| Type |
Details |
Score |
| Allele |
| Name: |
mechanistic target of rapamycin kinase; endonuclease-mediated mutation 1, Mike Fainzilber |
| Allele Type: |
Endonuclease-mediated |
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1335
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
455 |
| Description: |
Phosphoserine; by MTOR and PKB/AKT1 |
| Type: |
modified residue |
| End: |
455 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
863 |
| Description: |
Phosphoserine; by MAPK8 and MTOR |
| Type: |
modified residue |
| End: |
863 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
99
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
297
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
248
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
307
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
658
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1556
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1033
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
102
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guertin DA |
| Year: |
2007 |
| Journal: |
Cancer Cell |
| Title: |
Defining the role of mTOR in cancer. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
9-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hong X |
| Year: |
2016 |
| Journal: |
Mol Cell Endocrinol |
| Title: |
Exendin-4 decreases ghrelin levels through mTOR signaling. |
| Volume: |
437 |
|
| Pages: |
201-212 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ying L |
| Year: |
2021 |
| Journal: |
Front Cell Dev Biol |
| Title: |
Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure. |
| Volume: |
9 |
|
| Pages: |
672032 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakatani T |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
3333 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
mTOR complex-2 activates ENaC by phosphorylating SGK1. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
124
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
36
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
124
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lamming DW |
| Year: |
2013 |
| Journal: |
Cell Metab |
| Title: |
A Central role for mTOR in lipid homeostasis. |
| Volume: |
18 |
| Issue: |
4 |
| Pages: |
465-9 |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Morrison MM |
| Year: |
2015 |
| Journal: |
PLoS Genet |
| Title: |
mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis. |
| Volume: |
11 |
| Issue: |
7 |
| Pages: |
e1005291 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saito M |
| Year: |
2020 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
Active mTOR in Lung Epithelium Promotes Epithelial-Mesenchymal Transition and Enhances Lung Fibrosis. |
| Volume: |
62 |
| Issue: |
6 |
| Pages: |
699-708 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Berezhnoy A |
| Year: |
2014 |
| Journal: |
J Clin Invest |
| Title: |
Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity. |
| Volume: |
124 |
| Issue: |
1 |
| Pages: |
188-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alejandro EU |
| Year: |
2017 |
| Journal: |
Diabetes |
| Title: |
Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass. |
| Volume: |
66 |
| Issue: |
8 |
| Pages: |
2150-2162 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Soma-Nagae T |
| Year: |
2013 |
| Journal: |
J Cell Sci |
| Title: |
The lysosomal signaling anchor p18/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes. |
| Volume: |
126 |
| Issue: |
Pt 16 |
| Pages: |
3575-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lamberti G |
| Year: |
2020 |
| Journal: |
FEBS Lett |
| Title: |
LAMTOR/Ragulator regulates lipid metabolism in macrophages and foam cell differentiation. |
| Volume: |
594 |
| Issue: |
1 |
| Pages: |
31-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rion N |
| Year: |
2019 |
| Journal: |
Development |
| Title: |
mTOR controls embryonic and adult myogenesis via mTORC1. |
| Volume: |
146 |
| Issue: |
7 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GarcÃa-MartÃnez JM |
| Year: |
2008 |
| Journal: |
Biochem J |
| Title: |
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). |
| Volume: |
416 |
| Issue: |
3 |
| Pages: |
375-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Souroullas GP |
| Year: |
2015 |
| Journal: |
Cancer Cell |
| Title: |
mTOR signaling in melanoma: oncogene-induced pseudo-senescence? |
| Volume: |
27 |
| Issue: |
1 |
| Pages: |
3-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun SY |
| Year: |
2013 |
| Journal: |
Cancer Lett |
| Title: |
mTOR kinase inhibitors as potential cancer therapeutic drugs. |
| Volume: |
340 |
| Issue: |
1 |
| Pages: |
1-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iyer DP |
| Year: |
2024 |
| Journal: |
Cell |
| Title: |
mTOR activity paces human blastocyst stage developmental progression. |
| Volume: |
187 |
| Issue: |
23 |
| Pages: |
6566-6583.e22 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
473 |
| Description: |
Phosphoserine; by IKKE, MTOR and TBK1; alternate |
| Type: |
modified residue |
| End: |
473 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu G |
| Year: |
2015 |
| Journal: |
Diabetologia |
| Title: |
Intestinal mTOR regulates GLP-1 production in mouse L cells. |
| Volume: |
58 |
| Issue: |
8 |
| Pages: |
1887-97 |
|
•
•
•
•
•
|