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Search results 1201 to 1300 out of 2260 for Erbb2

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Type Details Score
Publication
23474764 | J:212377
First Author: Allen-Petersen BL
Year: 2014
Journal: Oncogene
Title: Protein kinase Cδ is required for ErbB2-driven mammary gland tumorigenesis and negatively correlates with prognosis in human breast cancer.
Volume: 33
Issue: 10
Pages: 1306-15
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Publication
26096931 | J:224546
First Author: Castillo-Lluva S
Year: 2015
Journal: Oncogene
Title: A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development.
Volume: 34
Issue: 36
Pages: 4777-90
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Publication
22952421 | J:315059
First Author: Deng X
Year: 2012
Journal: Neoplasia
Title: Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis.
Volume: 14
Issue: 8
Pages: 678-89
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Publication
29959151 | J:264287
First Author: Volker SE
Year: 2018
Journal: Cancer Res
Title: Cyclophilin A Function in Mammary Epithelium Impacts Jak2/Stat5 Signaling, Morphogenesis, Differentiation, and Tumorigenesis in the Mammary Gland.
Volume: 78
Issue: 14
Pages: 3877-3887
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Publication
17145873 | J:116215
First Author: Yen L
Year: 2006
Journal: Cancer Res
Title: Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth.
Volume: 66
Issue: 23
Pages: 11279-86
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Publication
10718486 | J:61198
First Author: Rao GN
Year: 1999
Journal: Breast Cancer Res Treat
Title: Changes associated with delay of mammary cancer by retinoid analogues in transgenic mice bearing c-neu oncogene.
Volume: 58
Issue: 3
Pages: 241-54
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Protein Coding Gene
MGI:104771 | Erbb4
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Erbb2<tm3(Erbb2)Mul> | MGI:2449788
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 3, William Muller
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Publication
10557086 | J:58363
First Author: Diévart A
Year: 1999
Journal: Oncogene
Title: Involvement of Notch1 in the development of mouse mammary tumors.
Volume: 18
Issue: 44
Pages: 5973-81
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Publication
10344755 | J:71658
First Author: Cool M
Year: 1999
Journal: Cancer Res
Title: Elevated frequency of loss of heterozygosity in mammary tumors arising in mouse mammary tumor virus/neu transgenic mice.
Volume: 59
Issue: 10
Pages: 2438-44
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Publication
16258954 | J:103450
First Author: Cool M
Year: 2006
Journal: Genes Chromosomes Cancer
Title: Fine allelotyping of Erbb2-induced mammary tumors in mice reveals multiple discontinuous candidate regions of tumor-suppressor loci.
Volume: 45
Issue: 2
Pages: 191-202
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Allele
Tg(MMTV-Erbb2)NF1Mul | MGI:3050869
Name: transgene insertion NF1, William Muller
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(MMTV-Erbb2)NB1Mul | MGI:3050875
Name: transgene insertion NB1, William Muller
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(KRT5-Erbb2)1Jdg | MGI:3510988
Name: transgene insertion 1, John DiGiovanni
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Erbb2<tm4(Erbb2)Mul> | MGI:3521857
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 4, William J Muller
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Allele
Erbb2<tm5(Erbb2)Mul> | MGI:3521858
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 5, William J Muller
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Allele
Erbb2<tm6(Erbb2)Mul> | MGI:3521859
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 6, William J Muller
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Allele
Erbb2<tm7(Erbb2)Mul> | MGI:3521860
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 7, William J Muller
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Allele
Pds5b<Tg(Wap-ERBB2)229Wzw> | MGI:3850477
Name: PDS5 cohesin associated factor B; transgene insertion 229, Wei-Zen Wei
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
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Strain
MGI:6386216 | FVB/N-Tg(MMTV-Erbb2*,-cre)1Mul/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5013933 | FVB-Tg(MMTV-ERBB2*,-luc)6177Aami
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:5013934 | FVB-Tg(MMTV-ERBB2*,-luc)6180Aami
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5013932 | FVB-Tg(MMTV-ERBB2*,-luc)6157Aami
Attribute String: coisogenic, mutant strain, transgenic
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Publication
27475932 | J:234986
First Author: Tilio M
Year: 2016
Journal: Cancer Lett
Title: Irreversible inhibition of Δ16HER2 is necessary to suppress Δ16HER2-positive breast carcinomas resistant to Lapatinib.
Volume: 381
Issue: 1
Pages: 76-84
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Allele
Tg(MMTV-ERBB2)5Erick | MGI:5527316
Name: transgene insertion 5, Sharon Erickson
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Erbb2-Erbb2)NN60Led | MGI:5824244
Name: transgene insertion NN60, Philip Leder
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Erbb2-Erbb2*V664E)#Led | MGI:5824245
Name: transgene insertion, Philip Leder
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(tetO-ERBB2*)#Mul | MGI:6758103
Name: transgene insertion, William Muller
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Allele
Tg(tetO-ERBB2*,-cre)#Mul | MGI:6758105
Name: transgene insertion, William Muller
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Recombinase
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Allele
Tg(tetO-ERBB2,-cre)#Mul | MGI:6758107
Name: transgene insertion, William Muller
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Recombinase
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Genotype
Genotype
Symbol: Erbb2/Erbb2<+>
Background: involves: 129P2/OlaHsd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Erbb2/Erbb2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Erbb2/Erbb2
Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MMTV-Erbb2*,-cre)1Mul/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MMTV-ERBB2*,-luc)6157Aami/?
Background: FVB-Tg(MMTV-ERBB2*,-luc)6157Aami
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MMTV-ERBB2*,-luc)6177Aami/?
Background: FVB-Tg(MMTV-ERBB2*,-luc)6177Aami
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MMTV-ERBB2*,-luc)6180Aami/?
Background: FVB-Tg(MMTV-ERBB2*,-luc)6180Aami
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Erbb2)6Kaga/?
Background: involves: C57BL/6J * SJL/J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MMTV-Erbb2)10Pjo/?
Background: involves: BALB/c * C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MMTV-Erbb2)9Pjo/?
Background: involves: BALB/c * C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MMTV-Erbb2)12Pjo/?
Background: involves: BALB/c * C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MMTV-Erbb2)17Pjo/?
Background: involves: BALB/c * C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MMTV-Erbb2*,-cre)1Mul/?
Background: involves: FVB
Zygosity: ot
Has Mutant Allele: true
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Protein Coding Gene
MGI:95290 | Egf
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16652155 | J:115842
First Author: Jackson-Fisher AJ
Year: 2006
Journal: Oncogene
Title: Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4.
Volume: 25
Issue: 41
Pages: 5664-72
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Publication
19491266 | J:149659
First Author: Dillon RL
Year: 2009
Journal: Cancer Res
Title: Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.
Volume: 69
Issue: 12
Pages: 5057-64
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Protein
Q61526
Organism: Mus musculus/domesticus
Length: 1339  
Fragment?: false
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Publication
25573952 | J:220187
First Author: Yallowitz AR
Year: 2015
Journal: Mol Cancer Res
Title: Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigenesis.
Volume: 13
Issue: 4
Pages: 743-54
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Publication
35065238 | J:319626
 
First Author: Ghaleb A
Year: 2022
Journal: Cancer Lett
Title: Low-dose but not high-dose γ-irradiation elicits the dominant-negative effect of mutant p53 in vivo.
Volume: 530
Pages: 128-141
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Publication
14737104 | J:88101
First Author: Adriance MC
Year: 2004
Journal: Oncogene
Title: Downregulation of Muc1 in MMTV-c-Neu tumors.
Volume: 23
Issue: 3
Pages: 697-705
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Publication
22271573 | J:181875
First Author: Schulz R
Year: 2012
Journal: J Exp Med
Title: Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.
Volume: 209
Issue: 2
Pages: 275-89
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Publication
29487713 | J:294708
First Author: Yuan H
Year: 2018
Journal: Oncotarget
Title: MMTV-NeuT/ATTAC mice: a new model for studying the stromal tumor microenvironment.
Volume: 9
Issue: 8
Pages: 8042-8053
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Publication
36380187 | J:331598
First Author: Xu M
Year: 2022
Journal: Commun Biol
Title: Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Volume: 5
Issue: 1
Pages: 1251
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Protein
A0A3F2YNL8
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
A0A3B2W4G7
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
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Protein
A0A3B2W7C9
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
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Protein
Q3TWT2
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein
A0A3B2W4I2
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Protein
A0A3B2WCC1
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Publication
15156151 | -
First Author: Marone R
Year: 2004
Journal: Nat Cell Biol
Title: Memo mediates ErbB2-driven cell motility.
Volume: 6
Issue: 6
Pages: 515-22
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Publication
18955552 | -
First Author: Zaoui K
Year: 2008
Journal: J Cell Biol
Title: Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells.
Volume: 183
Issue: 3
Pages: 401-8
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Publication
22412880 | -
First Author: Schlatter ID
Year: 2012
Journal: PLoS One
Title: MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth.
Volume: 7
Issue: 3
Pages: e32501
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Publication
22824790 | -
First Author: Sorokin AV
Year: 2013
Journal: Oncogene
Title: MEMO1, a new IRS1-interacting protein, induces epithelial-mesenchymal transition in mammary epithelial cells.
Volume: 32
Issue: 26
Pages: 3130-8
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Protein Domain
IPR002737 | MEMO1_fam
Type: Family
Description: This entry is composed of Memo 1 (mediator of ErbB2-driven cell motility 1) and related proteins from eukaryotes, archaea and bacteria whose molecular function is unclear.Memo 1 is an effector of the ErbB2 receptor tyrosine kinase involved in breast carcinoma cell migration []. Its increased expression is associated with cancer aggressiveness. In breast cancer it regulates insulin-like growth factor-I receptor-dependent signaling pathway []. It binds to a specific ErbB2-derived phosphopeptide []. It regulates the localisation of the small G protein RhoA and its effector mDia1 at the plasma membrane, and thereby coordinates the organisation of the lamellipodial actin network, adhesion site formation, and MT outgrowth within the cell leading edge to sustain cell motility []. In yeast, the homologue is known as Mho1, and inhibits haploid invasive growth when overexpressed [].
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Publication
31597089 | J:284492
First Author: Hirukawa A
Year: 2019
Journal: Cell Rep
Title: Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy.
Volume: 29
Issue: 2
Pages: 249-257.e8
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Publication
30463015 | J:270675
First Author: Wehde BL
Year: 2018
Journal: Cell Rep
Title: Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression.
Volume: 25
Issue: 8
Pages: 2192-2207.e5
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Publication
11417997 | J:70644
First Author: Zelazny E
Year: 2001
Journal: Exp Mol Pathol
Title: Cooperating oncogenic events in murine mammary tumorigenesis: assessment of ErbB2, mutant p53, and mouse mammary tumor virus.
Volume: 70
Issue: 3
Pages: 183-93
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Publication
14991053 | J:121570
First Author: Bulavin DV
Year: 2004
Journal: Nat Genet
Title: Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.
Volume: 36
Issue: 4
Pages: 343-50
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Publication
22665265 | J:189292
First Author: Lahlou H
Year: 2012
Journal: Cancer Res
Title: Uncoupling of PI3K from ErbB3 impairs mammary gland development but does not impact on ErbB2-induced mammary tumorigenesis.
Volume: 72
Issue: 12
Pages: 3080-90
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Publication
21127199 | J:169326
First Author: Yang C
Year: 2011
Journal: Cancer Res
Title: The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers.
Volume: 71
Issue: 3
Pages: 937-45
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Publication
27157621 | J:309306
First Author: Turpin J
Year: 2016
Journal: Oncogene
Title: The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.
Volume: 35
Issue: 47
Pages: 6053-6064
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Protein Coding Gene
MGI:96224 | Hras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1097165 | Nrg3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891731 | Stub1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99683 | Ptk6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99147 | Yes1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P70424
Organism: Mus musculus/domesticus
Length: 1256  
Fragment?: false
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Protein
Q61527
Organism: Mus musculus/domesticus
Length: 1308  
Fragment?: false
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Protein
Q9WUD1
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
O35181
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
P56974
Organism: Mus musculus/domesticus
Length: 756  
Fragment?: false
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Protein
Q04736
Organism: Mus musculus/domesticus
Length: 541  
Fragment?: false
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Protein
Q64434
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
A0A140LHZ9
Organism: Mus musculus/domesticus
Length: 858  
Fragment?: false
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Protein Coding Gene
MGI:98354 | Sos1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31222103 | J:278177
First Author: Gomez ML
Year: 2019
Journal: Oncogene
Title: SOD1 is essential for oncogene-driven mammary tumor formation but dispensable for normal development and proliferation.
Volume: 38
Issue: 29
Pages: 5751-5765
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Publication
19638583 | J:151772
First Author: Sakamoto K
Year: 2009
Journal: Cancer Res
Title: Targeting janus kinase 2 in Her2/neu-expressing mammary cancer: Implications for cancer prevention and therapy.
Volume: 69
Issue: 16
Pages: 6642-50
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Publication
23977064 | J:206347
First Author: Wallace JA
Year: 2013
Journal: PLoS One
Title: Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer.
Volume: 8
Issue: 8
Pages: e71533
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Allele
Tg(MMTVneu)202Mul | MGI:1930204
Name: transgene insertion 202, William Muller
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:3785832 | FVB/N-Tg(MMTV-Erbb2)NF1Mul
Attribute String: transgenic
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Publication
15492286 | J:93643
First Author: Takeuchi N
Year: 2004
Journal: Cancer Res
Title: Anti-HER-2/neu immune responses are induced before the development of clinical tumors but declined following tumorigenesis in HER-2/neu transgenic mice.
Volume: 64
Issue: 20
Pages: 7588-95
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Allele
Tg(MMTV-Erbb2)NK1Mul | MGI:3050871
Name: transgene insertion NK1, William Muller
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(TetO-Erbb2)1Lach | MGI:3511877
Name: transgene insertion 1, Lewis A Chodosh
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Publication
27197158 | J:234852
First Author: Morrison Joly M
Year: 2016
Journal: Cancer Res
Title: Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers.
Volume: 76
Issue: 16
Pages: 4752-64
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Allele
Erbb2<tm8.1(Erbb2)Mul> | MGI:3793285
 
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 8.1, William J Muller
Allele Type: Targeted
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Publication
31862778 | J:285701
First Author: Citron F
Year: 2020
Journal: Cancer Res
Title: Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer.
Volume: 80
Issue: 5
Pages: 1064-1077
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Strain
MGI:3850522 | B6.Cg-Pds5b<Tg(Wap-ERBB2)229Wzw>/J
Attribute String: congenic, transgenic
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Publication
14634087 | J:132829
First Author: Piechocki MP
Year: 2003
Journal: J Immunol
Title: Human ErbB-2 (Her-2) transgenic mice: a model system for testing Her-2 based vaccines.
Volume: 171
Issue: 11
Pages: 5787-94
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Publication
26334628 | J:233887
First Author: Yong CS
Year: 2015
Journal: PLoS One
Title: Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene.
Volume: 10
Issue: 9
Pages: e0136817
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Publication
19118005 | J:143031
First Author: Radkevich-Brown O
Year: 2009
Journal: Cancer Res
Title: Genetic regulation of the response to Her-2 DNA vaccination in human Her-2 transgenic mice.
Volume: 69
Issue: 1
Pages: 212-8
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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