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Search results 1101 to 1200 out of 1467 for Wap

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Type Details Score
Publication
First Author: Wagner KU
Year: 2002
Journal: Development
Title: An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal.
Volume: 129
Issue: 6
Pages: 1377-86
Publication
First Author: Frau E
Year: 2007
Journal: Cancer Gene Ther
Title: A gene transfer comparative study of HSA-conjugated antiangiogenic factors in a transgenic mouse model of metastatic ocular cancer.
Volume: 14
Issue: 3
Pages: 251-61
Publication
First Author: Druso JE
Year: 2016
Journal: J Biol Chem
Title: An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland.
Volume: 291
Issue: 17
Pages: 8886-95
Publication  
First Author: Stoelzle T
Year: 2009
Journal: BMC Biol
Title: c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland.
Volume: 7
Pages: 63
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: mutant strain, congenic, transgenic
Strain
Attribute String: mutant strain, transgenic, congenic
Allele
Name: transgene insertion 1, David Salomon
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Jak2/Jak2 Tg(Wap-cre)11738Mam/?
Background: involves: 129X1/SvJ * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: n-TUtca2/n-TUtca2 Tg(Wap-cre)11738Mam/?
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Il6st/Il6st Tg(Wap-cre)11738Mam/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nit1/Nit1 Tg(Wap-cre)11738Mam/?
Background: involves: 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(WapNotch4)10Rnc/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(WapNotch4)10Rnc/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Wap-cre)11738Mam/?
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(Wap-cre)11738Mam/?
Background: 129S2.Cg-Tg(Wap-cre)11738Mam
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Lam MH
Year: 2004
Journal: Cancer Cell
Title: Chk1 is haploinsufficient for multiple functions critical to tumor suppression.
Volume: 6
Issue: 1
Pages: 45-59
Publication
First Author: Simin K
Year: 2004
Journal: PLoS Biol
Title: pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia.
Volume: 2
Issue: 2
Pages: E22
Publication
First Author: Li M
Year: 1996
Journal: Cell Growth Differ
Title: Apoptosis and remodeling of mammary gland tissue during involution proceeds through p53-independent pathways.
Volume: 7
Issue: 1
Pages: 13-20
Publication
First Author: Zhang D
Year: 2004
Journal: Oncogene
Title: Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models.
Volume: 23
Issue: 54
Pages: 8720-30
Publication
First Author: Wintermantel TM
Year: 2005
Journal: Mol Endocrinol
Title: The epithelial glucocorticoid receptor is required for the normal timing of cell proliferation during mammary lobuloalveolar development but is dispensable for milk production.
Volume: 19
Issue: 2
Pages: 340-9
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Publication
First Author: Sanz-Moreno A
Year: 2014
Journal: PLoS One
Title: Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylation.
Volume: 9
Issue: 2
Pages: e89187
Publication
First Author: Peddibhotla S
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.
Volume: 106
Issue: 13
Pages: 5159-64
Publication
First Author: Van Dycke KC
Year: 2015
Journal: Curr Biol
Title: Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice.
Volume: 25
Issue: 14
Pages: 1932-7
Publication
First Author: Weiler S
Year: 2009
Journal: Dev Growth Differ
Title: Mammary epithelial-specific knockout of the ephrin-B2 gene leads to precocious epithelial cell death at lactation.
Volume: 51
Issue: 9
Pages: 809-19
Publication
First Author: Suburu J
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Fatty acid synthase is required for mammary gland development and milk production during lactation.
Volume: 306
Issue: 10
Pages: E1132-43
Publication
First Author: Schilperoort M
Year: 2019
Journal: Sci Rep
Title: Time-restricted feeding improves adaptation to chronically alternating light-dark cycles.
Volume: 9
Issue: 1
Pages: 7874
Strain
Attribute String: coisogenic, mutant strain, transgenic
Publication
First Author: Sun Y
Year: 2005
Journal: Am J Pathol
Title: Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis.
Volume: 167
Issue: 2
Pages: 585-97
Strain
Attribute String: coisogenic, mutant strain, targeted mutation, endonuclease-mediated mutation
Genotype
Symbol: Chek1/Chek1 Tg(Wap-cre)11738Mam/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Chek1/Chek1<+> Tg(Wap-cre)11738Mam/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Stat5b/Stat5b Tg(Wap-cre)11738Mam/?
Background: involves: 129S6/SvEvTac * Black Swiss
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nr3c1/Nr3c1 Tg(Wap-cre)1Gsc/?
Background: involves: 129P2/OlaHsd * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Arnt/Arnt Tg(Wap-cre)11738Mam/?
Background: involves: 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Brca1/Brca1 Tg(Wap-cre)11738Mam/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Wap-cre)11738Mam/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Trp53/Trp53<+> Tg(Wap-cre)11738Mam/?
Background: involves: 129S4/SvJae * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Jak1/Jak1 Tg(Wap-cre)11738Mam/?
Background: involves: 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Zbtb17/Zbtb17 Tg(Wap-cre)11738Mam/?
Background: 129S2.Cg-Zbtb17 Tg(Wap-cre)11738Mam
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Bademci G
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.
Volume: 119
Issue: 26
Pages: e2204084119
Publication
First Author: Andrade AD
Year: 2021
Journal: Biol Reprod
Title: Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice†.
Volume: 104
Issue: 1
Pages: 144-158
Protein
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
Publication
First Author: Cal S
Year: 2002
Journal: Gene
Title: Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
Volume: 283
Issue: 1-2
Pages: 49-62
Publication
First Author: Moreau T
Year: 2008
Journal: Biochimie
Title: Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family.
Volume: 90
Issue: 2
Pages: 284-95
Publication
First Author: Trexler M
Year: 2002
Journal: Biol Chem
Title: Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules.
Volume: 383
Issue: 1
Pages: 223-8
Protein Domain
Type: Domain
Description: The PLAC (protease and lacunin) domain is a six-cysteine region of about 40 residues that is present at or near the C-terminal of various enzymes and matrix proteins, including: mammalian PACE4 (paired basic amino acid cleaving enzyme 4), mammalian PCSK5 (proprotein convertase subtilisin/kexin type 5), mammalian metalloproteinases ADAMTS-2, -3, -10, -12, -14, -16, -17, and -19, and manduca Sexta matrix protein lacunin []. The PLAC domain is often associated with other domains, such as the thrombospondin type I repeat (TSP1) (), the Kunitz proteinase inhibitor domain (), the Ig-like domain (), the WAP domain (), the subtilase domain (), or the ADAM-type metalloprotease domain ().
Protein Domain
Type: Repeat
Description: Trappin-2,a protease inhibitor, has a unique N-terminal domain that enables it to become cross-linked to extracellular matrix proteins by transglutaminase []. This domain contains several repeated motifs (rpresented by this entry) with the consensus sequence Gly-Gln-Asp-Pro-Val-Lys, and these together can anchor the whole molecule to extracellular matrix proteins, such as laminin, fibronectin, beta-crystallin, collagen IV, fibrinogen, and elastin, by transglutaminase-catalysed cross-links. The whole domain is rich in glutamine and lysine, thus allowing and transglutaminase(s) to catalyse the formation of an intermolecular epsilon-(gamma-glutamyl)lysine isopeptide bond []. Cementoin is associated with the WAP family, , at the C terminus.
Protein Domain
Type: Family
Description: WFIKKN proteins are secreted multidomain proteins containing a WAP (whey acidic protein)-, a follistatin/Kazal-, an immunoglobulin-, two Kunitz-type protease inhibitor-domains, and an NTR (netrin) domain. They have been reported to inhibit the activity of trypsin, and to bind GDF11 (growth and differentiation factor 11) and myostatin (GDF8) []. Due to the presence of multiple domains that frequently serve as protease inhibitors, WFIKKN proteins are presumed to control the action of diverse serine proteases as well as metalloproteinases [].In humans, WFIKKN1 expression is observed in pancreas, liver, thymus, kidney, testis and lung and WFIKKN2 (also known as WFIKKNRP) expression is observed in ovary, testis, pancreas, brain and lung [].
Publication
First Author: Andres AC
Year: 1988
Journal: Genes Dev
Title: Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice.
Volume: 2
Issue: 11
Pages: 1486-95
Publication
First Author: Zeng X
Year: 2020
Journal: Exp Mol Med
Title: The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy.
Volume: 52
Issue: 4
Pages: 682-690
Publication
First Author: Paek H
Year: 2012
Journal: Dev Dyn
Title: Increased β-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics.
Volume: 241
Issue: 2
Pages: 242-6
Publication  
First Author: Cao Z
Year: 2022
Journal: Front Mol Neurosci
Title: Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli.
Volume: 15
Pages: 901466
Publication
First Author: Renou JP
Year: 2003
Journal: Oncogene
Title: Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin.
Volume: 22
Issue: 29
Pages: 4594-610
Publication
First Author: Raafat A
Year: 2017
Journal: Sci Rep
Title: The ANK repeats of Notch-4/Int3 activate NF-κB canonical pathway in the absence of Rbpj and causes mammary tumorigenesis.
Volume: 7
Issue: 1
Pages: 13690
Publication
First Author: Wijnhoven SW
Year: 2005
Journal: Cancer Res
Title: Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.
Volume: 65
Issue: 18
Pages: 8166-73
Strain
Attribute String: congenic, targeted mutation, transgenic, mutant strain
Strain
Attribute String: targeted mutation, transgenic, mutant strain
Publication
First Author: Valenti G
Year: 2017
Journal: Cancer Res
Title: Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors.
Volume: 77
Issue: 8
Pages: 2134-2147
Publication
First Author: Dyer LM
Year: 2017
Journal: Breast Cancer Res Treat
Title: ATM is required for SOD2 expression and homeostasis within the mammary gland.
Volume: 166
Issue: 3
Pages: 725-741
Publication
First Author: Li L
Year: 2018
Journal: J Clin Invest
Title: Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.
Volume: 128
Issue: 10
Pages: 4525-4542
Publication
First Author: Zhao L
Year: 2020
Journal: Nat Commun
Title: TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh.
Volume: 11
Issue: 1
Pages: 341
Publication  
First Author: Kassouf T
Year: 2019
Journal: Cancers (Basel)
Title: The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex.
Volume: 11
Issue: 12
Publication
First Author: Field SL
Year: 2024
Journal: PLoS One
Title: Exploring the contribution of mammary-derived serotonin on liver and pancreas metabolism during lactation.
Volume: 19
Issue: 6
Pages: e0304910
Publication  
First Author: Munir J
Year: 2025
Journal: J Nutr Biochem
Title: Tsg101 knockout in the mammary gland leads to a decrease in small extracellular vesicles in milk from C57BL/6J dams and contributes to leakiness of the gut mucosa and reduced postnatal weight gain in suckling pups.
Volume: 135
Pages: 109782
Publication
First Author: Krishnan R
Year: 2023
Journal: Nucleic Acids Res
Title: RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells.
Volume: 51
Issue: 19
Pages: 10484-10505
Publication
First Author: Humphreys RC
Year: 2002
Journal: Endocrinology
Title: Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.
Volume: 143
Issue: 9
Pages: 3641-50
Publication
First Author: Kuwahara K
Year: 2016
Journal: Cancer Sci
Title: GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.
Volume: 107
Issue: 4
Pages: 469-77
Publication  
First Author: Stedile M
Year: 2023
Journal: Front Cell Dev Biol
Title: Tristetraprolin promotes survival of mammary progenitor cells by restraining TNFα levels.
Volume: 11
Pages: 1265475
Publication
First Author: Goddio MV
Year: 2018
Journal: Oncotarget
Title: Expression of the mRNA stability regulator Tristetraprolin is required for lactation maintenance in the mouse mammary gland.
Volume: 9
Issue: 9
Pages: 8278-8289
Publication
First Author: Apostoli AJ
Year: 2014
Journal: Int J Cancer
Title: Loss of PPARγ expression in mammary secretory epithelial cells creates a pro-breast tumorigenic environment.
Volume: 134
Issue: 5
Pages: 1055-66
Publication
First Author: Sternlicht MD
Year: 1999
Journal: Cell
Title: The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis.
Volume: 98
Issue: 2
Pages: 137-46
Publication
First Author: Alexander CM
Year: 1996
Journal: J Cell Biol
Title: Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene.
Volume: 135
Issue: 6 Pt 1
Pages: 1669-77
Publication
First Author: Dorward AM
Year: 2005
Journal: Br J Cancer
Title: Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation.
Volume: 93
Issue: 10
Pages: 1137-43
Genotype
Symbol: Erbb4/Erbb4 Tg(Wap-cre)11738Mam/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Stat5a/Stat5a Stat5b/Stat5b Tg(Wap-cre)11738Mam/?
Background: involves: 129S6/SvEvTac * Black Swiss
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tsg101/Tsg101 Tg(Wap-cre)11738Mam/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Brca1/Brca1 Tg(Wap-cre)11738Mam/?
Background: involves: 129S6/SvEvTac * Black Swiss
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Itgb1/Itgb1 Tg(Wap-cre)1Gsc/?
Background: involves: 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tsg101/Tsg101 Tg(Wap-cre)11738Mam/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnna1/Ctnna1 Tg(Wap-cre)11738Mam/?
Background: involves: 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Pparg/Pparg Tg(Wap-cre)11738Mam/?
Background: involves: 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Bin1/Bin1<+> Tg(Wap-cre)11738Mam/?
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Brca1/Brca1 Chek2/Chek2 Tg(Wap-cre)11738Mam/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Esr1/Esr1 Tg(Wap-cre)11738Mam/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Wap-cre)11738Mam/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Wap-cre)11738Mam/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Stat1/Stat1 Tg(Wap-cre)11738Mam/?
Background: involves: 129S/SvEv * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Wap-cre)1Gsc/?
Background: involves: BALB/c * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Phb2/Phb2<+> Tg(Wap-cre)11738Mam/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Phb2/Phb2 Tg(Wap-cre)11738Mam/?
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnnb1/Ctnnb1<+> Tg(Wap-cre)11738Mam/?
Background: FVB.Cg-Ctnnb1 Tg(Wap-cre)11738Mam
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnnb1/Ctnnb1<+> Tg(Wap-cre)11738Mam/? Tg(Wap-Hgf)402Mig/?
Background: FVB.Cg-Ctnnb1 Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Pten/Pten Tg(Wap-cre)11738Mam/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nfib/Nfib Tg(Wap-cre)11738Mam/?
Background: involves: 129S4/SvJae * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Wu Y
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Wdnm1-like, a new adipokine with a role in MMP-2 activation.
Volume: 295
Issue: 1
Pages: E205-15
Publication
First Author: Rowan S
Year: 2004
Journal: Development
Title: Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10.
Volume: 131
Issue: 20
Pages: 5139-52
Publication
First Author: Zhou Y
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye.
Volume: 110
Issue: 22
Pages: 8966-71