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Search results 1201 to 1300 out of 1412 for Des

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Hits by Strain

Type Details Score
Genotype
Symbol: Ush1g/Ush1g
Background: involves: 129S1/SvImJ
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Otof/Otof<+>
Background: involves: 129S2/SvPas
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Des/Des
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
DO Term
Publication
First Author: Vaillant F
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Ivabradine and metoprolol differentially affect cardiac glucose metabolism despite similar heart rate reduction in a mouse model of dyslipidemia.
Volume: 311
Issue: 4
Pages: H991-H1003
Publication
First Author: Liu Y
Year: 2023
Journal: FASEB J
Title: Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia.
Volume: 37
Issue: 12
Pages: e23257
Publication  
First Author: Ruiz M
Year: 2019
Journal: JCI Insight
Title: Lipidomics unveils lipid dyshomeostasis and low circulating plasmalogens as biomarkers in a monogenic mitochondrial disorder.
Volume: 4
Issue: 14
Publication
First Author: Cuillerier A
Year: 2021
Journal: Commun Biol
Title: Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice.
Volume: 4
Issue: 1
Pages: 989
Publication
First Author: Cuillerier A
Year: 2017
Journal: Hum Mol Genet
Title: Loss of hepatic LRPPRC alters mitochondrial bioenergetics, regulation of permeability transition and trans-membrane ROS diffusion.
Volume: 26
Issue: 16
Pages: 3186-3201
Publication
First Author: Ruiz M
Year: 2016
Journal: Diabetes
Title: MK2 Deletion in Mice Prevents Diabetes-Induced Perturbations in Lipid Metabolism and Cardiac Dysfunction.
Volume: 65
Issue: 2
Pages: 381-92
Publication
First Author: Gélinas R
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Prolonged QT interval and lipid alterations beyond β-oxidation in very long-chain acyl-CoA dehydrogenase null mouse hearts.
Volume: 301
Issue: 3
Pages: H813-23
Publication
First Author: Galvao TF
Year: 2012
Journal: Cardiovasc Res
Title: High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects.
Volume: 93
Issue: 1
Pages: 24-32
Publication
First Author: Stewart MK
Year: 2014
Journal: PLoS One
Title: Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function.
Volume: 9
Issue: 7
Pages: e101546
Publication
First Author: Stewart MK
Year: 2015
Journal: Oncotarget
Title: Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer.
Volume: 6
Issue: 35
Pages: 37185-99
Publication
First Author: Nagy JI
Year: 2011
Journal: Eur J Neurosci
Title: Connexin26 expression in brain parenchymal cells demonstrated by targeted connexin ablation in transgenic mice.
Volume: 34
Issue: 2
Pages: 263-71
Publication
First Author: Marx-Stoelting P
Year: 2008
Journal: Toxicol Sci
Title: Tumor promotion in liver of mice with a conditional Cx26 knockout.
Volume: 103
Issue: 2
Pages: 260-7
Publication
First Author: Ott T
Year: 2006
Journal: Eur J Cell Biol
Title: Ablation of gap junctional communication in hepatocytes of transgenic mice does not lead to disrupted cellular homeostasis or increased spontaneous tumourigenesis.
Volume: 85
Issue: 8
Pages: 717-28
Publication
First Author: Cartagena-Rivera AX
Year: 2019
Journal: Sci Adv
Title: Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.
Volume: 5
Issue: 2
Pages: eaat9934
Strain
Attribute String: mutant strain, congenic, targeted mutation, transgenic
Publication
First Author: Liang C
Year: 2012
Journal: Neurosci Lett
Title: Cell degeneration is not a primary causer for Connexin26 (GJB2) deficiency associated hearing loss.
Volume: 528
Issue: 1
Pages: 36-41
Publication  
First Author: Takada Y
Year: 2014
Journal: Hear Res
Title: Connexin 26 null mice exhibit spiral ganglion degeneration that can be blocked by BDNF gene therapy.
Volume: 309
Pages: 124-35
Publication  
First Author: Fetoni AR
Year: 2018
Journal: Redox Biol
Title: Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway.
Volume: 19
Pages: 301-317
Publication
First Author: Crispino G
Year: 2011
Journal: PLoS One
Title: BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf Cx26Sox10Cre mice.
Volume: 6
Issue: 8
Pages: e23279
Publication
First Author: Neef J
Year: 2014
Journal: J Neurosci
Title: Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.
Volume: 34
Issue: 3
Pages: 705-16
Genotype
Symbol: Gsdme/Gsdme Pjvk/Pjvk
Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Gjb2/Gjb2 Tg(Sox10-cre)1Wdr/?
Background: involves: 129S2/SvPasCrl * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gjb2/Gjb2 Tg(Sox10-cre)1Wdr/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
DO Term
Publication
First Author: Cox BC
Year: 2012
Journal: J Assoc Res Otolaryngol
Title: Conditional gene expression in the mouse inner ear using Cre-loxP.
Volume: 13
Issue: 3
Pages: 295-322
Publication
First Author: Delmaghani S
Year: 2006
Journal: Nat Genet
Title: Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy.
Volume: 38
Issue: 7
Pages: 770-8
Publication
First Author: Pepermans E
Year: 2014
Journal: EMBO Mol Med
Title: The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.
Volume: 6
Issue: 7
Pages: 984-92
Publication  
First Author: Chang Q
Year: 2015
Journal: Neurobiol Dis
Title: Timed conditional null of connexin26 in mice reveals temporary requirements of connexin26 in key cochlear developmental events before the onset of hearing.
Volume: 73
Pages: 418-27
Strain
Attribute String: mutant stock, targeted mutation
Publication
First Author: Ortolano S
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear.
Volume: 105
Issue: 48
Pages: 18776-81
Publication  
First Author: Xu K
Year: 2020
Journal: Front Cell Dev Biol
Title: Local Macrophage-Related Immune Response Is Involved in Cochlear Epithelial Damage in Distinct Gjb2-Related Hereditary Deafness Models.
Volume: 8
Pages: 597769
Publication  
First Author: Green KL
Year: 2016
Journal: Sci Rep
Title: ACEMg Diet Supplement Modifies Progression of Hereditary Deafness.
Volume: 6
Pages: 22690
Publication
First Author: Chen S
Year: 2018
Journal: Cell Death Dis
Title: The spatial distribution pattern of Connexin26 expression in supporting cells and its role in outer hair cell survival.
Volume: 9
Issue: 12
Pages: 1180
Publication  
First Author: Zhu Y
Year: 2013
Journal: Nat Commun
Title: Active cochlear amplification is dependent on supporting cell gap junctions.
Volume: 4
Pages: 1786
Publication
First Author: Lukashkina VA
Year: 2017
Journal: Sci Rep
Title: Amplification mode differs along the length of the mouse cochlea as revealed by connexin 26 deletion from specific gap junctions.
Volume: 7
Issue: 1
Pages: 5185
Publication
First Author: Chan DK
Year: 2016
Journal: PLoS One
Title: Sound-Induced Intracellular Ca2+ Dynamics in the Adult Hearing Cochlea.
Volume: 11
Issue: 12
Pages: e0167850
Publication
First Author: Zhao HB
Year: 2022
Journal: J Neurophysiol
Title: Efferent neurons control hearing sensitivity and protect hearing from noise through the regulation of gap junctions between cochlear supporting cells.
Volume: 127
Issue: 1
Pages: 313-327
Publication
First Author: Crispino G
Year: 2017
Journal: Sci Rep
Title: In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors.
Volume: 7
Issue: 1
Pages: 6567
Publication  
First Author: Zhu Y
Year: 2015
Journal: Neuroscience
Title: Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss.
Volume: 284
Pages: 719-29
Publication  
First Author: Sun L
Year: 2022
Journal: Front Cell Neurosci
Title: Failure Of Hearing Acquisition in Mice With Reduced Expression of Connexin 26 Correlates With the Abnormal Phasing of Apoptosis Relative to Autophagy and Defective ATP-Dependent Ca(2+) Signaling in Kölliker's Organ.
Volume: 16
Pages: 816079
Publication
First Author: Chen S
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Down regulated connexin26 at different postnatal stage displayed different types of cellular degeneration and formation of organ of Corti.
Volume: 445
Issue: 1
Pages: 71-7
Publication
First Author: Zong L
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Progressive age-dependence and frequency difference in the effect of gap junctions on active cochlear amplification and hearing.
Volume: 489
Issue: 2
Pages: 223-227
Publication  
First Author: Xie L
Year: 2019
Journal: Neurochem Int
Title: Reduced postnatal expression of cochlear Connexin26 induces hearing loss and affects the developmental status of pillar cells in a dose-dependent manner.
Volume: 128
Pages: 196-205
Publication
First Author: Zhou XX
Year: 2016
Journal: Int J Mol Sci
Title: Reduced Connexin26 in the Mature Cochlea Increases Susceptibility to Noise-Induced Hearing Lossin Mice.
Volume: 17
Issue: 3
Pages: 301
Publication  
First Author: Liu XZ
Year: 2021
Journal: Front Mol Neurosci
Title: F-Actin Dysplasia Involved in Organ of Corti Deformity in Gjb2 Knockdown Mouse Model.
Volume: 14
Pages: 808553
Publication      
First Author: Petit C
Year: 2014
Journal: MGI Direct Data Submission
Title: Direct Data Submission for Pcdh15 floxed allele from Ugds
Publication
First Author: Trouillet A
Year: 2018
Journal: Sci Rep
Title: Cone degeneration is triggered by the absence of USH1 proteins but prevented by antioxidant treatments.
Volume: 8
Issue: 1
Pages: 1968
Publication
First Author: Cortada M
Year: 2023
Journal: iScience
Title: mTORC2 regulates auditory hair cell structure and function.
Volume: 26
Issue: 9
Pages: 107687
Genotype
Symbol: Gjb2/Gjb2 Tg(Otog-cre)1Ugds/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdh23/Cdh23 Myo15a/Myo15a<+>
Background: involves: 129S1/SvImJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Pcdh15/Pcdh15 Myo15a/Myo15a<+>
Background: involves: 129S1/SvImJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Myo15a/Myo15a<+> Myo7a/Myo7a
Background: involves: 129S1/SvImJ * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Freude K
Year: 2004
Journal: Am J Hum Genet
Title: Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation.
Volume: 75
Issue: 2
Pages: 305-9
Publication
First Author: Hata M
Year: 2023
Journal: Science
Title: Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation.
Volume: 379
Issue: 6627
Pages: 45-62
Publication
First Author: Lloyd AF
Year: 2019
Journal: Nat Neurosci
Title: Central nervous system regeneration is driven by microglia necroptosis and repopulation.
Volume: 22
Issue: 7
Pages: 1046-1052
Publication
First Author: van Weeghel M
Year: 2018
Journal: Cardiovasc Res
Title: Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.
Volume: 114
Issue: 10
Pages: 1324-1334
Publication  
First Author: Lebar MD
Year: 2018
Journal: Fungal Genet Biol
Title: Identification and functional analysis of the aspergillic acid gene cluster in Aspergillus flavus.
Volume: 116
Pages: 14-23
Publication
First Author: Wollenberg RD
Year: 2017
Journal: J Nat Prod
Title: Chrysogine Biosynthesis Is Mediated by a Two-Module Nonribosomal Peptide Synthetase.
Volume: 80
Issue: 7
Pages: 2131-2135
Publication
First Author: Bonsch B
Year: 2016
Journal: Chem Commun (Camb)
Title: Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues.
Volume: 52
Issue: 41
Pages: 6777-80
Publication
First Author: Bai J
Year: 2017
Journal: Angew Chem Int Ed Engl
Title: A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A.
Volume: 56
Issue: 17
Pages: 4782-4786
Protein Domain
Type: Family
Description: This entry includes a group of oxidoreductases, including AsaB from Aspergillus flavus [], Oxidoreductase R1/R2 from Phoma sp., DES from Gibberella fujikuroi, and Chry3 from Gibberella zeae. AsaB is involved in secondary metabolite biosynthesis. It converts aspergillic acid to hydroxyaspergillic acid []. R1/R2 is part of the gene cluster that mediates the biosynthesis of squalestatin S1 []. Chry3 is part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine []. DES is part of the gene cluster that mediates the biosynthesis of gibberellins (GAs), diterpenoids that may provide a selective advantage during infection of the preferred host plant, rice [, , , , ].Proteins in this entry are related to RbtB and RbtG from Penicillium dangeardii. RbtB and RbtG are alpha-ketoglutarate-dependent dioxygenases involved in rubratoxin biosynthesis [].
Publication
First Author: Lelli A
Year: 2016
Journal: J Cell Biol
Title: Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.
Volume: 212
Issue: 2
Pages: 231-44
Publication
First Author: Delmaghani S
Year: 2015
Journal: Cell
Title: Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.
Volume: 163
Issue: 4
Pages: 894-906
Publication
First Author: Lefèvre G
Year: 2008
Journal: Development
Title: A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.
Volume: 135
Issue: 8
Pages: 1427-37
Publication
First Author: Decrock E
Year: 2009
Journal: Cell Death Differ
Title: Connexin-related signaling in cell death: to live or let die?
Volume: 16
Issue: 4
Pages: 524-36
Publication
First Author: Beurg M
Year: 2010
Journal: J Neurosci
Title: Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.
Volume: 30
Issue: 40
Pages: 13281-90
Publication
First Author: Bry C
Year: 2004
Journal: Dev Biol
Title: Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development.
Volume: 267
Issue: 2
Pages: 418-29
Publication
First Author: Liu LM
Year: 2023
Journal: Sci Adv
Title: Cx26 heterozygous mutations cause hyperacusis-like hearing oversensitivity and increase susceptibility to noise.
Volume: 9
Issue: 6
Pages: eadf4144
Publication
First Author: Wang Y
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Targeted connexin26 ablation arrests postnatal development of the organ of Corti.
Volume: 385
Issue: 1
Pages: 33-7
Publication
First Author: Verpy E
Year: 2008
Journal: Nature
Title: Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.
Volume: 456
Issue: 7219
Pages: 255-8
Publication  
First Author: Chen S
Year: 2018
Journal: Dis Model Mech
Title: Developmental abnormalities in supporting cell phalangeal processes and cytoskeleton in the Gjb2 knockdown mouse model.
Volume: 11
Issue: 2
Publication
First Author: Johnson SL
Year: 2017
Journal: J Neurosci
Title: Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea.
Volume: 37
Issue: 2
Pages: 258-268
Publication  
First Author: Mei L
Year: 2017
Journal: Neurobiol Dis
Title: A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall.
Volume: 108
Pages: 195-203
Publication
First Author: Chen J
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Deafness induced by Connexin 26 (GJB2) deficiency is not determined by endocochlear potential (EP) reduction but is associated with cochlear developmental disorders.
Volume: 448
Issue: 1
Pages: 28-32
Publication
First Author: Sun Y
Year: 2009
Journal: J Comp Neurol
Title: Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea.
Volume: 516
Issue: 6
Pages: 569-79
Publication  
First Author: Zhu Y
Year: 2015
Journal: Sci Rep
Title: Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development.
Volume: 5
Pages: 15647
Publication
First Author: Conrad LJ
Year: 2024
Journal: J Physiol
Title: The upregulation of K(+) and HCN channels in developing spiral ganglion neurons is mediated by cochlear inner hair cells.
Volume: 602
Issue: 20
Pages: 5329-5351
Publication
First Author: Calvet C
Year: 2022
Journal: iScience
Title: The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses.
Volume: 25
Issue: 12
Pages: 105628
Genotype
Symbol: Myo15a/Myo15a<+> Ush1g/Ush1g
Background: involves: 129S1/SvImJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Clrn1/Clrn1 Myo15a/Myo15a<+>
Background: involves: 129S1/SvImJ * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Blomme J
Year: 2017
Journal: Plant Cell
Title: The Mitochondrial DNA-Associated Protein SWIB5 Influences mtDNA Architecture and Homologous Recombination.
Volume: 29
Issue: 5
Pages: 1137-1156
Publication
First Author: Gélinas R
Year: 2018
Journal: Nat Commun
Title: AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation.
Volume: 9
Issue: 1
Pages: 374
Publication
First Author: Zemni R
Year: 2000
Journal: Nat Genet
Title: A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation.
Volume: 24
Issue: 2
Pages: 167-70
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Wiemann P
Year: 2013
Journal: PLoS Pathog
Title: Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.
Volume: 9
Issue: 6
Pages: e1003475
Publication
First Author: Tudzynski B
Year: 1998
Journal: Fungal Genet Biol
Title: Gibberellin biosynthetic pathway in Gibberella fujikuroi: evidence for a gene cluster.
Volume: 25
Issue: 3
Pages: 157-70
Publication
First Author: Linnemannstöns P
Year: 1999
Journal: Appl Environ Microbiol
Title: Deletions in the gibberellin biosynthesis gene cluster of Gibberella fujikuroi by restriction enzyme-mediated integration and conventional transformation-mediated mutagenesis.
Volume: 65
Issue: 6
Pages: 2558-64
Publication
First Author: Malonek S
Year: 2005
Journal: Phytochemistry
Title: Distribution of gibberellin biosynthetic genes and gibberellin production in the Gibberella fujikuroi species complex.
Volume: 66
Issue: 11
Pages: 1296-311
Publication
First Author: Verpy E
Year: 2011
Journal: J Comp Neurol
Title: Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.
Volume: 519
Issue: 2
Pages: 194-210
Publication
First Author: Michel V
Year: 2020
Journal: Sci Rep
Title: Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.
Volume: 10
Issue: 1
Pages: 16430
Publication
First Author: Libé-Philippot B
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.
Volume: 114
Issue: 30
Pages: 7765-7774
Publication
First Author: Etournay R
Year: 2010
Journal: Development
Title: Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.
Volume: 137
Issue: 8
Pages: 1373-83
Publication  
First Author: Chen J
Year: 2015
Journal: Sci Rep
Title: Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing.
Volume: 5
Pages: 10762
Publication
First Author: Dulon D
Year: 2018
Journal: J Clin Invest
Title: Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome.
Volume: 128
Issue: 8
Pages: 3382-3401
Publication
First Author: Underhill A
Year: 2025
Journal: Proc Natl Acad Sci U S A
Title: MYO7A is required for the functional integrity of the mechanoelectrical transduction complex in hair cells of the adult cochlea.
Volume: 122
Issue: 1
Pages: e2414707122