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Search results 1201 to 1279 out of 1279 for Ntrk1

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Hits by Pathway

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Hits by Strain

Type Details Score
Protein
P81269
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
Q68FD5
Organism: Mus musculus/domesticus
Length: 1675  
Fragment?: false
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Protein
O08585
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein
Q8K3G5
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
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Publication
14976160 | J:90363
First Author: Einarsdottir E
Year: 2004
Journal: Hum Mol Genet
Title: A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception.
Volume: 13
Issue: 8
Pages: 799-805
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Protein Domain
IPR020437 | Nerve_growth_factor_bsu_mml
Type: Family
Description: During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is nerve growth factor (NGF), which is involved in the survival of some classes of embryonic neuron (e.g., peripheral sympathetic neurons) []. NGF is mostly found outside the central nervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has also been found in several snake venoms [, ]. Proteins similar to NGF include brain-derived neurotrophic factor (BDNF) and neurotrophins 3 to 7, all of which demonstrate neuron survival and outgrowth activities. Although NGF was originally identified in snake venom, its most abundant and best studied source is the submaxillary gland of adult male mice []. Mouse NGF is a high molecular weight hexamer, composed of 2 subunits each of alpha, beta and gamma polypeptides. The beta subunit (NGF-beta) is responsible for the physiological activity of the complex []. NGF-beta induces its cell survival effects through activation of neurotrophic tyrosine kinase receptor type 1 (NTRK1; also called TrkA), and can induce cell death by binding to the low affinity nerve growth factor receptor, p75NTR []. The neurotophin has been shown to be involved in sympathetic axon growth and innervation of target fields []. Mammalian NGF-beta tend to be higher potency NTRK1 agonsits than their snake venom counterparts []. In humans, NGF-beta gene mutations can cause a loss of pain perception [].
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Protein Coding Gene
MGI:88494 | Creb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109298 | Mapkapk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1100860 | Frs2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346347 | Mapk7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338024 | Mapk11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1342290 | Rps6ka2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891917 | Ywhab
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104558 | Rps6ka1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922019 | Pik3cb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1096342 | Rhoa
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104557 | Rps6ka3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9CQV8
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein
P49138
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: false
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Protein
P18654
Organism: Mus musculus/domesticus
Length: 740  
Fragment?: false
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Protein
Q9WUI1
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: false
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Protein
Q9WUT3
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
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Protein
P18653
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
Q8C180
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Protein
Q01147
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: false
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Protein
Q9WVS8
Organism: Mus musculus/domesticus
Length: 806  
Fragment?: false
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Protein
Q9QUI0
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
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Protein
P98083-3
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q8BTI9
Organism: Mus musculus/domesticus
Length: 1064  
Fragment?: false
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Protein Coding Gene
MGI:1346865 | Mapk14
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2388481 | Ppp2r5d
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97376 | Nras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96680 | Kras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96224 | Hras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098772 | Pik3r2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61411
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P32883
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P08556
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P47811
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: false
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Protein
O08908
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
Q7TNL5
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Publication
1055377 | -
First Author: Wlodawer A
Year: 1975
Journal: Proc Natl Acad Sci U S A
Title: Crystallization of nerve growth factor from mouse submaxillary glands.
Volume: 72
Issue: 3
Pages: 777-9
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Publication
11437236 | -
First Author: Wiesmann C
Year: 2001
Journal: Cell Mol Life Sci
Title: Nerve growth factor: structure and function.
Volume: 58
Issue: 5-6
Pages: 748-59
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Publication
14529729 | -
First Author: Katzir I
Year: 2003
Journal: Toxicon
Title: Characterization of nerve growth factors (NGFs) from snake venoms by use of a novel, quantitative bioassay utilizing pheochromocytoma (PC12) cells overexpressing human trkA receptors.
Volume: 42
Issue: 5
Pages: 481-90
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Protein Coding Gene
MGI:97583 | Pik3r1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98354 | Sos1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1206581 | Pik3ca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1321161 | Ppp2cb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920949 | Ppp2r1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q7TNP2
Organism: Mus musculus/domesticus
Length: 601  
Fragment?: false
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Protein
P26450
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
Q62245
Organism: Mus musculus/domesticus
Length: 1319  
Fragment?: false
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Protein
P62715
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
P42337
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: false
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Protein Coding Gene
MGI:1321159 | Ppp2ca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346858 | Mapk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926334 | Ppp2r1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346859 | Mapk3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q76MZ3
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
P63085
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Protein
Q63844
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
P63330
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q60631-1
 
Organism: Mus musculus/domesticus
Length:  
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Protein
Q6LDU8
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
A0A0G2JEK0
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
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Publication
2369898 | J:18432
First Author: Hofer M
Year: 1990
Journal: EMBO J
Title: Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.
Volume: 9
Issue: 8
Pages: 2459-64
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Protein
B5BQV3
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
A0A286YDA0
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
A0A286YCV8
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q3UHE3
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
A0A286YDA3
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
B5BQV4
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: false
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Publication
1477101 | -
First Author: Koyama J
Year: 1992
Journal: Biochim Biophys Acta
Title: Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli.
Volume: 1160
Issue: 3
Pages: 287-92
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Publication
1995338 | -
First Author: Inoue S
Year: 1991
Journal: FEBS Lett
Title: Amino acid sequences of nerve growth factors derived from cobra venoms.
Volume: 279
Issue: 1
Pages: 38-40
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Protein
Q6VNS1
Organism: Mus musculus/domesticus
Length: 825  
Fragment?: false
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Protein
P15209
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
A0A0A6YWL7
Organism: Mus musculus/domesticus
Length: 864  
Fragment?: false
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Protein
A0A0A6YWF9
Organism: Mus musculus/domesticus
Length: 839  
Fragment?: false
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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