Type |
Details |
Score |
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tsuboi M |
Year: |
2010 |
Journal: |
Int J Oncol |
Title: |
Secreted form of EphA7 in lung cancer. |
Volume: |
36 |
Issue: |
3 |
Pages: |
635-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guan M |
Year: |
2009 |
Journal: |
Int J Cancer |
Title: |
Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features. |
Volume: |
124 |
Issue: |
1 |
Pages: |
88-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakanishi H |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias. |
Volume: |
104 |
Issue: |
36 |
Pages: |
14442-7 |
|
•
•
•
•
•
|
Allele |
Name: |
Eph receptor A7; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1336944 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-06-21 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1629713 |
Pattern: |
Uniform |
Stage: |
TS13 |
Assay Id: |
MGI:1338287 |
Age: |
embryonic day 8.5 |
Image: |
6. H |
Note: |
Specimen was double hydridized with Egr2 and Epha7 probes and expression was inferred from previous specimens. |
Specimen Label: |
6. H |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1336944 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-06-21 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1630513 |
Pattern: |
Uniform |
Stage: |
TS13 |
Assay Id: |
MGI:1338287 |
Age: |
embryonic day 8.5 |
Image: |
6. H |
Note: |
Specimen was double hydridized with Egr2 and Epha7 probes and expression was inferred from previous specimens. |
Specimen Label: |
6. H |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7788193 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-12-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754927 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7788195 |
Age: |
postnatal day 3 |
Image: |
5d/f |
Note: |
Expression distributed in patches and bands, only partially overlapping with Epha7 expression. Highest levels adjacent to regions of peak Epha7 expression. |
Specimen Label: |
5d/f |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion FX17, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4453649 |
Assay Type: |
RNA in situ |
Annotation Date: |
2015-11-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5695630 |
Age: |
embryonic day 14.5 |
Image: |
1F/I/J |
Note: |
Expression was detected in a lateral-medial band within the dorsal thalamus. Expressing cells were largely distinct from cells expressing Efna5. Co-localization with Epha7 was noted in discrete portions of the positive expression domain. |
Specimen Label: |
1F/I/J |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Miller K |
Year: |
2006 |
Journal: |
J Comp Neurol |
Title: |
EphA7-ephrin-A5 signaling in mouse somatosensory cortex: developmental restriction of molecular domains and postnatal maintenance of functional compartments. |
Volume: |
496 |
Issue: |
5 |
Pages: |
627-42 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the ligand-binding domain found in ephrin type-A receptor 7 (EphA7). EphA7 has been implicated in various cancers, including lung, prostate, as well as leukemia [, , ]. EphA7 has also been suggested to play a role in the development and maintenance of cortical domains within the cerebral cortex [].Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands [, ]. Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Mansour MR |
Year: |
2011 |
Journal: |
Cancer Cell |
Title: |
Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma. |
Volume: |
20 |
Issue: |
5 |
Pages: |
559-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park E |
Year: |
2013 |
Journal: |
Cell Death Differ |
Title: |
EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development. |
Volume: |
20 |
Issue: |
1 |
Pages: |
169-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yan Y |
Year: |
2022 |
Journal: |
Neuron |
Title: |
ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder. |
Volume: |
110 |
Issue: |
7 |
Pages: |
1156-1172.e9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wurzman R |
Year: |
2015 |
Journal: |
Behav Brain Res |
Title: |
Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders. |
Volume: |
278 |
|
Pages: |
115-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katoh M |
Year: |
2006 |
Journal: |
Int J Oncol |
Title: |
Comparative integromics on Eph family. |
Volume: |
28 |
Issue: |
5 |
Pages: |
1243-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Nieva P |
Year: |
2012 |
Journal: |
Carcinogenesis |
Title: |
EPHA7, a new target gene for 6q deletion in T-cell lymphoblastic lymphomas. |
Volume: |
33 |
Issue: |
2 |
Pages: |
452-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herath NI |
Year: |
2012 |
Journal: |
Eur J Cancer |
Title: |
Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis. |
Volume: |
48 |
Issue: |
5 |
Pages: |
753-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Glendining KA |
Year: |
2017 |
Journal: |
BMC Neurosci |
Title: |
Downstream mediators of Ten-m3 signalling in the developing visual pathway. |
Volume: |
18 |
Issue: |
1 |
Pages: |
78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iguchi T |
Year: |
2021 |
Journal: |
J Neurosci |
Title: |
Mutually Repulsive EphA7-EfnA5 Organize Region-to-Region Corticopontine Projection by Inhibiting Collateral Extension. |
Volume: |
41 |
Issue: |
22 |
Pages: |
4795-4808 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lackmann M |
Year: |
2008 |
Journal: |
Sci Signal |
Title: |
Eph, a protein family coming of age: more confusion, insight, or complexity? |
Volume: |
1 |
Issue: |
15 |
Pages: |
re2 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
610
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
451
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Himanen JP |
Year: |
2003 |
Journal: |
Trends Neurosci |
Title: |
Eph signaling: a structural view. |
Volume: |
26 |
Issue: |
1 |
Pages: |
46-51 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
998
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
994
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
994
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|