Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Knöfler M |
Year: |
1998 |
Journal: |
Gene |
Title: |
Molecular cloning of the human Hand1 gene/cDNA and its tissue-restricted expression in cytotrophoblastic cells and heart. |
Volume: |
224 |
Issue: |
1-2 |
Pages: |
77-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pearton DJ |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression. |
Volume: |
392 |
Issue: |
2 |
Pages: |
344-57 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta. |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Paul R Riley |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
myosin, light polypeptide 2, regulatory, cardiac, slow; targeted mutation 1, Makoto Tanaka |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Allele |
Name: |
heart and neural crest derivatives expressed 1; targeted mutation 3, Anthony B Firulli |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
Allele |
Name: |
heart and neural crest derivatives expressed 1; targeted mutation 4, Anthony B Firulli |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Anthony B Firulli |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase, Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Myl2/Myl2<+> |
Background: |
involves: 129X1/SvJ * C57BL/6J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hand1/Hand1<+> Tg(tetO-Hand1)1Prri/? |
Background: |
involves: 129/Sv * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Mizugishi K |
Year: |
2004 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Myogenic repressor I-mfa interferes with the function of Zic family proteins. |
Volume: |
320 |
Issue: |
1 |
Pages: |
233-40 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
247
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kusano S |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. |
Volume: |
22 |
Issue: |
18 |
Pages: |
6393-405 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
207
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
189
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
68
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
329
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
200
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
143
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
153
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
186
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
112
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Thébault S |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression. |
Volume: |
275 |
Issue: |
7 |
Pages: |
4848-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gautier VW |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity. |
Volume: |
102 |
Issue: |
45 |
Pages: |
16362-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Young TM |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. |
Volume: |
23 |
Issue: |
18 |
Pages: |
6373-84 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This family consists of MyoD family inhibitor (I-mfa, MDFI) and MyoD family inhibitor domain-containing protein. I-mfa acts as a transcriptional activator or repressor. It retains nuclear Zic family proteins (ZIC1, ZIC2 and ZIC3) in the cytoplasm and consequently inhibits their transcriptional activation ability []. I-mfa domain-containing protein interacts with HAND1 (bHLH transcription factor), leading to sequester HAND1 into the nucleolus and prevent its activity []. In humans modulates the expression from both cellular and viral promoters. It down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. It also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR [, , ]. Both I-mfa and I-mfa domain-containing protein interact with the axin complex and affect axin regulation of both the Wnt and the JNK activation pathways []. |
|
•
•
•
•
•
|
Allele |
Name: |
heart and neural crest derivatives expressed 1; targeted mutation 2.1, Anthony B Firulli |
Allele Type: |
Targeted |
Attribute String: |
Hypomorph |
|
•
•
•
•
•
|
Allele |
Name: |
heart and neural crest derivatives expressed 1; targeted mutation 2, Anthony B Firulli |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hand1/Hand1<+> Tg(Mpz-cre)94Imeg/? |
Background: |
Not Specified |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hand1/Hand1 |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hand1/Hand1 |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hand1/Hand1 Hand2/Hand2 |
Background: |
involves: 129S7/SvEvBrd |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hand1/Hand1 E2f1/E2f1<+> |
Background: |
involves: 129S6/SvEvTac * C3H * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hand1/Hand1<+> E2f1/E2f1<+> |
Background: |
involves: C3H * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hand1/Hand1<+> E2f1/E2f1<+> |
Background: |
involves: C3H * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Hand1/Hand1 E2f1/E2f1<+> |
Background: |
involves: 129S6/SvEvTac * C3H * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Hand1-EGFP/cre)#Abfi/? |
Background: |
involves: 129S4/SvJaeSor * C3HeB/FeJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Karantzali E |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Sall1 regulates embryonic stem cell differentiation in association with nanog. |
Volume: |
286 |
Issue: |
2 |
Pages: |
1037-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lewis AL |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Combinatorial interactions regulate cardiac expression of the murine adenylosuccinate synthetase 1 gene. |
Volume: |
274 |
Issue: |
20 |
Pages: |
14188-97 |
|
•
•
•
•
•
|