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Search results 1201 to 1300 out of 3906 for Cd40

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Type Details Score
Publication
First Author: Nguyen LT
Year: 1999
Journal: Immunity
Title: TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.
Volume: 11
Issue: 3
Pages: 379-89
Publication
First Author: Ichikawa D
Year: 2006
Journal: Biochem Biophys Res Commun
Title: TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: involvement of reactive oxygen species.
Volume: 351
Issue: 1
Pages: 93-8
Publication
First Author: Ito S
Year: 2002
Journal: J Biol Chem
Title: Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution.
Volume: 277
Issue: 8
Pages: 6631-6
Protein
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
Publication
First Author: Cha SS
Year: 1998
Journal: J Biol Chem
Title: High resolution crystal structure of a human tumor necrosis factor-alpha mutant with low systemic toxicity.
Volume: 273
Issue: 4
Pages: 2153-60
Publication
First Author: Hymowitz SG
Year: 2000
Journal: Biochemistry
Title: A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.
Volume: 39
Issue: 4
Pages: 633-40
Publication
First Author: Oren DA
Year: 2002
Journal: Nat Struct Biol
Title: Structural basis of BLyS receptor recognition.
Volume: 9
Issue: 4
Pages: 288-92
Publication
First Author: Bogin O
Year: 2002
Journal: Structure
Title: Insight into Schmid metaphyseal chondrodysplasia from the crystal structure of the collagen X NC1 domain trimer.
Volume: 10
Issue: 2
Pages: 165-73
Publication
First Author: Min X
Year: 2012
Journal: FEBS Lett
Title: Crystal structure of a single-chain trimer of human adiponectin globular domain.
Volume: 586
Issue: 6
Pages: 912-7
Publication
First Author: Pan W
Year: 2013
Journal: Ir J Med Sci
Title: Peripheral blood CD40-CD40L expression in human breast cancer.
Volume: 182
Issue: 4
Pages: 719-21
Protein Domain
Type: Domain
Description: Tumor necrosis factor receptor superfamily member 5 (TNFRSF5), commonly known as CD40 and also as CDW40, p50 or Bp50, is widely expressed in diverse cell types including B lymphocytes, dendritic cells, platelets, monocytes, endothelial cells, and fibroblasts []. It is essential in mediating a wide variety of immune and inflammatory responses, including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal centre formation [, , , ]. Its natural immunomodulating ligand is CD40L, and a primary defect in the CD40/CD40L system is associated with X-linked hyper-IgM (XHIM) syndrome []. It is also involved in tumorigenesis; CD40 expression is significantly higher in gastric carcinomas and it is associated with the lymphatic metastasis of cancer cells and their tumor node metastasis (TNM) classification []. Upregulated levels of CD40/CD40L on B cells and T cells may play an important role in the immune pathogenesis of breast cancer []. Consequently, the CD40/CD40L system serves as a link between tumorigenesis, atherosclerosis, and the immune system, and offers a potential target for drug therapy for related diseases, such as cancer, atherosclerosis, diabetes mellitus, and immunological rejection [].This entry represents the N-terminal domain of TNFRSF5. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].
Protein Domain
Type: Homologous_superfamily
Description: The tumour necrosis factor (TNF)-like domains are found in both TNF and C1q protein families. Structurally these domains self-associate to make a compact bell-shaped homotrimer, each monomer being composed of an anti-parallel β-sheet sandwich with a jellyroll topology. Both TNF and C1q family members can be expressed as soluble plasma proteins or as type II membrane-bound proteins.TNF family members bind extracellularly to cysteine-rich receptors, thereby inducing a clustering of the receptors, which subsequently triggers the intracellular apoptotic cascade. The TNF proteins are important mediators in inflammation, immune responses and cytotoxicity through their interaction with the TNF-R55 and the TNF-R75 cell-surface receptors []. Other TNF family members include the CD40 ligand (C-terminal TNF-like domain) which is involved in the immune response via the CD40 receptor []; TRAIL, which selectively induces apoptosis in tumour cells via DR4 and DR5 receptors []; the RANK ligand (TNFSF11), which triggers osteoclastogenesis via the RANK receptor []; and TALL-1 (soluble domain), which is involved in the immune response via the TACI, BCMA, and BAFF-R receptors [].C1q proteins also contain TNF-like domains. C1q family members include the Adiponectin/ACRP30 (C-terminal TNF-like domain), which regulates metabolism and energy homeostasis [], and NC1 (non-collagenous domain 1), the C-terminal TNF-like domain of collagen X, which is crucial for collagen X assembly in bone tissue [].
Publication
First Author: Gardam S
Year: 2011
Journal: Blood
Title: Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.
Volume: 117
Issue: 15
Pages: 4041-51
Publication    
First Author: Whillock AL
Year: 2021
Journal: J Biol Chem
Title: TNF receptor-associated factor 3 restrains B cell receptor signaling in normal and malignant B cells.
Pages: 100465
Publication
First Author: Garceau N
Year: 2000
Journal: J Exp Med
Title: Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40.
Volume: 191
Issue: 2
Pages: 381-6
Publication  
First Author: Wang LW
Year: 2017
Journal: J Virol
Title: Epstein-Barr Virus LMP1-Mediated Oncogenicity.
Volume: 91
Issue: 21
Publication
First Author: Wang X
Year: 1996
Journal: Dev Biol
Title: A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.
Volume: 177
Issue: 1
Pages: 274-90
Publication
First Author: Berry CT
Year: 2020
Journal: Cell Rep
Title: BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells.
Volume: 31
Issue: 2
Pages: 107474
Protein
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
Publication
First Author: Yan H
Year: 2020
Journal: J Immunol
Title: B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-κB Activation for Antibody Class-Switching.
Volume: 204
Issue: 5
Pages: 1146-1157
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Clayton E
Year: 2002
Journal: J Exp Med
Title: A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation.
Volume: 196
Issue: 6
Pages: 753-63
Publication
First Author: Horai R
Year: 2004
Journal: J Clin Invest
Title: TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.
Volume: 114
Issue: 11
Pages: 1603-11
Publication
First Author: Schneider A
Year: 2008
Journal: FEBS Lett
Title: Selective contribution of Tyk2 to cell activation by lipopolysaccharide.
Volume: 582
Issue: 25-26
Pages: 3681-6
Publication
First Author: Franco A
Year: 2000
Journal: Nat Immunol
Title: Epitope affinity for MHC class I determines helper requirement for CTL priming.
Volume: 1
Issue: 2
Pages: 145-50
Publication
First Author: Kim EC
Year: 2015
Journal: Mol Immunol
Title: TMEM126A, a CD137 ligand binding protein, couples with the TLR4 signal transduction pathway in macrophages.
Volume: 64
Issue: 2
Pages: 244-51
Publication
First Author: Sotomayor EM
Year: 1999
Journal: Nat Med
Title: Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40.
Volume: 5
Issue: 7
Pages: 780-7
Publication
First Author: Riol-Blanco L
Year: 2009
Journal: Nat Immunol
Title: Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells.
Volume: 10
Issue: 7
Pages: 753-60
Publication
First Author: Vonderheide RH
Year: 2018
Journal: Cancer Cell
Title: The Immune Revolution: A Case for Priming, Not Checkpoint.
Volume: 33
Issue: 4
Pages: 563-569
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Brink R
Year: 1998
Journal: J Biol Chem
Title: Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kappaB activation.
Volume: 273
Issue: 7
Pages: 4129-34
Publication
First Author: Chen Z
Year: 2012
Journal: Diabetes
Title: Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses.
Volume: 61
Issue: 3
Pages: 566-73
Publication  
First Author: Okamura K
Year: 2016
Journal: Sci Rep
Title: Survival of mature T cells depends on signaling through HOIP.
Volume: 6
Pages: 36135
Publication
First Author: Tang Y
Year: 2018
Journal: J Immunol
Title: RNF31 Regulates Skin Homeostasis by Protecting Epidermal Keratinocytes from Cell Death.
Volume: 200
Issue: 12
Pages: 4117-4124
Publication
First Author: Park KJ
Year: 2002
Journal: J Biol Chem
Title: Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation.
Volume: 277
Issue: 15
Pages: 13122-8
Publication
First Author: Cannons JL
Year: 2002
Journal: J Immunol
Title: Cutting edge: profound defect in T cell responses in TNF receptor-associated factor 2 dominant negative mice.
Volume: 169
Issue: 6
Pages: 2828-31
Publication
First Author: Emmerich CH
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.
Volume: 110
Issue: 38
Pages: 15247-52
Publication
First Author: Fiil BK
Year: 2014
Journal: FEBS J
Title: Met1-linked ubiquitination in immune signalling.
Volume: 281
Issue: 19
Pages: 4337-50
Publication  
First Author: Yeung AT
Year: 2015
Journal: Sci Rep
Title: Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.
Volume: 5
Pages: 8908
Publication
First Author: Li J
Year: 2019
Journal: Cell Death Dis
Title: TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis.
Volume: 10
Issue: 5
Pages: 328
GXD Expression    
Probe: MGI:5300300
Assay Type: Northern blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5300316
Age: postnatal adult
Image: 3
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5300300
Assay Type: Northern blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5300316
Age: postnatal adult
Image: 3
Specimen Label: Heart
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5300300
Assay Type: Northern blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5300316
Age: postnatal adult
Image: 3
Specimen Label: Lung
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5300300
Assay Type: Northern blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:5300316
Age: postnatal adult
Image: 3
Specimen Label: Skeletal Muscle
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5300300
Assay Type: Northern blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5300316
Age: postnatal adult
Image: 3
Specimen Label: Kidney
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5300300
Assay Type: Northern blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5300316
Age: postnatal adult
Image: 3
Specimen Label: Liver
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:5300300
Assay Type: Northern blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:5300316
Age: postnatal day 2
Image: 3
Specimen Label: P2 Brain
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5300317
Age: postnatal adult
Image: 3
Specimen Label: Lung
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:5300317
Age: postnatal adult
Image: 3
Specimen Label: Skeletal Muscle
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5300317
Age: postnatal adult
Image: 3
Specimen Label: Brain
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5300317
Age: postnatal adult
Image: 3
Specimen Label: Heart
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5300317
Age: postnatal adult
Image: 3
Specimen Label: Kidney
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5300317
Age: postnatal adult
Image: 3
Specimen Label: Liver
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5300323
Age: postnatal adult
Image: 3
Specimen Label: Adult Lung
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5300323
Age: postnatal adult
Image: 3
Specimen Label: Adult Heart
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5300323
Age: postnatal adult
Image: 3
Specimen Label: Adult Brain
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:5300323
Age: postnatal adult
Image: 3
Specimen Label: Adult Skeletal Muscle
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672827
Stage: TS27
Assay Id: MGI:5300323
Age: postnatal day 0
Image: 3
Specimen Label: P0 Lung
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:5300323
Age: postnatal day 0
Image: 3
Specimen Label: P0 Heart
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:5300323
Age: postnatal day 0
Image: 3
Specimen Label: P0 Brain
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:5300303
Assay Type: Western blot
Annotation Date: 2012-01-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5300323
Age: postnatal day 0
Image: 3
Specimen Label: P0 Skeletal Muscle
Detected: true
Specimen Num: 8