Type |
Details |
Score |
Protein Domain |
Type: |
Domain |
Description: |
This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) from mammals and aves. This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim YD |
Year: |
2011 |
Journal: |
Nucleic Acids Res |
Title: |
NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo. |
Volume: |
39 |
Issue: |
10 |
Pages: |
4300-14 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
542
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
331
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
403
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim CH |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Nuclear Speckle-related Protein 70 Binds to Serine/Arginine-rich Splicing Factors 1 and 2 via an Arginine/Serine-like Region and Counteracts Their Alternative Splicing Activity. |
Volume: |
291 |
Issue: |
12 |
Pages: |
6169-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu Q |
Year: |
2010 |
Journal: |
Mol Cells |
Title: |
Identification of an Arabidopsis Nodulin-related protein in heat stress. |
Volume: |
29 |
Issue: |
1 |
Pages: |
77-84 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Nodulin-related protein 1 (NRP1) may play a role in the negative-feedback regulation of the abscisic acid (ABA) synthesis pathway. Overexpression of NRP1 enhanced susceptibility to heat stress and was accompanied of decreased accumulation of ABA after heat treatment []. The function of NRP2 is not clear. |
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•
•
•
•
•
|
Publication |
First Author: |
Lapierre M |
Year: |
2014 |
Journal: |
J Clin Invest |
Title: |
RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. |
Volume: |
124 |
Issue: |
5 |
Pages: |
1899-913 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
119
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
85
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
78
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Romi E |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A. |
Volume: |
5 |
|
Pages: |
4058 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mo Z |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. |
Volume: |
9 |
Issue: |
1 |
Pages: |
1007 |
|
•
•
•
•
•
|
Publication |
First Author: |
Snuderl M |
Year: |
2013 |
Journal: |
Cell |
Title: |
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. |
Volume: |
152 |
Issue: |
5 |
Pages: |
1065-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sörensen I |
Year: |
2009 |
Journal: |
Blood |
Title: |
DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. |
Volume: |
113 |
Issue: |
22 |
Pages: |
5680-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gemmill RM |
Year: |
2017 |
Journal: |
Sci Signal |
Title: |
The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer. |
Volume: |
10 |
Issue: |
462 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Long JB |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
VEGF-A and Semaphorin3A: modulators of vascular sympathetic innervation. |
Volume: |
334 |
Issue: |
1 |
Pages: |
119-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gehrmann U |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation. |
Volume: |
116 |
Issue: |
51 |
Pages: |
25839-25849 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ruhrberg C |
Year: |
2002 |
Journal: |
Genes Dev |
Title: |
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. |
Volume: |
16 |
Issue: |
20 |
Pages: |
2684-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng Y |
Year: |
2022 |
Journal: |
Cell Death Differ |
Title: |
Regulation of Semaphorin3A in the process of cutaneous wound healing. |
Volume: |
29 |
Issue: |
10 |
Pages: |
1941-1954 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamizu K |
Year: |
2011 |
Journal: |
Blood |
Title: |
The κ opioid system regulates endothelial cell differentiation and pathfinding in vascular development. |
Volume: |
118 |
Issue: |
3 |
Pages: |
775-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bielenberg DR |
Year: |
2012 |
Journal: |
Am J Pathol |
Title: |
Increased smooth muscle contractility in mice deficient for neuropilin 2. |
Volume: |
181 |
Issue: |
2 |
Pages: |
548-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maimon R |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS. |
Volume: |
38 |
Issue: |
24 |
Pages: |
5478-5494 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGowan SE |
Year: |
2020 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Platelet-derived Growth Factor-α and Neuropilin-1 Mediate Lung Fibroblast Response to Rigid Collagen Fibers. |
Volume: |
62 |
Issue: |
4 |
Pages: |
454-465 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dang P |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
TAG1 regulates the endocytic trafficking and signaling of the semaphorin3A receptor complex. |
Volume: |
32 |
Issue: |
30 |
Pages: |
10370-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrews WD |
Year: |
2016 |
Journal: |
J Comp Neurol |
Title: |
Altered proliferative ability of neuronal progenitors in PlexinA1 mutant mice. |
Volume: |
524 |
Issue: |
3 |
Pages: |
518-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lim KH |
Year: |
2021 |
Journal: |
Front Genet |
Title: |
Identifying New COVID-19 Receptor Neuropilin-1 in Severe Alzheimer's Disease Patients Group Brain Using Genome-Wide Association Study Approach. |
Volume: |
12 |
|
Pages: |
741175 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krilleke D |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Molecular mapping and functional characterization of the VEGF164 heparin-binding domain. |
Volume: |
282 |
Issue: |
38 |
Pages: |
28045-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boscolo E |
Year: |
2011 |
Journal: |
Am J Pathol |
Title: |
VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma. |
Volume: |
179 |
Issue: |
5 |
Pages: |
2266-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jahnsen ED |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Notch1 is pan-endothelial at the onset of flow and regulated by flow. |
Volume: |
10 |
Issue: |
4 |
Pages: |
e0122622 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blondeau A |
Year: |
2016 |
Journal: |
Neural Dev |
Title: |
Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells. |
Volume: |
11 |
Issue: |
1 |
Pages: |
13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharifpanah F |
Year: |
2016 |
Journal: |
Biochim Biophys Acta |
Title: |
Mechanical strain stimulates vasculogenesis and expression of angiogenesis guidance molecules of embryonic stem cells through elevation of intracellular calcium, reactive oxygen species and nitric oxide generation. |
Volume: |
1863 |
Issue: |
12 |
Pages: |
3096-3105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2015 |
Journal: |
Sci Signal |
Title: |
DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis. |
Volume: |
8 |
Issue: |
369 |
Pages: |
ra31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee PS |
Year: |
2019 |
Journal: |
Diabetes |
Title: |
Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy. |
Volume: |
68 |
Issue: |
4 |
Pages: |
807-818 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Barros SC |
Year: |
2020 |
Journal: |
J Immunol |
Title: |
Pleiotropic Roles of VEGF in the Microenvironment of the Developing Thymus. |
Volume: |
205 |
Issue: |
9 |
Pages: |
2423-2436 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loeffler I |
Year: |
2013 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Erythropoietin ameliorates podocyte injury in advanced diabetic nephropathy in the db/db mouse. |
Volume: |
305 |
Issue: |
6 |
Pages: |
F911-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yombo DJK |
Year: |
2024 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF. |
Volume: |
326 |
Issue: |
6 |
Pages: |
C1659-C1668 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tatura R |
Year: |
2015 |
Journal: |
Immunology |
Title: |
Relevance of Foxp3⁺ regulatory T cells for early and late phases of murine sepsis. |
Volume: |
146 |
Issue: |
1 |
Pages: |
144-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tezuka K |
Year: |
2018 |
Journal: |
J Virol |
Title: |
Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor. |
Volume: |
92 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
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