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Search results 1201 to 1300 out of 1430 for Cck

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Type Details Score
Publication
22514301 | J:184447
First Author: Hu J
Year: 2012
Journal: J Neurosci
Title: c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.
Volume: 32
Issue: 16
Pages: 5362-73
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Publication
20883684 | J:167091
First Author: Nyeng P
Year: 2011
Journal: Dev Biol
Title: Fibroblast growth factor 10 represses premature cell differentiation during establishment of the intestinal progenitor niche.
Volume: 349
Issue: 1
Pages: 20-34
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Publication
33238113 | J:298882
First Author: Roome RB
Year: 2020
Journal: Cell Rep
Title: Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans.
Volume: 33
Issue: 8
Pages: 108425
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Publication
10615124 | J:59312
First Author: Jensen J
Year: 2000
Journal: Nat Genet
Title: Control of endodermal endocrine development by Hes-1.
Volume: 24
Issue: 1
Pages: 36-44
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Publication
28228269 | J:247473
First Author: Martersteck EM
Year: 2017
Journal: Cell Rep
Title: Diverse Central Projection Patterns of Retinal Ganglion Cells.
Volume: 18
Issue: 8
Pages: 2058-2072
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Publication
26743624 | J:229471
First Author: Branchfield K
Year: 2016
Journal: Science
Title: Pulmonary neuroendocrine cells function as airway sensors to control lung immune response.
Volume: 351
Issue: 6274
Pages: 707-10
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Publication
24929016 | J:214986
First Author: Walker EM
Year: 2014
Journal: Dev Biol
Title: GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development.
Volume: 392
Issue: 2
Pages: 283-94
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Publication
34004146 | J:314776
First Author: Yao Z
Year: 2021
Journal: Cell
Title: A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation.
Volume: 184
Issue: 12
Pages: 3222-3241.e26
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Publication
1302014 | J:1064
First Author: Wilkie TM
Year: 1992
Journal: Nat Genet
Title: Evolution of the mammalian G protein alpha subunit multigene family.
Volume: 1
Issue: 2
Pages: 85-91
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Publication
29043563 | J:284637
First Author: Cuoco JA
Year: 2018
Journal: Cerebellum
Title: Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background.
Volume: 17
Issue: 2
Pages: 173-190
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Publication
25071457 | J:220523
 
First Author: Harris JA
Year: 2014
Journal: Front Neural Circuits
Title: Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation.
Volume: 8
Pages: 76
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Publication
36774552 | J:337820
First Author: Wang Q
Year: 2023
Journal: Cell Rep
Title: Regional and cell-type-specific afferent and efferent projections of the mouse claustrum.
Volume: 42
Issue: 2
Pages: 112118
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Publication
32386544 | J:347445
First Author: Wang Q
Year: 2020
Journal: Cell
Title: The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas.
Volume: 181
Issue: 4
Pages: 936-953.e20
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Publication
11208732 | J:66998
First Author: Lammert F
Year: 2001
Journal: Gastroenterology
Title: Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.
Volume: 120
Issue: 1
Pages: 221-38
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Publication
16987237 | J:119559
First Author: Bouwman J
Year: 2006
Journal: J Neurochem
Title: Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.
Volume: 99
Issue: 1
Pages: 84-96
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Publication
37298722 | J:336866
 
First Author: Puelles L
Year: 2023
Journal: Int J Mol Sci
Title: The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer.
Volume: 24
Issue: 11
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Publication
17953485 | J:127119
First Author: Visel A
Year: 2007
Journal: PLoS Genet
Title: Regulatory pathway analysis by high-throughput in situ hybridization.
Volume: 3
Issue: 10
Pages: 1867-83
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Publication
23431145 | J:196080
First Author: Elsen GE
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.
Volume: 110
Issue: 10
Pages: 4081-6
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Publication
- | J:101679
     
First Author: Deltagen Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Deltagen, Inc. mice into public repositories
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Publication
21862448 | J:198109
First Author: Oeschger FM
Year: 2012
Journal: Cereb Cortex
Title: Gene expression analysis of the embryonic subplate.
Volume: 22
Issue: 6
Pages: 1343-59
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
9575840 | J:47142
First Author: Wank SA
Year: 1998
Journal: Am J Physiol
Title: G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family.
Volume: 274
Issue: 4 Pt 1
Pages: G607-13
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Publication
25160855 | J:266537
 
First Author: Zhao CM
Year: 2014
Journal: Regul Pept
Title: Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors.
Volume: 192-193
Pages: 35-44
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Publication
23203156 | J:194676
First Author: Daly K
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion.
Volume: 304
Issue: 3
Pages: G271-82
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Publication
30052197 | J:316367
   
First Author: Hartzell AL
Year: 2018
Journal: Elife
Title: NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus.
Volume: 7
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GO Term
GO:0038188 | cholecystokinin signaling pathway
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Publication
10221600 | J:53742
First Author: Wang W
Year: 1998
Journal: Endocrine
Title: Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK: identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain.
Volume: 9
Issue: 3
Pages: 329-32
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Publication
12816741 | J:109372
First Author: Chi MM
Year: 2003
Journal: Am J Physiol Regul Integr Comp Physiol
Title: c-Kit mutant mouse behavioral phenotype: altered meal patterns and CCK sensitivity but normal daily food intake and body weight.
Volume: 285
Issue: 5
Pages: R1170-83
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Publication
2812281 | J:26005
First Author: Hendrie CA
Year: 1989
Journal: Neuropharmacology
Title: Differential effects of the CCK antagonist, MK-329, on analgesia induced by morphine, social conflict (opioid) and defeat experience (non-opioid) in male mice.
Volume: 28
Issue: 10
Pages: 1025-32
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HT Experiment
E-MTAB-2824 | Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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GXD Expression
GXD Expression
Probe: MGI:3529591
Assay Type: In situ reporter (knock in)
Annotation Date: 2020-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691626
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6451626
Age: embryonic day 18.5
Image: 5B2/B3
Note: Expression overlapping with Cck in same region within dorsolateral rostral hindbrain.
Specimen Label: 5B2/B3
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
Probe: MGI:3529591
Assay Type: In situ reporter (knock in)
Annotation Date: 2020-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691626
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6451626
Age: embryonic day 18.5
Image: 5B3 inset
Note: Expression overlapping with Cck in same region within dorsolateral rostral hindbrain.
Specimen Label: 5B3 inset
Detected: true
Specimen Num: 16
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Publication
15056274 | J:108016
First Author: Cain BM
Year: 2004
Journal: J Neurochem
Title: Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain.
Volume: 89
Issue: 2
Pages: 307-13
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Allele
Cck<em2(icre)Smoc> | MGI:7288692
Name: cholecystokinin; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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Publication
16738800 | -
First Author: Harro J
Year: 2006
Journal: Amino Acids
Title: CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies.
Volume: 31
Issue: 3
Pages: 215-30
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Strain
MGI:6428311 | C57BL/6JSmoc-Cck<em2(icre)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Cck<em1Smoc> | MGI:7288691
Name: cholecystokinin; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Protein Coding Gene
MGI:1891456 | Ripk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31281260 | J:327773
 
First Author: Argueta DA
Year: 2019
Journal: Front Physiol
Title: Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity.
Volume: 10
Pages: 704
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Allele
Tg(Cck-EGFP)2Mirn | MGI:5703921
Name: transgene insertion 2, Karoly Mirnics
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:7717976 | C57BL/6JSmoc-Cck<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(Cck-cre)CKres | MGI:4438218
Name: transgene insertion C, Kerry J Ressler
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Cck-cre,-lacZ)1Mini | MGI:5574585
Name: transgene insertion 1, Liliana Minichiello
Allele Type: Transgenic
Attribute String: Recombinase, Reporter
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Allele
Tg(Cck-cre)BKres | MGI:5571926
Name: transgene insertion B, Kerry J Ressler
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:5703926 | C57BL/6-Tg(Cck-EGFP)2Mirn/J
Attribute String: coisogenic, mutant strain, transgenic
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Publication
39529694 | J:358438
 
First Author: Eftychidis V
Year: 2024
Journal: Front Cell Neurosci
Title: Cholecystokinin-expressing neurons of the ventromedial hypothalamic nucleus control energy homeostasis.
Volume: 18
Pages: 1483368
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Publication
17235291 | J:154361
First Author: Chhatwal JP
Year: 2007
Journal: Gene Ther
Title: Identification of cell-type-specific promoters within the brain using lentiviral vectors.
Volume: 14
Issue: 7
Pages: 575-83
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Publication
29740596 | J:263284
 
First Author: Kotzadimitriou D
Year: 2018
Journal: eNeuro
Title: Neuregulin 1 Type I Overexpression Is Associated with Reduced NMDA Receptor-Mediated Synaptic Signaling in Hippocampal Interneurons Expressing PV or CCK.
Volume: 5
Issue: 2
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Publication
3778455 | -
First Author: Nachman RJ
Year: 1986
Journal: Biochem Biophys Res Commun
Title: Leucosulfakinin-II, a blocked sulfated insect neuropeptide with homology to cholecystokinin and gastrin.
Volume: 140
Issue: 1
Pages: 357-64
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Publication
3743781 | -
First Author: Dimaline R
Year: 1986
Journal: FEBS Lett
Title: Isolation from chicken antrum, and primary amino acid sequence of a novel 36-residue peptide of the gastrin/CCK family.
Volume: 205
Issue: 2
Pages: 318-22
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Publication
3753978 | -
First Author: Richter K
Year: 1986
Journal: J Biol Chem
Title: Sequence of preprocaerulein cDNAs cloned from skin of Xenopus laevis. A small family of precursors containing one, three, or four copies of the final product.
Volume: 261
Issue: 8
Pages: 3676-80
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Publication
2842322 | -
First Author: Nichols R
Year: 1988
Journal: J Biol Chem
Title: Identification and characterization of a Drosophila homologue to the vertebrate neuropeptide cholecystokinin.
Volume: 263
Issue: 25
Pages: 12167-70
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Publication
2303439 | -
First Author: Johnsen AH
Year: 1990
Journal: J Biol Chem
Title: Cionin: a disulfotyrosyl hybrid of cholecystokinin and gastrin from the neural ganglion of the protochordate Ciona intestinalis.
Volume: 265
Issue: 6
Pages: 3054-8
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Publication
3749893 | -
First Author: Nachman RJ
Year: 1986
Journal: Science
Title: Leucosulfakinin, a sulfated insect neuropeptide with homology to gastrin and cholecystokinin.
Volume: 234
Issue: 4772
Pages: 71-3
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Protein Domain
IPR013152 | Gastrin/cholecystokinin_CS
Type: Conserved_site
Description: Gastrin and cholecystokinin (CCK) are structurally and functionally related peptide hormones that function as hormonal regulators of various digestive processes and feeding behaviours. They are known to induce gastric secretion, stimulate pancreatic secretion, increase blood circulation and water secretion in the stomach and intestine, and stimulate smooth muscle contraction. Originally found in the gut, these hormones have since been shown to be present in various parts of the nervous system. Like many other active peptides they are synthesized as larger protein precursors that are enzymatically converted to their mature forms. They are found in several molecular forms due to tissue-specific post-translational processing. A number of other peptides are known to belong to the same family: Caerulein, an amphibian skin peptide, with a biological activity similar to that of CCK or gastrin. There are different types of caerulein []in which a single or up to four copies of the peptide are present. Leukosulfakinin I and II (LSK) [, ]are peptides, isolated from cockroach, that change the frequency and amplitude of contractions of the hindgut. Drosulfakinins I and II []are putative CCK-homologues from Drosophila. Those two peptides are part of a precursor sequence that was isolated using a probe based on the sequence of CCK and LSK. A chicken antrum peptide []which is a potent stimulus of avian gastric acid but not of pancreatic secretion. Cionin [], a neuropeptide from the protochordate Ciona intestinalis (Transparent sea squirt). The biological activity of gastrin and CCK is associated with the last five C-terminal residues. One or two positions downstream, there is a conserved sulphated tyrosine residue.
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Strain
MGI:4457100 | C57BL/6-Tg(Cck-cre)CKres/J
Attribute String: coisogenic, mutant strain, transgenic
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Publication
38438258 | J:354355
 
First Author: Bratsch-Prince JX
Year: 2024
Journal: J Neurosci
Title: Acetylcholine Engages Distinct Amygdala Microcircuits to Gate Internal Theta Rhythm.
Volume: 44
Issue: 17
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Protein Domain
IPR000596 | Cholcy_rcpt_A
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Cholecystokinins (CCKs) and gastrins are naturally-occurring peptides that share a common C-terminal sequence, GWMDF; full biological activity resides in this region. In the periphery, the principal physiological actions of CCK include gall bladder contraction, pancreatic enzyme secretion and regulation of secretion/absorption in the gastrointestinal tract. In the CNS, CCK induces analgesia, satiety and a decrease in exploratory behaviour. In mesolimbic andmesocortical neurons, CCK coexists with dopamine. It is found throughout the digestive tract, with high concentrations in the duodenum and jejunum. It is also found in peripheral nerves to other smooth muscles and to secretory glands, and is one of the most abundant peptides in the brain. The highest levels of the CCKA receptor are found in peripheral tissues, notably the pancreas, stomach, intestine and gall bladder. It has only a limited distribution in the brain. The receptor has been implicated in the pathogenesis of schizophrenia, Parkinson's disease, drug addiction and feeding disorders.
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Genotype
Genotype
Symbol: Bdnf/Bdnf Tg(Cck-cre)CKres/?
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ntrk2/Ntrk2 Tg(Cck-cre,-lacZ)1Mini/?
Background: involves: 129S2/SvPas * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cck-cre,-lacZ)1Mini/?
Background: involves: 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ntrk2/Ntrk2 Tg(Cck-cre,-lacZ)1Mini/?
Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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