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Search results 1201 to 1300 out of 1354 for Lgr5

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Type Details Score
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
HT Experiment
Series Id: E-GEOD-25109
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
Publication
First Author: Carmon KS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Volume: 108
Issue: 28
Pages: 11452-7
Publication
First Author: Novellasdemunt L
Year: 2020
Journal: EMBO J
Title: NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.
Volume: 39
Issue: 3
Pages: e102771
Allele
Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Hans Clevers
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Recombinase, Reporter
GXD Expression  
Probe: MGI:7596164
Assay Type: RNA in situ
Annotation Date: 2024-02-23
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3262722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7596266
Age: embryonic day 14.5
Note: Strong expression co-localized with Lgr5 in apical ectodermal ridge.
Specimen Label: 2h Lgr5/Rspo2 (upper)
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7596164
Assay Type: RNA in situ
Annotation Date: 2024-02-23
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3262722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7596266
Age: embryonic day 14.5
Note: Strong expression co-localized with Lgr5 in apical ectodermal ridge.
Specimen Label: 2h Lgr5/Rspo2 (lower)
Detected: true
Specimen Num: 4
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Yin H
Year: 2020
Journal: Oncogene
Title: Identification of Sca-1+Abcg1+ bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
Volume: 39
Issue: 18
Pages: 3754-3773
Interaction Experiment
Description: Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
GXD Expression
Probe: MGI:6822345
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3581428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7443063
Age: postnatal
Image: 2F
Note: Expression overlaps with, but is not limited to Lgr5 expressing cells.
Specimen Label: 2F
Detected: true
Specimen Num: 12
GXD Expression
Probe: MGI:6822345
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1763128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7443063
Age: postnatal
Image: 2F
Note: Expression overlaps with, but is not limited to Lgr5 expressing cells.
Specimen Label: 2F
Detected: true
Specimen Num: 12
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
Publication
First Author: Zebisch M
Year: 2015
Journal: J Struct Biol
Title: Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
Volume: 191
Issue: 2
Pages: 149-55
Allele
Name: leucine rich repeat containing G protein coupled receptor 5; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
Allele
Name: leucine rich repeat containing G protein coupled receptor 5; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase, Reporter
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: leucine rich repeat containing G protein coupled receptor 5; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: leucine rich repeat containing G protein coupled receptor 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: leucine rich repeat containing G protein coupled receptor 5; endonuclease-mediated mutation 1, Konrad Basler
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase, Reporter
Genotype
Symbol: Lgr5/Lgr5
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Lgr5/Lgr5<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
HT Experiment
Series Id: E-GEOD-36497
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: leucine rich repeat containing G protein coupled receptor 5; endonuclease-mediated mutation 1, Omer Yilmaz
Allele Type: Endonuclease-mediated
Attribute String: No functional change, Recombinase, Reporter
HT Experiment
Series Id: GSE32511
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: E-GEOD-52925
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
Allele
Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 3, Hans Clevers
Allele Type: Targeted
Attribute String: Inducible, Recombinase
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
Strain
Attribute String: endonuclease-mediated mutation, mutant strain
HT Experiment
Series Id: E-GEOD-39915
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: targeted mutation, congenic
Allele
Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Frederick J de Sauvage
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Recombinase
Allele
Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 2, Frederick J de Sauvage
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout, Reporter
Genotype
Symbol: Cdx2/Cdx2 Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdc42/Cdc42 Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Gata6os/Gata6os Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Bptf/Bptf Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Bptf/Bptf Ehf/Ehf Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Lgr5/Lgr5
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Lgr5/Lgr5
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Lgr5/Lgr5<+>
Background: B6.129P2-Lgr5
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Ayadi L
Year: 2008
Journal: Bioinformation
Title: Molecular modelling of the TSR domain of R-spondin 4.
Volume: 3
Issue: 3
Pages: 119-23
Publication
First Author: Blaydon DC
Year: 2006
Journal: Nat Genet
Title: The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.
Volume: 38
Issue: 11
Pages: 1245-7
Protein Domain
Type: Family
Description: The R-spondin (RSPO) family is a small group of four secreted proteins (RSPO1-RSPO4) that have pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. They contain an N-terminal secretory signal peptide sequence, two tandem furin-like cysteine-rich (Fu-CRD) domains, a thrombospondin type I repeat (TSP) domain, and a C-terminal basic amino acid-rich (BR) domain. Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors for RSPOs [].RSPO2 is a secreted protein that belongs to the R-spondin (RSPO) family. Interestingly, it is one of the two members (RSPO2 and RSPO3) of the family capable of potentiating WNT signaling in cells lacking all three LGRs (Leucine-rich repeat-containing G-protein-coupled receptor 4/5/6) []. It plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form []. It has been shown to promote midbrain dopaminergic neurogenesis and differentiation in human stem cells []. Its structures in complex with the ectodomains of its receptors LGR5 and ZNRF3 have been revealed []. RSPO4 is a secreted protein that belongs to the R-spondin (RSPO) family. It has been associated with embryonic nail development [, ].
HT Experiment
Series Id: GSE56911
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE12248
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE32210
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
Genotype
Symbol: Lgr5/Lgr5<+>
Background: involves: C57BL/6N
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Elp3/Elp3 Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Zeilstra J
Year: 2014
Journal: Oncogene
Title: Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling.
Volume: 33
Issue: 5
Pages: 665-70
Publication  
First Author: Tsuji S
Year: 2014
Journal: Nat Commun
Title: The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumourigenesis.
Volume: 5
Pages: 3150
Publication
First Author: Schuijers J
Year: 2014
Journal: Stem Cell Reports
Title: Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus.
Volume: 3
Issue: 2
Pages: 234-41
Publication
First Author: Sun T
Year: 2020
Journal: Cell Stem Cell
Title: AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration.
Volume: 26
Issue: 1
Pages: 97-107.e6
Publication
First Author: Qin G
Year: 2023
Journal: iScience
Title: Distinct niche structures and intrinsic programs of fallopian tube and ovarian surface epithelial cells.
Volume: 26
Issue: 1
Pages: 105861
Publication
First Author: Van Schoore G
Year: 2005
Journal: Histochem Cell Biol
Title: Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse.
Volume: 124
Issue: 1
Pages: 35-50
Publication
First Author: Ye B
Year: 2020
Journal: EMBO J
Title: The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.
Volume: 39
Issue: 13
Pages: e103786
Publication  
First Author: Wang L
Year: 2015
Journal: Sci Rep
Title: Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos.
Volume: 5
Pages: 17517
Publication
First Author: Huang PY
Year: 2017
Journal: Nat Genet
Title: Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma.
Volume: 49
Issue: 11
Pages: 1624-1632
Publication
First Author: Han H
Year: 2021
Journal: Mol Cancer Res
Title: Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in ApcS580/+; KrasG12D/+ Mice.
Volume: 19
Issue: 5
Pages: 771-783
Publication
First Author: Sun T
Year: 2021
Journal: Cell Stem Cell
Title: ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
Volume: 28
Issue: 10
Pages: 1822-1837.e10
Publication  
First Author: He J
Year: 2023
Journal: Biochem Biophys Res Commun
Title: PTEN/AKT and Wnt/β-catenin signaling pathways regulate the proliferation of Lgr5+ cells in liver cancer.
Volume: 683
Pages: 149117
Publication
First Author: Malagola E
Year: 2024
Journal: Cell
Title: Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury.
Volume: 187
Issue: 12
Pages: 3056-3071.e17
Genotype
Symbol: Nrbp1/Nrbp1 Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdc42/Cdc42 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Apc/Apc<+> Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Lgr5/Lgr5<+> Lrig1/Lrig1
Background: involves: 129 * 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Rnf43/Rnf43 Znrf3/Znrf3 Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnnb1/Ctnnb1<+> Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Col1a1/Col1a1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rab11a/Rab11a Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Slc39a7/Slc39a7 Lgr5/Lgr5<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Lgr5/Lgr5<+> Mex3a/Mex3a<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * C57BL/6NTac
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Rprd1b/Rprd1b Lgr5/Lgr5<+> Tg(Vil1-cre)20Syr/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Publication    
First Author: Lebensohn AM
Year: 2018
Journal: Elife
Title: R-spondins can potentiate WNT signaling without LGRs.
Volume: 7
Publication
First Author: Leach JDG
Year: 2021
Journal: Nat Commun
Title: Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Volume: 12
Issue: 1
Pages: 3464
Publication
First Author: Choi E
Year: 2018
Journal: Gut
Title: Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach.
Volume: 67
Issue: 9
Pages: 1595-1605
Publication
First Author: Parry L
Year: 2013
Journal: Stem Cells
Title: Evidence for a crucial role of paneth cells in mediating the intestinal response to injury.
Volume: 31
Issue: 4
Pages: 776-85