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Search results 1201 to 1300 out of 2039 for Met

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Met/Met Tg(SFTPC-rtTA)5Jaw/? Tg(tetO-cre)1Jaw/?
Background: involves: 129 * 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd44/Cd44 Met/Met<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Met/Met Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Met/Met Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Met/Met Trp53/Trp53
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Etv4/Etv4<+> Met/Met
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Allele
Tg(MtTPRMET)243Lng | MGI:3054048
Name: transgene insertion 243, T Jake Liang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(MtTPRMET)773Lng | MGI:3054636
Name: transgene insertion 773, T Jake Liang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Gt(ROSA)26Sor<tm1(Actb-Met)Fmai> | MGI:5052130
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Flavio Maina
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Allele
Txnip<em1Ngwu> | MGI:7482010
Name: thioredoxin interacting protein; endonuclease-mediated mutation 1, Ning Wu
Allele Type: Endonuclease-mediated
Attribute String: Epitope tag
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GO Term
GO:0004479 | methionyl-tRNA formyltransferase activity
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Publication
14500717 | -
First Author: Zou Y
Year: 2003
Journal: J Biol Chem
Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
Volume: 278
Issue: 49
Pages: 49573-81
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Publication
15713673 | -
First Author: Wang D
Year: 2005
Journal: J Biol Chem
Title: The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.
Volume: 280
Issue: 16
Pages: 16393-401
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Publication
31401849 | J:296416
First Author: de Juan A
Year: 2019
Journal: Circulation
Title: Artery-Associated Sympathetic Innervation Drives Rhythmic Vascular Inflammation of Arteries and Veins.
Volume: 140
Issue: 13
Pages: 1100-1114
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Protein Coding Gene
MGI:99435 | Arf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105071 | Rab4b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62331
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
Q91ZR1
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Genotype
Genotype
Symbol: Met/Met<+> Pax3/Pax3<+>
Background: involves: 129 * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Met/Met Pax3/Pax3<+>
Background: involves: 129 * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gab1/Gab1 Met/Met<+>
Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Met/Met Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Met/Met Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Met/Met Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Met/Met Sftpc/Sftpc<+>
Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Met/Met Speer6-ps1/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:2162354 | FVB/N-Tg(MtTPRMET)243Lng/J
Attribute String: mutant strain, transgenic
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Strain
MGI:3800957 | FVB/N-Tg(MtTPRMET)243Lng
Attribute String: transgenic, coisogenic
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Strain
MGI:3800960 | FVB/N-Tg(MtTPRMET)773Lng
Attribute String: coisogenic, transgenic
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Strain
MGI:2163406 | FVB/N-Tg(MtTPRMET)773Lng/J
Attribute String: mutant strain, transgenic
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Allele
Tg(tetO-MET)23Rwng | MGI:3810467
Name: transgene insertion 23, Rong Wang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Allele
Tg(Met-EGFP)18Lvt | MGI:6144427
Name: transgene insertion 18, Pat Levitt
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Islr-cre/ERT2)#Tobe | MGI:6718533
Name: transgene insertion, Kazuyuki Tobe
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Strain
MGI:7482011 | C57BL/6J-Txnip<em1Ngwu>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
29844158 | J:348558
First Author: Callender JA
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.
Volume: 115
Issue: 24
Pages: E5497-E5505
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Genotype
Genotype
Symbol: Tg(MtTPRMET)243Lng/?
Background: FVB/N-Tg(MtTPRMET)243Lng
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MtTPRMET)773Lng/?
Background: FVB/N-Tg(MtTPRMET)773Lng
Zygosity: ot
Has Mutant Allele: true
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HT Experiment
E-MTAB-10199 | RNA-seq from oocytes and zygotes of pabpn1l ko and wt female mice during different stages
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE246143 | MYO7a is required for the functional integrity of the mechanoelectrical transduction complex in the outer hair cells of the adult cochlea.
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Coding Gene
MGI:109321 | Lama4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96602 | Itga3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96600 | Itga2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2385039 | Muc20
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:700010 | Sh3gl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97806 | Ptpn2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104583 | Eps15
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:700011 | Sh3gl3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q06180
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
Q62469
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
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Protein
P42567
Organism: Mus musculus/domesticus
Length: 897  
Fragment?: false
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Protein
P97927
Organism: Mus musculus/domesticus
Length: 1816  
Fragment?: false
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Protein
Q62470
Organism: Mus musculus/domesticus
Length: 1053  
Fragment?: false
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Protein
Q62419
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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Protein
Q62421
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Genotype
Genotype
Symbol: Met/Met Speer6-ps1/Speer6-ps1<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lbx1/Lbx1<+> Met/Met
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Mesp1/Mesp1<+> Met/Met
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6NCrlj * CBA/JNCrlj
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
E-MTAB-10233 | RNA-seq of oocytes and zygotes from pabpn1l ko and wt female mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
8831789 | -
First Author: Clausen T
Year: 1996
Journal: J Mol Biol
Title: Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A.
Volume: 262
Issue: 2
Pages: 202-24
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Publication
20406824 | -
First Author: Hu D
Year: 2010
Journal: J Biol Chem
Title: Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells.
Volume: 285
Issue: 24
Pages: 18326-35
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Publication
25998963 | -
First Author: Voskoboinik I
Year: 2015
Journal: Nat Rev Immunol
Title: Perforin and granzymes: function, dysfunction and human pathology.
Volume: 15
Issue: 6
Pages: 388-400
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Protein Domain
IPR006233 | Cys_b_lyase_bac
Type: Family
Description: Cystathionine beta-lyase (alternate name: beta-cystathionase) is one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys [].
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Protein Domain
IPR006238 | Cys_b_lyase_euk
Type: Family
Description: This group of sequences represent cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
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Protein Domain
IPR033040 | GZMM
Type: Family
Description: Granzyme M is a chymotrypsin-like serine protease that preferentially cuts its substrates after Met or Leu []. It has been shown to be involved in inflammation, tumour immunity and cell death [].
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Publication
14565953 | -
First Author: Higuchi T
Year: 2004
Journal: J Biol Chem
Title: Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney.
Volume: 279
Issue: 3
Pages: 1968-79
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Protein
E9PUF1
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: false
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Protein Domain
IPR034551 | MUC20
Type: Family
Description: Mucin-20 (MUC20) was identifiied as a gene that is up-regulated in the renal tissues of patients with immunoglobulin A nephropathy []. It is a regulator of the Met signaling cascade. MUC20 associates with Met which is the hepatocyte growth factor (HGF) receptor, and has a role in suppressing the Grb2-Ras pathway. Production of MUC20 reduced HGF-induced matrix metalloproteinase expression and proliferation, which require the Grb2-Ras pathway [].
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Strain
MGI:3810932 | FVB-Tg(tetO-MET)23Rwng/J
Attribute String: transgenic, coisogenic
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Allele
Gfra1<tm4.1(cre/ERT2)Jmi> | MGI:6331276
Name: glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 4.1, Jeffrey Milbrandt
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Publication
20624990 | J:162562
First Author: Tolbert WD
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for agonism and antagonism of hepatocyte growth factor.
Volume: 107
Issue: 30
Pages: 13264-9
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Protein Coding Gene
MGI:1928741 | Ranbp9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88447 | Col11a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104574 | Ptprj
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1934029 | Usp8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88446 | Col11a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914549 | Dock7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105069 | Rab4a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q64739
Organism: Mus musculus/domesticus
Length: 1736  
Fragment?: false
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Protein
P69566
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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Protein
P56371
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q64455
Organism: Mus musculus/domesticus
Length: 1238  
Fragment?: false
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Protein
Q61245
Organism: Mus musculus/domesticus
Length: 1804  
Fragment?: false
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Protein
Q8R1A4
Organism: Mus musculus/domesticus
Length: 2130  
Fragment?: false
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Protein
Q80U87
Organism: Mus musculus/domesticus
Length: 1080  
Fragment?: false
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Protein
Q08048
Organism: Mus musculus/domesticus
Length: 728  
Fragment?: false
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GO Term
GO:1902203 | negative regulation of hepatocyte growth factor receptor signaling pathway
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GO Term
GO:1902204 | positive regulation of hepatocyte growth factor receptor signaling pathway
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lbx1/Lbx1<+> Met/Met<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Mesp1/Mesp1<+> Met/Met<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6NCrlj * CBA/JNCrlj
Zygosity: cn
Has Mutant Allele: true
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Publication
31819003 | J:284956
First Author: Aldahl J
Year: 2020
Journal: J Biol Chem
Title: Aberrant activation of hepatocyte growth factor/MET signaling promotes β-catenin-mediated prostatic tumorigenesis.
Volume: 295
Issue: 2
Pages: 631-644
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Publication
36418293 | J:348557
First Author: Lordén G
Year: 2022
Journal: Nat Commun
Title: Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.
Volume: 13
Issue: 1
Pages: 7200
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Publication
21949730 | J:177679
First Author: Ivanovska I
Year: 2011
Journal: PLoS One
Title: Gene signatures derived from a c-MET-driven liver cancer mouse model predict survival of patients with hepatocellular carcinoma.
Volume: 6
Issue: 9
Pages: e24582
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Allele
Tg(tetO-TPR/MET,-EGFP)12Tcre | MGI:4949465
Name: transgene insertion 12, Tiziana Crepaldi
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Reporter
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Allele
Igs2<tm1(CAG-Met)Zsu> | MGI:6507851
Name: intergenic site 2; targeted mutation 1, Zijie Sun
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(tetO-MET)23Rwng/? Tg(Cebpb-tTA)5Bjd/?
Background: involves: FVB/N * NMRI
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
E-GEOD-6399 | Transcription profiling of mouse heart from Emd KO and controls
Series Id: GSE6399
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:88458 | Col5a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:894315 | Rap1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104681 | Hgs
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104686 | Crkl
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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