
First Author: Coppini R
Year: 2017
Journal: Circ Heart Fail
Title: Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy.
Volume: 10
Issue: 3
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Publication
25541436 | J:308098
 
First Author: Chen Y
Year: 2015
Journal: J Steroid Biochem Mol Biol
Title: 17β-estradiol prevents cardiac diastolic dysfunction by stimulating mitochondrial function: a preclinical study in a mouse model of a human hypertrophic cardiomyopathy mutation.
Volume: 147
Pages: 92-102
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Publication
37064918 | J:345689
 
First Author: Langa P
Year: 2023
Journal: Front Physiol
Title: Altered coronary artery function, arteriogenesis and endothelial YAP signaling in postnatal hypertrophic cardiomyopathy.
Volume: 14
Pages: 1136852
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Publication
15165990 | J:95590
First Author: Stelzer JE
Year: 2004
Journal: Am J Physiol Heart Circ Physiol
Title: Expression of cardiac troponin T with COOH-terminal truncation accelerates cross-bridge interaction kinetics in mouse myocardium.
Volume: 287
Issue: 4
Pages: H1756-61
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Allele
Tg(Myh6-Tnnt2)191Lnwd | MGI:3692603
Name: transgene insertion 191, Leslie A Leinwand
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5908983 | B6.Cg-Tg(Myh6-Tnnt2*R92L)1Jcf
Attribute String: transgenic, mutant strain, congenic
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Publication
22907055 | J:202367
First Author: He H
Year: 2012
Journal: J Physiol
Title: Myosin-driven rescue of contractile reserve and energetics in mouse hearts bearing familial hypertrophic cardiomyopathy-associated mutant troponin T is mutation-specific.
Volume: 590
Issue: 21
Pages: 5371-88
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Publication
27022107 | J:308137
First Author: Gilda JE
Year: 2016
Journal: Mol Cell Proteomics
Title: Delineation of Molecular Pathways Involved in Cardiomyopathies Caused by Troponin T Mutations.
Volume: 15
Issue: 6
Pages: 1962-81
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Publication
19033660 | J:144735
First Author: Baudenbacher F
Year: 2008
Journal: J Clin Invest
Title: Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.
Volume: 118
Issue: 12
Pages: 3893-903
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Strain
MGI:3805464 | 129S.FVB-Tg(Myh6-Tnnt2*)1Feah
Attribute String: congenic, transgenic
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Publication
16487852 | J:308166
First Author: Marian AJ
Year: 2006
Journal: J Am Coll Cardiol
Title: Antifibrotic effects of antioxidant N-acetylcysteine in a mouse model of human hypertrophic cardiomyopathy mutation.
Volume: 47
Issue: 4
Pages: 827-34
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Allele
Tg(Tnnt2-TNNT2*R92Q)M-2Ajm | MGI:4819719
Name: transgene insertion M-2, Ali J Marian
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
18606313 | J:211769
First Author: Juan F
Year: 2008
Journal: Int J Cardiol
Title: The changes of the cardiac structure and function in cTnTR141W transgenic mice.
Volume: 128
Issue: 1
Pages: 83-90
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Publication
22198484 | J:186589
First Author: Zhang L
Year: 2012
Journal: Transgenic Res
Title: Cardioprotection by Hepc1 in cTnT(R141W) transgenic mice.
Volume: 21
Issue: 4
Pages: 867-78
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Publication
21352494 | J:188100
First Author: Zhang W
Year: 2011
Journal: FEBS J
Title: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice.
Volume: 278
Issue: 9
Pages: 1484-92
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Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2)117Lnwd/Tg(Myh6-Tnnt2)117Lnwd
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2)117Lnwd/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2)191Lnwd/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2*)1Feah/?
Background: 129S.FVB-Tg(Myh6-Tnnt2*)1Feah
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Tnnt2-TNNT2*R92Q)#Ajm/?
Background: involves: C3H * C57BL/6 * ICR
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Tnnt2-TNNT2*R92Q)M-2Ajm/?
Background: involves: C3H * C57BL/6 * ICR
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2*R92Q)1Lnwd/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2*R92Q)2Lnwd/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2*R92Q)3Lnwd/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-TNNT2*I79N)8Jdp/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-TNNT2*I79N)9Jdp/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-TNNT2)3Jdp/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2*R92L)1Jcf/?
Background: B6.Cg-Tg(Myh6-Tnnt2*R92L)1Jcf
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2*R92W)1Jcf/?
Background: B6.Cg-Tg(Myh6-Tnnt2*R92W)1Jcf
Zygosity: ot
Has Mutant Allele: true
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Allele
Tg(Tnnt2-rtTA,tetO-cre)1Wtp | MGI:3851371
Name: transgene insertion 1, William T Pu
Allele Type: Transgenic
Attribute String: Inducible, Recombinase, Transactivator
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Publication
26641069 | J:315856
First Author: Lu D
Year: 2016
Journal: Lab Invest
Title: Dkk3 prevents familial dilated cardiomyopathy development through Wnt pathway.
Volume: 96
Issue: 2
Pages: 239-48
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Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2*)1Feah/? Tnnt2/Tnnt2<+>
Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Protein
A0A087WQP1
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Publication
9482583 | -
First Author: Gerull B
Year: 1998
Journal: Hum Mutat
Title: A rapid protocol for cardiac troponin T gene mutation detection in familial hypertrophic cardiomyopathy.
Volume: 11
Issue: 2
Pages: 179-82
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Publication
10952871 | -
First Author: Johnston JJ
Year: 2000
Journal: Am J Hum Genet
Title: A novel nemaline myopathy in the Amish caused by a mutation in troponin T1.
Volume: 67
Issue: 4
Pages: 814-21
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Publication
11034944 | -
First Author: Ho CY
Year: 2000
Journal: Circulation
Title: Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy.
Volume: 102
Issue: 16
Pages: 1950-5
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Protein Domain
IPR027707 | TNNT
Type: Family
Description: The troponin (Tn) complex regulates calcium-induced muscle contraction. Tn contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT), which is required for Ca(2+)-mediated activation of actomyosin ATPase activity [, ]. Three different troponin T genes that encode tissue-specific isoforms of subunit T have been found in mammals and birds, encoding cardiac (TNNT2), slow (TNNT1), and fast (TNNT3) skeletal muscle TnT isoforms [, , , ].Mutations of the TNNT1gene cause nemaline myopathy [], while mutations of the TNNT2 gene cause familial hypertrophic cardiomyopathy [, ], and mutations of the TNNT3 gene cause Arthrogryposis, distal, 2B2 (DA2B2) [].
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Publication
28839205 | J:256565
First Author: Ishizu T
Year: 2017
Journal: Sci Rep
Title: Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes.
Volume: 7
Issue: 1
Pages: 9363
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Publication
36610028 | J:344822
First Author: Morita T
Year: 2023
Journal: FEBS Open Bio
Title: Actin-related protein 5 suppresses the cooperative activation of cardiac gene transcription by myocardin and MEF2.
Volume: 13
Issue: 2
Pages: 363-379
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Publication
32210830 | J:307837
 
First Author: Chowdhury SAK
Year: 2020
Journal: Front Physiol
Title: Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response.
Volume: 11
Pages: 107
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Publication
29155983 | J:284203
First Author: Lu D
Year: 2018
Journal: Cardiovasc Res
Title: Meox1 accelerates myocardial hypertrophic decompensation through Gata4.
Volume: 114
Issue: 2
Pages: 300-311
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Publication
23921644 | J:213466
First Author: Lu D
Year: 2013
Journal: Transgenic Res
Title: WIF1 causes dysfunction of heart in transgenic mice.
Volume: 22
Issue: 6
Pages: 1179-89
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Publication
16214409 | J:308074
First Author: Westermann D
Year: 2006
Journal: Eur J Heart Fail
Title: Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy.
Volume: 8
Issue: 2
Pages: 115-21
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Publication
23532597 | J:213305
First Author: Huke S
Year: 2013
Journal: Circ Res
Title: Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments.
Volume: 112
Issue: 10
Pages: 1334-44
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Publication
12600890 | J:135877
First Author: Knollmann BC
Year: 2003
Journal: Circ Res
Title: Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.
Volume: 92
Issue: 4
Pages: 428-36
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Publication
22647877 | J:212654
First Author: Schober T
Year: 2012
Journal: Circ Res
Title: Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia.
Volume: 111
Issue: 2
Pages: 170-9
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Publication
14993121 | J:162684
First Author: Tsybouleva N
Year: 2004
Journal: Circulation
Title: Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy.
Volume: 109
Issue: 10
Pages: 1284-91
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Protein
Q3TQ90
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
E9PZB4
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
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Protein
A0A087WRX3
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
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Protein
E9PVN9
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Publication
26023924 | J:233556
First Author: Prendiville TW
Year: 2015
Journal: PLoS One
Title: Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase.
Volume: 10
Issue: 5
Pages: e0128105
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Publication
24584570 | J:210662
First Author: Beraldi R
Year: 2014
Journal: Hum Mol Genet
Title: Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy.
Volume: 23
Issue: 14
Pages: 3779-91
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Publication
11685458 | J:72436
First Author: Morroll S
Year: 2001
Journal: Immunogenetics
Title: The genes encoding E-selectin (SELE) and lymphotactin (SCYC1) lie on separate chicken chromosomes although they are closely linked in human and mouse.
Volume: 53
Issue: 6
Pages: 477-82
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Publication
20083571 | J:175886
First Author: Luedde M
Year: 2010
Journal: Cardiovasc Res
Title: Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation.
Volume: 86
Issue: 3
Pages: 452-60
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Publication
32112822 | J:292407
 
First Author: Benitez-Amaro A
Year: 2020
Journal: Metabolism
Title: Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity.
Volume: 106
Pages: 154191
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Publication
29903739 | J:292060
First Author: Boogerd CJ
Year: 2018
Journal: Circ Res
Title: Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.
Volume: 123
Issue: 4
Pages: 428-442
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Publication
12414446 | J:82055
First Author: Lucas DT
Year: 2003
Journal: Am J Physiol Heart Circ Physiol
Title: Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy.
Volume: 284
Issue: 2
Pages: H575-83
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Publication
11600691 | J:133824
First Author: Montgomery DE
Year: 2001
Journal: J Physiol
Title: Cardiac troponin T mutations: correlation between the type of mutation and the nature of myofilament dysfunction in transgenic mice.
Volume: 536
Issue: Pt 2
Pages: 583-92
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Publication
29563334 | J:307897
 
First Author: Vakrou S
Year: 2018
Journal: JCI Insight
Title: Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models.
Volume: 3
Issue: 6
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Publication
31921893 | J:307875
 
First Author: Liu Y
Year: 2019
Journal: Front Cardiovasc Med
Title: Differences in microRNA-29 and Pro-fibrotic Gene Expression in Mouse and Human Hypertrophic Cardiomyopathy.
Volume: 6
Pages: 170
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Publication
34162896 | J:323703
First Author: Vakrou S
Year: 2021
Journal: Sci Rep
Title: Differences in molecular phenotype in mouse and human hypertrophic cardiomyopathy.
Volume: 11
Issue: 1
Pages: 13163
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Publication
30586744 | J:289047
First Author: Lehman SJ
Year: 2019
Journal: Circulation
Title: Chronic Calmodulin-Kinase II Activation Drives Disease Progression in Mutation-Specific Hypertrophic Cardiomyopathy.
Volume: 139
Issue: 12
Pages: 1517-1529
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Publication
9788962 | J:117554
First Author: Oberst L
Year: 1998
Journal: J Clin Invest
Title: Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice.
Volume: 102
Issue: 8
Pages: 1498-505
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Genotype
Genotype
Symbol: Znhit1/Znhit1 Tg(Tnnt2-rtTA,tetO-cre)1Wtp/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tnnt2/Tnnt2<+>
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Publication
35861960 | J:352487
First Author: Pedroza AJ
Year: 2022
Journal: Arterioscler Thromb Vasc Biol
Title: Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm.
Volume: 42
Issue: 9
Pages: 1154-1168
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Protein
P50752
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
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Publication
10095098 | J:53882
First Author: Huang QQ
Year: 1999
Journal: Gene
Title: Genomic sequence and structural organization of mouse slow skeletal muscle troponin T gene.
Volume: 229
Issue: 1-2
Pages: 1-10
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Protein
O88346
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
Q3TH80
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Protein
J3QQ13
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein
B7ZNV4
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
Q9CTJ8
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
J3QPC8
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
E9Q688
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
K3W4R7
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
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Protein
E9QA86
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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•
Protein
A2A6J2
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
•
•
•
•
•
Protein
E9Q0G9
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
•
•
•
•
•
Protein
K3W4R6
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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