|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1201 to 1300 out of 3891 for Gli2

0.022s
Type Details Score
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Protein
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: false
Publication
First Author: Joeng KS
Year: 2009
Journal: Development
Title: The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization.
Volume: 136
Issue: 24
Pages: 4177-85
Publication  
First Author: Ding J
Year: 2024
Journal: Cancer Lett
Title: TGF-β1/SMAD3-driven GLI2 isoform expression contributes to aggressive phenotypes of hepatocellular carcinoma.
Volume: 588
Pages: 216768
Publication
First Author: Niesen J
Year: 2023
Journal: iScience
Title: hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation.
Volume: 26
Issue: 9
Pages: 107501
Publication
First Author: Han B
Year: 2015
Journal: Cell Rep
Title: FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer.
Volume: 13
Issue: 5
Pages: 1046-58
Publication
First Author: Dennler S
Year: 2007
Journal: Cancer Res
Title: Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.
Volume: 67
Issue: 14
Pages: 6981-6
Publication
First Author: Kim J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector.
Volume: 107
Issue: 30
Pages: 13432-7
DO Term
Interaction Experiment
Description: Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.
Interaction Experiment
Description: Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.
Interaction Experiment
Description: Small Ubiquitin-like Modifier (SUMO) Modification Inhibits GLI2 Protein Transcriptional Activity in Vitro and in Vivo.
Interaction Experiment
Description: Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.
GXD Expression
Probe: MGI:1338477
Assay Type: Immunohistochemistry
Annotation Date: 2019-08-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614015
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6343551
Age: embryonic day 9.25
Image: S1 E9.25
Note: Compared to an adjacent section, Foxa2 expression overlaps with Gli2 at E9.25.
Specimen Label: S1 E9.25
Detected: true
Specimen Num: 17
Allele
Name: GLI-Kruppel family member GLI2; targeted mutation 4, Alexandra L Joyner
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Allele
Name: GLI-Kruppel family member GLI2; targeted mutation 1, Tien Peng
Allele Type: Targeted
Attribute String: Inducible, Recombinase, Reporter
Interaction Experiment
Description: Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.
Publication
First Author: Bhatia N
Year: 2006
Journal: J Biol Chem
Title: Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.
Volume: 281
Issue: 28
Pages: 19320-6
GXD Expression
Probe: MGI:1338477
Assay Type: Immunohistochemistry
Annotation Date: 2019-08-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:6343551
Age: embryonic day 12.5
Image: S1 E12.5
Note: Compared to an adjacent section, the dorsal limit of Foxa2 expression abuts the ventral limit of Gli2 expression at E12.5.
Specimen Label: S1 E12.5
Detected: true
Specimen Num: 19
GXD Expression
Probe: MGI:2684133
Assay Type: Immunohistochemistry
Annotation Date: 2019-08-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:6343549
Age: embryonic day 12.5
Image: S1 E12.5
Note: Compared to an adjacent section, there is a gap between Shh and Gli2 expression in the ventral midbrain.
Specimen Label: S1 E12.5
Detected: true
Specimen Num: 20
Publication
First Author: Grachtchouk M
Year: 2006
Journal: Am J Pathol
Title: Odontogenic keratocysts arise from quiescent epithelial rests and are associated with deregulated hedgehog signaling in mice and humans.
Volume: 169
Issue: 3
Pages: 806-14
Publication
First Author: Sheng H
Year: 2002
Journal: Cancer Res
Title: Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype.
Volume: 62
Issue: 18
Pages: 5308-16
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Junhao Mao
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
Allele
Name: GLI-Kruppel family member GLI2; targeted mutation 3, Jeremy Reiter
Allele Type: Targeted
Attribute String: Epitope tag, Reporter
Allele
Name: transgene insertion #, Chi-chung Hui
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
DO Term
Allele
Name: GLI-Kruppel family member GLI2; targeted mutation 4.1, Alexandra L Joyner
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Fanxin Long
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence, Reporter
Publication
First Author: Kerns ML
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex.
Volume: 104
Issue: 36
Pages: 14460-5
Publication
First Author: Persson M
Year: 2002
Journal: Genes Dev
Title: Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity.
Volume: 16
Issue: 22
Pages: 2865-78
Publication
First Author: Pavletich NP
Year: 1993
Journal: Science
Title: Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.
Volume: 261
Issue: 5129
Pages: 1701-7
Publication
First Author: Kinzler KW
Year: 1990
Journal: Mol Cell Biol
Title: The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.
Volume: 10
Issue: 2
Pages: 634-42
Publication
First Author: Jiang J
Year: 2008
Journal: Dev Cell
Title: Hedgehog signaling in development and cancer.
Volume: 15
Issue: 6
Pages: 801-12
Publication
First Author: Lo HW
Year: 2009
Journal: Cancer Res
Title: A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.
Volume: 69
Issue: 17
Pages: 6790-8
Protein Domain
Type: Family
Description: GLI1 (glioma-associated oncogene homologue 1) is a central effector of the Hedgehog (HH) pathway, a pathway that governs many developmental processes []. It is a member of the GLI family of transcription factors, which also includes GLI2 and GLI3 []. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions []. GLI1 is amplified in a subset of human tumours []. It contains five repeats of a zinc finger DNA-binding motif and binds DNA in a sequence-specific fashion [, ].
Allele
Name: GLI-Kruppel family member GLI2; targeted mutation 5, Alexandra L Joyner
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: GLI-Kruppel family member GLI2; targeted mutation 5.1, Alexandra L Joyner
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion 1, Andrzej A Dlugosz
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence, Reporter
Genotype
Symbol: Gli2/Gli2
Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Gli2/Gli2<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Di Girolamo D
Year: 2016
Journal: J Clin Invest
Title: Reciprocal interplay between thyroid hormone and microRNA-21 regulates hedgehog pathway-driven skin tumorigenesis.
Volume: 126
Issue: 6
Pages: 2308-20
Publication
First Author: Chung BM
Year: 2015
Journal: J Cell Biol
Title: Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.
Volume: 208
Issue: 5
Pages: 613-27
Genotype
Symbol: Gli2/Gli2
Background: involves: Swiss Webster
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Gli2/Gli2
Background: involves: Swiss Webster
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ihh/Ihh
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Col2a1-cre)3Amc/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Publication  
First Author: Hui CC
Year: 2011
Journal: Annu Rev Cell Dev Biol
Title: Gli proteins in development and disease.
Volume: 27
Pages: 513-37
Publication
First Author: Nguyen V
Year: 2005
Journal: Development
Title: Cooperative requirement of the Gli proteins in neurogenesis.
Volume: 132
Issue: 14
Pages: 3267-79
Protein
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
Publication
First Author: Wang C
Year: 2007
Journal: Dev Biol
Title: The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning.
Volume: 305
Issue: 2
Pages: 460-9
Publication
First Author: Kugler MC
Year: 2019
Journal: Exp Lung Res
Title: The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis.
Volume: 45
Issue: 1-2
Pages: 22-29
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Shi Y
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation.
Volume: 112
Issue: 15
Pages: 4678-83
Publication
First Author: Fleming JT
Year: 2019
Journal: Mol Cancer Res
Title: Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model.
Volume: 17
Issue: 5
Pages: 1024-1035
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ihh/Ihh Tg(Col2a1-cre)3Amc/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gli2/Gli2<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Protein Domain
Type: Family
Description: GLI3 is a member of the GLI family of transcription factors, which also includes GLI1 and GLI2. They are central effectors of the Hedgehog (Hh) pathway in vertebrates [, ]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions []. The full-length GLI3 form, after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while its C-terminally truncated form acts as a repressor (GLI3R). GLI3 participates in the patterning and growth of many organs, including the central nervous system (CNS) and limbs [, , , , ].
Publication
First Author: Kern D
Year: 2015
Journal: Oncogene
Title: Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.
Volume: 34
Issue: 42
Pages: 5341-51
Publication
First Author: Günther T
Year: 1994
Journal: Development
Title: Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord.
Volume: 120
Issue: 11
Pages: 3119-30
Publication
First Author: Eggenschwiler JT
Year: 2000
Journal: Dev Biol
Title: Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene.
Volume: 227
Issue: 2
Pages: 648-60
Publication
First Author: Eggenschwiler JT
Year: 2001
Journal: Nature
Title: Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway.
Volume: 412
Issue: 6843
Pages: 194-8
Publication
First Author: Evans TM
Year: 2003
Journal: Traffic
Title: Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway.
Volume: 4
Issue: 12
Pages: 869-84
Publication
First Author: Wang B
Year: 2000
Journal: Cell
Title: Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.
Volume: 100
Issue: 4
Pages: 423-34
Publication
First Author: Humke EW
Year: 2010
Journal: Genes Dev
Title: The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.
Volume: 24
Issue: 7
Pages: 670-82
Protein
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
Publication
First Author: Aoto K
Year: 2002
Journal: Dev Biol
Title: Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud.
Volume: 251
Issue: 2
Pages: 320-32
Publication
First Author: Anwar S
Year: 2015
Journal: Dev Growth Differ
Title: Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development.
Volume: 57
Issue: 8
Pages: 570-80
Publication
First Author: Marcos I
Year: 2003
Journal: Int J Mol Med
Title: Molecular cloning and characterization of human RAB23, a member of the group of Rab GTPases.
Volume: 12
Issue: 6
Pages: 983-7
Protein Domain
Type: Family
Description: Rab23 is a member of the Rab family of small GTPases. In mouse, Rab23 has been shown to function as a negative regulator in the sonic hedgehog (Shh) signaling pathway. Rab23 mediates the activity of Gli2 and Gli3, transcription factors that regulate Shh signaling in the spinal cord, primarily by preventing Gli2 activation in the absence of Shh ligand []. Rab23 also regulates a step in the cytoplasmic signal transduction pathway that mediates the effect of Smoothened (one of two integral membrane proteins that are essential components of the Shh signaling pathway in vertebrates) [, ].In humans, Rab23 is expressed in the retina []. Mice contain an isoform that shares 93% sequence identity with the human Rab23 and an alternative splicing isoform that is specific to the brain. This isoform causes the murine open brain phenotype, indicating it may have a role in the development of the central nervous system [, ]. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins [].
HT Experiment
Series Id: GSE17473
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO