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Search results 1201 to 1300 out of 1348 for Nrg1

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Type Details Score
Publication
First Author: Laforest B
Year: 2011
Journal: J Clin Invest
Title: Loss of Gata5 in mice leads to bicuspid aortic valve.
Volume: 121
Issue: 7
Pages: 2876-87
Publication
First Author: Vieira JR
Year: 2022
Journal: Neuron
Title: Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.
Volume: 110
Issue: 24
Pages: 4074-4089.e6
Publication
First Author: McKee KK
Year: 2012
Journal: J Cell Sci
Title: Schwann cell myelination requires integration of laminin activities.
Volume: 125
Issue: Pt 19
Pages: 4609-19
Publication
First Author: Nishimura S
Year: 2015
Journal: PLoS One
Title: Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
Volume: 10
Issue: 4
Pages: e0124295
Publication
First Author: Vijayaraj P
Year: 2012
Journal: Development
Title: Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis.
Volume: 139
Issue: 21
Pages: 3973-85
Publication
First Author: D'Amato G
Year: 2016
Journal: Nat Cell Biol
Title: Sequential Notch activation regulates ventricular chamber development.
Volume: 18
Issue: 1
Pages: 7-20
Publication
First Author: Nishida S
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Collagen VI suppresses fibronectin-induced enteric neural crest cell migration by downregulation of focal adhesion proteins.
Volume: 495
Issue: 1
Pages: 1461-1467
Publication  
First Author: Liu H
Year: 2023
Journal: Life Sci Alliance
Title: β-Catenin regulates endocardial cushion growth by suppressing p21.
Volume: 6
Issue: 9
Publication  
First Author: Wang Y
Year: 2018
Journal: J Mol Cell Cardiol
Title: NOTCH maintains developmental cardiac gene network through WNT5A.
Volume: 125
Pages: 98-105
Publication
First Author: Newbern JM
Year: 2011
Journal: Neuron
Title: Specific functions for ERK/MAPK signaling during PNS development.
Volume: 69
Issue: 1
Pages: 91-105
Publication
First Author: Watanabe Y
Year: 2006
Journal: Development
Title: Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse.
Volume: 133
Issue: 9
Pages: 1625-34
Publication
First Author: Cho E
Year: 2018
Journal: J Biol Chem
Title: Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.
Volume: 293
Issue: 30
Pages: 11659-11673
Publication  
First Author: Sandireddy R
Year: 2019
Journal: JCI Insight
Title: Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.
Volume: 4
Issue: 16
Publication  
First Author: Wang Y
Year: 2018
Journal: J Mol Cell Cardiol
Title: Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation.
Volume: 123
Pages: 150-158
Publication  
First Author: Moreau MX
Year: 2021
Journal: Development
Title: Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition.
Volume: 148
Issue: 14
Publication
First Author: Graef IA
Year: 2001
Journal: Cell
Title: Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.
Volume: 105
Issue: 7
Pages: 863-75
Publication    
First Author: Catela C
Year: 2022
Journal: Elife
Title: Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity.
Volume: 11
Publication
First Author: Guo Y
Year: 2024
Journal: Signal Transduct Target Ther
Title: Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy.
Volume: 9
Issue: 1
Pages: 32
Publication    
First Author: Qu X
Year: 2019
Journal: JCI Insight
Title: Tie2 regulates endocardial sprouting and myocardial trabeculation.
Volume: 5
Publication
First Author: Gacem N
Year: 2020
Journal: Nat Commun
Title: ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.
Volume: 11
Issue: 1
Pages: 198
Publication
First Author: Soleilhavoup C
Year: 2020
Journal: Nat Commun
Title: Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.
Volume: 11
Issue: 1
Pages: 3111
Publication
First Author: Patel VN
Year: 2024
Journal: Nat Commun
Title: Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.
Volume: 15
Issue: 1
Pages: 7584
Publication
First Author: Wu B
Year: 2023
Journal: J Am Heart Assoc
Title: Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development.
Volume: 12
Issue: 18
Pages: e029683
Publication
First Author: Lee JG
Year: 2024
Journal: Nat Commun
Title: PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
Volume: 15
Issue: 1
Pages: 1487
Publication      
First Author: Lexicon Genetics Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Lexicon Genetics, Inc. mice into public repositories
Publication
First Author: Shimogori T
Year: 2010
Journal: Nat Neurosci
Title: A genomic atlas of mouse hypothalamic development.
Volume: 13
Issue: 6
Pages: 767-75
Publication        
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Memic F
Year: 2018
Journal: Gastroenterology
Title: Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Volume: 154
Issue: 3
Pages: 624-636
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Publication      
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Allele
Name: transgene insertion, Cynthia S Weickert
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Modified isoform(s)
Allele
Name: neuregulin 1; targeted mutation 1, Junji Yamauchi
Allele Type: Targeted
Attribute String: Modified isoform(s)
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Buac K
Year: 2009
Journal: Pigment Cell Melanoma Res
Title: NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation.
Volume: 22
Issue: 6
Pages: 773-84
GO Term
Publication
First Author: Hegde GV
Year: 2013
Journal: Sci Transl Med
Title: Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer.
Volume: 5
Issue: 171
Pages: 171ra18
Allele
Name: transgene insertion 1, Klaus-Armin Nave
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1, Klaus-Armin Nave
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1, Shanghai Model Organisms Center
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
Strain
Attribute String: coisogenic, mutant strain, transgenic
Allele
Name: neuregulin 1; targeted mutation 1, Mingdong Zhou
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: transgene insertion 33, Steven L Carroll
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 34, Steven L Carroll
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: neuregulin 1; targeted mutation 1.1, David A Talmage
Allele Type: Targeted
Attribute String: Humanized sequence
Genotype
Symbol: Tg(Thy1-Nrg1*I)1Kan/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Thy1-Nrg1*III)1Kan/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Thy1-Nrg1*I)1Kan/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ot
Has Mutant Allele: true
Allele
Name: transgene insertion LS131, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: neuregulin 1; endonuclease-mediated mutation 2, Bin Zhou
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Inducible, Recombinase
Genotype
Symbol: Nrg1/Nrg1
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Nrg1/Nrg1<+>
Background: involves: 129S1/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Protein Domain
Type: Domain
Description: Neuregulins are a sub-family of EGF-like molecules that have been shown to play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses [, ]. Included in the family are heregulin; neu differentiation factor; acetylcholine receptor synthesis stimulator; glial growth factor; and sensory and motor-neuron derived factor []. Multiple family members are generated by alternate splicing or by use of several cell type-specific transcription initiation sites. In general, they bind to and activate the erbB family of receptor tyrosine kinases (erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4)), functioning both as heterodimers and homodimers.The transmembrane forms of neuregulin 1 (NRG1) are present within synaptic vesicles, including those containing glutamate []. After exocytosis, NRG1 is in the presynaptic membrane, where the ectodomain of NRG1 may be cleaved off. The ectodomain then migrates across the synaptic cleft and binds to and activates a member of the EGF-receptor family on the postsynaptic membrane. This has been shown to increase the expression of certain glutamate-receptor subunits. NRG1 appears to signal for glutamate-receptor subunit expression, localisation, and /or phosphorylation facilitating subsequent glutamate transmission. The NRG1 gene has been identified as a potential gene determining susceptibility to schizophrenia by a combination of genetic linkage and association approaches []. Membrane-anchored Nrg-1 isoforms consist of a variable N-terminal extracellular domain and a conserved transmembrane and C-terminal cytoplasmic domains []. This entry represents the C-terminal, intracellular domain.
Publication
First Author: Brosius SN
Year: 2014
Journal: Acta Neuropathol
Title: Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis.
Volume: 127
Issue: 4
Pages: 573-91
Publication
First Author: Fledrich R
Year: 2014
Journal: Nat Med
Title: Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A.
Volume: 20
Issue: 9
Pages: 1055-61
Strain
Attribute String: mutant stock, transgenic
Allele
Name: neuregulin 1; endonuclease-mediated mutation 1, Bin Zhou
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
Genotype
Symbol: Bace1/Bace1 Tg(Thy1-Nrg1*I)1Kan/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Nrg1/Nrg1<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
Allele
Name: transgene insertion FL, Markus H Schwab
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
Genotype
Symbol: Nrg1/Nrg1<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
Publication  
First Author: Kotzadimitriou D
Year: 2018
Journal: eNeuro
Title: Neuregulin 1 Type I Overexpression Is Associated with Reduced NMDA Receptor-Mediated Synaptic Signaling in Hippocampal Interneurons Expressing PV or CCK.
Volume: 5
Issue: 2
Allele
Name: transgene insertion GIEF, Markus H Schwab
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
Protein
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nrg1/Nrg1<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nrg1/Nrg1<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Grossmann KS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development.
Volume: 106
Issue: 39
Pages: 16704-9
Publication
First Author: D'Uva G
Year: 2015
Journal: Nat Cell Biol
Title: ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.
Volume: 17
Issue: 5
Pages: 627-38
Publication
First Author: Kim M
Year: 2018
Journal: Genes Dev
Title: Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Volume: 32
Issue: 9-10
Pages: 645-657
Publication
First Author: Forster N
Year: 2014
Journal: Dev Cell
Title: Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1.
Volume: 28
Issue: 2
Pages: 147-60
Publication
First Author: Grieco SF
Year: 2020
Journal: Curr Biol
Title: Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia.
Volume: 30
Issue: 18
Pages: 3591-3603.e8
Publication
First Author: Grieco SF
Year: 2021
Journal: Transl Psychiatry
Title: Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine.
Volume: 11
Issue: 1
Pages: 144