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Search results 1201 to 1300 out of 1513 for Gdnf

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Type Details Score
Allele
Gfral<em3Cya> | MGI:7793587
Name: GDNF family receptor alpha like; endonuclease-mediated mutation 3, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Gfral<em2Cya> | MGI:7793588
Name: GDNF family receptor alpha like; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
9592044 | J:45854
First Author: Dey BK
Year: 1998
Journal: Neuroreport
Title: Cloning of a novel murine isoform of the glial cell line-derived neurotrophic factor receptor.
Volume: 9
Issue: 1
Pages: 37-42
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Publication
37433299 | J:341053
First Author: Breit SN
Year: 2023
Journal: Cell Metab
Title: GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway.
Volume: 35
Issue: 8
Pages: 1341-1355.e3
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Protein
Q9R2D0
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Publication
10974669 | J:64539
First Author: Hiltunen JO
Year: 2000
Journal: Dev Dyn
Title: GDNF family receptors in the embryonic and postnatal rat heart and reduced cholinergic innervation in mice hearts lacking ret or GFRalpha2.
Volume: 219
Issue: 1
Pages: 28-39
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Publication
25434487 | J:218605
 
First Author: Battaglia G
Year: 2015
Journal: Neurobiol Dis
Title: Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.
Volume: 74
Pages: 126-36
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Publication
9811930 | J:50871
First Author: Grimm L
Year: 1998
Journal: Hum Mol Genet
Title: Analysis of the human GDNF gene reveals an inducible promoter, three exons, a triplet repeat within the 3'-UTR and alternative splice products.
Volume: 7
Issue: 12
Pages: 1873-86
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Allele
Gfral<tm1e(EUCOMM)Hmgu> | MGI:4435607
Name: GDNF family receptor alpha like; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Gfral<tm1a(EUCOMM)Hmgu> | MGI:4435930
Name: GDNF family receptor alpha like; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Gfral<tm2e(EUCOMM)Hmgu> | MGI:4436413
Name: GDNF family receptor alpha like; targeted mutation 2e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Gfral<tm2a(EUCOMM)Hmgu> | MGI:4436694
Name: GDNF family receptor alpha like; targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Gfral<Gt(527H8)Cmhd> | MGI:4957982
 
Name: GDNF family receptor alpha like; gene trap 527H8, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Strain
MGI:6140071 | B6.129S5-Gfral<tm1Lex>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5547412 | B6;129S5-Gfral<tm1Lex>/Mmucd
Attribute String: targeted mutation, mutant stock
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Strain
MGI:6440956 | B6;129S5-Gfral<tm1Lex>/Tac
Attribute String: mutant stock, targeted mutation
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Allele
Gfral<em1Gpt> | MGI:7299544
Name: GDNF family receptor alpha like; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Gfral<em2Gpt> | MGI:7299545
Name: GDNF family receptor alpha like; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Gfral<em1Smoc> | MGI:7289863
Name: GDNF family receptor alpha like; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7386830 | C57BL/6J-Gfral<em1Oyad>/Oyad
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7482594 | C57BL/6-Gfral<em1(cre)Lbrl>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Gfral<em3Rsy> | MGI:7546992
Name: GDNF family receptor alpha like; endonuclease-mediated mutation 3, Randy J Seeley
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Gfral<tm1(cre)Vwwt> | MGI:7546840
Name: GDNF family receptor alpha like; targeted mutation 1, Vicky Wang-Wei Tsai
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Gfral<tm2Vwwt> | MGI:7546842
Name: GDNF family receptor alpha like; targeted mutation 2, Vicky Wang-Wei Tsai
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Gfral<em1(GFRAL)Smoc> | MGI:7766109
Name: GDNF family receptor alpha like; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:7834923 | C57BL/6N-Gfral<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7837331 | C57BL/6JCya-Gfral<em3Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7839658 | C57BL/6JCya-Gfral<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Gfral/Gfral
Background: B6.129S5-Gfral
Zygosity: hm
Has Mutant Allele: true
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GO Term
GO:1990790 | response to glial cell derived neurotrophic factor
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GO Term
GO:1990792 | cellular response to glial cell derived neurotrophic factor
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GO Term
GO:0044467 | glial cell-derived neurotrophic factor production
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Publication
37380764 | J:340165
First Author: Wang D
Year: 2023
Journal: Nature
Title: GDF15 promotes weight loss by enhancing energy expenditure in muscle.
Volume: 619
Issue: 7968
Pages: 143-150
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Publication
38301257 | J:349347
First Author: Shah FA
Year: 2024
Journal: Am J Respir Cell Mol Biol
Title: Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury.
Volume: 70
Issue: 5
Pages: 379-391
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Publication
35202387 | J:342573
First Author: Lu JF
Year: 2022
Journal: PLoS Biol
Title: Camptothecin effectively treats obesity in mice through GDF15 induction.
Volume: 20
Issue: 2
Pages: e3001517
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Publication
34935522 | J:335400
First Author: Patel AR
Year: 2022
Journal: Am J Physiol Gastrointest Liver Physiol
Title: LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice.
Volume: 322
Issue: 2
Pages: G247-G255
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Publication
38056430 | J:347515
First Author: Lu JF
Year: 2023
Journal: Cell Metab
Title: GDF15 is a major determinant of ketogenic diet-induced weight loss.
Volume: 35
Issue: 12
Pages: 2165-2182.e7
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Publication
8657309 | J:33824
First Author: Treanor JJ
Year: 1996
Journal: Nature
Title: Characterization of a multicomponent receptor for GDNF.
Volume: 382
Issue: 6586
Pages: 80-3
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GO Term
GO:1900166 | regulation of glial cell-derived neurotrophic factor production
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Publication
38719753 | J:347979
 
First Author: Baur K
Year: 2024
Journal: Life Sci Alliance
Title: GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferation.
Volume: 7
Issue: 7
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Publication
9875703 | -
First Author: Wong YW
Year: 1998
Journal: Neuroreport
Title: Identification of mammalian GFRalpha-2 splice isoforms.
Volume: 9
Issue: 17
Pages: 3767-73
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Publication
12829325 | -
First Author: Too HP
Year: 2003
Journal: Brain Res Mol Brain Res
Title: Real time PCR quantification of GFRalpha-2 alternatively spliced isoforms in murine brain and peripheral tissues.
Volume: 114
Issue: 2
Pages: 146-53
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Strain
MGI:7382631 | C57BL/6N-Gfral<tm1a(EUCOMM)Hmgu>/Kmpc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6428717 | C57BL/6JSmoc-Gfral<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7767436 | BALB/cAn-Gfral<em1(GFRAL)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
35705049 | J:344017
First Author: Zhang C
Year: 2022
Journal: Cell Rep
Title: A brainstem circuit for nausea suppression.
Volume: 39
Issue: 11
Pages: 110953
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Publication
10860579 | J:63721
First Author: Lindahl M
Year: 2000
Journal: Mol Cell Neurosci
Title: Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development.
Volume: 15
Issue: 6
Pages: 522-33
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GO Term
GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway
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Publication
33278342 | J:307177
First Author: Zhang C
Year: 2021
Journal: Neuron
Title: Area Postrema Cell Types that Mediate Nausea-Associated Behaviors.
Volume: 109
Issue: 3
Pages: 461-472.e5
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Publication
10659850 | -
First Author: Ramer MS
Year: 2000
Journal: Nature
Title: Functional regeneration of sensory axons into the adult spinal cord.
Volume: 403
Issue: 6767
Pages: 312-6
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Protein Domain
IPR043401 | GDNF_fam
Type: Family
Description: The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFRalpha complex binds to and stimulates autophosphorylation of Ret. For instance, GDNF binds to GFRalpha1, Neurturin binds to GFRalpha2, artemin to GFRalpha3 and persephin activates Ret by binding to GFRalpha4. The GDNF family members support the survival of dopamine neurons and motoneurons, and some of them also regulate the development of enteric, sympathetic and parasympathetic neurons []. GDNF also functions in the regeneration of sensory axons after spinal cord injury [], regulation of spermatogonia renewal and differentiation during male spermatogenesis []. It is also involved in kidney development [].
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Publication
37473755 | J:340854
First Author: Sjøberg KA
Year: 2023
Journal: Cell Metab
Title: GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism.
Volume: 35
Issue: 8
Pages: 1327-1340.e5
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Publication
33151561 | J:302564
First Author: Lee J
Year: 2021
Journal: J Cell Physiol
Title: Macrophage inhibitory cytokine-1 promotes angiogenesis by eliciting the GFRAL-mediated endothelial cell signaling.
Volume: 236
Issue: 5
Pages: 4008-4023
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Allele
Tg(Gdnf-EGFP/Rpl10)ES2243Htz | MGI:7260296
Name: transgene insertion ES224, Nathaniel Heintz
Allele Type: Transgenic
Attribute String: Reporter
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GO Term
GO:1900168 | positive regulation of glial cell-derived neurotrophic factor production
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GO Term
GO:1900167 | negative regulation of glial cell-derived neurotrophic factor production
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Publication
29144449 | -
First Author: Hsu JY
Year: 2017
Journal: Nature
Title: Erratum: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Volume: 551
Issue: 7680
Pages: 398
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Allele
Gdnf<tm1Rosl> | MGI:2136843
Name: glial cell line derived neurotrophic factor; targeted mutation 1, Arnon Rosenthal
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Gdnf<tm1Bbd> | MGI:2136844
Name: glial cell line derived neurotrophic factor; targeted mutation 1, Mariano Barbacid
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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GO Term
GO:2000701 | glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
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GO Term
GO:2000733 | regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
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Protein
Q9Z0L2
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
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Protein
O70300
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
P97463
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: false
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Protein
A1L3Q1
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein Domain
IPR016017 | GDNF/GAS1
Type: Domain
Description: This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons [, ]. GDNF and neurturin promote neuronal survival by signalling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity [].
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HT Experiment
E-MTAB-3275 | Transcriptional analysis using E13.5 mouse eyes of TGFb2/GDNF mutants compared to WT
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE227845 | Ontogeny and Trophic Factor Sensitivity of Gastrointestinal Projecting Vagal Sensory Cell Types
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
32723474 | J:298668
   
First Author: Worth AA
Year: 2020
Journal: Elife
Title: The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling.
Volume: 9
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Allele
Tg(Gdnf-EGFP)KP206Gsat | MGI:4847080
Name: transgene insertion KP206, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Gdnf<tm1(cre/ERT2)Cos> | MGI:5553062
Name: glial cell line derived neurotrophic factor; targeted mutation 1, Frank Costantini
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Strain
MGI:7260297 | B6;FVB-Tg(Gdnf-EGFP/Rpl10)ES2243Htz/J
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Gdnf/Gdnf
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gdnf/Gdnf<+>
Background: involves: 129S1/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gdnf/Gdnf<+>
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gdnf/Gdnf
Background: involves: 129S2/SvPas
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gdnf/Gdnf<+>
Background: involves: 129S2/SvPas
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gdnf/Gdnf
Background: involves: 129S2/SvPas * CD-1
Zygosity: hm
Has Mutant Allele: true
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GO Term
GO:2000734 | negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
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GO Term
GO:2000735 | positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
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Publication
15044553 | J:90075
First Author: Kholodilov N
Year: 2004
Journal: J Neurosci
Title: Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets.
Volume: 24
Issue: 12
Pages: 3136-46
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Publication
9177201 | J:40969
First Author: Sanicola M
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins.
Volume: 94
Issue: 12
Pages: 6238-43
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Strain
MGI:5004077 | STOCK Tg(Gdnf-EGFP)KP206Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Strain
MGI:5552975 | B6;129S6-Gdnf<tm1(cre/ERT2)Cos>/J
Attribute String: mutant stock, targeted mutation
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Allele
Tg(Ctsl-Gdnf/EGFP)1Reb | MGI:6331132
Name: transgene insertion 1, Robert E Braun
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Gdnf/Gdnf
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gdnf/Gdnf<+> Spry1/Spry1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
24449858 | J:206435
First Author: Hedstrom KL
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling.
Volume: 111
Issue: 6
Pages: 2325-30
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Protein
Q01721
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Protein
A0A286YD87
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
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Protein
Q7TNT6
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: true
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Protein Domain
IPR003503 | GDNF_rcpt_A1
Type: Family
Description: Glial cell line-derived neurotrophic factor (GDNF) and its related factorsneurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNFfamily of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved inthe promotion of neurone survival, exerting their effects through specific receptors.The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked,cell surface receptors []. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. Homologues for the GFRalpha-1 receptor subtype have been cloned from mammalian and avian tissue. The receptor is activated by GDNF [], although there is evidence it can also bind neurturin, the principal ligand for GFRalpha-2 [].Activation of GFRalpha-1 triggers its interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma) dependent pathways [].
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Protein Domain
IPR041163 | Ret_CLD1
Type: Domain
Description: Ret is a single transmembrane-spanning receptor tyrosine kinase (RTK) that plays critical roles in the development of vertebrates. It contains four consecutive cadherin-like domains (CLD). This entry represents the first CLD at the N-terminal. Several regions within RET-CLD1 have been shown to be important for ligand-coreceptor binding. CLD1 and CLD2 have a distinctive clamshell shape and CLD1 is essential for CLD2 folding. CLD1 contains 2 sites for GDNF receptor alpha 1 binding [].
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Allele
Tg(tetO-Gdnf,lacZ)14Brke | MGI:3623289
Name: transgene insertion 14, Robert E Burke
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Reporter
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Allele
Tg(KRT14-Gdnf)097Kma | MGI:3829499
Name: transgene insertion 097, Katheryn M Albers
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(KRT14-Gdnf)324Kma | MGI:3829501
Name: transgene insertion 324, Katheryn M Albers
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Gdnf/Gdnf<+> Slit2/Slit2
Background: involves: 129S2/SvPas
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax Gdnf/Gdnf<+>
Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gdnf/Gdnf Nrtn/Nrtn
Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gdnf/Gdnf<+> Nrtn/Nrtn
Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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