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Search results 1201 to 1271 out of 1271 for Fgfr4

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0.011s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
E9Q2N2
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
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Protein
Q544I6
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
Q3TPG0
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
Q3TYJ7
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
E1APJ6
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
B1AU20
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: false
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Protein
E9Q864
Organism: Mus musculus/domesticus
Length: 30  
Fragment?: true
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Protein
A0A7U3JW48
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
A0A7U3JW69
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
A0A7U3L5J2
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
Q8C386
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Publication
16829530 | -
First Author: Duchesne L
Year: 2006
Journal: J Biol Chem
Title: N-glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co-receptor binding.
Volume: 281
Issue: 37
Pages: 27178-89
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Publication
9212826 | -
First Author: Hughes SE
Year: 1997
Journal: J Histochem Cytochem
Title: Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues.
Volume: 45
Issue: 7
Pages: 1005-19
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Publication
18216218 | -
First Author: Cotton LM
Year: 2008
Journal: Endocr Rev
Title: Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction.
Volume: 29
Issue: 2
Pages: 193-216
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Publication
18687777 | -
First Author: Coskun T
Year: 2008
Journal: Endocrinology
Title: Fibroblast growth factor 21 corrects obesity in mice.
Volume: 149
Issue: 12
Pages: 6018-27
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Protein Domain
IPR035444 | FGF15/19/21
Type: Family
Description: This entry includes fibroblast growth factor 15/19/21 (FGF15/19/21).Fibroblast growth factor 15 (FGF15) plays a key role in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis [, , ]. Mouse FGF15 has been shown to be stimulated when bile acids bind to farnesoid X receptor (FXR) [], and is therefore thought to a factor in chronic bile acid diarrhoea and in certain metabolic disorders [].FGF15 has been experimentally characterised in mouse, but has not been found in other species. However, there is an orthologous human protein, FGF19, and together they share about 50% amino acid identity and display similar endocrine functions, so are often referred to as FGF15/19 [, ]. FGF15 and FGF19 differ from other FGFs due to subtle changes in their tertiary structure, they have low heparin binding affinity enabling them to diffuse away from their site of secretion and signal to distant cells. FGF signaling through the FGF receptors is also different, as they require klotho protein cofactors rather than heparin sulfate proteoglycan [].Fibroblast growth factor 19 (FGF19) plays a key role in enterohepatic signaling, regulation of liver bile acid biosynthesis, gallbladder motility and metabolic homeostasis [, , ]. Human FGF19 expression has been shown to be stimulated approximately 300-fold by physiological concentrations of bile acids including chenodeoxycholic acid, glycochenodeoxycholic acid and obeticholic acid in explants of ileal mucosa []. The protein is thought to be a factor in chronic bile acid diarrhoea and in certain metabolic disorders [, ]. FGF19 has been experimentally characterised in humans and other species, but has not been found in mouse. However there is an orthologous mouse protein, FGF15, and together they share about 50% amino acid identity and display similar endocrine functions, so are often referred to as FGF15/19 [, ]. FGF15 and FGF19 differ from other FGFs due to subtle changes in their tertiary structure. They have low heparin binding affinity, enabling them to diffuse away from their site of secretion and signal to distant cells. FGF signaling through the FGF receptors is also different, as they require klotho protein cofactors rather than heparin sulfate proteoglycan []. Unlike other members of the family that can bind several FGF receptors, FGF19 is specific for FGFR4 [].FGF21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression []. FGF21 has been shown to protect animals from diet-induced obesity when overexpressed in transgenic mice. It also lowers blood glucoseand triglyceride levels when administered to diabetic rodents [], suggesting it may exhibit the therapeutic characteristics necessary for effective treatment of diabetes. Treatment of animals with FGF21 results in increased energy expenditure, fat utilisation and lipid excretion []. FGF21 is most abundantly expressed in the liver, and also expressed in the thymus at lower levels [].
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Protein Coding Gene
MGI:1925544 | Rps27a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98887 | Uba52
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98888 | Ubb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98889 | Ubc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62984
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
P0CG50
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P62983
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
P0CG49
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Protein
Q3TJ05
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: false
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Protein
P16092
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
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Protein
J3QN85
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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Protein
Q60818
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
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Protein
Q8CIM9
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
Q61851
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: false
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Protein
P21803
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
A1YYP0
Organism: Mus musculus/domesticus
Length: 704  
Fragment?: false
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Protein
A1YYN9
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q61563
Organism: Mus musculus/domesticus
Length: 782  
Fragment?: false
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Protein
E9QNJ9
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: false
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Protein
Q7TSI8
Organism: Mus musculus/domesticus
Length: 800  
Fragment?: false
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Protein
A1YYM5
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
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Protein
E9Q7T0
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: true
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Protein
E9Q7E8
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: true
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Protein
A1YYM9
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
A1YYN5
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
A1YYN0
Organism: Mus musculus/domesticus
Length: 813  
Fragment?: false
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Protein
E9PXV8
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: true
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Protein
Q3TQL1
Organism: Mus musculus/domesticus
Length: 762  
Fragment?: true
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Protein
E9Q5C2
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Protein
E9PVU6
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: true
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Protein
A1YYM7
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
E9QK53
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: false
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Protein
A1YYN2
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: false
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Protein
E9Q7C7
Organism: Mus musculus/domesticus
Length: 726  
Fragment?: false
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Protein
E9PX88
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: true
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Protein
E9PX67
Organism: Mus musculus/domesticus
Length: 813  
Fragment?: true
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Protein
A1YYN1
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: false
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Protein
E9Q708
Organism: Mus musculus/domesticus
Length: 731  
Fragment?: true
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Protein
A1YYN7
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
A1YYM4
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
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Protein
E9PX60
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: true
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Protein
F6TK14
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: false
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Protein
A1YYN6
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Protein
D3Z5M8
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: true
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Protein
A1YYM6
Organism: Mus musculus/domesticus
Length: 731  
Fragment?: false
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Protein
A0A0R4IZY3
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Protein
A1YYM8
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: false
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Protein
Q3UPE1
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: false
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Protein
Q99052
Organism: Mus musculus/domesticus
Length: 800  
Fragment?: false
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Protein
E9Q5C3
Organism: Mus musculus/domesticus
Length: 696  
Fragment?: true
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Protein
B9EKY4
Organism: Mus musculus/domesticus
Length: 725  
Fragment?: false
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Protein
A1YYM3
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
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Protein
A1YYP1
Organism: Mus musculus/domesticus
Length: 706  
Fragment?: false
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Protein
B7ZWP2
Organism: Mus musculus/domesticus
Length: 752  
Fragment?: false
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Protein
E9PX90
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom