| Type |
Details |
Score |
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
49
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Joeng KS |
| Year: |
2009 |
| Journal: |
Development |
| Title: |
The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. |
| Volume: |
136 |
| Issue: |
24 |
| Pages: |
4177-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ding J |
| Year: |
2024 |
| Journal: |
Cancer Lett |
| Title: |
TGF-β1/SMAD3-driven GLI2 isoform expression contributes to aggressive phenotypes of hepatocellular carcinoma. |
| Volume: |
588 |
|
| Pages: |
216768 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Niesen J |
| Year: |
2023 |
| Journal: |
iScience |
| Title: |
hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation. |
| Volume: |
26 |
| Issue: |
9 |
| Pages: |
107501 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Han B |
| Year: |
2015 |
| Journal: |
Cell Rep |
| Title: |
FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. |
| Volume: |
13 |
| Issue: |
5 |
| Pages: |
1046-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dennler S |
| Year: |
2007 |
| Journal: |
Cancer Res |
| Title: |
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. |
| Volume: |
67 |
| Issue: |
14 |
| Pages: |
6981-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim J |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. |
| Volume: |
107 |
| Issue: |
30 |
| Pages: |
13432-7 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Small Ubiquitin-like Modifier (SUMO) Modification Inhibits GLI2 Protein Transcriptional Activity in Vitro and in Vivo. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1338477 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2019-08-15 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1614015 |
| Pattern: |
Regionally restricted |
| Stage: |
TS15 |
| Assay Id: |
MGI:6343551 |
| Age: |
embryonic day 9.25 |
| Image: |
S1 E9.25 |
| Note: |
Compared to an adjacent section, Foxa2 expression overlaps with Gli2 at E9.25. |
| Specimen Label: |
S1 E9.25 |
| Detected: |
true |
| Specimen Num: |
17 |
|
•
•
•
•
•
|
| Allele |
| Name: |
GLI-Kruppel family member GLI2; targeted mutation 4, Alexandra L Joyner |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
GLI-Kruppel family member GLI2; targeted mutation 1, Tien Peng |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase, Reporter |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bhatia N |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase. |
| Volume: |
281 |
| Issue: |
28 |
| Pages: |
19320-6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1338477 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2019-08-15 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1697420 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:6343551 |
| Age: |
embryonic day 12.5 |
| Image: |
S1 E12.5 |
| Note: |
Compared to an adjacent section, the dorsal limit of Foxa2 expression abuts the ventral limit of Gli2 expression at E12.5. |
| Specimen Label: |
S1 E12.5 |
| Detected: |
true |
| Specimen Num: |
19 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:2684133 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2019-08-15 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1697420 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:6343549 |
| Age: |
embryonic day 12.5 |
| Image: |
S1 E12.5 |
| Note: |
Compared to an adjacent section, there is a gap between Shh and Gli2 expression in the ventral midbrain. |
| Specimen Label: |
S1 E12.5 |
| Detected: |
true |
| Specimen Num: |
20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grachtchouk M |
| Year: |
2006 |
| Journal: |
Am J Pathol |
| Title: |
Odontogenic keratocysts arise from quiescent epithelial rests and are associated with deregulated hedgehog signaling in mice and humans. |
| Volume: |
169 |
| Issue: |
3 |
| Pages: |
806-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sheng H |
| Year: |
2002 |
| Journal: |
Cancer Res |
| Title: |
Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype. |
| Volume: |
62 |
| Issue: |
18 |
| Pages: |
5308-16 |
|
•
•
•
•
•
|
| Allele |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Junhao Mao |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
GLI-Kruppel family member GLI2; targeted mutation 3, Jeremy Reiter |
| Allele Type: |
Targeted |
| Attribute String: |
Epitope tag, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion #, Chi-chung Hui |
| Allele Type: |
Transgenic |
| Attribute String: |
Epitope tag, Inserted expressed sequence |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Allele |
| Name: |
GLI-Kruppel family member GLI2; targeted mutation 4.1, Alexandra L Joyner |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Fanxin Long |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Constitutively active, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kerns ML |
| Year: |
2007 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex. |
| Volume: |
104 |
| Issue: |
36 |
| Pages: |
14460-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Persson M |
| Year: |
2002 |
| Journal: |
Genes Dev |
| Title: |
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. |
| Volume: |
16 |
| Issue: |
22 |
| Pages: |
2865-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pavletich NP |
| Year: |
1993 |
| Journal: |
Science |
| Title: |
Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. |
| Volume: |
261 |
| Issue: |
5129 |
| Pages: |
1701-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kinzler KW |
| Year: |
1990 |
| Journal: |
Mol Cell Biol |
| Title: |
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. |
| Volume: |
10 |
| Issue: |
2 |
| Pages: |
634-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiang J |
| Year: |
2008 |
| Journal: |
Dev Cell |
| Title: |
Hedgehog signaling in development and cancer. |
| Volume: |
15 |
| Issue: |
6 |
| Pages: |
801-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lo HW |
| Year: |
2009 |
| Journal: |
Cancer Res |
| Title: |
A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. |
| Volume: |
69 |
| Issue: |
17 |
| Pages: |
6790-8 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
GLI1 (glioma-associated oncogene homologue 1) is a central effector of the Hedgehog (HH) pathway, a pathway that governs many developmental processes []. It is a member of the GLI family of transcription factors, which also includes GLI2 and GLI3 []. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions []. GLI1 is amplified in a subset of human tumours []. It contains five repeats of a zinc finger DNA-binding motif and binds DNA in a sequence-specific fashion [, ]. |
|
•
•
•
•
•
|
| Allele |
| Name: |
GLI-Kruppel family member GLI2; targeted mutation 5, Alexandra L Joyner |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
GLI-Kruppel family member GLI2; targeted mutation 5.1, Alexandra L Joyner |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Andrzej A Dlugosz |
| Allele Type: |
Transgenic |
| Attribute String: |
Constitutively active, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gli2/Gli2 |
| Background: |
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gli2/Gli2<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
| Background: |
involves: 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Di Girolamo D |
| Year: |
2016 |
| Journal: |
J Clin Invest |
| Title: |
Reciprocal interplay between thyroid hormone and microRNA-21 regulates hedgehog pathway-driven skin tumorigenesis. |
| Volume: |
126 |
| Issue: |
6 |
| Pages: |
2308-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chung BM |
| Year: |
2015 |
| Journal: |
J Cell Biol |
| Title: |
Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes. |
| Volume: |
208 |
| Issue: |
5 |
| Pages: |
613-27 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gli2/Gli2 |
| Background: |
involves: Swiss Webster |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gli2/Gli2 |
| Background: |
involves: Swiss Webster |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ihh/Ihh |
| Background: |
involves: 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Col2a1-cre)3Amc/? |
| Background: |
involves: 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hui CC |
| Year: |
2011 |
| Journal: |
Annu Rev Cell Dev Biol |
| Title: |
Gli proteins in development and disease. |
| Volume: |
27 |
|
| Pages: |
513-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nguyen V |
| Year: |
2005 |
| Journal: |
Development |
| Title: |
Cooperative requirement of the Gli proteins in neurogenesis. |
| Volume: |
132 |
| Issue: |
14 |
| Pages: |
3267-79 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
93
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
142
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
93
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang C |
| Year: |
2007 |
| Journal: |
Dev Biol |
| Title: |
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. |
| Volume: |
305 |
| Issue: |
2 |
| Pages: |
460-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kugler MC |
| Year: |
2019 |
| Journal: |
Exp Lung Res |
| Title: |
The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis. |
| Volume: |
45 |
| Issue: |
1-2 |
| Pages: |
22-29 |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shi Y |
| Year: |
2015 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. |
| Volume: |
112 |
| Issue: |
15 |
| Pages: |
4678-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fleming JT |
| Year: |
2019 |
| Journal: |
Mol Cancer Res |
| Title: |
Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model. |
| Volume: |
17 |
| Issue: |
5 |
| Pages: |
1024-1035 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ihh/Ihh Tg(Col2a1-cre)3Amc/? |
| Background: |
involves: 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gli2/Gli2<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
| Background: |
involves: 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
GLI3 is a member of the GLI family of transcription factors, which also includes GLI1 and GLI2. They are central effectors of the Hedgehog (Hh) pathway in vertebrates [, ]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions []. The full-length GLI3 form, after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while its C-terminally truncated form acts as a repressor (GLI3R). GLI3 participates in the patterning and growth of many organs, including the central nervous system (CNS) and limbs [, , , , ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kern D |
| Year: |
2015 |
| Journal: |
Oncogene |
| Title: |
Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia. |
| Volume: |
34 |
| Issue: |
42 |
| Pages: |
5341-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Günther T |
| Year: |
1994 |
| Journal: |
Development |
| Title: |
Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. |
| Volume: |
120 |
| Issue: |
11 |
| Pages: |
3119-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eggenschwiler JT |
| Year: |
2000 |
| Journal: |
Dev Biol |
| Title: |
Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene. |
| Volume: |
227 |
| Issue: |
2 |
| Pages: |
648-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eggenschwiler JT |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. |
| Volume: |
412 |
| Issue: |
6843 |
| Pages: |
194-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Evans TM |
| Year: |
2003 |
| Journal: |
Traffic |
| Title: |
Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. |
| Volume: |
4 |
| Issue: |
12 |
| Pages: |
869-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang B |
| Year: |
2000 |
| Journal: |
Cell |
| Title: |
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. |
| Volume: |
100 |
| Issue: |
4 |
| Pages: |
423-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Humke EW |
| Year: |
2010 |
| Journal: |
Genes Dev |
| Title: |
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. |
| Volume: |
24 |
| Issue: |
7 |
| Pages: |
670-82 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
535
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aoto K |
| Year: |
2002 |
| Journal: |
Dev Biol |
| Title: |
Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. |
| Volume: |
251 |
| Issue: |
2 |
| Pages: |
320-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Anwar S |
| Year: |
2015 |
| Journal: |
Dev Growth Differ |
| Title: |
Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development. |
| Volume: |
57 |
| Issue: |
8 |
| Pages: |
570-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marcos I |
| Year: |
2003 |
| Journal: |
Int J Mol Med |
| Title: |
Molecular cloning and characterization of human RAB23, a member of the group of Rab GTPases. |
| Volume: |
12 |
| Issue: |
6 |
| Pages: |
983-7 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Rab23 is a member of the Rab family of small GTPases. In mouse, Rab23 has been shown to function as a negative regulator in the sonic hedgehog (Shh) signaling pathway. Rab23 mediates the activity of Gli2 and Gli3, transcription factors that regulate Shh signaling in the spinal cord, primarily by preventing Gli2 activation in the absence of Shh ligand []. Rab23 also regulates a step in the cytoplasmic signal transduction pathway that mediates the effect of Smoothened (one of two integral membrane proteins that are essential components of the Shh signaling pathway in vertebrates) [, ].In humans, Rab23 is expressed in the retina []. Mice contain an isoform that shares 93% sequence identity with the human Rab23 and an alternative splicing isoform that is specific to the brain. This isoform causes the murine open brain phenotype, indicating it may have a role in the development of the central nervous system [, ]. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins []. |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE17473 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|