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Search results 1201 to 1300 out of 1554 for L1cam

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Type Details Score
Publication
First Author: Yam PT
Year: 2012
Journal: Neuron
Title: 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing.
Volume: 76
Issue: 4
Pages: 735-49
Publication
First Author: Chen Y
Year: 2012
Journal: PLoS One
Title: Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain.
Volume: 7
Issue: 3
Pages: e33105
Publication
First Author: Yokota Y
Year: 2009
Journal: Neuron
Title: The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex.
Volume: 61
Issue: 1
Pages: 42-56
Publication
First Author: Woldeyesus MT
Year: 1999
Journal: Genes Dev
Title: Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.
Volume: 13
Issue: 19
Pages: 2538-48
Publication
First Author: Kim M
Year: 2018
Journal: Genes Dev
Title: Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Volume: 32
Issue: 9-10
Pages: 645-657
Publication
First Author: Shinozaki K
Year: 2002
Journal: Development
Title: Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex.
Volume: 129
Issue: 14
Pages: 3479-92
Publication
First Author: Mandai K
Year: 2014
Journal: Neuron
Title: Linx mediates interaxonal interactions and formation of the internal capsule.
Volume: 83
Issue: 1
Pages: 93-103
Publication
First Author: Sánchez-Camacho C
Year: 2011
Journal: Dev Neurobiol
Title: Appropriate Bmp7 levels are required for the differentiation of midline guidepost cells involved in corpus callosum formation.
Volume: 71
Issue: 5
Pages: 337-50
Publication
First Author: Putoux A
Year: 2019
Journal: Hum Mol Genet
Title: Altered GLI3 and FGF8 signaling underlies acrocallosal syndrome phenotypes in Kif7 depleted mice.
Volume: 28
Issue: 6
Pages: 877-887
Publication    
First Author: Luck R
Year: 2019
Journal: Elife
Title: VEGF/VEGFR2 signaling regulates hippocampal axon branching during development.
Volume: 8
Publication
First Author: Cunningham JG
Year: 2022
Journal: Dev Dyn
Title: Early construction of the thalamocortical axon pathway requires c-Jun N-terminal kinase signaling within the ventral forebrain.
Volume: 251
Issue: 3
Pages: 459-480
Publication
First Author: Blackshear PJ
Year: 1997
Journal: Exp Neurol
Title: Widespread neuronal ectopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice.
Volume: 145
Issue: 1
Pages: 46-61
Publication  
First Author: Alpár A
Year: 2014
Journal: Nat Commun
Title: Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.
Volume: 5
Pages: 4421
Publication
First Author: Denaxa M
Year: 2005
Journal: Dev Biol
Title: The adhesion molecule TAG-1 is required for proper migration of the superficial migratory stream in the medulla but not of cortical interneurons.
Volume: 288
Issue: 1
Pages: 87-99
Publication
First Author: Chatzopoulou E
Year: 2008
Journal: J Neurosci
Title: Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve.
Volume: 28
Issue: 30
Pages: 7624-36
Publication
First Author: Ashrafi S
Year: 2014
Journal: Neuron
Title: Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord.
Volume: 81
Issue: 1
Pages: 120-9
Publication
First Author: Clements R
Year: 2018
Journal: Dev Biol
Title: Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan.
Volume: 442
Issue: 2
Pages: 210-219
Publication
First Author: Williams SE
Year: 2006
Journal: Neuron
Title: A role for Nr-CAM in the patterning of binocular visual pathways.
Volume: 50
Issue: 4
Pages: 535-47
Publication
First Author: Pan L
Year: 2008
Journal: Development
Title: ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells.
Volume: 135
Issue: 11
Pages: 1981-90
Publication
First Author: Guénette S
Year: 2006
Journal: EMBO J
Title: Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.
Volume: 25
Issue: 2
Pages: 420-31
Publication    
First Author: Minocha S
Year: 2015
Journal: Elife
Title: NG2 glia are required for vessel network formation during embryonic development.
Volume: 4
Publication
First Author: Yu WM
Year: 2009
Journal: Glia
Title: Disruption of laminin in the peripheral nervous system impedes nonmyelinating Schwann cell development and impairs nociceptive sensory function.
Volume: 57
Issue: 8
Pages: 850-9
Publication
First Author: Kraushar ML
Year: 2015
Journal: J Neurosci
Title: Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes.
Volume: 35
Issue: 31
Pages: 10911-26
Publication
First Author: Pagliardini S
Year: 2005
Journal: Am J Pathol
Title: Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin.
Volume: 167
Issue: 1
Pages: 175-91
Publication
First Author: Leone DP
Year: 2015
Journal: Cereb Cortex
Title: Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.
Volume: 25
Issue: 10
Pages: 3406-19
Publication
First Author: Armentano M
Year: 2006
Journal: Development
Title: COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth.
Volume: 133
Issue: 21
Pages: 4151-62
Publication
First Author: Kajimura D
Year: 2007
Journal: Gene
Title: Identification of genes regulated by transcription factor KLF7 in differentiating olfactory sensory neurons.
Volume: 388
Issue: 1-2
Pages: 34-42
Publication
First Author: Bravo-Ambrosio A
Year: 2012
Journal: Development
Title: Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling.
Volume: 139
Issue: 8
Pages: 1435-46
Publication
First Author: Zhou Z
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity.
Volume: 117
Issue: 36
Pages: 22193-22203
Publication
First Author: Herman GE
Year: 1991
Journal: Genomics
Title: Genetic mapping of the mouse X chromosome in the region homologous to human Xq27-Xq28.
Volume: 9
Issue: 4
Pages: 670-7
Publication
First Author: Inaki K
Year: 2004
Journal: J Comp Neurol
Title: Laminar organization of the developing lateral olfactory tract revealed by differential expression of cell recognition molecules.
Volume: 479
Issue: 3
Pages: 243-56
Publication
First Author: Nakamura K
Year: 2006
Journal: J Neurosci Res
Title: Murine neocortical histogenesis is perturbed by prenatal exposure to low doses of Bisphenol A.
Volume: 84
Issue: 6
Pages: 1197-205
Publication
First Author: Wolf AM
Year: 2008
Journal: J Neurosci
Title: Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.
Volume: 28
Issue: 13
Pages: 3456-67
Publication
First Author: Namba T
Year: 2014
Journal: Neuron
Title: Pioneering axons regulate neuronal polarization in the developing cerebral cortex.
Volume: 81
Issue: 4
Pages: 814-29
Publication
First Author: Cheng J
Year: 2016
Journal: Neuron
Title: Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.
Volume: 92
Issue: 1
Pages: 126-142
Publication
First Author: Altounian M
Year: 2023
Journal: Cell Rep
Title: Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure.
Volume: 42
Issue: 9
Pages: 113020
Publication
First Author: Masuda A
Year: 2024
Journal: Sci Adv
Title: A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types.
Volume: 10
Issue: 21
Pages: eadk2149
Publication
First Author: Sessa A
Year: 2008
Journal: Neuron
Title: Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex.
Volume: 60
Issue: 1
Pages: 56-69
Publication
First Author: Barnes AP
Year: 2007
Journal: Cell
Title: LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.
Volume: 129
Issue: 3
Pages: 549-63
Publication
First Author: Wright KM
Year: 2012
Journal: Neuron
Title: Dystroglycan organizes axon guidance cue localization and axonal pathfinding.
Volume: 76
Issue: 5
Pages: 931-44
Publication
First Author: Matsugami TR
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development.
Volume: 103
Issue: 32
Pages: 12161-6
Publication
First Author: Britanova O
Year: 2008
Journal: Neuron
Title: Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.
Volume: 57
Issue: 3
Pages: 378-92
Publication    
First Author: Dragich JM
Year: 2016
Journal: Elife
Title: Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.
Volume: 5
Publication
First Author: Burmeister M
Year: 1996
Journal: Nat Genet
Title: Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.
Volume: 12
Issue: 4
Pages: 376-84
Publication
First Author: Caubit X
Year: 2016
Journal: Nat Genet
Title: TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.
Volume: 48
Issue: 11
Pages: 1359-1369
Publication
First Author: Laub F
Year: 2005
Journal: Mol Cell Biol
Title: Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system.
Volume: 25
Issue: 13
Pages: 5699-711
Publication
First Author: Ha HY
Year: 2005
Journal: Dev Biol
Title: The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1.
Volume: 277
Issue: 1
Pages: 184-99
Publication
First Author: de Melo J
Year: 2005
Journal: Development
Title: Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina.
Volume: 132
Issue: 2
Pages: 311-22
Publication
First Author: Uemura M
Year: 2007
Journal: Nat Neurosci
Title: OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections.
Volume: 10
Issue: 9
Pages: 1151-9
Publication  
First Author: Manuel M
Year: 2008
Journal: BMC Dev Biol
Title: Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance.
Volume: 8
Pages: 59
Publication
First Author: Coulter ME
Year: 2018
Journal: Cell Rep
Title: The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles.
Volume: 24
Issue: 4
Pages: 973-986.e8
Publication
First Author: López-Bendito G
Year: 2006
Journal: Cell
Title: Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation.
Volume: 125
Issue: 1
Pages: 127-42
Publication
First Author: Shafer B
Year: 2011
Journal: Dev Cell
Title: Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance.
Volume: 20
Issue: 2
Pages: 177-91
Publication
First Author: Grossmann KS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development.
Volume: 106
Issue: 39
Pages: 16704-9
Publication
First Author: Finotto S
Year: 1999
Journal: Development
Title: Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells.
Volume: 126
Issue: 13
Pages: 2935-44
Publication
First Author: Kadison SR
Year: 2006
Journal: Dev Biol
Title: The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord.
Volume: 296
Issue: 2
Pages: 499-513
Publication
First Author: Qiu Z
Year: 2010
Journal: J Neurosci
Title: Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum.
Volume: 30
Issue: 43
Pages: 14430-9
Publication
First Author: Coffinier C
Year: 2011
Journal: Mol Biol Cell
Title: Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons.
Volume: 22
Issue: 23
Pages: 4683-93
Publication
First Author: Vallejo-Illarramendi A
Year: 2009
Journal: J Clin Invest
Title: Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development.
Volume: 119
Issue: 8
Pages: 2218-30
Publication  
First Author: Comer JD
Year: 2015
Journal: Front Neural Circuits
Title: Sensory and spinal inhibitory dorsal midline crossing is independent of Robo3.
Volume: 9
Pages: 36
Publication
First Author: Kaur N
Year: 2020
Journal: Neuron
Title: Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold.
Volume: 107
Issue: 6
Pages: 1197-1211.e9
Publication
First Author: Shim S
Year: 2012
Journal: Nature
Title: Cis-regulatory control of corticospinal system development and evolution.
Volume: 486
Issue: 7401
Pages: 74-9
Publication
First Author: Chen L
Year: 2007
Journal: J Neurosci
Title: Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.
Volume: 27
Issue: 14
Pages: 3884-93
Publication
First Author: Ezan J
Year: 2021
Journal: Sci Rep
Title: Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity.
Volume: 11
Issue: 1
Pages: 9106
Publication
First Author: Sessa A
Year: 2010
Journal: Genes Dev
Title: Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons.
Volume: 24
Issue: 16
Pages: 1816-26
Publication
First Author: Clegg JM
Year: 2014
Journal: J Neurosci
Title: Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.
Volume: 34
Issue: 6
Pages: 2389-401
Publication
First Author: Gil-Sanz C
Year: 2014
Journal: J Neurosci
Title: Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon.
Volume: 34
Issue: 32
Pages: 10475-87
Publication
First Author: Ambrozkiewicz MC
Year: 2021
Journal: Mol Psychiatry
Title: The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
Volume: 26
Issue: 6
Pages: 1980-1995
Publication
First Author: Ishibashi M
Year: 1995
Journal: Genes Dev
Title: Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.
Volume: 9
Issue: 24
Pages: 3136-48
Publication
First Author: Deck M
Year: 2013
Journal: Neuron
Title: Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.
Volume: 77
Issue: 3
Pages: 472-84
Publication
First Author: Mihalas AB
Year: 2016
Journal: Cell Rep
Title: Intermediate Progenitor Cohorts Differentially Generate Cortical Layers and Require Tbr2 for Timely Acquisition of Neuronal Subtype Identity.
Volume: 16
Issue: 1
Pages: 92-105
Publication
First Author: Smith KM
Year: 2006
Journal: Nat Neurosci
Title: Midline radial glia translocation and corpus callosum formation require FGF signaling.
Volume: 9
Issue: 6
Pages: 787-97
Publication
First Author: Brudvig JJ
Year: 2018
Journal: Mol Neurobiol
Title: MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation.
Volume: 55
Issue: 11
Pages: 8388-8402
Publication
First Author: Pontoriero GF
Year: 2008
Journal: Dev Dyn
Title: Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype.
Volume: 237
Issue: 3
Pages: 602-17
Publication  
First Author: Doyle DZ
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Chromatin remodeler Arid1a regulates subplate neuron identity and wiring of cortical connectivity.
Volume: 118
Issue: 21
Publication
First Author: Bielle F
Year: 2011
Journal: Neuron
Title: Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution.
Volume: 69
Issue: 6
Pages: 1085-98
Publication
First Author: Hu XL
Year: 2011
Journal: Cereb Cortex
Title: Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model.
Volume: 21
Issue: 9
Pages: 2158-65
Publication
First Author: Vitureira N
Year: 2010
Journal: PLoS One
Title: Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation.
Volume: 5
Issue: 8
Pages: e12003
Publication
First Author: Mulder J
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.
Volume: 105
Issue: 25
Pages: 8760-5
Publication
First Author: Yamasaki T
Year: 2011
Journal: J Neurosci
Title: Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.
Volume: 31
Issue: 46
Pages: 16872-83
Publication
First Author: Onishi K
Year: 2013
Journal: J Neurosci
Title: Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.
Volume: 33
Issue: 49
Pages: 19071-85
Publication
First Author: Lee CS
Year: 2001
Journal: Dev Biol
Title: Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant.
Volume: 236
Issue: 1
Pages: 17-29
Publication
First Author: Pan L
Year: 2005
Journal: Development
Title: Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis.
Volume: 132
Issue: 4
Pages: 703-12
Publication
First Author: Yoshihara S
Year: 2005
Journal: Development
Title: Arx homeobox gene is essential for development of mouse olfactory system.
Volume: 132
Issue: 4
Pages: 751-62
Publication
First Author: Funk OH
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity.
Volume: 119
Issue: 32
Pages: e2116956119
Publication    
First Author: Hoye ML
Year: 2022
Journal: Elife
Title: Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model.
Volume: 11
Publication  
First Author: Cifuentes-Diaz C
Year: 2023
Journal: Front Neurosci
Title: Differential impacts of Cntnap2 heterozygosity and Cntnap2 null homozygosity on axon and myelinated fiber development in mouse.
Volume: 17
Pages: 1100121
Publication  
First Author: Schmid MT
Year: 2014
Journal: Front Cell Neurosci
Title: The role of α-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration.
Volume: 8
Pages: 215
Publication
First Author: Amaniti EM
Year: 2013
Journal: Dev Biol
Title: Gli3 is required in Emx1+ progenitors for the development of the corpus callosum.
Volume: 376
Issue: 2
Pages: 113-24
Publication
First Author: Wu Z
Year: 2019
Journal: Neuron
Title: Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells.
Volume: 101
Issue: 4
Pages: 635-647.e4
Publication
First Author: Markham K
Year: 2007
Journal: Mol Cell Neurosci
Title: STAT5A/B activity is required in the developing forebrain and spinal cord.
Volume: 35
Issue: 2
Pages: 272-82
Publication
First Author: Ouyang Q
Year: 2013
Journal: Neuron
Title: Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development.
Volume: 80
Issue: 1
Pages: 97-112
Publication
First Author: Esteve P
Year: 2011
Journal: Nat Neurosci
Title: SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.
Volume: 14
Issue: 5
Pages: 562-9
Publication
First Author: Crabtree GW
Year: 2017
Journal: J Neurosci
Title: Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.
Volume: 37
Issue: 15
Pages: 4158-4180
Publication  
First Author: Kastriti ME
Year: 2019
Journal: Front Cell Neurosci
Title: Ablation of CNTN2+ Pyramidal Neurons During Development Results in Defects in Neocortical Size and Axonal Tract Formation.
Volume: 13
Pages: 454
Publication
First Author: Owa T
Year: 2018
Journal: J Neurosci
Title: Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation.
Volume: 38
Issue: 5
Pages: 1277-1294
Publication
First Author: Favero CB
Year: 2013
Journal: J Comp Neurol
Title: Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain.
Volume: 521
Issue: 3
Pages: 677-96
Publication
First Author: Steele-Perkins G
Year: 2005
Journal: Mol Cell Biol
Title: The transcription factor gene Nfib is essential for both lung maturation and brain development.
Volume: 25
Issue: 2
Pages: 685-98
Publication
First Author: Wang X
Year: 2007
Journal: Mol Cell Biol
Title: Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.
Volume: 27
Issue: 22
Pages: 7935-46
Publication
First Author: Bormuth I
Year: 2013
Journal: J Neurosci
Title: Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions.
Volume: 33
Issue: 2
Pages: 641-51