| Type |
Details |
Score |
| Publication |
| First Author: |
Chaves de Souza JA |
| Year: |
2016 |
| Journal: |
Immunology |
| Title: |
NOD1 in the modulation of host-microbe interactions and inflammatory bone resorption in the periodontal disease model. |
| Volume: |
149 |
| Issue: |
4 |
| Pages: |
374-385 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
González-Ramos S |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
NOD1 deficiency promotes an imbalance of thyroid hormones and microbiota homeostasis in mice fed high fat diet. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
12317 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakajima A |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Commensal bacteria regulate thymic Aire expression. |
| Volume: |
9 |
| Issue: |
8 |
| Pages: |
e105904 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Netea MG |
| Year: |
2005 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. |
| Volume: |
102 |
| Issue: |
45 |
| Pages: |
16309-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Delgado C |
| Year: |
2015 |
| Journal: |
Cardiovasc Res |
| Title: |
NOD1, a new player in cardiac function and calcium handling. |
| Volume: |
106 |
| Issue: |
3 |
| Pages: |
375-86 |
|
•
•
•
•
•
|
| Allele |
| Name: |
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; mutation 5, Bruce Beutler |
| Allele Type: |
Chemically induced (ENU) |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
chemically induced mutation, coisogenic, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nod1/Nod1 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 |
| Background: |
C57BL/6J-Nfkb1 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen GY |
| Year: |
2008 |
| Journal: |
Cancer Res |
| Title: |
The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. |
| Volume: |
68 |
| Issue: |
24 |
| Pages: |
10060-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Asano J |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. |
| Volume: |
184 |
| Issue: |
2 |
| Pages: |
736-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park JH |
| Year: |
2007 |
| Journal: |
J Immunol |
| Title: |
Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. |
| Volume: |
179 |
| Issue: |
1 |
| Pages: |
514-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Berrington WR |
| Year: |
2010 |
| Journal: |
Eur J Immunol |
| Title: |
NOD1 and NOD2 regulation of pulmonary innate immunity to Legionella pneumophila. |
| Volume: |
40 |
| Issue: |
12 |
| Pages: |
3519-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee J |
| Year: |
2019 |
| Journal: |
Innate Immun |
| Title: |
NOD1/NOD2-mediated recognition of non-typeable Haemophilus influenzae activates innate immunity during otitis media. |
| Volume: |
25 |
| Issue: |
8 |
| Pages: |
503-512 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hasegawa M |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen. |
| Volume: |
186 |
| Issue: |
8 |
| Pages: |
4872-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iyer JK |
| Year: |
2010 |
| Journal: |
Infect Immun |
| Title: |
Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking. |
| Volume: |
78 |
| Issue: |
6 |
| Pages: |
2418-28 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nod1/Nod1 Nod2/Nod2 |
| Background: |
involves: 129 * 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miao EA |
| Year: |
2006 |
| Journal: |
Nat Immunol |
| Title: |
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. |
| Volume: |
7 |
| Issue: |
6 |
| Pages: |
569-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
González-Ramos S |
| Year: |
2020 |
| Journal: |
Cells |
| Title: |
Deletion or Inhibition of NOD1 Favors Plaque Stability and Attenuates Atherothrombosis in Advanced Atherogenesis †. |
| Volume: |
9 |
| Issue: |
9 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
González-Ramos S |
| Year: |
2019 |
| Journal: |
FASEB J |
| Title: |
Endothelial NOD1 directs myeloid cell recruitment in atherosclerosis through VCAM-1. |
| Volume: |
33 |
| Issue: |
3 |
| Pages: |
3912-3921 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fernández-García V |
| Year: |
2022 |
| Journal: |
Biomed Pharmacother |
| Title: |
NOD1 splenic activation confers ferroptosis protection and reduces macrophage recruitment under pro-atherogenic conditions. |
| Volume: |
148 |
|
| Pages: |
112769 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fernández-García V |
| Year: |
2022 |
| Journal: |
Cell Mol Life Sci |
| Title: |
High-fat diet activates splenic NOD1 and enhances neutrophil recruitment and neutrophil extracellular traps release in the spleen of ApoE-deficient mice. |
| Volume: |
79 |
| Issue: |
8 |
| Pages: |
396 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiao Y |
| Year: |
2013 |
| Journal: |
Cell Host Microbe |
| Title: |
Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity. |
| Volume: |
13 |
| Issue: |
5 |
| Pages: |
595-601 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim YG |
| Year: |
2008 |
| Journal: |
Immunity |
| Title: |
The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. |
| Volume: |
28 |
| Issue: |
2 |
| Pages: |
246-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Loving CL |
| Year: |
2009 |
| Journal: |
Infect Immun |
| Title: |
Nod1/Nod2-mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure. |
| Volume: |
77 |
| Issue: |
10 |
| Pages: |
4529-37 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE23497 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li SK |
| Year: |
2015 |
| Journal: |
J Immunol |
| Title: |
Identification of a negative regulatory role for spi-C in the murine B cell lineage. |
| Volume: |
194 |
| Issue: |
8 |
| Pages: |
3798-807 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kosoy R |
| Year: |
2005 |
| Journal: |
Genes Immun |
| Title: |
Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
231-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park JH |
| Year: |
2007 |
| Journal: |
J Immunol |
| Title: |
RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. |
| Volume: |
178 |
| Issue: |
4 |
| Pages: |
2380-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu AI |
| Year: |
2020 |
| Journal: |
Cell Rep |
| Title: |
Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
107471 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vlacil AK |
| Year: |
2020 |
| Journal: |
Basic Res Cardiol |
| Title: |
Deficiency of Nucleotide-binding oligomerization domain-containing proteins (NOD) 1 and 2 reduces atherosclerosis. |
| Volume: |
115 |
| Issue: |
4 |
| Pages: |
47 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Amer A |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. |
| Volume: |
281 |
| Issue: |
46 |
| Pages: |
35217-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ferwerda G |
| Year: |
2005 |
| Journal: |
PLoS Pathog |
| Title: |
NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. |
| Volume: |
1 |
| Issue: |
3 |
| Pages: |
279-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shaw PJ |
| Year: |
2011 |
| Journal: |
Immunity |
| Title: |
Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity. |
| Volume: |
34 |
| Issue: |
1 |
| Pages: |
75-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim DJ |
| Year: |
2013 |
| Journal: |
Eur J Immunol |
| Title: |
The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells. |
| Volume: |
43 |
| Issue: |
10 |
| Pages: |
2650-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Su Y |
| Year: |
2023 |
| Journal: |
Theranostics |
| Title: |
Inactivating IL34 promotes regenerating muscle stem cell expansion and attenuates Duchenne muscular dystrophy in mouse models. |
| Volume: |
13 |
| Issue: |
8 |
| Pages: |
2588-2604 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dooher JE |
| Year: |
2011 |
| Journal: |
Mol Cancer Res |
| Title: |
C/EBPα, C/EBPα oncoproteins, or C/EBPβ preferentially bind NF-κB p50 compared with p65, focusing therapeutic targeting on the C/EBP:p50 interaction. |
| Volume: |
9 |
| Issue: |
10 |
| Pages: |
1395-405 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nollet M |
| Year: |
2014 |
| Journal: |
Autophagy |
| Title: |
Autophagy in osteoblasts is involved in mineralization and bone homeostasis. |
| Volume: |
10 |
| Issue: |
11 |
| Pages: |
1965-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sowa AK |
| Year: |
2013 |
| Journal: |
Am J Pathol |
| Title: |
Functional interaction of osteogenic transcription factors Runx2 and Vdr in transcriptional regulation of Opn during soft tissue calcification. |
| Volume: |
183 |
| Issue: |
1 |
| Pages: |
60-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ermann J |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice. |
| Volume: |
111 |
| Issue: |
25 |
| Pages: |
E2559-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Anand PK |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. |
| Volume: |
286 |
| Issue: |
50 |
| Pages: |
42981-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Motomura Y |
| Year: |
2015 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis. |
| Volume: |
35 |
| Issue: |
6 |
| Pages: |
1423-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ippagunta SK |
| Year: |
2012 |
| Journal: |
Nat Immunol |
| Title: |
Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines. |
| Volume: |
13 |
| Issue: |
7 |
| Pages: |
701-2 |
|
•
•
•
•
•
|
| Allele |
| Name: |
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; targeted mutation 1, David Baltimore |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meunier C |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Positional mapping and candidate gene analysis of the mouse Ccs3 locus that regulates differential susceptibility to carcinogen-induced colorectal cancer. |
| Volume: |
8 |
| Issue: |
3 |
| Pages: |
e58733 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alkaissi H |
| Year: |
2018 |
| Journal: |
PLoS One |
| Title: |
Bank1 and NF-kappaB as key regulators in anti-nucleolar antibody development. |
| Volume: |
13 |
| Issue: |
7 |
| Pages: |
e0199979 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang S |
| Year: |
2019 |
| Journal: |
Sci Rep |
| Title: |
FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell proliferation and EMT in gastric cancer. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
5281 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hasegawa M |
| Year: |
2010 |
| Journal: |
Infect Immun |
| Title: |
Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development. |
| Volume: |
78 |
| Issue: |
2 |
| Pages: |
639-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oosting M |
| Year: |
2012 |
| Journal: |
Arthritis Res Ther |
| Title: |
Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3. |
| Volume: |
14 |
| Issue: |
6 |
| Pages: |
R247 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kanneganti TD |
| Year: |
2007 |
| Journal: |
Immunity |
| Title: |
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. |
| Volume: |
26 |
| Issue: |
4 |
| Pages: |
433-43 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, targeted mutation, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 Nfkbia/Nfkbia |
| Background: |
involves: 129S4/SvJae * C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 Rela/Rela Tnf/Tnf |
| Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 |
| Background: |
B6;129P-Nfkb1/J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 Rel/Rel |
| Background: |
involves: 129P2/OlaHsd * 129S1/Sv |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 Rela/Rela |
| Background: |
involves: 129P2/OlaHsd * 129S4/SvJae |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 Rela/Rela<+> |
| Background: |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 Tg(Tnfsf13b)1Fma/? |
| Background: |
B6.Cg-Nfkb1 Tg(Tnfsf13b)1Fma |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 |
| Background: |
B6.Cg-Nfkb1/J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 Nfkb2/Nfkb2 |
| Background: |
involves: 129P2/OlaHsd * 129S4/SvJae |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mir146/Mir146 Nfkb1/Nfkb1 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nfkb1/Nfkb1 Rel/Rel Rela/Rela Tg(Cd4-cre)1Cwi/? |
| Background: |
involves: 129 * 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bharadwaj R |
| Year: |
2023 |
| Journal: |
Immunity |
| Title: |
Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity. |
| Volume: |
56 |
| Issue: |
5 |
| Pages: |
998-1012.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kamimura Y |
| Year: |
2015 |
| Journal: |
Cell Rep |
| Title: |
Homeostatic control of memory cell progenitors in the natural killer cell lineage. |
| Volume: |
10 |
| Issue: |
2 |
| Pages: |
280-91 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
467
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
467
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
467
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kayagaki N |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
Non-canonical inflammasome activation targets caspase-11. |
| Volume: |
479 |
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7371 |
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117-21 |
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2009 |
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J Exp Med |
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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. |
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206 |
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Shenderov K |
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2013 |
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J Immunol |
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Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. |
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190 |
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11 |
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5722-30 |
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Karki R |
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2015 |
| Journal: |
Cell Host Microbe |
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Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection. |
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17 |
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3 |
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357-368 |
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Kang SJ |
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2008 |
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Immunity |
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29 |
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Han JH |
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2024 |
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Nat Commun |
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NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress. |
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15 |
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