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Search results 1201 to 1300 out of 1300 for Foxn1

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Type Details Score
Allele  
Name: forkhead box N1; nude Yurlovo
Allele Type: Spontaneous
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Allele
Name: forkhead box N1; targeted mutation 1, Thomas Boehm
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele  
Name: forkhead box N1; nude 2 Jackson
Allele Type: Spontaneous
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Publication
First Author: Li J
Year: 2007
Journal: Differentiation
Title: Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C.
Volume: 75
Issue: 8
Pages: 694-701
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Allele
Name: transgene insertion 1, Janice L Brissette
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Name: transgene insertion 6, Janice L Brissette
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Dong-Ming Su
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, No functional change, Reporter
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Allele
Name: transgene insertion E1, Tasuku Honjo
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Name: transgene insertion G2, Tasuku Honjo
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Symbol: Fosl2/Fosl2 Tg(Foxn1-cre)1Tbo/?
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Symbol: Foxn1/Foxn1
Background: involves: 129S1/Sv
Zygosity: hm
Has Mutant Allele: true
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Genotype
Symbol: Foxn1/Foxn1
Background: 101/HY-Foxn1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Symbol: Foxn1/Foxn1
Background: B6(SJL)-Foxn1/GrsrJ
Zygosity: hm
Has Mutant Allele: true
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DO Term
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Publication
First Author: Dong X
Year: 2022
Journal: Eur J Immunol
Title: Trappc1 deficiency impairs thymic epithelial cell development by breaking endoplasmic reticulum homeostasis.
Volume: 52
Issue: 11
Pages: 1789-1804
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Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, C Clare Blackburn
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Genotype
Symbol: Tg(Foxn1)1Jlb/?
Background: involves: C57BL/6 * DBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Symbol: Tg(Foxn1)6Jlb/?
Background: involves: C57BL/6 * DBA
Zygosity: ot
Has Mutant Allele: true
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Allele
Name: forkhead box N1; nude
Allele Type: Spontaneous
Attribute String: Null/knockout
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Genotype
Symbol: Foxn1/Foxn1
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Publication
First Author: Liang Z
Year: 2021
Journal: J Immunol
Title: The Development and Survival of Thymic Epithelial Cells Require TSC1-Dependent Negative Regulation of mTORC1 Activity.
Volume: 207
Issue: 8
Pages: 2039-2050
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Publication
First Author: Liang Z
Year: 2022
Journal: iScience
Title: The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance.
Volume: 25
Issue: 10
Pages: 105233
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Publication
First Author: Liang Z
Year: 2018
Journal: Autophagy
Title: MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.
Volume: 14
Issue: 3
Pages: 505-517
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Publication
First Author: Zhang Q
Year: 2022
Journal: Commun Biol
Title: Sirt6-mediated epigenetic modification of DNA accessibility is essential for Pou2f3-induced thymic tuft cell development.
Volume: 5
Issue: 1
Pages: 544
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Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, C Clare Blackburn
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Inserted expressed sequence
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Strain
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Symbol: Furin/Furin Tg(Foxn1-cre)1Tbo/?
Background: involves: C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
Series Id: GSE23759
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
First Author: Di Stefano B
Year: 2014
Journal: Nat Cell Biol
Title: Hi-TEC reprogramming for organ regeneration.
Volume: 16
Issue: 9
Pages: 824-5
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HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Domain
Type: Domain
Description: This entry represents the forkhead (FH) domain of human FOXN1 and similar sequences from vertebrates. The FH domain is a winged helix DNA-binding domain.Forkhead box protein N1 (FOXN1) acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) [, ], both in the prenatal and postnatal thymus [, , , ]. Loss of function of this transcription factor leads to the human counterpart of the nude mouse characterised by athymia with severe T cell immunodeficiency, congenital alopecia, and nail dystrophy []. It has been reported that FOXN1 duplication leads to congenital hypertrichosis []. It is also an important factor in controlling the skin wound healing process, as it actively participates in re-epithelialization and is responsible for scar formation [, ].
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Publication
First Author: Haljasorg U
Year: 2017
Journal: J Immunol
Title: Irf4 Expression in Thymic Epithelium Is Critical for Thymic Regulatory T Cell Homeostasis.
Volume: 198
Issue: 5
Pages: 1952-1960
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Publication  
First Author: Dong X
Year: 2022
Journal: Front Immunol
Title: Cytosolic Nuclear Sensor Dhx9 Controls Medullary Thymic Epithelial Cell Differentiation by p53-Mediated Pathways.
Volume: 13
Pages: 896472
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Allele
Name: forkhead box N1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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Genotype
Symbol: Foxn1/Foxn1 Tg(Foxn1)G2Hon/?
Background: involves: CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Symbol: Foxn1/Foxn1 Tg(Foxn1)E1Hon/?
Background: involves: CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Symbol: Wls/Wls Tg(Foxn1-cre)1Tbo/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Symbol: Ascl1/Ascl1 Tg(Foxn1-cre)1Tbo/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline and WT vs. Mutant
Source: GEO
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Publication
First Author: Michel C
Year: 2017
Journal: J Immunol
Title: Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation.
Volume: 199
Issue: 10
Pages: 3488-3503
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Publication  
First Author: Romano R
Year: 2013
Journal: Front Immunol
Title: FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program.
Volume: 4
Pages: 187
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Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
First Author: Ribeiro C
Year: 2024
Journal: Cell Death Dis
Title: Foxo3 regulates cortical and medullary thymic epithelial cell homeostasis with implications in T cell development.
Volume: 15
Issue: 5
Pages: 352
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Publication
First Author: Koble C
Year: 2009
Journal: J Exp Med
Title: The thymic medulla: a unique microenvironment for intercellular self-antigen transfer.
Volume: 206
Issue: 7
Pages: 1505-13
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Publication
First Author: Liu B
Year: 2013
Journal: Development
Title: Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.
Volume: 140
Issue: 4
Pages: 780-8
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Publication
First Author: Ucar O
Year: 2016
Journal: Cell Rep
Title: A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-?.
Volume: 17
Issue: 2
Pages: 448-457
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Genotype
Symbol: Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Foxn1-cre)1Tbo/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Symbol: Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Foxn1-cre)1Tbo/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Symbol: Ctnnb1/Ctnnb1 Tg(Foxn1-cre)1Tbo/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Symbol: Cbx4/Cbx4 Tg(Foxn1-cre)1Tbo/?
Background: involves: 129S2/SvPas * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
First Author: Wurm S
Year: 2015
Journal: Genes Dev
Title: Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2.
Volume: 29
Issue: 2
Pages: 144-56
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Publication
First Author: Rodrigues PM
Year: 2017
Journal: Blood
Title: Thymic epithelial cells require p53 to support their long-term function in thymopoiesis in mice.
Volume: 130
Issue: 4
Pages: 478-488
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Publication
First Author: Ferreirinha P
Year: 2026
Journal: iScience
Title: KLF2 controls thymic epithelial cell homeostasis, impacting regulatory T cell development and immune tolerance.
Volume: 29
Issue: 4
Pages: 115161
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Publication
First Author: Rattay K
Year: 2015
Journal: J Immunol
Title: Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.
Volume: 194
Issue: 3
Pages: 921-8
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Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Foxn1/Foxn1<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
Series Id: E-GEOD-33268
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
First Author: Mato N
Year: 2017
Journal: Sci Rep
Title: Memory-type ST2(+)CD4(+) T cells participate in the steroid-resistant pathology of eosinophilic pneumonia.
Volume: 7
Issue: 1
Pages: 6805
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Publication
First Author: Ripen AM
Year: 2011
Journal: Eur J Immunol
Title: Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit ?5t.
Volume: 41
Issue: 5
Pages: 1278-87
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Publication
First Author: Tsai PT
Year: 2003
Journal: Blood
Title: BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis.
Volume: 102
Issue: 12
Pages: 3947-53
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Publication
First Author: Schwakopf J
Year: 2026
Journal: iScience
Title: Molecular heterogeneity and differential metabolic signatures in thymic adipocytes.
Volume: 29
Issue: 8
Pages: 117143
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Publication
First Author: Li S
Year: 2004
Journal: Neuron
Title: Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors.
Volume: 43
Issue: 6
Pages: 795-807
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Publication
First Author: Li S
Year: 2011
Journal: Dev Dyn
Title: Foxn4 influences alveologenesis during lung development.
Volume: 240
Issue: 6
Pages: 1512-7
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Publication
First Author: Luo H
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.
Volume: 109
Issue: 9
Pages: E553-62
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Publication
First Author: Kunzevitzky NJ
Year: 2011
Journal: Mol Cell Neurosci
Title: Foxn4 is required for retinal ganglion cell distal axon patterning.
Volume: 46
Issue: 4
Pages: 731-41
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Publication
First Author: Campbell EP
Year: 2016
Journal: Development
Title: Foxn4 promotes gene expression required for the formation of multiple motile cilia.
Volume: 143
Issue: 24
Pages: 4654-4664
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Publication
First Author: Xiang M
Year: 2013
Journal: Sci China Life Sci
Title: Foxn4: a multi-faceted transcriptional regulator of cell fates in vertebrate development.
Volume: 56
Issue: 11
Pages: 985-93
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Publication
First Author: Chen X
Year: 2014
Journal: J Mol Neurosci
Title: Up-regulation of FoxN4 expression in adult spinal cord after injury.
Volume: 52
Issue: 3
Pages: 403-9
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Publication
First Author: Boije H
Year: 2013
Journal: Differentiation
Title: Forkheadbox N4 (FoxN4) triggers context-dependent differentiation in the developing chick retina and neural tube.
Volume: 85
Issue: 1-2
Pages: 11-9
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Protein Domain
Type: Family
Description: This family includes Forkhead box protein N41 and N4.Forkhead box protein N1 (FOXN1) acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) [, ], both in the prenatal and postnatal thymus [, , , ]. Loss of function of this transcription factor leads to the human counterpart of the nude mouse characterised by athymia with severe T cell immunodeficiency, congenital alopecia, and nail dystrophy []. It has been reported that FOXN1 duplication leads to congenital hypertrichosis []. It is also an important factor in controlling the skin wound healing process, as it actively participates in re-epithelialization and is responsible for scar formation [, ].Forkhead box protein N4 (FOXN4) acts as a transcription factor essential for neural and some non-neural tissue development, such as retina and lung, respectively [, , , , ]. During development of the central nervous system, FOXN4 is required in specifying the amacrine and horizontal cell fates from multipotent retinal progenitors, while suppressing alternative photoreceptor cell fates [, , ]. In non-neural tissues, it plays an essential role in specifying the atrioventricular canal and is indirectly required for patterning the distal airway during lung development []. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
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HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
First Author: Danilova N
Year: 2004
Journal: Brain Res Dev Brain Res
Title: Expression of the winged helix/forkhead gene, foxn4, during zebrafish development.
Volume: 153
Issue: 1
Pages: 115-9
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Protein
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: false
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Publication
First Author: Augustin I
Year: 2013
Journal: J Exp Med
Title: Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.
Volume: 210
Issue: 9
Pages: 1761-77
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Publication
First Author: Katoh M
Year: 2004
Journal: Int J Oncol
Title: Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico.
Volume: 25
Issue: 1
Pages: 219-23
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Publication
First Author: Kulessa H
Year: 2000
Journal: EMBO J
Title: Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle.
Volume: 19
Issue: 24
Pages: 6664-74
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Publication
First Author: M?ller SM
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture.
Volume: 102
Issue: 30
Pages: 10587-92
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Publication
First Author: Liang CC
Year: 2013
Journal: Immunol Cell Biol
Title: Thymic epithelial ?-catenin is required for adult thymic homeostasis and function.
Volume: 91
Issue: 8
Pages: 511-23
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Publication
First Author: Andl T
Year: 2004
Journal: Development
Title: Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development.
Volume: 131
Issue: 10
Pages: 2257-68
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Publication
First Author: Baik S
Year: 2016
Journal: Eur J Immunol
Title: Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK(+) medullary epithelial progenitors.
Volume: 46
Issue: 4
Pages: 857-62
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Publication  
First Author: Dumont-Lagac? M
Year: 2015
Journal: Sci Rep
Title: Sex hormones have pervasive effects on thymic epithelial cells.
Volume: 5
Pages: 12895
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Publication
First Author: Kim KY
Year: 2015
Journal: Mol Cells
Title: Expression Analyses Revealed Thymic Stromal Co-Transporter/Slc46A2 Is in Stem Cell Populations and Is a Putative Tumor Suppressor.
Volume: 38
Issue: 6
Pages: 548-61
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Publication
First Author: Shitara S
Year: 2013
Journal: J Immunol
Title: IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCR??+ intraepithelial lymphocytes.
Volume: 190
Issue: 12
Pages: 6173-9
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Publication
First Author: Fiorini E
Year: 2013
Journal: Genesis
Title: Inducible gene expression in fetal thymic epithelium: a new BAC transgenic model.
Volume: 51
Issue: 10
Pages: 717-24
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Publication
First Author: Peaudecerf L
Year: 2012
Journal: J Exp Med
Title: Thymocytes may persist and differentiate without any input from bone marrow progenitors.
Volume: 209
Issue: 8
Pages: 1401-8
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Publication
First Author: Hirakawa M
Year: 2018
Journal: Sci Rep
Title: Fundamental parameters of the developing thymic epithelium in the mouse.
Volume: 8
Issue: 1
Pages: 11095
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Publication      
First Author: Schwakopf J
Year: 2026
Journal: bioRxiv
Title: Molecular heterogeneity and differential metabolic signatures in thymic adipocytes.
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Publication  
First Author: Riemann M
Year: 2017
Journal: J Autoimmun
Title: Central immune tolerance depends on crosstalk between the classical and alternative NF-?B pathways in medullary thymic epithelial cells.
Volume: 81
Pages: 56-67
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Publication
First Author: Rudloff S
Year: 2012
Journal: Development
Title: Differential requirements for ?-catenin during mouse development.
Volume: 139
Issue: 20
Pages: 3711-21
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Protein
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: true
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Publication
First Author: Andreas N
Year: 2019
Journal: J Immunol
Title: RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells.
Volume: 203
Issue: 10
Pages: 2602-2613
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