Type |
Details |
Score |
Protein Domain |
Type: |
Family |
Description: |
This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation [, ]. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion []. |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
603
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
539
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
603
 |
Fragment?: |
false |
|
•
•
•
•
•
|
CL Term |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
503
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
150
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
178
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
503
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
465
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Podocalyxin-like protein 2 (PODXL2), also known as Endoglycan, is a ligand for the vascular selectins []. It belongs to the CD34 family, whose members contain an N-terminal acidic region appended to the sialomucin domain []. |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Daniel G Tenen |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence, Transactivator |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion MF6, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 29, Daniel G Tenen |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(CD34-tTA,-CD34)1Dgt/? |
Background: |
involves: FVB/N |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Bernitz JM |
Year: |
2016 |
Journal: |
Cell |
Title: |
Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions. |
Volume: |
167 |
Issue: |
5 |
Pages: |
1296-1309.e10 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(CD34)29Dgt/? |
Background: |
involves: FVB/N |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Pereira CF |
Year: |
2016 |
Journal: |
Dev Cell |
Title: |
Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells. |
Volume: |
36 |
Issue: |
5 |
Pages: |
525-39 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
CL Term |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Strasser A |
Year: |
1993 |
Journal: |
Oncogene |
Title: |
E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells. |
Volume: |
8 |
Issue: |
1 |
Pages: |
1-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao MA |
Year: |
2000 |
Journal: |
Leukemia |
Title: |
CD34: to select or not to select? That is the question. |
Volume: |
14 |
Issue: |
5 |
Pages: |
773-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
le Viseur C |
Year: |
2008 |
Journal: |
Cancer Cell |
Title: |
In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. |
Volume: |
14 |
Issue: |
1 |
Pages: |
47-58 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE68725 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE68724 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE68723 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-68958 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-76974 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Girousse A |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
The Release of Adipose Stromal Cells from Subcutaneous Adipose Tissue Regulates Ectopic Intramuscular Adipocyte Deposition. |
Volume: |
27 |
Issue: |
2 |
Pages: |
323-333.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bistrup A |
Year: |
1999 |
Journal: |
J Cell Biol |
Title: |
Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. |
Volume: |
145 |
Issue: |
4 |
Pages: |
899-910 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buffolo M |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling. |
Volume: |
29 |
Issue: |
2 |
Pages: |
270-282.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boitano AE |
Year: |
2010 |
Journal: |
Science |
Title: |
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. |
Volume: |
329 |
Issue: |
5997 |
Pages: |
1345-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Freitas I |
Year: |
2003 |
Journal: |
Anticancer Res |
Title: |
Stem cell recruitment and liver de-differentiation in MMTV-neu (ErbB-2) transgenic mice. |
Volume: |
23 |
Issue: |
5A |
Pages: |
3783-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jia Q |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
miR-17-92 promotes leukemogenesis in chronic myeloid leukemia via targeting A20 and activation of NF-κB signaling. |
Volume: |
487 |
Issue: |
4 |
Pages: |
868-874 |
|
•
•
•
•
•
|
Publication |
First Author: |
Law S |
Year: |
2001 |
Journal: |
Immunol Lett |
Title: |
Facilitation of functional compartmentalization of bone marrow cells in leukemic mice by biological response modifiers: an immunotherapeutic approach. |
Volume: |
76 |
Issue: |
3 |
Pages: |
145-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ottersbach K |
Year: |
2005 |
Journal: |
Dev Cell |
Title: |
The murine placenta contains hematopoietic stem cells within the vascular labyrinth region. |
Volume: |
8 |
Issue: |
3 |
Pages: |
377-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jensen UB |
Year: |
2008 |
Journal: |
J Cell Sci |
Title: |
A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus. |
Volume: |
121 |
Issue: |
Pt 5 |
Pages: |
609-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
McKinney-Freeman SL |
Year: |
2009 |
Journal: |
Blood |
Title: |
Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells. |
Volume: |
114 |
Issue: |
2 |
Pages: |
268-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santini MP |
Year: |
2011 |
Journal: |
Biochem Biophys Res Commun |
Title: |
IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines. |
Volume: |
410 |
Issue: |
2 |
Pages: |
201-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang H |
Year: |
2014 |
Journal: |
Stem Cells |
Title: |
Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. |
Volume: |
32 |
Issue: |
1 |
Pages: |
191-203 |
|
•
•
•
•
•
|
Publication |
First Author: |
GarcÃa-Prat L |
Year: |
2020 |
Journal: |
Nat Cell Biol |
Title: |
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age. |
Volume: |
22 |
Issue: |
11 |
Pages: |
1307-1318 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang B |
Year: |
2017 |
Journal: |
J Cell Mol Med |
Title: |
Telocytes: a potential defender in the spleen of Npc1 mutant mice. |
Volume: |
21 |
Issue: |
5 |
Pages: |
848-859 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ming M |
Year: |
2014 |
Journal: |
Exp Dermatol |
Title: |
Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin. |
Volume: |
23 |
Issue: |
3 |
Pages: |
207-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sastourné-Arrey Q |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury. |
Volume: |
14 |
Issue: |
1 |
Pages: |
80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou Y |
Year: |
2012 |
Journal: |
Am J Pathol |
Title: |
Gsdma3 mutation causes bulge stem cell depletion and alopecia mediated by skin inflammation. |
Volume: |
180 |
Issue: |
2 |
Pages: |
763-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seo W |
Year: |
2009 |
Journal: |
Blood |
Title: |
CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis. |
Volume: |
114 |
Issue: |
17 |
Pages: |
3567-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishimura S |
Year: |
2007 |
Journal: |
Diabetes |
Title: |
Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. |
Volume: |
56 |
Issue: |
6 |
Pages: |
1517-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stepniewski J |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
Induced pluripotent stem cells as a model for diabetes investigation. |
Volume: |
5 |
|
Pages: |
8597 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masum MA |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis. |
Volume: |
8 |
Issue: |
1 |
Pages: |
10276 |
|
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•
•
•
•
|
Publication |
First Author: |
Arthur A |
Year: |
2016 |
Journal: |
Stem Cells |
Title: |
Twist-1 Enhances Bone Marrow Mesenchymal Stromal Cell Support of Hematopoiesis by Modulating CXCL12 Expression. |
Volume: |
34 |
Issue: |
2 |
Pages: |
504-9 |
|
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•
•
•
•
|
Publication |
First Author: |
Ito R |
Year: |
2020 |
Journal: |
Int Immunol |
Title: |
Bovine β-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-3/hGM-CSF transgenic mice. |
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•
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•
•
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Publication |
First Author: |
Shi Y |
Year: |
2005 |
Journal: |
Am J Pathol |
Title: |
CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue. |
Volume: |
166 |
Issue: |
1 |
Pages: |
303-12 |
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•
•
•
•
|
Publication |
First Author: |
RodrÃguez Mdel C |
Year: |
2004 |
Journal: |
Blood |
Title: |
Interleukin-6 deficiency affects bone marrow stromal precursors, resulting in defective hematopoietic support. |
Volume: |
103 |
Issue: |
9 |
Pages: |
3349-54 |
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•
•
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•
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Publication |
First Author: |
Thom SR |
Year: |
2006 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Stem cell mobilization by hyperbaric oxygen. |
Volume: |
290 |
Issue: |
4 |
Pages: |
H1378-86 |
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•
•
•
•
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Publication |
First Author: |
Schober M |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling. |
Volume: |
108 |
Issue: |
26 |
Pages: |
10544-9 |
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•
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•
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Publication |
First Author: |
Diao Y |
Year: |
2016 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Effects of Long-Term Type I Interferon on the Arterial Wall and Smooth Muscle Progenitor Cells Differentiation. |
Volume: |
36 |
Issue: |
2 |
Pages: |
266-73 |
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•
•
•
•
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Publication |
First Author: |
Xu J |
Year: |
2011 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis. |
Volume: |
301 |
Issue: |
2 |
Pages: |
H538-47 |
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•
•
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•
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Publication |
First Author: |
Liang X |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking Ctip2 in epidermis. |
Volume: |
7 |
Issue: |
2 |
Pages: |
e29999 |
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Publication |
First Author: |
Carragher D |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
A stroma-derived defect in NF-kappaB2-/- mice causes impaired lymph node development and lymphocyte recruitment. |
Volume: |
173 |
Issue: |
4 |
Pages: |
2271-9 |
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Publication |
First Author: |
Sakai N |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis. |
Volume: |
103 |
Issue: |
38 |
Pages: |
14098-103 |
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Publication |
First Author: |
Becker L |
Year: |
2012 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Divergent fate and origin of neurosphere-like bodies from different layers of the gut. |
Volume: |
302 |
Issue: |
9 |
Pages: |
G958-65 |
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Publication |
First Author: |
Cool SM |
Year: |
2005 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Role of growth hormone receptor signaling in osteogenesis from murine bone marrow progenitor cells. |
Volume: |
338 |
Issue: |
2 |
Pages: |
1048-58 |
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Publication |
First Author: |
Nowakowski A |
Year: |
2010 |
Journal: |
Mol Cell Neurosci |
Title: |
Ventricular enlargement associated with the panneural ablation of the podocalyxin gene. |
Volume: |
43 |
Issue: |
1 |
Pages: |
90-7 |
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Publication |
First Author: |
Sur I |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis. |
Volume: |
119 |
Issue: |
Pt 17 |
Pages: |
3593-601 |
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Publication |
First Author: |
Patel J |
Year: |
2018 |
Journal: |
J Invest Dermatol |
Title: |
Accelerated Endothelial to Mesenchymal Transition Increased Fibrosis via Deleting Notch Signaling in Wound Vasculature. |
Volume: |
138 |
Issue: |
5 |
Pages: |
1166-1175 |
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Publication |
First Author: |
Rao D |
Year: |
2015 |
Journal: |
Mol Carcinog |
Title: |
Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. |
Volume: |
54 |
Issue: |
2 |
Pages: |
121-33 |
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Publication |
First Author: |
Pericacho M |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Diminished thrombogenic responses by deletion of the Podocalyxin Gene in mouse megakaryocytes. |
Volume: |
6 |
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10 |
Pages: |
e26025 |
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Publication |
First Author: |
Fei Z |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. |
Volume: |
286 |
Issue: |
31 |
Pages: |
27761-8 |
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Publication |
First Author: |
Heliövaara E |
Year: |
2009 |
Journal: |
Am J Pathol |
Title: |
The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas. |
Volume: |
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2501-7 |
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Publication |
First Author: |
Jiang N |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Hematopoietic Stem Cells in Neural-crest Derived Bone Marrow. |
Volume: |
6 |
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Pages: |
36411 |
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•
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Publication |
First Author: |
Bosnakovski D |
Year: |
2008 |
Journal: |
Stem Cells |
Title: |
Prospective isolation of skeletal muscle stem cells with a Pax7 reporter. |
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26 |
Issue: |
12 |
Pages: |
3194-204 |
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Publication |
First Author: |
Pillebout E |
Year: |
2001 |
Journal: |
Am J Pathol |
Title: |
Proliferation and remodeling of the peritubular microcirculation after nephron reduction: association with the progression of renal lesions. |
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159 |
Issue: |
2 |
Pages: |
547-60 |
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•
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Publication |
First Author: |
Elefanty AG |
Year: |
1997 |
Journal: |
Blood |
Title: |
Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells. |
Volume: |
90 |
Issue: |
4 |
Pages: |
1435-47 |
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•
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Publication |
First Author: |
Deutsch D |
Year: |
2006 |
Journal: |
Eur J Oral Sci |
Title: |
Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system. |
Volume: |
114 Suppl 1 |
|
Pages: |
183-9; discussion 201-2, 381 |
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Publication |
First Author: |
Miglarese MR |
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J Biol Chem |
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Differential regulation of c-Myb-induced transcription activation by a phosphorylation site in the negative regulatory domain. |
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Publication |
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Yamaguchia Y |
Year: |
1997 |
Journal: |
Biochim Biophys Acta |
Title: |
Functional characterization of the promoter for the gene encoding murine CD34. |
Volume: |
1350 |
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2 |
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Publication |
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Year: |
2004 |
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J Immunol |
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Kinetics of in vivo elimination of suicide gene-expressing T cells affects engraftment, graft-versus-host disease, and graft-versus-leukemia after allogeneic bone marrow transplantation. |
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Exp Cell Res |
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Dev Biol |
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J Cell Physiol |
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PLoS Genet |
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Mol Cell Proteomics |
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